Preprint Article Version 1 Preserved in Portico This version is not peer-reviewed

Association of Periodontal Disease with Activity of Crohn's Disease

Miloš Živić
ORCID logo ,
Nebojsa Zdravkovic
ORCID logo ,
Bojan Stojanovic
ORCID logo ,
Bojan Milosevic
,
Zeljko Todorovic
* ORCID logo ,
Miljan Adamović
,
Natasa Zdravkovic
Version 1 : Received: 1 November 2023 / Approved: 2 November 2023 / Online: 2 November 2023 (10:51:54 CET)

A peer-reviewed article of this Preprint also exists.

Živić, M.; Zdravković, N.; Stojanović, B.; Milošević, B.; Todorović, Ž.; Adamović, M.; Zdravković, N. Association of Periodontal Disease with Activity of Crohn’s Disease. Medicina 2023, 59, 2154. Živić, M.; Zdravković, N.; Stojanović, B.; Milošević, B.; Todorović, Ž.; Adamović, M.; Zdravković, N. Association of Periodontal Disease with Activity of Crohn’s Disease. Medicina 2023, 59, 2154.

Abstract

Introduction: Crohn's disease (CD) is a chronic inflammatory granulomatous disease that can affect the entire gastrointestinal tract. It is characterized by various extraintestinal manifestations (EIM), of which oral manifestations (OM) are often possible. One of the possible OM is periodontal disease (PD) a chronic inflammatory condition of the supporting tissues of the teeth. This study aimed to show the existence of a mutual relationship between the clinical activity of PD and the clinical and endoscopic activity of CD. Materials and methods: Using one clinical and two endoscopic indexes for the assessment of CD activity and clinical attachment loss (CAL), bleeding on probing (BOP), pocket probing depth (PPD) and radiographic bone loss (RDL) on dental panoramic tomogram to assess PD in CD patients. Results: A total of 38 patients underwent the entire study process, of which 20 patients with CD and 18 patients with CD and PD. Considering all CD activity scores, there were 26 patients with active disease, and half of them had PD, and 85.7% of operated patients had active CD. Values of CAL, PPD, BOP and RBL were higher in active CD than remission, except BOP when compared to CDAI score which was higher in remission of CD. Discussion and conclusion: The results of this study indicate that there is a connection between the activity of CD and the worse condition of the supporting tissues of the gums in the oral cavity which is important to keep in mind the necessity of referring patients with CD to a dentist for timely and adequate therapeutic measures.

Keywords

Crohn’s disease; periodontal disease; Crohn’s disease activity indexes; periodontal indexes

Subject

Medicine and Pharmacology, Gastroenterology and Hepatology

Copyright: This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

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