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Preprint ARTICLE | doi:10.20944/preprints202409.0870.v1

Prenatal Exposure to a Human Relevant Mixture of EDCs Affects Mandibular Development in Mice

Vagelis Rinotas, Antonios Stamatakis, Athanasios Stergiopoulos, Carl-Gustaf Bornehag, Joëlle Rüegg, Marietta Armaka, Efthymia Kitraki

Subject: Biology And Life Sciences, Endocrinology And Metabolism Keywords: EDCs; mandible; mice; micro-CT

Online: 11 September 2024 (17:08:57 CEST)

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Preprint BRIEF REPORT | doi:10.20944/preprints202408.2148.v1

Sleeve Gastrectomy Reduces Body Weight and Food Intake in Diet-Induced Obese Mice with No Alterations in Anorexigenic and Orexigenic Hypothalamic Genes

Sandra Lucinei Balbo, Gabriela Moreira Soares, Joseane Morari, Antônio Machado Felisberto Júnior, Jean Franciesco Vettorazzi, Gabriela Alves Bronczek, Maria Lúcia Bonfleur, Everardo Magalhães Carneiro, Licio Augusto Velloso, Antonio Carlos Boschero

Subject: Biology And Life Sciences, Endocrinology And Metabolism Keywords: obesity; bariatric surgery; food intake; hypothalamus

Online: 29 August 2024 (11:31:58 CEST)

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Preprint ARTICLE | doi:10.20944/preprints202408.1944.v1

miR-10a/b-5p-NCOR2 Regulates Insulin-Resistant Diabetes in Female Mice

Se Eun Ha, Rajan Singh, Byungchang Jin, Gain Baek, Brian G. Jorgensen, Hannah Zogg, Sushmita Debnath, Hahn Sung Park, Hayeong Cho, Claudia Marie Watkins, Sumin Cho, Min-Seob Kim, Moon Young Lee, Tae Yang Yu, Jin Woo Jeong, Seungil Ro

Subject: Biology And Life Sciences, Endocrinology And Metabolism Keywords: MicroRNAs; diabetes mellitus; estrogen; pancreatic β -cells

Online: 27 August 2024 (18:40:19 CEST)

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Preprint ARTICLE | doi:10.20944/preprints202408.1908.v1

Possibility of Total Cholesterol/High-Density Lipoprotein Ratio as a Prognostic Indicator through Correlation Analysis with Hyperlipidemia Related Diseases in Dogs

Kyuhyung Choi

Subject: Biology And Life Sciences, Endocrinology And Metabolism Keywords: Hyperlipidemia; High-density lipoprotein; Total cholesterol; Cushing’s disease; Hypothyroidism; Total cholesterol/High-density lipoprotein ratio

Online: 27 August 2024 (10:20:58 CEST)

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Preprint ARTICLE | doi:10.20944/preprints202408.0883.v1

NR5A1/SF-1 Collaborates with Inhibin α and the Androgen Receptor to Reveal a Complex DSD Phenotype

Rawda Naamneh Elzenaty, Chrysanthi Kouri, Idoia Martinez de Lapiscina, Kay Sara Sauter, Francisca Moreno, Núria Camats Tarruella, Christa E. Flück

Subject: Biology And Life Sciences, Endocrinology And Metabolism Keywords: steroidogenic factor 1 (SF-1/NR5A1); inhibin , androgen receptor; differences of sex development (DSD); 46,XY DSD; hypospadias; oligogenicity

Online: 14 August 2024 (09:17:30 CEST)

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Preprint ARTICLE | doi:10.20944/preprints202408.0611.v1

SIK2 Controls the Homeostatic Character of POMC Secretome Acutely in Response to Pharmacological ER Stress Induction

Mehmet Soner Türküner, Ayşe Yazıcı, Ferruh Özcan

Subject: Biology And Life Sciences, Endocrinology And Metabolism Keywords: SIK2; POMC; inflammation; neuronal secretome; ER stress; hypothalamic obesity

Online: 8 August 2024 (12:32:44 CEST)

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Preprint ARTICLE | doi:10.20944/preprints202408.0167.v1

Elucidating the Causal Link Between Hearing and Chronic Kidney Disease Through Mendelian Randomization and Development of Predictive Machine Learning Models Based on NHANES Data

Yanting Yang, Yuqing Li, Zhongquan Huang, Rongrong Lin, Zhuoni Chen, Ning Zhang, Nan Zheng, Jiean Xu, Yaqi Zhou

