Version 1
: Received: 18 April 2023 / Approved: 19 April 2023 / Online: 19 April 2023 (07:52:17 CEST)
How to cite:
Tomasetti, C.; Autullo, G.; Ballerini, A.; De Bartolomeis, A.; Dell'Osso, B.M.; Fiorentini, A.; Tonioni, F.; Villari, V.; De Berardis, D. Treating Depression in Patients with Borderline Personality Disorder: Clinical Clues on the Use of Antidepressants. Preprints2023, 2023040564. https://doi.org/10.20944/preprints202304.0564.v1
Tomasetti, C.; Autullo, G.; Ballerini, A.; De Bartolomeis, A.; Dell'Osso, B.M.; Fiorentini, A.; Tonioni, F.; Villari, V.; De Berardis, D. Treating Depression in Patients with Borderline Personality Disorder: Clinical Clues on the Use of Antidepressants. Preprints 2023, 2023040564. https://doi.org/10.20944/preprints202304.0564.v1
Tomasetti, C.; Autullo, G.; Ballerini, A.; De Bartolomeis, A.; Dell'Osso, B.M.; Fiorentini, A.; Tonioni, F.; Villari, V.; De Berardis, D. Treating Depression in Patients with Borderline Personality Disorder: Clinical Clues on the Use of Antidepressants. Preprints2023, 2023040564. https://doi.org/10.20944/preprints202304.0564.v1
APA Style
Tomasetti, C., Autullo, G., Ballerini, A., De Bartolomeis, A., Dell'Osso, B.M., Fiorentini, A., Tonioni, F., Villari, V., & De Berardis, D. (2023). Treating Depression in Patients with Borderline Personality Disorder: Clinical Clues on the Use of Antidepressants. Preprints. https://doi.org/10.20944/preprints202304.0564.v1
Chicago/Turabian Style
Tomasetti, C., Vincenzo Villari and Domenico De Berardis. 2023 "Treating Depression in Patients with Borderline Personality Disorder: Clinical Clues on the Use of Antidepressants" Preprints. https://doi.org/10.20944/preprints202304.0564.v1
Abstract
Personality disorders (PD) are described as enduring patterns of markedly deviant and pervasive inner experiences and behaviors, with onset in adolescence, which lead to severe distress or impairment. Patients suffering with major depressive disorder (MDD) display higher rates of comorbidity with personality disorders, often complicating the treatment, and worsening the outcome. Borderline personality disorder (BPD) is the most common of PD and is frequently associated with MDD, with which shares several features. The most part of research agrees on the fact that comorbid BPD in MDD patients quite double the poor response to treatments. Moreover, no treatment strategy stands out currently to emerge as more effective in these cases, thus urging the call for the need of a new approach. Herein, we revise the current literature on BPD, its neurobiology and comorbidity with MDD, as well as the more recent treatment strategies used. Then, based on its pharmacology, we propose a possible role of trazodone as a valuable tool to approach underlying BPD in MDD
Medicine and Pharmacology, Psychiatry and Mental Health
Copyright:
This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
