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Preprint ARTICLE | doi:10.20944/preprints201901.0220.v1

Renoprotective Effect of Laminaria japonica Polysaccharide in Adenine-Induced Chronic Renal Failure

Miao Long, Qiang-Ming Li, Qing Fang, Li-Hua Pan, Xue-Qiang Zha, Jian-Ping Luo

Subject: Biology And Life Sciences, Biochemistry And Molecular Biology Keywords: Laminaria japonica; polysaccharide; chronic renal failure

Online: 22 January 2019 (11:50:15 CET)

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Preprint REVIEW | doi:10.20944/preprints202106.0609.v1

Treatment-Free Remission in Chronic Myeloid Leukaemia: Can We Identify Prognostic Factors?

Hilbeen Hisham Saifullah, Claire Marie Lucas

Subject: Medicine And Pharmacology, Immunology And Allergy Keywords: Chronic myeloid leukaemia; chronic phase; Tyrosine kinase inhibitor; Treatment free remission; deep molecular response; BCR-ABL.

Online: 25 June 2021 (08:13:40 CEST)

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Preprint ARTICLE | doi:10.20944/preprints202004.0301.v2

Therapeutic Effects of Traditional Chinese Medicine Formula Qianlie Tongli Decoction on Chronic Prostatitis/Chronic Pelvic Pain Syndrome Induced by Peptide T2 in Mice

Xingxing Cui, Muhammad Naveed, Mirza Muhammad Faran Ashraf Baig, Wenlu Wang, Reyaj Mikrani, Ziwei Liu, Bilal Ahmed, Meng Tang, Junaid Wazir, Xiaohui Zhou

Subject: Medicine And Pharmacology, Urology And Nephrology Keywords: Qianlie Tongli decoction; chronic prostatitis/chronic pelvic pain syndrome (CP/CPPS); anti-inflammation; therapeutic effects; immunization

Online: 24 April 2020 (04:30:56 CEST)

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Preprint REVIEW | doi:10.20944/preprints202311.0804.v1

Metabolic Dysfunction-Associated Fatty Liver Disease and Chronic Viral Hepatitis: The Interlink

Cornelius J Fernandez, Mohammed Alkhalifah, Hafsa Afzar, Joseph M Pappachan

Subject: Medicine And Pharmacology, Endocrinology And Metabolism Keywords: metabolic dysfunction-associated fatty liver disease (MAFLD); chronic viral hepatitis; Hepatitis B virus (HBV); Hepatitis C virus; Hepatic Fibrosis; Cirrhosis; and Hepatocellular carcinoma

Online: 14 November 2023 (05:28:01 CET)

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Preprint REVIEW | doi:10.20944/preprints202005.0340.v1

Roles of Cannabidiol in Reversing Proteinopathies

Raju Dash, Md. Chayan Ali, Israt Jahan, Yeasmin Akter Munni, Sarmistha Mitra, Md. Abdul Hannan, Binod Timalsina, Diyah Fatimah Oktaviani, Ho Jin Choi, Il Soo Moon

Subject: Medicine And Pharmacology, Pharmacology And Toxicology Keywords: Cannabidiol; Alzheimer's disease; Huntington's disease; Multiple sclerosis; Parkinson’s disease; Prion disease; Proteinopathies

Online: 21 May 2020 (09:43:09 CEST)

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Preprint REVIEW | doi:10.20944/preprints202402.1353.v1

Advancements in Fish Vaccination: Current Innovations and Future Horizons in Aquaculture Health Management

Garima S Rathor, Banikalyan Swain

Subject: Biology And Life Sciences, Immunology And Microbiology Keywords: Infectious disease agents in aquaculture; Fish Vaccine, Fish immunology; Bacterial, viral, and parasitic diseases in aquaculture; Recombinant live attenuated, subunit, DNA, and RNA vaccines for fish; Sustainability of aquaculture; The innate and adaptive immune system of fish; Fish immunological mechanisms

Online: 24 February 2024 (08:58:46 CET)

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Preprint ARTICLE | doi:10.20944/preprints202201.0338.v1

Emergent Viral Disease in Alfalfa (Medicago sativa L.) Plots in Cochabamba, Bolivia, a Preliminary Evaluation

Mario Coca Morante, Nilo Acha Molina, Arnold Calani Lucas, Ruddy Meneses Arce

Subject: Biology And Life Sciences, Virology Keywords: disease incidence; emerging disease; Cultivated forage crops; plant pathology; disease incidence; emerging disease

Online: 24 January 2022 (09:57:58 CET)

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Preprint CASE REPORT | doi:10.20944/preprints202403.1619.v1

A Rare Onset of T Lymphoid Blast Crisis in Chronic Myeloid Leukemia with Two Distinct Blast Populations

Alessandra Mongia, Francesca Romano, Sara Ciullini Mannurita, Benedetta Peruzzi, Sara Bencini, Daniela Parrini, Laura Fasano, Alessandra Fanelli

Subject: Medicine And Pharmacology, Hematology Keywords: chronic myeloid leukemia; T lymphoid blastic crisis

Online: 27 March 2024 (06:21:04 CET)

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Preprint ARTICLE | doi:10.20944/preprints202403.1518.v1

Changes of Periodontal Parameters and Microbiome Composition of Tooth Pocket in Patients with Chronic Inflammatory Diseases Receiving Targeted Anti-Cytokine Therapy

Juliane Wagner, Luisa Haker, Louisa Mewes, Corinna Bang, Malte Rühlemann, Hendrik Naujokat, Johannes Heinrich Spille, Wolfgang Lieb, André Franke, Stefan Schreiber, Matthias Laudes, Christof Dörfer, Jörg Wiltfang, Christian Graetz, Dominik Maria Schulte

Subject: Medicine And Pharmacology, Dentistry And Oral Surgery Keywords: chronic inflammation; periodontitis; microbiome; anti-cytokine therapy

Online: 26 March 2024 (11:03:52 CET)

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Preprint REVIEW | doi:10.20944/preprints202402.1023.v1

The Potential Role of Stem Cells in Wound Healing: A Systematic Review

Banu Farabi, Katie Roster, Rahim Hirani, Katharine Tepper, Mehmet Fatih Atak, Bijan Safai

Subject: Medicine And Pharmacology, Dermatology Keywords: stem cells; chronic wound; wound healing; dermatology

Online: 19 February 2024 (08:19:53 CET)

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Introduction: Wound healing is a complex cascade involving the orchestration of inflammatory cells, skin fibroblasts, keratinocytes, and endothelial cells. These cells achieve tissue repair through an interchange of cytokines and growth factors through a controlled inflammation, angiogenesis, and remodeling process. Disruptions in the wound-healing process by comorbid conditions lead to significant morbidity and mortality. Stem cell therapy has emerged as a new strategy to facilitate the wound healing process. Stem cells harvested from different sources can be used for wound repair and regeneration (endothelial progenitor cells, bone marrow, adipose tissue, dermal and inducible pluripotent stem cells). We aimed to review clinical, translational, and primary literature on stem cell therapies in chronic wounds and summarize practical clinical applications to dermatological care. Materials and Methods: A comprehensive search of Pubmed, Embase, Web of Science, Google Scholar, and Cochrane Library was conducted for studies relating to stem cells and wound healing. Duplicate results were removed using Covidence. Titles and abstracts were screened by two independent researchers (BF and KR), with discrepancies resolved through discussion and mutual agreement. Articles were excluded if they were review-type or commentary-type articles. Results: A total of 22,454 articles were retrieved from the search. Deduplication removed 905, and automation removed an additional 18,363 articles. After an initial screening of titles and abstracts, 170 articles remained. Full-text screening resulted in an additional 126 articles being removed, leaving 44 included studies. Discussion: Stem cells used for wound repair and regeneration include endothelial progenitor stem cells and adult stem cells, in the forms of bone marrow-derived mesenchymal stem cells, adipose tissue stem cells, and inducible pluripotent stem cells. Among these sources, adipose tissue-derived mesenchymal stem cells (AD-MSCs) are ideally used due to the abundant supply of fat tissue, ease of isolation, extensive proliferative capacities ex vivo, and their ability to secrete pro-angiogenic factors. AD-MSCs have been used to enhance wound healing in peripheral arterial disease, diabetic wounds, hypertensive ulcers, bullous diabeticorum, venous ulcers, and postsurgical wounds after Mohs micrographic surgery. These cells have been delivered to the tissue topically, with scaffolds, combined with plasma-rich proteins, and through atelocollagen in various human studies. These approaches, when combined with local wound care practices, resulted in decreased pain, shorter wound healing times, and better cosmesis. Conclusions: Stem cell transplantation is a potential therapeutic approach in the wound healing process. Transplanted stem cells do not only differentiate into multiple skin cell types but also provide cytokine and growth factors required for wound healing resulting in increased angiogenesis. Thus, this approach may be regarded as an attractive option for intractable wounds that cause major clinical problems, especially chronic lower leg wounds. It can also be used after Mohs micrographic surgery for defects left to heal by secondary intention. Stem cell application may reduce the overall cost burden on the healthcare system and improve the quality of life for patients.

Preprint REVIEW | doi:10.20944/preprints202401.1632.v1

The Efficacy of a Novel Compound from Bovine Milk Colostrum Exosomes and Its Growth Factors in Enhancing the Process of Wound Healing

Mojgan Najafzadeh, Shohreh Jafarinejad, Adi Baumgartner, Jacobo Elies Gomez

Subject: Medicine And Pharmacology, Dermatology Keywords: Bovine Colostrum; Wound healing; Repair; Chronic wound

Online: 23 January 2024 (07:27:48 CET)

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Preprint REVIEW | doi:10.20944/preprints202401.0959.v1

Unraveling the Complex Web of Fibromyalgia: A Narrative Review

Sarah Al Sharie, Scott J. Varga, Lou’i Al-Husinat, Piercarlo Sarzi-Puttini, Mohammad Araydah, Batool Riyad Bal’awi, Giustino Varrassi

Subject: Medicine And Pharmacology, Anesthesiology And Pain Medicine Keywords: Fibromyalgia, Chronic pain, Diagnosis, Management, Emerging treatments.

