Shenoy, P.V.; Nag, R.; Kolathur, K.K.; Malik, Y.; Varanasi, S.M.; Angom, R.S.; Mukhopadhyay, D. Molecular, Genetic Susceptibility and Immunotherapy of Melanoma. Preprints2023, 2023090120. https://doi.org/10.20944/preprints202309.0120.v1
APA Style
Shenoy, P.V., Nag, R., Kolathur, K.K., Malik, Y., Varanasi, S.M., Angom, R.S., & Mukhopadhyay, D. (2023). Molecular, Genetic Susceptibility and Immunotherapy of Melanoma. Preprints. https://doi.org/10.20944/preprints202309.0120.v1
Chicago/Turabian Style
Shenoy, P.V., Ramcharan Singh Angom and Debabrata Mukhopadhyay. 2023 "Molecular, Genetic Susceptibility and Immunotherapy of Melanoma" Preprints. https://doi.org/10.20944/preprints202309.0120.v1
Abstract
Skin cancer is a prevalent and heterogenous disease with several subtypes, such as melanoma, basal cell carcinoma, and squamous cell carcinoma. Among them, melanoma is the most aggressive subtype, with a higher propensity to spread compared to most solid tumors. The application of OMICS approaches has revolutionized the field of melanoma research by providing comprehensive insights into the molecular alterations and biological processes underlying melanoma development and progression. This review aims to offer an overview of melanoma biology, covering its transition from primary to malignant melanoma, as well as the key genes and pathways involved in the initiation and progression of this disease. Utilizing online databases, we extensively explored the general expression profile of genes, identified the most frequently altered genes, and gene mutations, and examined genetic alterations responsible for drug resistance. Additionally, we studied the mechanisms responsible for immune checkpoint inhibitors resistance in melanoma.
Biology and Life Sciences, Cell and Developmental Biology
Copyright:
This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
,
*
