Article
Version 2
Preserved in Portico This version is not peer-reviewed
Chronic Inflammation and Blood Cancer
Version 1
: Received: 17 November 2022 / Approved: 21 November 2022 / Online: 21 November 2022 (03:32:01 CET)
Version 2 : Received: 24 November 2022 / Approved: 24 November 2022 / Online: 24 November 2022 (02:55:44 CET)
Version 2 : Received: 24 November 2022 / Approved: 24 November 2022 / Online: 24 November 2022 (02:55:44 CET)
How to cite: Tzenios, N.; Tazanios, M.; Chahine, M. Chronic Inflammation and Blood Cancer. Preprints 2022, 2022110365. https://doi.org/10.20944/preprints202211.0365.v2 Tzenios, N.; Tazanios, M.; Chahine, M. Chronic Inflammation and Blood Cancer. Preprints 2022, 2022110365. https://doi.org/10.20944/preprints202211.0365.v2
Abstract
Chronic inflammation may have a detrimental impact on human health as it tends to result in cancer. In addition, it is often linked to different steps that participate in tumorigenesis, including cellular transformation, survival, promotion, invasion, proliferation, angiogenesis, and metastasis. Hence, inflammation predisposes cancer development and plays a vital role in promoting all tumorigenesis stages. Inflammation is caused by many factors, such as bacterial and viral infections, tobacco smoking, autoimmune diseases, obesity, asbestos exposure, and many others, increasing cancer risk. Moreover, cancer can be enhanced by mutations that proceed to cancer progression. Consequently, it leads to immunosuppression and provides a favorable background for tumor development. Although many studies address the question of relationships between inflammation and cancer development, little attention is paid to the link between inflammation and blood cancer. Therefore, the current study reviews the role of inflammation in cancer development, particularly in blood cancer. A meta-analysis research approach meets the research objective and answers the research question. The review results indicate that chronic inflammation directly relates to the development of many cancer types, blood cancer in particular.
Keywords
blood cancer; chronic inflammation; inflammation; mutation; tumor
Subject
Medicine and Pharmacology, Oncology and Oncogenics
Copyright: This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
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Commenter: Nikolaos Tzenios
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