Hypothesis
Version 1
Preserved in Portico This version is not peer-reviewed
Lymphatics — Future Perspectives Unrealized Potential
Version 1
: Received: 15 May 2023 / Approved: 16 May 2023 / Online: 16 May 2023 (08:51:13 CEST)
A peer-reviewed article of this Preprint also exists.
Houck, P.D.; Dandapantula, H.K.; Massey, J.M. Lymphatics: Future Perspectives Unrealized Potential. Lymphatics 2023, 1, 87-96. Houck, P.D.; Dandapantula, H.K.; Massey, J.M. Lymphatics: Future Perspectives Unrealized Potential. Lymphatics 2023, 1, 87-96.
Abstract
Proposed fundamental laws of biology and a model of health and disease underscore the importance of the lymphatic system. The lymphatics are responsible for two of the laws of biology and the fulcrum of health and disease balancing proliferation with regeneration through the immune system. It is responsible for protection from the environment and repair of senile and damaged tissue. Life is constantly bombarded by forces that increase entropy. Lymphatics provide negative entropy to maintain health. Lymphatics help maintain cellular homeostasis removing products of metabolism. Using these principles, the role of lymphatics is investigated in salt sensitivity hypertension, cardiorenal system, the new pillar of heart failure and kidney disease - Sodium-Glucose Transport Protein 2 (SGLT2) Inhibitors, and brain diseases. The realization of organ lymphatics in maintenance of health and disease opens the avenue to new therapeutics. This is the unrealized potential of lymphatic study.
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Keywords
Lymphangiontrope; salt sensitivity; cardiorenal syndrome; SGLT2 inhibitors; Down’s syndrome; depression; schizophrenia; C Reactive Protein
Subject
Biology and Life Sciences, Anatomy and Physiology
Copyright: This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
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