Online: 12 January 2024 (10:01:35 CET)

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Preprint COMMUNICATION | doi:10.20944/preprints202305.1381.v1

Chronic Viral Hepatitis in Children: Socio-Economic Implications in Romania

Irina Dijmărescu, Alexandra Coroleuca, Adrian Dumitru Dijmarescu

Subject: Public Health And Healthcare, Public Health And Health Services Keywords: chronic viral hepatitis; socio-economic status; children

Online: 19 May 2023 (05:07:14 CEST)

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Preprint REVIEW | doi:10.20944/preprints202304.1093.v1

Microglial Responses to Stress-Induced Depression: Causes and Consequences

Ruqayya Afridi, Kyoungho Suk

Subject: Biology And Life Sciences, Neuroscience And Neurology Keywords: chronic stress; depression; microglia; neuroinflammation; proinflammatory cytokines

Online: 28 April 2023 (03:28:05 CEST)

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Preprint ARTICLE | doi:10.20944/preprints202301.0168.v1

Microbiome Responses to Fecal Microbiota Transplantation in Cats with Chronic Digestive Issues

Connie Rojas, Zhandra Entrolezo, Jessica K. Jarett, Guillaume Jospin, Dawn Kingsbury, Alex Martin, Jonathan A. Eisen, Holly H Ganz

Subject: Medicine And Pharmacology, Veterinary Medicine Keywords: fecal microbiota transplant; domestic cat; chronic enteropathies

Online: 10 January 2023 (02:15:25 CET)

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There is growing interest in the application of fecal microbiota transplants (FMTs) in small animal medicine, but there are few published studies that have tested their effectiveness in the domestic cat (Felis catus). Here we use 16S rRNA gene sequencing to examine fecal microbiome changes in 68 domestic cats with chronic digestive issues that underwent FMT treatment using lyophilized stool that was delivered in oral capsules. Fecal samples were collected from FMT recipients before and two weeks after treatment, as well as from their stool donors, and healthy animals. We found that according to their owners, 77% of cats were reported to show improvement in their clinical signs (termed ‘Responders’), and 23% were reported to exhibit no change or a worsening of their clinical signs (termed ‘Non-Responders’). Variation in the fecal microbiomes of FMT recipients most strongly correlated with host clinical signs, diet, and IBD diagnosis. The relative abundances of Collinsella, Negativibacillus, Parabacteroides, and Peptoclostridium changed differentially in FMT recipients. Overall, on average 13% of the bacterial amplicon sequence variants (ASVs) were shared between stool donors and FMT recipients (excluding ASVs already present in FMT recipients prior to treatment). The most commonly shared ASVs were classified as Prevotella 9, Peptoclostridium, Bacteroides, Collinsella and unclassified Lachnospiraceae. Lastly, FMT recipients that had recently taken antibiotics exhibited increases in microbiome similarity to an age-matched healthy reference set compared to other cats. Cats that had diarrhea or diarrhea with vomiting became more similar to healthy cats than did cats exhibiting other clinical signs. Overall, our results suggest that oral capsule FMT treatment was effective in this group of cats and microbiome responses may be modulated by the FMT recipient’s initial presenting clinical signs, prior IBD diagnosis, recent antibiotic use, and their diet.

Preprint ARTICLE | doi:10.20944/preprints202211.0365.v2

Chronic Inflammation and Blood Cancer

Nikolaos Tzenios, Mary Tazanios, Mohamad Chahine

Subject: Medicine And Pharmacology, Oncology And Oncogenics Keywords: blood cancer; chronic inflammation; inflammation; mutation; tumor

Online: 24 November 2022 (02:55:44 CET)

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Preprint REVIEW | doi:10.20944/preprints202207.0341.v1

Regulation and Impact of Hepatitis B x Protein in Persistence and Oncogenesis of Hepatitis B Virus

Garima Garg, Shashank Purwar, Anirudh K. Singh, Ashish Kumar Vyas

Subject: Biology And Life Sciences, Virology Keywords: Hepatitis B Virus; Chronic Hepatitis infection; Oncogenesis

Online: 22 July 2022 (13:18:26 CEST)

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Preprint ARTICLE | doi:10.20944/preprints202207.0198.v1

Association of Serum and Urinary Magnesium Levels With Body Composition and Inflammatory Markers in Patients With Non-dialysis Chronic Kidney Disease: A Longitudinal Approach

Raimunda Sheyla Carneiro Dias, Dyego José de Araújo Brito, Cleodice Alves Martins, Elton Jonh Freitas Santos, Erika Cristina Ribeiro de Lima Carneiro, Elisangela Milhomen dos Santos, Denizar Vianna Araújo, Natalino Salgado Filho, Mario Bernardo Filho

Subject: Biology And Life Sciences, Biochemistry And Molecular Biology Keywords: Magnesium deficiency; Body composition; Chronic kidney failure.

Online: 13 July 2022 (09:27:18 CEST)

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Preprint ARTICLE | doi:10.20944/preprints202103.0645.v1

Can a single trial of a thoracolumbar myofascial release technique reduce pain and disability in chronic low back pain? Randomized balanced cross-over study

Luana Rocha Paulo, Ana Cristina Rodrigues Lacerda, Fábio Luiz Mendonça Martins, José Sebastião Cunha Fernandes, Leonardo Sette Vieira, Cristiano Queiroz Guimarães, Sílvia de Simoni Guedes Ballesteros, Marco Túlio Saldanha dos Anjos, Patrícia Aparecida Tavares, Sueli Ferreira da Fonseca, Murilo Xavier Oliveira, Mário Bernardo-Filho, Danúbia da Cunha de Sá-Caputo, Vanessa Amaral Mendonça, Redha Taiar

Subject: Medicine And Pharmacology, Orthopedics And Sports Medicine Keywords: fascia; chronic low back pain; myofascial release

Online: 25 March 2021 (16:24:46 CET)

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Preprint ARTICLE | doi:10.20944/preprints202103.0577.v1

Association of Edentulism With Various Chronic Diseases in Mexican Elders 60+ Years: Results of a Population-Based Survey

Alejandro José Casanova-Rosado, Juan Fernando Casanova-Rosado, Mirna Minaya-Sánchez, José Luís Robles-Minaya, Juan Alejandro Casanova-Sarmiento, María de Lourdes Márquez-Corona, América Patricia Pontigo-Loyola, Horacio Isla-Granillo, Mariana Mora-Acosta, Sonia Márquez-Rodríguez, Carlo Eduardo Medina-Solís, Gerardo Maupomé

Subject: Medicine And Pharmacology, Immunology And Allergy Keywords: Oral health; edentulism; chronic diseases; elders; Mexico

Online: 24 March 2021 (11:38:36 CET)

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Preprint ARTICLE | doi:10.20944/preprints202103.0186.v1

Microglia and Inhibitory Circuitry in the Medullary Dorsal Horn: Laminar and Time-Dependent Changes in a Trigeminal Model of Neuropathic Pain

Nuria García-Magro, Yasmina B. Martin, Pilar Negredo, Francisco Zafra, Carlos Avendaño

Subject: Biology And Life Sciences, Biochemistry And Molecular Biology Keywords: chronic pain; allodynia; trigeminocervical complex; glycine transporters

Online: 5 March 2021 (11:47:51 CET)

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Preprint ARTICLE | doi:10.20944/preprints202008.0199.v1

Clinicopathological Variables and Outcome in Chronic Phase Chronic Myeloid Leukemia Associated with BCR-ABL1 Transcript Type and Body Weight

Mohammad Abdulla, Prem Chandra, Susanna El Akiki, Claudio Sorio, Luisa Tomasello, Christian Boni, Mohamed Yassin

Subject: Medicine And Pharmacology, Oncology And Oncogenics Keywords: chronic myeloid leukemia; BCR-ABL1 transcript; obesity

Online: 7 August 2020 (13:07:53 CEST)

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Preprint ARTICLE | doi:10.20944/preprints201905.0235.v1

The Cost of Chronic Wounds in Argentina: An Estimation of the Burden in a Public Hospital

Romina Chavez-Jara, Nicolas Cerusico, Maria Lazarte, Carla Cabrera, Andrea Herrera Bruno, Eugenia Sesto Cabral, Alberto Nicolas Ramos

Subject: Public Health And Healthcare, Public Health And Health Services Keywords: chronic wound; hospital cost; epidemiology; public health

Online: 20 May 2019 (09:53:44 CEST)

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Preprint ARTICLE | doi:10.20944/preprints201809.0028.v2

Motivating Diabetic and Hypertensive Patients to Engage in Regular Physical Activity: A Multi-Component Intervention Derived from the Concept of Photovoice

Angela Y. M. Leung, Pui Hing Chau, Isaac S. H. Leung, Michael Tse, Perick Lai Choi Wong, Wai Ming Tam, Doris Y. P. Leung

Subject: Public Health And Healthcare, Physical Therapy, Sports Therapy And Rehabilitation Keywords: photovoice; chronic illness; physical activity; barriers; facilitator

Online: 2 April 2019 (07:48:28 CEST)

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Aims: A community-based multi-component intervention (increasing awareness of the importance of physical activity in chronic illness management through reading comic books, training regarding warm-up stretching exercises, identifying facilitators and barriers to exercise through photosharing, supporting self-reflection and development of action plans) was developed to promote physical activity (PA) among patients with diabetes and hypertension. This study aimed to evaluate the efficacy of this intervention on health behaviour (walking) and health outcomes. Design: A non-randomized controlled trial with waitlisted control and pre- and post-measures. Setting: Community centres for the elderly. Participants: A total of 204 older adults with diabetes and/or hypertension were recruited. They were assigned to either the intervention group (IG) or waitlisted to the control group (CG). Intervention: Under the supervision of a nurse, six weekly group meetings were arranged in community centres for the elderly in which the participants freely exchanged their views regarding the barriers and facilitators of regular physical activity. Participants were encouraged to take photos in their neighbourhood or at home and brought these photos to share at the group meetings. The photos showed both the barriers and the facilitators to PA. In the last meeting, each participant worked out a plan to perform PA in the coming four weeks. Measures: PA referred to the number of steps taken per day and it was measured by a Garmin Accelerometer at baseline, Week 6 and Week 10. Other measures included the nine-item Self-Efficacy Scale for Exercise - Chinese version (SEE-C), the 23-item Chinese Barriers to Exercise Scale and Senior Fitness Tests. Generalised Estimating Equations (GEE) models compared the outcomes over time between IG and CG. Results: A statistically significant difference in the changes in the average number of steps taken daily between the two groups at Week 10 (mean difference = 965.4; 95% confidence interval: 92.2, 1838.6, p = 0.030) was observed, although the difference at Week 6 was non-significant (mean difference = 777.6; 95% confidence interval: −35.3, 1590.5, p = 0.061). IG participants also showed significant improvements in lower body strength (mean difference = 0.967; 95% confidence interval: 0.029, 1.904, p = 0.043) and lower limb flexibility (mean difference = 2.068; 95% confidence interval: 0.404, 3.731, p = 0.015) at Week 10 compared to CG participants. Conclusion: This multi-component intervention improved the participants’ physical activity level and physical fitness, particularly in lower limb flexibility and body strength.