Subject: Biology And Life Sciences, Endocrinology And Metabolism Keywords: Chronic kidney disease; Hearing; Mendelian randomization; Machine learning models; Predictions

Online: 2 August 2024 (10:56:30 CEST)

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Preprint ARTICLE | doi:10.20944/preprints202407.2490.v1

Influence of Northern Wild Rice on Gut Dysbiosis and Short Chain Fatty Acids: Correlation with Metabolic and Inflammatory Markers in High Fat Diet-Induced Insulin Resistant Mice

Ruozhi Zhao, Janice Fajardo, Garry X. Shen

Subject: Biology And Life Sciences, Endocrinology And Metabolism Keywords: wild rice; gut microbiota; short chain fatty acids; high fat diet; mice; metabolism; chronic inflammation; Lactobacillus gasseri; propionic acid

Online: 31 July 2024 (07:06:29 CEST)

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Preprint ARTICLE | doi:10.20944/preprints202407.2417.v1

Characterization of Stealth Liposome-Based Nanoparticles Encapsulating the ACAT1/SOAT1 Inhibitor F26: Efficacy and Toxicity Studies In Vitro and in Wild-Type Mice

Junghoon Lee, Adrianna L. De La Torre, Felix L. Rawlinson, Dylan B. Ness, Lionel D. Lewis, William F. Hickey, Catherine C.Y. Chang, Ta Yuan Chang

Subject: Biology And Life Sciences, Endocrinology And Metabolism Keywords: ACAT1/SOAT1; nanoparticle; F1251; F26; cholesterol; cholesteryl ester; DSPE-PEG; phosphatidylcholine; neurodegenerative diseases; Alzheimer’s disease

Online: 30 July 2024 (07:35:59 CEST)

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Preprint ARTICLE | doi:10.20944/preprints202407.2207.v1

Insights into the Metabolite Profiles of Two Camellia (Theaceae) Species in Yunnan Province through Metabolomic and Transcriptomic Analysis

Miao Niu, Ranyang Li, Xiongyu Li, Hongyan Yang, Jianliang Ding, Xianxiu Zhou, Yuqi He, Yawen Xu, Qian Qu, Zhiwei Liu, Jiahua Li

Subject: Biology And Life Sciences, Endocrinology And Metabolism Keywords: tea species evaluation; Camellia sinensis; Camellia taliensis; metabolome; transcriptome

Online: 29 July 2024 (10:46:08 CEST)

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Preprint REVIEW | doi:10.20944/preprints202407.2111.v1

Relevance of Diet in Schizophrenia: Focusing on Prenatal Nutritional Deficiency, Obesity, Oxidative Stress and Inflammation

Amalia Vasile, Viorica Rarinca, Vasile Burlui, Gabriela Halitchi, Alin Ciobică, Ana-Maria Singeap, Romeo Dobrin, Ecaterina Burlui, Anca Trifan

Subject: Biology And Life Sciences, Endocrinology And Metabolism Keywords: Schizophrenia; Diet; Nutrients; Obesity; Oxidative Stress; Inflammation; Antioxidants

Online: 26 July 2024 (11:30:36 CEST)

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Preprint ARTICLE | doi:10.20944/preprints202407.1811.v1

Evidence for a Pro-inflammatory State of Macrophages from Non-obese Type-2 Diabetic Goto-Kakizaki Rats

Amanda Santos de Almeida Silveira, Amara Cassandra dos Anjos Alves, Gabriela Mandú Gimenes, Patrícia da Silva Quessada, Tiago Bertola Lobato, Beatriz Belmiro Dias, Ana Carolina Gomes Pereira, Patrícia Nancy Iser-Bem, Joice Naiara Bertaglia Pereira, Elaine Hatanaka, Laureane Nunes Masi, Tânia Cristina Pithon-Curi, Vânia Gomes de Moura Mattaraia, Sandro Massao Hirabara, Amanda Rabello Crisma, Renata Gorjão, Rui Curi

Subject: Biology And Life Sciences, Endocrinology And Metabolism Keywords: type 2 diabetes mellitus; insulin resistance; inflammation; GK; GM-CSF; M1; M2; TNF-α

Online: 24 July 2024 (10:09:23 CEST)

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Preprint ARTICLE | doi:10.20944/preprints202407.1754.v1

Angiotensin II alters Mitochondrial Membrane Potential and Lipid Metabolism in Rat Colonic Epithelial Cells

