Long, M.; Li, Q.-M.; Fang, Q.; Pan, L.-H.; Zha, X.-Q.; Luo, J.-P. Renoprotective Effect of Laminaria japonica Polysaccharide in Adenine-Induced Chronic Renal Failure. Molecules2019, 24, 1491.
Long, M.; Li, Q.-M.; Fang, Q.; Pan, L.-H.; Zha, X.-Q.; Luo, J.-P. Renoprotective Effect of Laminaria japonica Polysaccharide in Adenine-Induced Chronic Renal Failure. Molecules 2019, 24, 1491.
Long, M.; Li, Q.-M.; Fang, Q.; Pan, L.-H.; Zha, X.-Q.; Luo, J.-P. Renoprotective Effect of Laminaria japonica Polysaccharide in Adenine-Induced Chronic Renal Failure. Molecules2019, 24, 1491.
Long, M.; Li, Q.-M.; Fang, Q.; Pan, L.-H.; Zha, X.-Q.; Luo, J.-P. Renoprotective Effect of Laminaria japonica Polysaccharide in Adenine-Induced Chronic Renal Failure. Molecules 2019, 24, 1491.
Abstract
Chronic renal failure (CRF) is a major public health problem worldwide. In this work, we investigated the effects of a purified Laminaria japonica polysaccharide (LJP61A) on the renal function using adenine-induced CRF mice model. Results exhibited that adenine treatment caused serious renal pathological damages and elevation of serum creatinine and blood urea nitrogen of mice. However, these changes could be significantly reversed by the administration of LJP61A in a dose-dependent manner. Additionally, LJP61A could dramatically reduce the weight loss, improve the urine biochemical index, and regulate the electrolyte disturbance of CRF mice. These results suggested that the renal functions of adenine-induced CRF mice could be improved by LJP61A, which might be developed to a potential therapeutic agent for CRF patients.
Biology and Life Sciences, Biochemistry and Molecular Biology
Copyright:
This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