Preprint ARTICLE | doi:10.20944/preprints201807.0545.v1

Can the Mindful Awareness and Resilience Skills for Adolescents (MARS-A) program be provided online? Voices from the Youth

Nicholas Chadi, Elli Weisbaum, Catherine Malboeuf-Hurtubise, Sara Ahola Kohut, Christine Viner, Miriam Kaufman, Jake Locke, Dzung X. Vo

Subject: Medicine And Pharmacology, Pediatrics, Perinatology And Child Health Keywords: qualitative, mindfulness, meditation, chronic illness, adolescents, eHealth

Online: 27 July 2018 (15:34:58 CEST)

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Preprint REVIEW | doi:10.20944/preprints202007.0534.v1

Renal Disease in Patients with Crohn's Disease

Linda Atencio Ibarra, Roberto Navarro Quiroz, Gustavo Aroca Martinez, Joany Sarmiento Gutierrez, Andres Cadena Bonfanti, Leandro Sierra Carrero, Lorena Gomez Escorcia, Roberto Garcia Alzate, Maria Ospino Rodriguez, Daisy Lozano Arias, Henry Gonzales Torres, Carmen Carrero Gonzalez, Cecilia Fernandez-Ponce, Elkin Navarro Quiroz

Subject: Medicine And Pharmacology, Gastroenterology And Hepatology Keywords: Crohn's disease; renal disease; amyloidosis

Online: 23 July 2020 (07:50:19 CEST)

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Preprint REVIEW | doi:10.20944/preprints202002.0036.v1

Amyloidosis and Renal Disease in Patients with Crohn's Disease

Roberto Navarro Quiroz, Gustavo Aroca Martinez, Linda Atencio Ibarra, Maria Ospino Rodriguez, Joany Sarmiento Gutierrez, Andres Cadena Bonfanti, Esperanza Diaz Arroyo, Lorena Gomez Escorcia, Jose Luis Villarreal, Roberto Garcia Alzate, Henry Gonzales Torres, Daisy Lozano Arias, Carmen Carrero Gonzalez, Elkin Navarro Quiroz

Subject: Biology And Life Sciences, Biochemistry And Molecular Biology Keywords: Crohn's disease; renal disease; amyloidosis

Online: 4 February 2020 (04:51:50 CET)

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Preprint ARTICLE | doi:10.20944/preprints202311.0166.v1

Association of Periodontal Disease with Activity of Crohn's Disease

Miloš Živić, Nebojsa Zdravkovic, Bojan Stojanovic, Bojan Milosevic, Zeljko Todorovic, Miljan Adamović, Natasa Zdravkovic

Subject: Medicine And Pharmacology, Gastroenterology And Hepatology Keywords: Crohn’s disease; periodontal disease; Crohn’s disease activity indexes; periodontal indexes

Online: 2 November 2023 (10:51:54 CET)

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Preprint REVIEW | doi:10.20944/preprints202306.1762.v1

Genetic Diversity of Weedy Rice and Its Potential Application as a Novel Source of Disease Resistance

Aron Osakina, Yulin Jia

Subject: Biology And Life Sciences, Agricultural Science And Agronomy Keywords: Disease resistance; rice blast disease; sheath blight disease; weedy rice

Online: 26 June 2023 (08:57:43 CEST)

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Preprint REVIEW | doi:10.20944/preprints202404.0295.v1

Vitamin D: A Bridge between Kidney and Heart

Carmine Secondulfo, Valeria Visco, Nicola Virtuoso, Martino Fortunato, Serena Migliarino, Antonella Rispoli, Lucia La Mura, Adolfo Stellato, Giuseppe Caliendo, Emanuela Settembre, Fabiana Galluccio, Sarah Hamzeh, Giancarlo Bilancio

Subject: Endocrinology And Metabolism, Medicine And Pharmacology Keywords: vitamin D; calcitriol; calcidiol; kidney disease; cardiovascular disease; hypertension; osteoporosis; mineral-bone disease; metabolic disease.

Online: 3 April 2024 (12:57:54 CEST)

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Preprint ARTICLE | doi:10.20944/preprints202111.0460.v1

Low-Phosphate Meals Accompanied by a Minimum Dose of CaCO₃ Downregulates Pro-inflammation by Reducing CKD-MBD Indicators and Triggers by Decreasing Dietary Phosphate Intake

Barbara Ying-Jung Chen, Mei-Yi Wu, Mei-Yun Chin, Mai-Szu Wu, Jiun-Rong Chen

Subject: Medicine And Pharmacology, Dietetics And Nutrition Keywords: Maintenance hemodialysis (MHD) patient; Low-phosphate meal; CKD-MBD (chronic kidney disease-related mineral and bone disorder); Proinflammatory cytokine; TNF-α (tumor necrosis factor-alpha)

Online: 24 November 2021 (15:27:03 CET)

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High dietary phosphate intake and poor adherence to phosphate-binding-therapy elevate the risk of hyperphosphatemia in maintenance hemodialysis (HD; MHD) patients. Therefore, chronic kidney disease-related mineral and bone disorder (CKD-MBD) indicators increase; consequently, risks of CKD-MBDs and inflammation are elevated. This double-blind, randomized control trial intervention study was designed to investigate the possibility of reducing blood CKD-MBD indicators and modulating inflammatory indicators by consuming low-phosphate (LP) meals accompanied by a minimum dose of a calcium-based phosphate binder (CaCO3). MHD patients were recruited and randomly assigned to an LP meal group (LP group) or a control group. After initial data collection, blood collection, and dietary counseling, subjects were asked to consume a washout diet for 1 week. During the washout diet period, subjects consumed their usual diet but took 1 tablet of calcium carbonate (1CaCO3) as a phosphate binder with each meal. After the washout diet period, subjects in the LP group and control group respectively consumed LP meals and regular meals twice a day for 1 week. Meat in the LP meals was boiled before the regular cooking process, but meat in control meals was not. All meals were supplied by a central kitchen so that the contents of phosphate and other nutrients could be identified. In total, 40 MHD patients completed the study program. After 1 week of the dietary intervention, the blood Ca x P product and dietary phosphate had significantly decreased in the LP group compared to the control group (p<0.05). The LP group had significantly lower variations in dietary phosphate intake, blood calcium, Ca x P product, and tumor necrosis factor (TNF)-α than the control group by comparing differences between after the dietary intervention and the baseline (△after intervention - baseline, p<0.05). The increase in dietary phosphate intake (△3rd - 2nd dietary phosphate intake) augmented the increase in the TNF-α level by 6.24-fold (odds ratio [95% confidence interval]: 6.24 [1.12~34.92], p<0.05). These results highlighted the conclusion that LP meals accompanied by a minimum dose of CaCO3 downregulated pro-inflammation by reducing CKD-MBD indicators which was triggered by decreasing dietary phosphate intake.

Preprint CONCEPT PAPER | doi:10.20944/preprints202106.0486.v1

The Oxygen Transport Triad in High Altitude Pulmonary Edema: a Perspective from the High Andes

Gustavo Zubieta-Calleja, Natalia Zubieta-DeUrioste

Subject: Medicine And Pharmacology, Immunology And Allergy Keywords: high altitude, chronic hypobaric hypoxia, physiologic adaptation, travel to high altitude cities, high altitude physiology, pulmonary hypertension, lung disease, hemoglobin, tolerance to hypoxia, oxygen content.

Online: 18 June 2021 (15:22:04 CEST)

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Preprint ARTICLE | doi:10.20944/preprints201804.0278.v1

MCP-1/CCL2 in a Bulgarian Cohort of Children with Bronchial Asthma and Cystic Fibrosis

Tsvetelina Velikova, Ekaterina Krasimirova, Snezhina Lazova, Penka Perenovska, Anna Valerieva, Dimitrinka Miteva, Vasil Dimitrov, Maria Staevska, Dobroslav Kyurkchiev, Guergana Petrova

Subject: Medicine And Pharmacology, Pediatrics, Perinatology And Child Health Keywords: monocyte chemoattractant protein-1; MCP-1; C-C motif chemokine ligand 2; CCL2; childhood asthma; bronchial asthma; severe asthma; cystic fibrosis; chronic obstructive pulmonary disease

Online: 23 April 2018 (09:00:00 CEST)

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Preprint REVIEW | doi:10.20944/preprints202403.0306.v1

Putting Functional Gastrointestinal Disorders within the Spectrum of Inflammatory Disorders Can Improve Classification and Diagnostics of These Disorders

Šojat Dunja, Volarić Mile, Tanja Keškić, Nikola Volarić, Venija Cerovečki, Ljiljana Majnarić Trtica

Subject: Medicine And Pharmacology, Clinical Medicine Keywords: gastrointestinal diseases; chronic diseases; cytokines; gastrointestinal microbiome; inflammation

Online: 6 March 2024 (10:57:20 CET)

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Preprint ARTICLE | doi:10.20944/preprints202401.0145.v1

Associations between Physical Disability and Chronic Diseases with Depressive Symptoms in Vietnamese-Origin Older Adults in the United States

Christina E Miyawaki, Joshua M Garcia, Luis D Medina, Kim N Nguyen, Oanh L Meyer, Kyriakos S Markides

Subject: Public Health And Healthcare, Public Health And Health Services Keywords: chronic diseases; depressive symptoms; disability; older adults; Vietnamese

Online: 3 January 2024 (08:39:27 CET)

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Preprint ARTICLE | doi:10.20944/preprints202309.0253.v1

Links between Serotonin Levels and Stress: Cortisol, Candida A./Mycetes, Omega 3/6 Ratio and Dysbiosis (Skatole/Indoxyl Sulfate) Role in Chronic Fatigue Syndrome (CFS) and Depression

Daniele Orlandoni, Giuseppe Di Fede, Mauro Mantovani, Consuelo Rubina Nava, Marco Tomasi, Paola Fusi

Subject: Biology And Life Sciences, Other Keywords: stess; chronic fatigue syndrome; depression; dysbiosis; serotonin/cortisol

Online: 5 September 2023 (07:52:50 CEST)

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Intestinal microbiota attracts daily attention of a growing number of study which have attempted to link gut dysbiosIs with a variety of disease states: irritable bowel syndrome (IBS), inflamed bowel disease (IBD), Crohn's disease (CD), leaky gut syndrome (LGS), food intolerance, diabetes, metabolic syndrome, cancer, etc.. In our study we analyzed how intestinal dysbiosis may be related to chronic fatigue syndrome (CFS) and depression through the exchange of information through the gut-brain axis (GBA). We studied 33 subjects, 13 males and 20 females, who reported CFS or/and depression: we investigated their salivary cortisol levels, blood serotonin, omega 3/6 ratio, intestinal dysbiosis (calculated on the urinary levels of indoxyl sulfate and skatole), and we looked for the presence of Candida a. or mycetes in the stool; the data accumulated with this research show a correlation between the presence of Candida a./miceti, indoxyl sulfate urine values beyond the physiological and low serotonin levels. In addition, data analysis showed that the EPA/DHA values also show pro-inflammatory levels in case of dysbiosis and low serotonina levels. The relationship, however, with cortisol levels requires further research although this study showed a statistically significant positive correlation between these values, measured at specific times, and serotonin levels. Aims its connections with We investigated the relationship between stress (evaluated through the measurement of salivary cortisol levels) and gastrointestinal efficiency measured as a function of intestinal fermentative and putrefactive dysbiosis, evaluating the levels of urinary indoxyl sulfate in the first case (a possible correlation with the presence of Candida spp or Mycetes in the subjects feces was investigated), urinary skatole levels in the second one, in patients with chronic fatigue syndrome (SFC) and depression. In these patients we also have studied omega 3/6 ratio, and finally we have analized the impact that the alteration of these parameters can have on the serotonin levels. This research attemps to highlight the contact points, in some cases not so obvious, among these topics, contact points that, although they give us interesting indications, show the need to be further deepened by analyzing a larger amount of data.