Darby D. Toth, Christopher L Souders II, Sarah J Patuel, Cole D English, Isaac Konig, Emma Ivantsova, Wendi Malphurs, Jacqueline Watkins, Kaylie A Costa, John A Bowden, Jasenka Zubcevic, Christopher J. Martyniuk

Subject: Biology And Life Sciences, Endocrinology And Metabolism Keywords: colonocytes; bioenergetics; lipidomics; lipids; mitochondria; angiotensin II

Online: 23 July 2024 (07:31:44 CEST)

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Preprint ARTICLE | doi:10.20944/preprints202407.1697.v1

3,5-dimethyl-2,4,6-trimethoxychalcone Lessens Obesity and Metabolic Dysfunction-Associated Fatty Liver Disease (MAFLD) in Leptin-Deficient ob/ob Mice

Stéphanie Gaige, Anne Abysique, Rym Barbouche, Attilio Di Maio, Maxime Robin, Anh Tuan Lormier, Jean-Denis Troadec

Subject: Biology And Life Sciences, Endocrinology And Metabolism Keywords: chalcone; food intake; brainstem; hypothalamus; leptin; steatosis; liver

Online: 22 July 2024 (10:10:16 CEST)

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Preprint REVIEW | doi:10.20944/preprints202407.1352.v1

The Role of Gut Microbiota Dysbiosis Induced by Circadian Rhythm Disruption in Cardiometabolic Diseases

Qin-yao Li, Chang Liu, Yi-xin Zhang, Jia-cen Sun, Wei-Zhong Wang

Subject: Biology And Life Sciences, Endocrinology And Metabolism Keywords: Cardiometabolic diseases; Circadian rhythm disruption; Gut microbiota

Online: 16 July 2024 (14:59:13 CEST)

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Preprint ARTICLE | doi:10.20944/preprints202407.1245.v1

From iPSCs to Pancreatic β Cells: Unveiling Molecular Pathways and Enhancements With Vitamin C and Retinoic Acid in Diabetes Research

Felipe Arroyave, Yomaira Uscategui, Fernando Lizcano

Subject: Biology And Life Sciences, Endocrinology And Metabolism Keywords: islet beta cells; differentiation; iPSC; insulin; diabetes; cell therapy

Online: 16 July 2024 (04:05:10 CEST)

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Preprint ARTICLE | doi:10.20944/preprints202407.1120.v1

Moderate Overweight of Male Rats Chronically Fed with a Hyperlipidic Diet Developed Early Silent Ang-(3–4)-Sensitive Myocardial Molecular Lesions and Preserved Echographic Parameters

Thuany Crisóstomo, Rafael Luzes, Matheus Leonardo Lima Gonçalves, Marco Antônio Estrela Pardal, Humberto Muzi-Filho, Glória Costa-Sarmento, Debora B. Mello, Adalberto Vieyra

Subject: Biology And Life Sciences, Endocrinology And Metabolism Keywords: overweight/obesity; hypertension; hyperlipidic diets; pro-inflammatory cytokines; cardiometabolic diseases; renin-angiotensin-aldosterone system; Ang-(3–4); cardiac ion-transporting ATPases; cardiac echocardiography

Online: 15 July 2024 (10:33:35 CEST)

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Preprint ARTICLE | doi:10.20944/preprints202407.1132.v1

Impact of Succinate Supplements on Metabolic Health and Muscle Mass after Functional Overloading and Denervation in Mice Fed High-Fat Diet

Mantas Dirmontas, Petras Minderis, Aivaras Ratkevicius

Subject: Biology And Life Sciences, Endocrinology And Metabolism Keywords: glucose tolerance; high-fat diet; ketogenic diet; muscle hypertrophy

Online: 15 July 2024 (08:07:22 CEST)

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Preprint ARTICLE | doi:10.20944/preprints202407.0194.v1

Normal Values for the fT3/fT4 Ratio: Centile Charts (0-29 Years) and Their Application for the Differential Diagnosis of Children with Developmental Delay

Nina-Maria Wilpert, Roma Thamm, Michael Thamm, Jürgen Kratzsch, Dominik Seelow, Mandy Vogel, Heiko Krude, Markus Schuelke

Subject: Biology And Life Sciences, Endocrinology And Metabolism Keywords: thyroid hormone; TSH; reference values; fT3/fT4 ratio; peripheral thyroid hormone resistance; MCT8 deficiency; THRA mutations; SECSIBP2 mutations; SLC16A2 mutations

Online: 2 July 2024 (10:48:35 CEST)

