Preprint Article Version 1 This version is not peer-reviewed

Renoprotective Effect of Laminaria japonica Polysaccharide in Adenine-Induced Chronic Renal Failure

Version 1 : Received: 21 January 2019 / Approved: 22 January 2019 / Online: 22 January 2019 (11:50:15 CET)

How to cite: Long, M.; Li, Q.; Fang, Q.; Pan, L.; Zha, X.; Luo, J. Renoprotective Effect of Laminaria japonica Polysaccharide in Adenine-Induced Chronic Renal Failure. Preprints 2019, 2019010220 (doi: 10.20944/preprints201901.0220.v1). Long, M.; Li, Q.; Fang, Q.; Pan, L.; Zha, X.; Luo, J. Renoprotective Effect of Laminaria japonica Polysaccharide in Adenine-Induced Chronic Renal Failure. Preprints 2019, 2019010220 (doi: 10.20944/preprints201901.0220.v1).

Abstract

Chronic renal failure (CRF) is a major public health problem worldwide. In this work, we investigated the effects of a purified Laminaria japonica polysaccharide (LJP61A) on the renal function using adenine-induced CRF mice model. Results exhibited that adenine treatment caused serious renal pathological damages and elevation of serum creatinine and blood urea nitrogen of mice. However, these changes could be significantly reversed by the administration of LJP61A in a dose-dependent manner. Additionally, LJP61A could dramatically reduce the weight loss, improve the urine biochemical index, and regulate the electrolyte disturbance of CRF mice. These results suggested that the renal functions of adenine-induced CRF mice could be improved by LJP61A, which might be developed to a potential therapeutic agent for CRF patients.

Subject Areas

Laminaria japonica; polysaccharide; chronic renal failure

Readers' Comments and Ratings (0)

Leave a public comment
Send a private comment to the author(s)
Views 0
Downloads 0
Comments 0
Metrics 0


×
Alerts
Notify me about updates to this article or when a peer-reviewed version is published.