Preprint ARTICLE | doi:10.20944/preprints202308.1662.v1

A Systematic Review and Meta-Epidemiology study on Multimorbidity

Gayathri Delanerolle, Yassine Bouchareb, Priyanka Jagadeesan, Guanpeng Li, Xiaojie Yang, Heitor Cavalini, Shaheen Kazali, Alain Zemokoho, David Benfield, Ashish Shetty, Peter Phiri, Jian qing Shi

Subject: Medicine And Pharmacology, Clinical Medicine Keywords: Multimorbidity; Chronic condition; Health Inequalities; Global health; Epidemiology

Online: 23 August 2023 (11:25:08 CEST)

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With enhanced life expectancy and ageing global populations, the prevalence of multimorbidity continues to increase. However, there is a dearth of evidence linked to multimorbidity diagnoses, treatments and health outcomes which remains a concern for future proofing optimal healthcare services. Generating evidence is critical to managing multimorbidity, promoting public health and minimizing health inequalities via effective healthcare policies that improve quality of life for vulnerable populations. This study assessed meta-epidemiology of multimorbidity to report the gaps in scientific knowledge and clinical practice. A systematic methodology was designed and published in PROSPERO (CRD42022347308) to report meta-epidemiology analyses using databases including PubMed, Web of Science, ScienceDirect, EMBASE, The Cochrane Gynaecology and Fertility Group Specialised Register of Controlled Trials and MEDLINE for studies published between the 1^st of January 1980 - 31^st December 2022. A random-effects model was used to estimate the pooled proportion of multimorbidity in adults. Forest plots, pooled odds ratios and statistical heterogeneity metrics were used to assess the association between multimorbidity and investigated factors. Funnel plots and Egger’s regression were used to detect and correct for publication bias. Our findings identified women to be 0.32 times more likely to have multimorbidity in comparison to males. In regard to ethnicity, white people were 0.47 times less likely to develop comorbidities than black people. People who identified as a drinker or unmarried were more likely to develop comorbidities than those who are non-drinkers or married, respectively. Regardless of smoking status, people were equally likely to have comorbidity. In terms of environmental influences, people in rural areas were found to be 0.2 times less likely to have comorbidity in comparison to those living in urban areas. Interestingly, people with a higher education level were 0.57 times more likely to develop comorbidities than those with only a high school education. It is evident that multimorbidity has a significant burden globally and impacts the provision of care necessitated across populations given its association with several social determinants of health. Robust research and healthcare policies are required to better manage multimorbidity in patients. An example of such intervention includes employing prevention programs to reduce risk and incidence of multimorbidity within at-risk populations.

Preprint ARTICLE | doi:10.20944/preprints202307.2096.v1

The Late Asymptomatic and Terminal Immunodeficiency Phases in Experimentally FIV-Infected Cats- a Long-Term Study

Brian G Murphy, Diego Castillo, Sarah Elisabeth Cook, Chrissy Eckstrand, Samantha Evans, Ellen Sparger, Chris Grant

Subject: Biology And Life Sciences, Virology Keywords: Cat; FIV; lentivirus; FAIDS; lymphoma; chronic renal failure

Online: 31 July 2023 (10:29:19 CEST)

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Preprint REVIEW | doi:10.20944/preprints202306.0567.v1

Stable Coronary Artery Disease: Who Finally Benefits from Coronary Revascularization in the Modern Era? The ISCHEMIA and Interim ISCHEMIA-EXTEND Analysis

Leonid L Bershtein, Alexey Sumin, Elizaveta Zbyshevskaya, Victoria Gumerova, Darejan Tsurtsumia, Igor Kochanov, Alina Andreeva, Vartan Piltakian, Sergey Sayganov

Subject: Medicine And Pharmacology, Cardiac And Cardiovascular Systems Keywords: chronic coronary syndromes; revascularization; prognosis; ISCHEMIA; ISCHEMIA-EXTEND

Online: 8 June 2023 (02:13:16 CEST)

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Preprint REVIEW | doi:10.20944/preprints202305.0643.v1

Cells and Processes in Wound Healing: More Recent Advances

Montserrat Fernández-Guarino, María Luisa Hernández-Bule, Stefano Bacci

Subject: Biology And Life Sciences, Life Sciences Keywords: Acute Wounds; Cellular Infiltrate; Chronic Wounds; Keloids; Scars

Online: 9 May 2023 (11:06:05 CEST)

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Preprint BRIEF REPORT | doi:10.20944/preprints202305.0453.v1

Development of a Modified Global Physical Activity Questionnaire and its Construct Validity among Adults in Kerala, India

Thirunavukkarasu Sathish, Elezebeth Mathews

Subject: Public Health And Healthcare, Other Keywords: physical activity; GPAQ; validity; self-reports; chronic diseases

Online: 8 May 2023 (05:20:04 CEST)

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Preprint ARTICLE | doi:10.20944/preprints202301.0158.v1

Relationship between Joint and Ligament Structures of the Subtalar Joint and Degeneration of the Subtalar Articular Facet

Ryoya Togashi, Mutsuaki Edama, Mayuu Shagawa, Haruki Osanami, Hrotake Yokota, Ryo Hirabayashi, Chie Sekine, Tomonobu Ishigaki, Hiroshi Akuzawa, Yuki Yamada, Taku Toriumi, Ikuo Kageyama

Subject: Physical Sciences, Biophysics Keywords: subtalar joint instability; chronic ankle instability; footprint osteoarthritis

Online: 9 January 2023 (09:22:22 CET)

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Preprint REVIEW | doi:10.20944/preprints202212.0298.v1

Insights of Endocytosis Signaling in Health and Disease

Chandramani Pathak, Foram U. Vaidya, Bhargav N. Waghela, Pradeep Kumar Jaiswara, Vishal Kumar Gupta, Ajay Kumar, Barani Kumar Rajendran, Kishu Ranjan

Subject: Biology And Life Sciences, Biochemistry And Molecular Biology Keywords: Endocytosis; Phagocytosis; Pinocytosis; Receptor endocytosis signaling; Chronic diseases

Online: 16 December 2022 (08:07:01 CET)

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Preprint ARTICLE | doi:10.20944/preprints202212.0224.v1

Autoantibody Correlation Signatures in Fibromyalgia and Myalgic Encephalomyelitis/Chronic Fatigue Syndrome: Association with Symptom Severity

Varvara A Ryabkova, Natalia Y Gavrilova, Alina A Poletaeva, Aleksandr I Pukhalenko, Irina A Koshkina, Leonid P Churilov, Yehuda Shoenfeld

Subject: Medicine And Pharmacology, Immunology And Allergy Keywords: fibromyalgia; myalgic encephalomyelitis/chronic fatigue syndrome; autoantibodies; autoimmunity

Online: 13 December 2022 (02:47:48 CET)

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(1) Background: Recent studies provide some evidence for the contribution of antibody-mediated autoimmune mechanisms to the nature of fibromyalgia (FM) and myalgic encephalomyelitis/chronic fatigue syndrome (ME/CFS). Much attention was paid to the autoantibodies (AAb) targeting G protein-coupled receptors as natural components of the immune system. However, natural AAb network is much more extensive, and has not been previously investigated in these disorders; (2) Methods: The enzyme immunoassays ELI-Viscero-Test and ELI-Neuro-Test were used to determine changes in serum content of a 33 natural AAb to neural, organ-specific and non-tissue-specific autoantigens a) in 11 FM patients with comorbid ME/CFS; b) in 11 ME/CFS patients without FM; c) in 11 healthy controls. Individual autoantibody profiles and their correlation with some clinical symptoms were analyzed. (3) Results: both patients with ME/CFS and ME/CFS+FM were characterized by more frequent and pronounced deviations in the immunoreactivity to GABA-receptors than healthy controls. Although the level of other natural AAb did not differ between study groups, AAb correlation signatures were changing in patients compared to healthy controls. Both in patients and healthy controls the level of natural AAb to various neural and tissue-specific antigens correlated with the severity of fatigue, bodily pain, depression, anxiety, physical and mental-health related quality of life. Notably, that widely different correlation patterns were observed between study groups. (4) Conclusions: Findings from this pilot study provide some evidence that the homeostasis of autoimmune relationships, which are possibly a physiological part of our immune system, may break down in FM and ME/CFS. The correlation of disease-induced perturbations in individual AAb profiles with some clinical symptoms may arise from the immune system's ability to reflect qualitative and quantitative changes in antigenic composition of the body.