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Preprint ARTICLE | doi:10.20944/preprints202406.0773.v1

Propionic Acidemia, Methylmalonic Acidemia, and cblC Defect: Comparison of Untargeted Metabolomic Profiles

Anna Sidorina, Giulio Catesini, Elisa Sacchetti, Cristiano Rizzo, Carlo Dionisi-Vici

Subject: Biology And Life Sciences, Endocrinology And Metabolism Keywords: methylmalonic acidemia; propionic acidemia; cblC deficiency; untargeted metabolomics

Online: 12 June 2024 (12:23:13 CEST)

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Preprint ARTICLE | doi:10.20944/preprints202406.0820.v1

Manuka Honey Inhibits Human Breast Cancer Progression in Preclinical Models

Diana Márquez-Garbán, Cristian D Yanes, Gabriela Llarena, David Elashoff, Nalo Hamilton, Mary Hardy, Madhuri Wadehra, Susan A. McCloskey, Richard J Pietras

Subject: Biology And Life Sciences, Endocrinology And Metabolism Keywords: Manuka honey, breast cancer, estrogen receptor positive breast cancer, triple negative breast cancer, in vivo xenografts, AMP Kinase signaling, mTOR, STAT3.

Online: 12 June 2024 (10:11:39 CEST)

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Preprint ARTICLE | doi:10.20944/preprints202406.0334.v1

The Autophagic Activator GHF-201 can Alleviate Pathology in a Mouse Model and in Patient Fibroblasts of Type III Glycogenosis

Kumudesh Mishra, Sahar Sweetat, Saja Baraghithy, Uri Sprecher, Monzer Marisat, Sultan Bastu, Hava Glickstein, Joseph Tam, Hanna Rosenmann, Miguel Weil, Edoardo Malfatti, Or Kakhlon

Subject: Biology And Life Sciences, Endocrinology And Metabolism Keywords: glycogen; glycogen storage disease type III; pharmacotherapy

Online: 6 June 2024 (07:54:06 CEST)

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Preprint ARTICLE | doi:10.20944/preprints202406.0235.v1

Lactiplantibacillus plantarum Lp20 Alleviates High Fat Diet-Induced Obesity in Mice via Its Bile Salt Hydrolase Activity

Fangzhou Lu, Hui Wang, Haidong Qian, Zhengyuan Zhai, Yanling Hao

Subject: Biology And Life Sciences, Endocrinology And Metabolism Keywords: Lactiplantibacillus plantarum; bile salt hydrolase; gene knock-out; anti-obesity

Online: 5 June 2024 (15:22:34 CEST)

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Preprint ARTICLE | doi:10.20944/preprints202405.2163.v1

A Low Fiber Diet Minimize Colonic Short Chain Fatty Acids, Increase Severity and Prolongs Recovery in DSS Induced Colitis, Independent of Free Fatty Acid Receptor 2 and 3 Signaling

Jenna Elizabeth Hunt, Charlotte Bayer Christiansen, Mohammad Yassin, Bolette Hartmann, Stefan Offermanns, Lars Ove Dragsted, Jens Juul Holst, Hannelouise Kissow

Subject: Biology And Life Sciences, Endocrinology And Metabolism Keywords: SCFA; colitis; mice; glp-1; fibre

Online: 31 May 2024 (14:29:49 CEST)

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Preprint REVIEW | doi:10.20944/preprints202405.1951.v1

Immune Disorders Connecting Type2 Diabetes and Cardiovascular Complications

YUNMENG LIU

Subject: Biology And Life Sciences, Endocrinology And Metabolism Keywords: Type2 diabetes; cardiovascular complications; cytokines; insulin; adiponectins; immune disorder

Online: 29 May 2024 (12:14:40 CEST)

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Preprint ARTICLE | doi:10.20944/preprints202405.0906.v1

Influence Use of the Bacillus Calmette- Guérin Vaccine on the Incidence Type 1 Diabetes Mellitus Onset in a Child and Adolescent Population

Sandra Maeso Mendez, Ruth Gago Martin, Eider Jauregui Benito, Laura Costa Serra, Andrea Gainzarain Serna, Annabel Prigent Diaz, Carlos Sola Sarabia, Mikel Ogueta Lana, Ignacio Diez Lopez

Subject: Biology And Life Sciences, Endocrinology And Metabolism Keywords: BCG vaccine; Diabetes Mellitus type 1; Mycobacterium tuberculosis.

