Preprint Review Version 2 Preserved in Portico This version is not peer-reviewed

Role of LFA-1 and ICAM-1 in Cancer

Version 1 : Received: 28 September 2017 / Approved: 28 September 2017 / Online: 28 September 2017 (15:12:52 CEST)
Version 2 : Received: 28 September 2017 / Approved: 29 September 2017 / Online: 29 September 2017 (03:17:31 CEST)

A peer-reviewed article of this Preprint also exists.

Reina, M.; Espel, E. Role of LFA-1 and ICAM-1 in Cancer. Cancers 2017, 9, 153. Reina, M.; Espel, E. Role of LFA-1 and ICAM-1 in Cancer. Cancers 2017, 9, 153.


The lymphocyte function–associated antigen-1 (LFA-1) (also CD11a/CD18 and αLβ2), is just one of many integrins in the human body, but its significance derives from its exclusive presence in leukocytes. In this review, we summarize the studies relating LFA-1 and its major ligand ICAM-1 (CD54) with cancer, through the function of lymphocytes and myeloid cells on tumor cells. We consider how LFA-1 mediates the interaction of leukocytes with tumors and the role of ICAM-1 in tumor dynamics, which can be independent of its interaction with LFA-1. A more detailed examination of LFA’s role within B-cell chronic lymphocytic leukemia is made. Finally, we discuss the role of LFA-1-harboring exosomes in tumor growth and metastasis.


cancer metastasis; chronic lymphocytic leukemia; exosomes; tumor microenvironment


Biology and Life Sciences, Cell and Developmental Biology

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