Preprint ARTICLE | doi:10.20944/preprints202112.0415.v1

Multicenter Retro-Prospective Observational Study on Chronic Hypoparathyroidism and rhPTH (1-84) Treatment

Gemma Marcucci, Guglielmo Beccuti, Giulia Carosi, Filomena Cetani, Luisella Cianferotti, Anna Maria Colao, Carolina Di Somma, Mirko Duradoni, Antonia Elefante, Lucia Ghizzoni, Massimo Giusti, Andrea Gerardo Lania, Elisabetta Lavezzi, Bruno Madeo, Giovanna Mantovani, Claudio Marcocci, Laura Masi, Simone Parri, Francesca Pigliaru, Assunta Santonati, Antonio Spada, Lara Vera, Maria Luisa Brandi

Subject: Medicine And Pharmacology, Endocrinology And Metabolism Keywords: Chronic Hypoparathyroidism; rhPTH (1-84); Natpar®; Treatment

Online: 24 December 2021 (23:55:38 CET)

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Preprint REVIEW | doi:10.20944/preprints202110.0318.v1

Probiotics Role in Chronic Rhinosinusitis Treatment: an Update of the Current Literature

Maria Rita Bianco, Massimo Ralli, Domenico Michele Modica, Marta Amata, Salvatore Poma, Gianfranco Mattina, Eugenia Allegra

Subject: Biology And Life Sciences, Immunology And Microbiology Keywords: Chronic rhinosinusitis; probiotics; microbiome; nasal microbiota; microbiome therapy

Online: 21 October 2021 (23:00:15 CEST)

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Working Paper ARTICLE

Calcineurin Suppresses Cardiomyocyte-protective Autophagy Under Chronic Intermittent Hypoxia by Downregulating the AMPK Pathway

Sheng Xie, Wei Liu, Meng Jin, Xiaochen Li, Tao Wang, Shaolin Zeng, Hanxiang Nie, Zhao Dong, Zhenghua Ke, Ke Hu

Subject: Biology And Life Sciences, Biochemistry And Molecular Biology Keywords: chronic intermittent hypoxia; autophagy; apoptosis; cardiomyocyte damage; calcineurin

Online: 24 June 2021 (14:58:22 CEST)

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Working Paper ARTICLE

Effects of Chronic Lithium Treatment on Anxious Behaviors and Serotonergic Genes Expression in the Midbrain Raphe Nuclei of Defeated Male Mice

Dmitriy A. Smagin, Irina L Kovalenko, Anna G. Galyamina, Irina V Belozertseva, Nikolay V Tamkovich, Konstantin O Baranov, Natalia N. Kudryavtseva

Subject: Medicine And Pharmacology, Immunology And Allergy Keywords: chronic social defeat stress; anxiety; lithium chloride; mice

Online: 3 June 2021 (11:41:28 CEST)

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Preprint ARTICLE | doi:10.20944/preprints202102.0599.v1

Development of the Survey of the Concept of Pain: A Measure to Study How Children Conceptualize Pain

Isabel Salvat, Cristina Adillón, Eva Maria Andrés, Sonia Monterde, Jordi Miró

Subject: Medicine And Pharmacology, Immunology And Allergy Keywords: Survey; children; health knowledge; chronic pain; pain education.

Online: 26 February 2021 (09:30:20 CET)

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Preprint ARTICLE | doi:10.20944/preprints202101.0346.v1

A Highly Transparent and Explainable Artificial Intelligence Tool for Chronic Wound Classification: XAI-CWC

Salih Sarp, Murat Kuzlu, Emmanuel Wilson, Umit Cali, Ozgur Guler

Subject: Engineering, Control And Systems Engineering Keywords: Chronic wound classification; transfer learning; explainable artificial intelligence.

Online: 18 January 2021 (14:28:04 CET)

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Preprint ARTICLE | doi:10.20944/preprints202011.0170.v1

Functional Disability in Adolescents with Chronic Pain: Comparing an Interdisciplinary Exposure Program to Usual Care

Carolien Dekker, Mariëlle Goossens, Bjorn Winkens, Silvia Remerie, Caroline Bastiaenen, Jeanine Verbunt

Subject: Social Sciences, Psychology Keywords: Chronic musculoskeletal pain; Adolescents; functional disability; multidisciplinary rehabilitation.

Online: 3 November 2020 (15:41:07 CET)

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Preprint ARTICLE | doi:10.20944/preprints201912.0395.v1

Post-Operative Chronic Pain Control in Mediastinal Lymphomas in An Elderly Population: the Role of Physical Activity

Antonello Sica, Beniamino Casale, Caterina Sagnelli, Armando Calogero, Maria Teresa Di Dato, Alessandro Spada, Marco Rispoli, Mario Santagata, Pietro Buonavolontà, Alfonso Fiorelli, Vincenzo Tammaro, Massimo Ciccozzi, Anna Salzano, Evangelista Sagnelli, Elisabetta Saracco, Dario Tammaro, Alfonso Papa

Subject: Medicine And Pharmacology, Oncology And Oncogenics Keywords: physical activity; elderly population; chronic pain; mediastinal lymphomas

Online: 30 December 2019 (09:44:54 CET)

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Preprint ARTICLE | doi:10.20944/preprints201906.0243.v1

Serum Agrin and Talin, Two Muscular Proteins, are Significantly Increased in Major Depression and Increased Agrin and Lowered Creatine Phosphokinase are Associated with Chronic Fatigue and Fibromyalgia Symptoms in Depression

Hussein Kadhem Al-Hakeim, Ameer Abdul Razzaq Al-Issa, Michael Maes

Subject: Medicine And Pharmacology, Psychiatry And Mental Health Keywords: major depression; chronic fatigue; fibromyalgia; neuro-immune; inflammation

Online: 24 June 2019 (10:19:29 CEST)

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Preprint ARTICLE | doi:10.20944/preprints201901.0001.v1

System-level Insights into the Adaptation of Domestic Dairy Buffalo to Chronic Heat Stress

Zhaobing Gu, Shoukun Tang, Xianhai Fu, Chuanbin Liu, Huaming Mao

Subject: Biology And Life Sciences, Endocrinology And Metabolism Keywords: chronic heat stress; dairy buffaloes; proteomics; adaptation mechanisms

Online: 3 January 2019 (08:32:13 CET)

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Preprint ARTICLE | doi:10.20944/preprints201810.0448.v1

MERTK rs4374383 Polymorphism Predicts Progression of Liver Fibrosis in HCV-Infected Patients: A Longitudinal Study

Maria Angeles Jimenez-Sousa, Ana Zaida Gómez-Moreno, Daniel Pineda-Tenor, Oscar Brochado-Kith, Juan José Sánchez-Ruano, Tomás Artaza-Varasa, Alicia Gómez-Sanz, Amanda Fernández-Rodríguez, Salvador Resino

Subject: Biology And Life Sciences, Virology Keywords: liver stiffness; MERTK; chronic hepatitis C; cirrhosis; SNPs

Online: 19 October 2018 (10:56:19 CEST)

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Preprint REVIEW | doi:10.20944/preprints201805.0396.v1

Smart Wound Dressings for Diabetic Chronic Wounds

Elizabeth Gianino, Craig Miller, Jordon Gilmore

Subject: Medicine And Pharmacology, Pathology And Pathobiology Keywords: diabetes; chronic wounds; smart wound dressing; biochemical sensor

Online: 28 May 2018 (10:22:39 CEST)

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Preprint ARTICLE | doi:10.20944/preprints201802.0137.v1

Burden of Serious Fungal Diseases in Romania

Mihai Mareș, Valentina Ruxandra Moroti-Constantinescu, David W. Denning

Subject: Biology And Life Sciences, Immunology And Microbiology Keywords: mycoses; epidemiology; Romania; candidaemia; aspergillosis; chronic pulmonary conditions

Online: 21 February 2018 (16:41:29 CET)

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Objective: To estimate for the first time the burden of serious fungal infections in Romania; Methods: Data derived from the World Health Organization (WHO), National Institute of Statistics, Romanian public health agencies and non-profit health organizations and published annual reports on local epidemiology were used in the present study. When no data was available, specific at-risk populations were used to calculate frequencies of serious fungal diseases, using previously published epidemiological parameters. All data refer to the year 2016; 3) Results: The estimated number of serious fungal infections in Romanian population was 435,930 in 2016. Recurrent vulvovaginal candidiasis accounts for up to 80% of total cases (more than 350,000 women annually). Concerning the HIV related infections, among 14349 infected persons, Pneumocystis pneumonia occurred in about 10% of late presenters (30 cases in 2016), while cryptococcal meningitis is rarely diagnosed (less than 20 cases). Annually, the total number of oesophageal candidiasis and oral thrush cases in HIV-positive patients may be as high as 1229 and 3066, respectively. In immunocompromised and cancer patient population, the annual incidence of candidaemia is 295, and at least 158 invasive aspergillosis cases and 4 mucormycosis cases occur yearly. With 4,966 critical care beds and approximately 200,000 abdominal surgeries performed, the estimated annual incidence of candidaemia and Candida peritonitis is 689 and 344, respectively. The annual incidence of pulmonary tuberculosis is still high in Romania (12,747 cases). Thus, the prevalence of post-TB chronic pulmonary aspergillosis is estimated to be 8.98/100,000 (1768 cases). The prevalence of chronic obstructive pulmonary disease (COPD) and asthma in adults is 6% and 6.5%, respectively. Therefore, allergic bronchopulmonary aspergillosis prevalence is estimated at 29,387 and severe asthma with fungal sensitisation at 38,731 cases annually. 4) Conclusions: Not being on the list of reportable diseases, the number of patients presenting with severe mycoses in Romania can only be roughly estimated. Based on local reports and prevalence estimation, we consider that at least 2.2% of Romanians suffer a serious form of fungal disease.

Preprint REVIEW | doi:10.20944/preprints201709.0146.v2

Role of LFA-1 and ICAM-1 in Cancer

Manuel Reina, Enric Espel

Subject: Biology And Life Sciences, Cell And Developmental Biology Keywords: cancer metastasis; chronic lymphocytic leukemia; exosomes; tumor microenvironment

Online: 29 September 2017 (03:17:31 CEST)

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Preprint ARTICLE | doi:10.20944/preprints201703.0220.v1

Service Innovations in Health Care Service Ecosystem: A Case Study

Maria Vincenza Ciasullo, Silvia Cosimato

Subject: Business, Economics And Management, Business And Management Keywords: innovation; service innovation; healthcare; chronic diseases; SD Logic

Online: 30 March 2017 (17:10:41 CEST)

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Preprint ARTICLE | doi:10.20944/preprints202108.0527.v1

Finite Mixture Models Based on Pain Intensity, Functional Disability and Psychological Distress Composite Assessment Allow to Identify Two Distinct Classes of Persistent Spinal Pain Syndrome after Surgery Patients Related to Their Quality of Life

Amine Ounajim, Maxime Billot, Pierre-Yves Louis, Yousri Slaoui, Denis Frasca, Lisa Goudman, Manuel Roulaud, Nicolas Naiditch, Bertille Lorgeoux, Sandrine Baron, Kevin Nivole, Mathilde Many, Nihel Adjali, Philippe Page, Bénédicte Bouche, Elodie Charrier, Laure Poupin, Delphine Rannou, Géraldine Brumauld de Montgazon, Brigitte Roy-Moreau, Chantal H. Wood, Raphael Rigoard, Romain David, Maarten Moens, Philippe Rigoard

Subject: Medicine And Pharmacology, Clinical Medicine Keywords: PSPS; FBSS; chronic pain; health-related quality of life; mixture models analysis; personalized pain management; chronic pain after spinal surgery

Online: 27 August 2021 (15:23:27 CEST)

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Preprint ARTICLE | doi:10.20944/preprints202112.0041.v1

Genetics of Vascular Inflammation in Lower Limb Ischemia: The TNF-α Hypothesis in Peripheral Arterial Disease

Diego Caicedo, Clara V. Álvarez, Sihara Pérez, Jesús Devesa

Subject: Medicine And Pharmacology, Endocrinology And Metabolism Keywords: Vascular inflammation; Peripheral arterial disease (PAD); Chronic limb-threatening ischemia (CLTI); GHAS trial; TNF-α; hs-CRP; Neutrophil-to-lymphocyte ratio (NLR); NOX4; eNOS; VEGF-A.

