Version 1
: Received: 21 July 2022 / Approved: 22 July 2022 / Online: 22 July 2022 (13:18:26 CEST)
How to cite:
Garg, G.; Purwar, S.; Singh, A.K.; Vyas, A.K. Regulation and Impact of Hepatitis B x Protein in Persistence and Oncogenesis of Hepatitis B Virus. Preprints2022, 2022070341. https://doi.org/10.20944/preprints202207.0341.v1
Garg, G.; Purwar, S.; Singh, A.K.; Vyas, A.K. Regulation and Impact of Hepatitis B x Protein in Persistence and Oncogenesis of Hepatitis B Virus. Preprints 2022, 2022070341. https://doi.org/10.20944/preprints202207.0341.v1
Garg, G.; Purwar, S.; Singh, A.K.; Vyas, A.K. Regulation and Impact of Hepatitis B x Protein in Persistence and Oncogenesis of Hepatitis B Virus. Preprints2022, 2022070341. https://doi.org/10.20944/preprints202207.0341.v1
APA Style
Garg, G., Purwar, S., Singh, A.K., & Vyas, A.K. (2022). Regulation and Impact of Hepatitis B x Protein in Persistence and Oncogenesis of Hepatitis B Virus. Preprints. https://doi.org/10.20944/preprints202207.0341.v1
Chicago/Turabian Style
Garg, G., Anirudh K. Singh and Ashish Kumar Vyas. 2022 "Regulation and Impact of Hepatitis B x Protein in Persistence and Oncogenesis of Hepatitis B Virus" Preprints. https://doi.org/10.20944/preprints202207.0341.v1
Abstract
Chronic Hepatitis B (CHB) Virus infection is major etiological factor for liver cirrhosis and/ or liver cancer. The viral protein, major contributor in predisposition of chronicity and Hepatocellular Carcinoma (HCC) is Hepatitis B x (HBx) protein. Its dynamic subcellular distribution to an extent determines its multifactorial role. It is a regulatory protein which modulates viral as well as host machinery in favours to HBV persistence. An insight on HBx stabilising factors is critical for therapeutic purpose. The precise role of HBx in the pathogenesis of Chronicity of HBV is not known. Summary: This review comprehensively summarizing different mechanisms and their regulation by HBx protein with respect to chronicity and HCC emphasising viral persistence. Key Messages 1. HBx is a key protein for viral persistence. 2. Dynamic subcellular distribution of HBx determines its function. 3. HBx modulates cellular machinery to favours HBV survival. 4. HBx affects various intermediary mechanisms contributing to disease progression. 5. HBx may be a potent target to prevent the disease progression towards HCC.
Keywords
Hepatitis B Virus; Chronic Hepatitis infection; Oncogenesis
Subject
Biology and Life Sciences, Virology
Copyright:
This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
