Narimatsu, Y.; Kato, M.; Iwakoshi-Ukena, E.; Moriwaki, S.; Ogasawara, A.; Furumitsu, M.; Ukena, K. Neurosecretory Protein GM–Expressing Neurons Participate in Lipid Storage and Inflammation in Newly Developed Cre Driver Male Mice. Biomedicines2023, 11, 3230.
Narimatsu, Y.; Kato, M.; Iwakoshi-Ukena, E.; Moriwaki, S.; Ogasawara, A.; Furumitsu, M.; Ukena, K. Neurosecretory Protein GM–Expressing Neurons Participate in Lipid Storage and Inflammation in Newly Developed Cre Driver Male Mice. Biomedicines 2023, 11, 3230.
Narimatsu, Y.; Kato, M.; Iwakoshi-Ukena, E.; Moriwaki, S.; Ogasawara, A.; Furumitsu, M.; Ukena, K. Neurosecretory Protein GM–Expressing Neurons Participate in Lipid Storage and Inflammation in Newly Developed Cre Driver Male Mice. Biomedicines2023, 11, 3230.
Narimatsu, Y.; Kato, M.; Iwakoshi-Ukena, E.; Moriwaki, S.; Ogasawara, A.; Furumitsu, M.; Ukena, K. Neurosecretory Protein GM–Expressing Neurons Participate in Lipid Storage and Inflammation in Newly Developed Cre Driver Male Mice. Biomedicines 2023, 11, 3230.
Abstract
Obesity induces inflammation in the hypothalamus and adipose tissue, resulting in metabolic disorders. A novel hypothalamic neuropeptide, neurosecretory protein GM (NPGM), was previously identified in the hypothalamus of vertebrates. While NPGM plays an important role in lipid metabolism in chicks, its metabolic regulatory effects in mammals remain unclear. In this study, a novel Cre driver line, NPGM-Cre, was generated for cell-specific manipulation. Cre-dependent overexpression of Npgm led to fat accumulation without increased food consumption in NPGM-Cre mice. Chemogenetic activation of NPGM neurons acutely promoted feeding behavior and chronically resulted in a transient increase in body mass gain. Furthermore, the ablated NPGM neurons exhibited a tendency to be glucose intolerant, with infiltration of proinflammatory macrophages into the adipose tissue. These results suggest that NPGM neurons may regulate lipid storage and inflammatory responses, thereby maintaining glucose homeostasis.
Keywords
neurosecretory protein GM; hypothalamus; neuropeptide; obesity; chronic inflammation; chemogenetics
Subject
Biology and Life Sciences, Endocrinology and Metabolism
Copyright:
This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