Online: 3 December 2021 (09:44:42 CET)

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Preprint ARTICLE | doi:10.20944/preprints202309.0020.v1

The Combination of Predictive Factors of Pharmacokinetic Origin Associates with Enhanced Disease Control During Treatment of Pediatric Crohn’s Disease with Infliximab

Marla C Dubinsky, Shervin Rabizadeh, John C Pannetta, Elizabeth A Spencer, Annelie Everts-van der Wind, Thierry Dervieux

Subject: Medicine And Pharmacology, Medicine And Pharmacology Keywords: infliximab; pharmacokinetics; disease control; inflammatory bowel disease

Online: 1 September 2023 (11:52:39 CEST)

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Preprint ARTICLE | doi:10.20944/preprints201806.0329.v1

Ethical, Legal and Social Implications of Susceptibility Genetic Testing for Late-Onset Neurodegenerative Diseases

Amaranta Manrique de Lara, Elisa Núñez-Acosta, Garbiñe Saruwatari-Zavala, Liliana Soto-Gómez, Miguel E. Rentería

Subject: Biology And Life Sciences, Biochemistry And Molecular Biology Keywords: Alzheimer’s disease; Parkinson’s disease; Genetic testing; bioethics

Online: 21 June 2018 (04:38:35 CEST)

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Preprint ARTICLE | doi:10.20944/preprints201705.0023.v1

Gluten Sensitivity Biomarkers in Menière's Disease: Is It a Gluten Related Disorder?

Federica Di Berardino, Diego Zanetti, Marina Socci, Luca Elli

Subject: Medicine And Pharmacology, Immunology And Allergy Keywords: gluten; celiac disease; antibodies; Ménière’s disease; vertigo

Online: 2 May 2017 (05:49:26 CEST)

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Preprint REVIEW | doi:10.20944/preprints202011.0396.v1

Searching for Peripheral Biomarkers in Neurodegenerative Diseases: The Tryptophan-Kynurenine Metabolic Pathway

Nóra Török, Masaru Tanaka, László Vécsei

Subject: Medicine And Pharmacology, Neuroscience And Neurology Keywords: neurodegenerative disease; Alzheimer’s disease; Parkinson’s disease; amyotrophic lateral sclerosis; Huntington’s disease; multiple sclerosis; tryptophan; kynurenines; biomarkers; personalized medicine

Online: 13 November 2020 (20:57:22 CET)

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Preprint ARTICLE | doi:10.20944/preprints202010.0392.v1

Incorporating Point-of-Care Bacterial Fluorescence into a Wound Clinic Antimicrobial Stewardship Program

Thomas Serena

Subject: Medicine And Pharmacology, Immunology And Allergy Keywords: antimicrobial stewardship; detection of bacteria in chronic wounds, chronic wounds, clinical decision support; diagnostic pathway; joint commission; fluorescence imaging; wound clinic

Online: 19 October 2020 (15:35:25 CEST)

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Background: In 2014 the World Health Organization (WHO) warned of an emerging world-wide crisis of antibiotic resistant microorganisms. In response, government and professional organizations recommended that health care systems adopt antimicrobial stewardship programs (ASPs). In the United States, the Centers for Medicare Services (CMS) mandated antimicrobial stewardship in the hospital inpatient setting. Effective January 1, 2020, the Joint Commission required ambulatory centers that prescribe antibiotics, such as wound centers, to institute an ASP. Chronic wounds often remain open for months, during which time patients may receive multiple courses of antibiotics and numerous antimicrobial topical treatments. The wound clinician plays an integral role in reducing antimicrobial resistance in the outpatient setting: antibiotics prescribed for skin and soft tissue infections are among the most common in an outpatient setting. One of the most challenging aspects of antimicrobial stewardship in treating chronic wounds is the inaccuracy of bacterial and infection diagnosis. Methods: Joint Commission lists five elements of performance (EP): (1) Identifying an antimicrobial stewardship leader, (2) establishing an annual antimicrobial stewardship goal, (3) implementing evidence-based practice guidelines related to the antimicrobial stewardship goal, (4) providing clinical staff with educational resources related to the antimicrobial stewardship goal, and (5) collecting, analyzing, and reporting data related to the antimicrobial stewardship goal. This article focuses on choosing and implementing an evidence-based ASP goal for 2020. Discussion: Clinical trials have demonstrated the ability of fluorescence imaging (MLiX) to detect clinically significant levels of bacteria in chronic wounds. Combined with clinical examination of signs and symptoms of infection, the MLiX procedure improves the clinician’s ability to diagnose infection and can guide antimicrobial use. In order to satisfy the elements of performance, the MLiX procedure was incorporated into the annual ASP goal for several wound care centers. Clinicians were educated on the fluorescence imaging device and guidelines were instituted. Collection of antimicrobial utilization data is underway.

Working Paper REVIEW

The ‘Jekyll and Hyde’ of Gluconeogenesis: Early-Life Adversity, Later Life Stress, and Metabolic Disturbances

Snehaa V. Seal, Jonathan D. Turner

Subject: Biology And Life Sciences, Biochemistry And Molecular Biology Keywords: glucose; glycogen; gluconeogenesis; early life adversity; acute stress; chronic stress; psychosocial stress; hypothalamus-pituitary-adrenal axis; ageing; immuno-senescence; inflamm-ageing; Developmental origins of health and disease

Online: 23 March 2021 (09:04:41 CET)

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Preprint ARTICLE | doi:10.20944/preprints202403.0465.v1

Stable Variable Selection Method with Shrinkage Regression Applied to the Selection of Genetic Variants Associated with Alzheimer’s Disease

Vera Afreixo, Ana Helena Tavares, Vera Enes, Miguel Pinheiro, Leonor Rodrigues, Gabriela Moura

Subject: Computer Science And Mathematics, Applied Mathematics Keywords: penalized regression; Akaike’ s Information Criterion; high-dimensional data; stability; overall weighted coefficients; Alzheimer’ s disease; SNP

Online: 8 March 2024 (04:29:51 CET)

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Preprint ARTICLE | doi:10.20944/preprints202405.0142.v1

Dynamic Interrelations between Sensory and Affective Aspects of Pain in Patients with Chronic Pain

Tatyana Telbizova

Subject: Psychiatry And Mental Health, Medicine And Pharmacology Keywords: chronic pain; depressive episode; state and trait anxiety, correlations

Online: 3 May 2024 (04:06:07 CEST)

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Preprint ARTICLE | doi:10.20944/preprints202404.1629.v1

Burr Hole Craniostomy Versus Craniotomy for Chronic Subdural Hematoma – A Multicenter Study

Nenad Koruga, Djula Djilvesi, Anamarija Soldo Koruga, Vjekoslav Kopačin, Tatjana Rotim, Tajana Turk, Slavko Čičak, Josip Kocur, Marija Perić, Tomislav Ištvanić, Vedran Farkaš, Sonja Škiljić, Alen Rončević

Subject: Neuroscience And Neurology, Medicine And Pharmacology Keywords: Burr hole craniostomy; Craniotomy; Chronic subdural Hematoma; Multicenter study

Online: 25 April 2024 (08:38:33 CEST)

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Preprint REVIEW | doi:10.20944/preprints202312.1329.v1

A Review about Lateral Ankle Instability and Emerging Alternative Outcome Monitoring Tools in Patients Following Ankle Ligament Reconstruction Surgery

Ibrahim Saliba, Alexandre Hardy, Wenzheng Wang, Raphael Vialle, Sylvain Feruglio

Subject: Public Health And Healthcare, Physical Therapy, Sports Therapy And Rehabilitation Keywords: ankle instability; chronic ankle instability; postoperative management; diagnostics; NIRS

Online: 18 December 2023 (12:45:48 CET)

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Preprint ARTICLE | doi:10.20944/preprints202311.0113.v1

Neurosecretory Protein GM-Expressing Neurons Participate in Lipid Storage and Inflammation in Newly Developed Cre Driver Mice

Yuki Narimatsu, Masaki Kato, Eiko Iwakoshi-Ukena, Shogo Moriwaki, Ayano Ogasawara, Megumi Furumitsu, Kazuyoshi Ukena

Subject: Biology And Life Sciences, Endocrinology And Metabolism Keywords: neurosecretory protein GM; hypothalamus; neuropeptide; obesity; chronic inflammation; chemogenetics

Online: 2 November 2023 (07:43:58 CET)

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Preprint REVIEW | doi:10.20944/preprints202310.0374.v1

A Manifesto in Defense of Pain Complexity: A Critical Review of Essential Insights in Pain Neuroscience

Javier Picañol Párraga, Aida Castellanos Esparraguera

Subject: Biology And Life Sciences, Neuroscience And Neurology Keywords: pain; chronic pain; nociception; sensory neuron; pain neuroscience education

Online: 9 October 2023 (09:31:37 CEST)

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Preprint CASE REPORT | doi:10.20944/preprints202309.1533.v1

Germline CSF3R Variant in Chronic Myelomonocytic Leukemia: Linking Genetic Predisposition to Uncommon Hemorrhagic Symptoms

Maria Teresa Bochicchio, Giorgia Micucci, Silvia Asioli, Martina Ghetti, Giorgia Simonetti, Alessandro Lucchesi

Subject: Biology And Life Sciences, Biochemistry And Molecular Biology Keywords: chronic myelomonocytic leukemia; CSF3R; bleeding disorders; predisposing genes; NGS

Online: 22 September 2023 (08:35:11 CEST)

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Preprint ARTICLE | doi:10.20944/preprints202306.0902.v1

Mucosal Metabolomic Signatures in Chronic Colitis: Novel Insights into the Pathophysiology of Inflammatory Bowel Disease

Nathan Calzadilla, Aisha Qazi, Anchal Sharma, Kai Mongan, Shane Comiskey, Jahnavi Manne, Alvin G. Youkhana, Sonam Khanna, Seema Saksena, Pradeep K. Dudeja, Waddah A. Alrefai, Ravinder K. Gill

Subject: Medicine And Pharmacology, Gastroenterology And Hepatology Keywords: chronic colitis; mucosal inflammation; host-microbe interactions; mucosal metabolomics

Online: 13 June 2023 (08:39:45 CEST)

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Preprint REVIEW | doi:10.20944/preprints202304.0843.v2

Zanubrutinib: Coming of Age for BTK Inhibitors in the Treatment of Chronic Lymphocytic Leukemia?

