Preprint Article Version 1 Preserved in Portico This version is not peer-reviewed

The Late Asymptomatic and Terminal Immunodeficiency Phases in Experimentally FIV-Infected Cats- a Long-Term Study

Brian G Murphy
* ORCID logo ,
Diego Castillo
,
Sarah Elisabeth Cook
,
Chrissy Eckstrand
,
Samantha Evans
,
Ellen Sparger
,
Chris Grant
Version 1 : Received: 29 July 2023 / Approved: 31 July 2023 / Online: 31 July 2023 (10:29:19 CEST)

A peer-reviewed article of this Preprint also exists.

Murphy, B.G.; Castillo, D.; Cook, S.; Eckstrand, C.; Evans, S.; Sparger, E.; Grant, C.K. The Late Asymptomatic and Terminal Immunodeficiency Phases in Experimentally FIV-Infected Cats—A Long-Term Study. Viruses 2023, 15, 1775. Murphy, B.G.; Castillo, D.; Cook, S.; Eckstrand, C.; Evans, S.; Sparger, E.; Grant, C.K. The Late Asymptomatic and Terminal Immunodeficiency Phases in Experimentally FIV-Infected Cats—A Long-Term Study. Viruses 2023, 15, 1775.

Abstract

Feline immunodeficiency virus (FIV) is a lentivirus in the family Retroviridae that infects domestic cats resulting in an immunodeficiency disease featuring a progressive and profound decline in multiple sets of peripheral lymphocytes. Despite compelling evidence of FIV-associated immunopathology, there are conflicting data concerning the clinical effects of FIV infection on host morbidity and mortality. To explore FIV-associated immunopathogenesis and clinical disease, we experimentally inoculated a cohort of 4 specific pathogen free kittens with a biological isolate of FIV clade C and continuously monitored these animals along with 2 uninfected control animals for more than 13 years, from the time of inoculation to the humane euthanasia endpoint. Here we report the results obtained during the late asymptomatic and terminal phases of FIV infection in this group of experimentally FIV-infected cats.

Keywords

Cat; FIV; lentivirus; FAIDS; lymphoma; chronic renal failure

Subject

Biology and Life Sciences, Virology

Copyright: This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

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