Role of LFA-1 and ICAM-1 in Cancer

Manuel Reina; Enric Espel

doi:10.20944/preprints201709.0146.v1

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preprints.org > biology and life sciences > cell and developmental biology > doi: 10.20944/preprints201709.0146.v1

Preprint Review Version 1 Preserved in Portico This version is not peer-reviewed

Role of LFA-1 and ICAM-1 in Cancer

Manuel Reina

^* and

Enric Espel

Version 1 : Received: 28 September 2017 / Approved: 28 September 2017 / Online: 28 September 2017 (15:12:52 CEST)
Version 2 : Received: 28 September 2017 / Approved: 29 September 2017 / Online: 29 September 2017 (03:17:31 CEST)

A peer-reviewed article of this Preprint also exists.

Reina, M.; Espel, E. Role of LFA-1 and ICAM-1 in Cancer. Cancers 2017, 9, 153. Reina, M.; Espel, E. Role of LFA-1 and ICAM-1 in Cancer. Cancers 2017, 9, 153.

Abstract

The lymphocyte function–associated antigen-1 (LFA-1) (also CD11a/CD18 and alphaLbeta2), is just one of many integrins in the human body, but its significance derives from its exclusive presence in leukocytes. In this review, we summarize the studies relating LFA-1 and its major ligand ICAM-1 (CD54) with cancer, through the function of lymphocytes and myeloid cells on tumor cells. We consider how LFA-1 mediates the interaction of leukocytes with tumors and the role of ICAM-1 in tumor dynamics, which can be independent of its interaction with LFA-1. A more detailed examination of LFA’s role within B-cell chronic lymphocytic leukemia is made. Finally, we discuss the role of LFA-1-harboring exosomes in tumor growth and metastasis.

Keywords

cancer metastasis, chronic lymphocytic leukemia, exosomes, tumor microenvironment

Subject

Biology and Life Sciences, Cell and Developmental Biology

Copyright: This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

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