Stefano Molica, Constantine Tam, David Allsup, Aaron Polliack

Subject: Medicine And Pharmacology, Hematology Keywords: CLL, Zanubrutinib, BTK inhibitors, efficacy, safety, chronic lymphocytic leukemia

Online: 22 May 2023 (16:15:16 CEST)

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Preprint ARTICLE | doi:10.20944/preprints202302.0475.v2

Liver Fibrosis in Individuals with Hepatitis C Virus Genotype 1B from Brazilian Eastern Amazon

Tatiane Lobato Da Silva, Apio Ricardo Nazareth Dias, Juarez Antônio Simões Quaresma, Luiz Fábio Magno Falcão

Subject: Biology And Life Sciences, Virology Keywords: Hepatitis C virus; Genetic; Chronic Hepatitis C; Liver; Elastography

Online: 22 May 2023 (13:56:53 CEST)

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Preprint ARTICLE | doi:10.20944/preprints202305.0580.v1

Prevalence of Clinical Signs and Symptoms of Temporomandibular Joint Disorders Registered in the EUROTMJ Database: A Prospective Study in a Portuguese Center

David Faustino Ângelo, Beatriz Mota, Ricardo São João, David Sanz, Henrique José Cardoso

Subject: Medicine And Pharmacology, Surgery Keywords: Temporomandibular joint disorders; parafunctional habits; risk factors; chronic diseases

Online: 9 May 2023 (07:10:29 CEST)

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Preprint ARTICLE | doi:10.20944/preprints202212.0211.v1

Klotho Regulated by Estrogen Plays a Key Role in Sex Differences in Stress Resilience

Zhinei Tan, Yongxia Li, Yinzheng Guan, Javed Iqbal, Chenyue Wang, Xinming Ma

Subject: Biology And Life Sciences, Biochemistry And Molecular Biology Keywords: klotho; estrogen; hippocampus; chronic stress; sex difference; stress resilience

Online: 13 December 2022 (01:09:36 CET)

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Preprint ARTICLE | doi:10.20944/preprints202212.0152.v1

Eugenio Martelli, Matilde Zamboni, Giovanni Sotgiu, Laura Saderi, Massimo Federici, Giuseppe Massimo Sangiorgi, Mariangela Valentina Puci, Allegra Rosa Martelli, Teresa Messina, Paolo Frigatti, Maria Pia Borrelli, Carlo Ruotolo, Ilaria Ficarelli, Paolo Rubino, Francesco Pezzo, Luciano Carbonari, Andrea Angelini, Edoardo Galeazzi, Luca Calia Di Pinto, Franco Michelino Fiore, Armado Palmieri, Giorgio Ventoruzzo, Giulia Mazzitelli, Franco Ragni, Antonio Bozzani, Enzo Forliti, Claudio Castagno, Pietro Volpe, Mafalda Massara, Diego Moniaci, Elisa Pagliasso, Tania Peretti, Mauro Ferrari, Nicola Troisi, Pietro Modugno, Maurizio Maiorano, Umberto Marcello Bracale, Marco Panagrosso, Mario Monaco, Giovanni Giordano, Giuseppe Natalicchio, Antonella Biello, Giovanni Maria Celoria, Alessio Amico, Mauro Di Bartolo, Massimiliano Martelli, Roberta Munaó, Davide Razzano, Giovanni Colacchio, Francesco Bussetti, Gaetano Lanza, Antonio Cardini, Bartolomeo Di Benedetto, Mario De Laurentis, Maurizio Taurino, Pasqualino Sirignano, Pierluigi Cappiello, Andrea Esposito, Santi Trimarchi, Silvia Romagnoli, Andrea Padricelli, Giorgio Giudice, Adolfo Crinisio, Giovanni Di Nardo, Giuseppe Battaglia, Rosario Tringale, Salvatore De Vivo, Rita Compagna, Valerio Stefano Tolva, Ilenia D'Alessio, Ruggiero Curci, Simona Giovannetti, Giuseppe D'Arrigo, Giusi Basile, Dalmazio Frigerio, Gian Franco Veraldi, Luca Mezzetto, Arnaldo Ippoliti, Fabio Massimo Oddi, Alberto Maria Settembrini

Subject: Medicine And Pharmacology, Hematology Keywords: chronic limb-threatening ischemia; outcome; sex; age; limb salvage

Online: 8 December 2022 (09:39:30 CET)

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Preprint ARTICLE | doi:10.20944/preprints202110.0171.v1

The Antineoplastic Role of STAT5 Inhibition in BCRABL1-Positive Cells Exposed to Pimozide Alone and in Combination with Dasatinib and Ponatinib

Marco Santoro, Salvatrice Mancuso, Manlio Tolomeo, Rosaria Maria Pipitone, Stefania Grimaudo, Sergio Siragusa

Subject: Medicine And Pharmacology, Oncology And Oncogenics Keywords: chronic myeloid leukemia; dasatinib; ponatinib; pimozide; STAT inhibitors; K562

Online: 11 October 2021 (16:17:32 CEST)

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Preprint ARTICLE | doi:10.20944/preprints202108.0376.v1

Association of Migraine and Irritable Bowel Syndrome in Saudi Arabia: A Nationwide Survey.

Khalid A. Bin Abdulrahman, Nawaf S. Alenazi, Saad B. Albishri, Faisal F. Alshehri

Subject: Medicine And Pharmacology, Neuroscience And Neurology Keywords: Migraine; Headache; Irritable Bowel Syndrome; Chronic Pain; Saudi Arabia

Online: 18 August 2021 (11:21:40 CEST)

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Working Paper REVIEW

CANOMAD : A Multi-Faceted Disease

Júlia Machado Rickli, Gabriela Pomaleski, Marcus Vinícius Magno Gonçalves

Subject: Medicine And Pharmacology, Neuroscience And Neurology Keywords: chronic-ataxic neuropathy; anti-disialosyl; IgM monoclonal gammopathy; CANOMAD

Online: 5 October 2020 (11:07:50 CEST)

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Preprint ARTICLE | doi:10.20944/preprints202003.0432.v1

Chronic Fatigue Syndrome and Fibromyalgia-Like Symptoms Are an Integral Component of the Phenome of Schizophrenia: Neuro-Immune and Opioid System Correlates

Rana Fadhil Mousa, Hussein Kadhem Al-Hakeim, Amir Alhaidari, Michael Maes

Subject: Medicine And Pharmacology, Psychiatry And Mental Health Keywords: chronic fatigue syndrome; myalgic encephalomyelitis; schizophrenia; neuroimmunomodulation; inflammation; biomarkers

Online: 29 March 2020 (10:52:40 CEST)

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Preprint REVIEW | doi:10.20944/preprints202001.0087.v1

DPP-4/GLP-1 Axis as a Potential Therapeutic Target in Chronic Stress-related Vascular Aging and Atherosclerosis

Ying Wan, Limei Piao, Yongshan Nan, Xian-Wu Cehng

Subject: Biology And Life Sciences, Animal Science, Veterinary Science And Zoology Keywords: Chronic stress; Vascular senescence; inflamamtion; atherosclerosis; dipeptidyl peptidase-4

Online: 9 January 2020 (13:05:26 CET)

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Preprint REVIEW | doi:10.20944/preprints201906.0261.v1

Diagnostic Imaging in Pediatric Chronic Rhinosinusitis: A Guide for Clinicians

Giorgio Conte, Luca Caschera, Sandro Magnani, Claudia Cinnante, Fabio Maria Triulzi, Lorenzo Pignataro, Sara Torretta

Subject: Medicine And Pharmacology, Pediatrics, Perinatology And Child Health Keywords: rhinosinusitis; pediatric chronic rhinosinusitis; computed tomography; magnetic resonance imaging

Online: 26 June 2019 (07:21:24 CEST)

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Preprint REVIEW | doi:10.20944/preprints201810.0033.v1

Viral Persistence and Chronicity in Hepatitis C Virus Infection: Role of T-Cell Apoptosis, Senescence and Exhaustion

Muttiah Barathan, Rosmawati Mohamed, Yean K. Yong, Meganathan Kannan, Jamuna Vadivelu, Alireza Saeidi, Marie Larsson, Esaki Muthu Shankar

Subject: Biology And Life Sciences, Immunology And Microbiology Keywords: apoptosis; viral persistence, hepatitis C virus; immunity; chronic infection

Online: 2 October 2018 (16:34:19 CEST)

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Preprint ARTICLE | doi:10.20944/preprints201805.0050.v1

The FDA and the State of Chronic Diseases: Cardiovascular, Endocrine, Pulmonary, and Renal Diseases

Mona Fiuzat, Michael P. Gray, Grace Anne Dorney Koppel, Aaron Kowalski, Prabir Roy-Chaudhury, Mary Norine Walsh, Daniel W. Jones, Enid Neptune, Robert Ratner, Melissa West, Brad A. Wong, Robert Califf

Subject: Medicine And Pharmacology, Cardiac And Cardiovascular Systems Keywords: chronic diseases; cardiovascular; renal; endocrine; diabetes; therapeutic advances; tobacco

Online: 3 May 2018 (05:08:44 CEST)

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Preprint REVIEW | doi:10.20944/preprints202405.0588.v1

An Overview of Cardiovascular Risk in Pituitary Disorders

Georgia Ntali, Vyron Markussis, Alexandra Chrisoulidou

Subject: Endocrinology And Metabolism, Medicine And Pharmacology Keywords: cardiovascular disease; pituitary; acromegaly; Cushing's disease; prolactinoma; hypopituitarism

Online: 9 May 2024 (11:55:35 CEST)

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Preprint ARTICLE | doi:10.20944/preprints202311.0030.v1

