Preprint Article Version 1 Preserved in Portico This version is not peer-reviewed

Finite Mixture Models Based on Pain Intensity, Functional Disability and Psychological Distress Composite Assessment Allow to Identify Two Distinct Classes of Persistent Spinal Pain Syndrome after Surgery Patients Related to Their Quality of Life

Version 1 : Received: 27 August 2021 / Approved: 27 August 2021 / Online: 27 August 2021 (15:23:27 CEST)

A peer-reviewed article of this Preprint also exists.

Ounajim, A.; Billot, M.; Louis, P.-Y.; Slaoui, Y.; Frasca, D.; Goudman, L.; Roulaud, M.; Naiditch, N.; Lorgeoux, B.; Baron, S.; Nivole, K.; Many, M.; Adjali, N.; Page, P.; Bouche, B.; Charrier, E.; Poupin, L.; Rannou, D.; de Montgazon, G.B.; Roy-Moreau, B.; Wood, C.; Rigoard, R.; David, R.; Moens, M.; Rigoard, P. Finite Mixture Models Based on Pain Intensity, Functional Disability and Psychological Distress Composite Assessment Allow Identification of Two Distinct Classes of Persistent Spinal Pain Syndrome after Surgery Patients Related to Their Quality of Life. J. Clin. Med. 2021, 10, 4676. Ounajim, A.; Billot, M.; Louis, P.-Y.; Slaoui, Y.; Frasca, D.; Goudman, L.; Roulaud, M.; Naiditch, N.; Lorgeoux, B.; Baron, S.; Nivole, K.; Many, M.; Adjali, N.; Page, P.; Bouche, B.; Charrier, E.; Poupin, L.; Rannou, D.; de Montgazon, G.B.; Roy-Moreau, B.; Wood, C.; Rigoard, R.; David, R.; Moens, M.; Rigoard, P. Finite Mixture Models Based on Pain Intensity, Functional Disability and Psychological Distress Composite Assessment Allow Identification of Two Distinct Classes of Persistent Spinal Pain Syndrome after Surgery Patients Related to Their Quality of Life. J. Clin. Med. 2021, 10, 4676.

Journal reference: J. Clin. Med. 2021, 10, 4676
DOI: 10.3390/jcm10204676

Abstract

Persistent Spinal Pain Syndrome Type 2 (PSPS-T2), (Failed Back Surgery Syndrome), dramatically impacts on patient quality of life, as evidenced by Health-Related Quality of Life (HRQoL) assessment tools. However, the importance of functioning, pain perception and psychological status in HRQoL can substantially vary between subjects. Our goal was to extract patient profiles based on HRQoL dimensions in a sample of PSPS-T2 patients and to identify factors associated with these profiles. Two classes were clearly identified using a mixture of mixed effect models from a clinical data set of 200 patients enrolled in “PREDIBACK”, a multicenter observational prospective study including PSPS-T2 patients with 1-year follow-up. We observed that HRQoL was more impacted by functional disability for first class patients (n=136) and by pain perception for second class patients (n=62). Males that perceive their work as physical were more impacted by disability than pain intensity. Lower education level, lack of adaptive coping strategies and higher pain intensity were significantly associated with HRQoL being more impacted by pain perception. The identification of such classes allows for a better understanding of HRQoL dimensions and opens the gate towards optimized health-related quality of life evaluation and personalized pain management.

Keywords

PSPS; FBSS; chronic pain; health-related quality of life; mixture models analysis; personalized pain management; chronic pain after spinal surgery

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