Online: 14 May 2024 (11:21:01 CEST)

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Preprint ARTICLE | doi:10.20944/preprints202405.0766.v1

Analysis of Metabolite Differences in Co-culture of Trichoderma atroviride and Metarhizium anisopliae Based on LC-MSnon-Targeted Metabolomics

Yongkun Wang, Jingyi Liu, Yi Han, Lusheng Chen, Bo Lang, Hongyi Liu, Yaqian Li, Jie Chen, Xinhua Wang

Subject: Biology And Life Sciences, Endocrinology And Metabolism Keywords: Trichoderma atroviride; Metarhizium anisopliae; non-targeted metabolomics

Online: 13 May 2024 (12:30:06 CEST)

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Preprint ARTICLE | doi:10.20944/preprints202405.0545.v1

Protective Effects of Phyllanthus emblica L. Extract against Renal Dysfunction, Angiogenesis, and Fibrosis Occur through the Regulation of PKCα Activation, Vegf, and TGF-β1 in a Diabetic Nephropathy Model

Cheng-Hsiu Lin, Chun-Ching Shih

Subject: Biology And Life Sciences, Endocrinology And Metabolism Keywords: Phyllanthus emblica L.; db/db mice; diabetic nephropathy

Online: 9 May 2024 (16:10:12 CEST)

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Oil-Gan, also known as emblica, is the fruit of the genus Phyllanthus emblica L. The fruits of these trees are high in nutrients and have excellent effects on health care and development values. There are many methods for the management of diabetic nephropathy (DN). However, there is a lack of effective drugs for treating DN from throughout the disease course. The primary aim of this study was to examine the protective effects (including urine analyses, the measurement of inflammatory cytokine levels, and histological examination) and mechanisms of action of an ethyl acetate extract of P. emblica (EPE) on db/db mice, an animal model of diabetic nephropathy, as well as a secondary aim of examining the expression levels of protein kinase Cα (PKCα) in the kidney and its downregulation of vascular endothelial growth factor (VEGF) and fibrosis gene transforming growth factor-β1 (TGF-β1) by Western blot analyses. Eight db/m C57BLKS/J mice were used as the control group. Forty db/db mice were randomly divided into five groups. Treatments included vehicle, EPE1, EPE2, EPE3 (at doses of 100, 200, or 400 mg/kg EPE), or the comparative drug aminoguanidine for 8 weeks. After 8 weeks of treatment, blood samples were collected for analyses of blood glucose, insulin, and HbA1c levels, and pancreatic and kidney tissues were dissected for histological analyses. The present study indicated that the administration of EPE to db/db mice effectively controlled hyperglycemia and hyperinsulinemia by markedly lowering blood glucose, insulin, and glycosylated HbA1c levels. Administration of EPE to db/db mice decreased the levels of BUN and creatinine both in blood and urine and reduced urinary albumin excretion and the albumin creatine ratio (UACR) in urine. Moreover, EPE treatment decreased the blood levels of inflammatory cytokines, including kidney injury molecule-1 (KIM-1), C-reactive protein (CRP), and NLR family pyrin domain containing (NLRP3). Our findings showed that EPE not only had antihyperglycemic effects but also improved renal function in db/db mice. Histological examination of the kidney by immunohistochemistry indicated that EPE can improve kidney function by ameliorating glomerular morphological damage following glomerular injury; alleviating proteinuria by upregulating the expression of nephrin, a biomarker of early glomerular damage; and inhibiting glomerular expansion and tubular fibrosis. Moreover, the administration of EPE to db/db mice increased the expression levels of p- PKCα/t-PKCα but decreased the expression levels of VEGF and renal fibrosis biomarkers (TGF-β1, collagen IV, p-Smad2, p-Smad3, and Smad4), as shown by Western blot analyses. These results implied that EPE as a supplement has a protective effect against renal dysfunction through the amelioration of insulin resistance as well as the suppression of nephritis and fibrosis in a DN model.