Impacts and Prevalence of Sarcopenia in Patients with MASLD: A Cross-Sectional Study

Kally Janaina Berleze, Luis Fernando Ferreira, André Ferreira D'Ávila, Caroline Buss, Cristiane Valle Tovo, Luis Henrique Telles da Rosa

Subject: Medicine And Pharmacology, Gastroenterology And Hepatology Keywords: Sarcopenia; MASLD; Liver Disease; Aging.; Steatotic liver disease

Online: 1 November 2023 (07:06:18 CET)

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Introduction: Sarcopenia, muscle loss, often coexists with MASLD, a common liver disorder, which is more prevalent in those with sarcopenia. Sarcopenia also increases the risk of liver conditions like steatosis and fibrosis. Studies on sarcopenia in MASLD are common in developed countries, but fewer follow the EWGSOP2 guidelines in Brazil. Aim: to assess sarcopenia prevalence in MASLD patients. Methods: Cross-sectional study conducted at the Gastroen-terology/Hepatology Service of ISCMPA with patients diagnosed with MASLD. The EWGSOP2 criteria were used to evaluate sarcopenia. Categorical data presented as absolute and relative frequency; parametric continuous data ex-pressed as mean±standard deviation; non-parametric continuous data as me-dian and IQR. Gender differences in were analyzed using Fisher's Exact Test or Chi-squared tests, and for continuous variables, T Student tests (parametric) and Mann-Whitney U tests for independent samples (non-parametric). The significance level was set at 5% (p<0.05). Results: The study involved 103 MASLD patients with an average age of 60.39 years, comprising 48 (46.60%) adults and 55 (53.40%) older individuals. Concerning sarcopenia diagnosis, four individuals exhibited decreased muscle strength; two had reduced MME (sarcopenia); and one showed decreased walking speed (severe sarcopenia). Among the participants, 63 (60.6%) were physically active. 35 (62.5%) had mild to moderate steatosis, while 21 (37.5%) had severe steatosis. In terms of EHNA, 13 subjects (24.08%) had moderate to severe EHNA. Regarding fibrosis classi-fication, 68 (72.34%) individuals had undetermined or high probability based on the NAFLD score, with higher prevalence in males (n=23; 88.5%). Fibrosis assessment via liver biopsy revealed 27 (28.72%) in F1 and F2 and 15 (16.96%) in F3 and F4. Stratification of fibrosis into F3 and F4 was more com-mon among men (n=9; 47.4%). Conclusion: Most of the population was physi-cally active. The parameters indicating sarcopenia exceeded the thresholds recommended by EWGSOP2. The prevalence of sarcopenia was low in individuals with MASLD.

Preprint CONCEPT PAPER | doi:10.20944/preprints202306.0809.v1

Intrathecal Autologous Thrombin-Activated Condensed Platelet Cytokines in Chronic Neurodegenerative Disease: Anti-inflammatory and Regenerative Responses, Phase I

E. Scott Sills

Subject: Biology And Life Sciences, Neuroscience And Neurology Keywords: Alzheimer’s disease; Parkinson’s disease; condensed cytokines; intrathecal; PRP

Online: 12 June 2023 (09:12:30 CEST)

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Preprint ARTICLE | doi:10.20944/preprints202306.0616.v1

Negative Contrast: A Simple And Efficient Image Augmentation Method In Crop Disease Classification

Jiqing Li, Zhendong Yin, Dasen Li, Yanlong Zhao

Subject: Computer Science And Mathematics, Artificial Intelligence And Machine Learning Keywords: Crop Disease Classification; Crop Disease Dataset; Image Augmentation

Online: 8 June 2023 (09:47:54 CEST)

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Preprint REVIEW | doi:10.20944/preprints202107.0116.v1

Is Parkinson's Disease the Ideal Preclinical Population for Alzheimer's Disease Therapeutics?

Thomas F Tropea, Alice Chen-Plotkin

Subject: Medicine And Pharmacology, Immunology And Allergy Keywords: Parkinson’s disease; Alzheimer’s Disease; Clinical trial; Precision medicine.

Online: 5 July 2021 (16:08:41 CEST)

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Preprint ARTICLE | doi:10.20944/preprints202308.0937.v1

Challenges and Opportunities in One Health: Google Trends Search Data

Lauren Wisnieski, Karen Gruszynski, Vina Faulkner, Barbara Shock

Subject: Public Health And Healthcare, Public, Environmental And Occupational Health Keywords: Google Trends; disease prediction; Lyme disease; Lyme; Big Data; One Health; negative binomial; mixed models; zoonotic disease; tick-borne disease

Online: 11 August 2023 (11:01:40 CEST)

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Preprint REVIEW | doi:10.20944/preprints202208.0383.v1

Calabria as a Genetic Isolate, a Model for the Study of Neurodegenerative Diseases

Francesco Bruno, Valentina Laganà, Raffaele Di Lorenzo, Amalia Cecilia Bruni, Raffaele Maletta

Subject: Biology And Life Sciences, Biochemistry And Molecular Biology Keywords: Calabria; Italy; neurodegenerative diseases; Alzheimer’s disease; Frontotemporal dementia; Par-kinson’s disease; Niemann Pick type C disease; Spino-cerebellar ataxia; Creutzfeldt–Jakob disease; Gerstmann Straussler Scheincker disease

Online: 22 August 2022 (11:23:49 CEST)

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Preprint REVIEW | doi:10.20944/preprints202309.1883.v1

Role of Neutrophil Extracellular Traps in Health and Disease Pathophysiology: Recent Advancements and Future Insights

Md. Monirul Islam, Naoshi Takeyama

Subject: Medicine And Pharmacology, Immunology And Allergy Keywords: neutrophil extracellular traps (NETs); innate immunity; sepsis; lung disease; cardiovascular disease; liver disease; kidney disease; diabetes; COVID-19; coagulopathy and thrombotic microangiopathy; cancer; autoimmunity; preeclampsia; Kawasaki disease

Online: 28 September 2023 (04:00:59 CEST)

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Preprint REVIEW | doi:10.20944/preprints202305.1229.v1

Unraveling Molecular and Genetic Insights into Neurodegenerative Diseases: Advances in Understanding Alzheimer's, Parkinson's, ALS, and Huntington's Disease

Alexandru Vlad Ciurea, Aurel George Mohan, Razvan-Adrian Covache-Busuioc, Horia Petre Costin, Luca Andrei Glavan, Antonio Daniel Corlatescu, Vicentiu Mircea Saceleanu

Subject: Medicine And Pharmacology, Neuroscience And Neurology Keywords: Molecular Genetics; Neurodegenerative Disease; Molecular pathology; Epigenetics; Gene expression; Therapeutic targets; Biomarkers; Alzheimer’s Disease; Parkinson’s Disease; Huntington Disease; Amyotrphic Lateral Sclerosis

Online: 17 May 2023 (10:28:26 CEST)

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Preprint REVIEW | doi:10.20944/preprints202404.0437.v1

Drug Development for Alzheimer’s and Parkinson’s Disease: Where Do We Go Now?

Lisa Sequeira, Sofia Benfeito, Carlos Fernandes, Alexandra Gaspar, Inês Lima, Joana Peixoto, Catarina Alves, Cláudia Sofia Machado, Fernanda Borges, Daniel Chavarria

Subject: Chemistry And Materials Science, Medicinal Chemistry Keywords: neurodegenerative diseases; Parkinson’ s disease; Alzheimer’ s disease; drug discovery; disease-modifying drugs

Online: 5 April 2024 (12:39:57 CEST)

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Preprint REVIEW | doi:10.20944/preprints202309.0808.v1

Overlapping Neuroimmune Mechanisms and Therapeutic Targets in Neurodegenerative Disorders

Fabiola De Marchi, Lea Vidatic, Eliša Papić, Valentino Rački, Jerneja Nimac, Igor Jurak, Boris Rogelj, Vladimira Vuletic, Rajka M. Liscic, Jason R. Cannon, Emanuele Buratti, Letizia Mazzini, Ivana Munitic, Silva Hecimovic

Subject: Medicine And Pharmacology, Neuroscience And Neurology Keywords: Alzheimer’s disease; Parkinson’s disease; Niemann-Pick type C disease; neurodegeneration; neuroinflammation; immunomodulatory therapies; rare diseases

Online: 13 September 2023 (07:33:01 CEST)

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Preprint ARTICLE | doi:10.20944/preprints202010.0393.v1

Common Factors in Neurodegeneration: A Meta-Study revealing Shared Patterns on a Multi-Omics Scale

Nicolas Ruffini, Susanne Klingenberg, Susann Schweiger, Susanne Gerber

Subject: Biology And Life Sciences, Biochemistry And Molecular Biology Keywords: Parkinson's disease; Huntington's disease; Integration; Shared patterns; Neurodegeneration; Multi-Omics; Alzheimer's Disease; Amyotrophic Lateral Sclerosis

Online: 19 October 2020 (15:44:47 CEST)

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Neurodegenerative diseases such as Alzheimer's disease, Parkinson's disease, Huntington's disease, and Amyotrophic Lateral Sclerosis are heterogeneous, progressive diseases with frequently overlapping symptoms characterized by a loss of neurons. Studies suggested relations between neurodegenerative diseases for many years, e.g., regarding the aggregation of toxic proteins or triggering endogenous cell death pathways. Within this study, publicly available genomic, transcriptomic and proteomic data were gathered from 188 studies and more than one million patients to detect shared genetic patterns between the neurodegenerative diseases and the analyzed omics-layers within conditions. The results show a remarkably high number of shared genes between the transcriptomic and proteomic levels for all diseases while showing a significant relation between genomic and proteomic data only in some cases. A set of 139 genes was found to be differentially expressed in several transcriptomic experiments of all four diseases. These 139 genes showed overrepresented GO-Terms and pathways mainly involved in stress response, cell development, cell adhesion, and the cytoskeleton. Furthermore, the overlap of two and three omics-layers per disease were used to search for overrepresented pathways and GO-Terms. Taken together, we could confirm the existence of many relations between Alzheimer's disease, Parkinson's disease, Huntington's disease, and Amyotrophic Lateral Sclerosis on the transcriptomic and proteomic level by analyzing the pathways and GO-Terms arising in these intersections. The significance of the connection between the transcriptomic and proteomic data for all four analyzed neurodegenerative diseases showed that exploring these omics-layers simultaneously holds new insights that do not emerge from analyzing these omics-layers separately. Our data therefore suggests addressing human patients with neurodegenerative diseases as complex biological systems by integrating multiple underlying data sources.

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