Preprint REVIEW | doi:10.20944/preprints202405.0538.v1

Thyrotropin Releasing Hormone and Food-Intake in Mammals: An Update

Yamili Vargas, Ana Elena Castro Tron, Jean-Louis Charli, Adair Rodríguez Rodríguez, Rosa Maria Uribe, Patricia Joseph-Bravo

Subject: Biology And Life Sciences, Endocrinology And Metabolism Keywords: TRH; hypothalamus; arcuate nucleus; lateral hypothalamus; nucleus accumbens; raphe nuclei; brain stem; TRH-R1; TRH-DE; food-intake

Online: 9 May 2024 (15:48:36 CEST)

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Preprint ARTICLE | doi:10.20944/preprints202405.0400.v1

Cholesterol Dietary Intake and Tumour Cell Metabolism Drive Early Epithelial Tumorigenesis

Marine VIALAT, Elissa BAABDATY, Amalia TROUSSON, Ayhan KOCER, Jean-Marc A. LOBACCARO, Silvère BARON, Laurent MOREL, Cyrille de JOUSSINEAU

Subject: Biology And Life Sciences, Endocrinology And Metabolism Keywords: prostate cancer; cholesterol; early tumorigenesis; basal extrusion

Online: 7 May 2024 (13:20:15 CEST)

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Preprint ARTICLE | doi:10.20944/preprints202405.0356.v1

IL-6 Polymorphism as a Predisposing Genetic Factor for Gestational Diabetes or Preeclampsia Development in Pregnancy with Obesity: VEGF and VEGFF Receptor Related Gene Expression Modalities

Panagiotis Halvatsiotis, Theodora Tsokaki, Vassileios Tsitsis, Lina Palaiodimou, Georgios Tsivgoulis, Iraklis Tsangaris, Ourania Panagiotou, Dimitra Houhoula

Subject: Biology And Life Sciences, Endocrinology And Metabolism Keywords: pregnancy; obesity; gestational diabetes; preeclampsia; interleukin 6; VEGF; VEGF receptor; type 2 diabetes mellitus ;

Online: 7 May 2024 (10:19:41 CEST)

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Preprint ARTICLE | doi:10.20944/preprints202405.0255.v1

Updated Risk Factors of Early Endothelial Deregulation in Type-1 Diabetes: A Meta-Analysis

Ranmali Ranasinghe, Michael Mathai, Mohammed Abdullah Alshawsh, Anthony Zulli

Subject: Biology And Life Sciences, Endocrinology And Metabolism Keywords: ; diabetes mellitus; type-1 diabetes; risk factors; biomarkers; therapeutic targets; meta-analysis ;

Online: 6 May 2024 (07:45:46 CEST)

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Preprint ARTICLE | doi:10.20944/preprints202404.1997.v1

Pre and Postmenopausal Females Have Different Inflammatory Cytokine and BDNF Responses to High-Intensity Interval Training Exercise

Anthony Giannopoulos, Ahmad Mohammad, Maria Ilektra Retsidou, Jessica AL Tucker, Derek PD Bornath, Seth F McCarthy, Rebecca E K MacPherson, Tom J Hazell, Panagiota Klentrou

Subject: Biology And Life Sciences, Endocrinology And Metabolism Keywords: Menopause; high-intensity interval training exercise; interleukin 6; interleukin 10; tumour necrosis factor-alpha; brain-derived neurotrophic factor

Online: 30 April 2024 (11:23:33 CEST)

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Preprint ARTICLE | doi:10.20944/preprints202404.1446.v1

Synthesis and Characterisation of DOTA-Kisspeptin-10 as a Potential Gallium-68/Lutetium-177 Theranostic Radiopharmaceutical

Janke Kleynhans, Robert Reeve, Cathryn HS Driver, Biljana Marjanovic-Painter, Mike M Sathekge, Jan Rijn Zeevaart, Thomas Ebenhan, Robert P Millar

Subject: Biology And Life Sciences, Endocrinology And Metabolism Keywords: Theranostics; Peptide Receptor Radionuclide Therapy (PRRT); antimetastatic; Radiopharmaceutical; Positron Emission Computed Tomography (PET); Pharmacokinetics; Pharmacodynamics; tumorigenesis

Online: 23 April 2024 (11:24:27 CEST)

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Preprint ARTICLE | doi:10.20944/preprints202404.1036.v1

Protective Effects of Hepatocyte Stress Defenders, Nrf1 and Nrf2, Against MASLD Progression

May G Akl, Lei Li, Scott B Widenmaier

Subject: Biology And Life Sciences, Endocrinology And Metabolism Keywords: Nrf2; Nrf1; HCC; liver fibrosis; mash; masld

Online: 16 April 2024 (14:01:06 CEST)

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Preprint ARTICLE | doi:10.20944/preprints202404.0040.v1

Speculating on the Evolutionary Pathway of the Hypothalamus-Pituitary-Thyroid Axis

Claudia Ricci, Kumar Reddy Kakularam, Carlotta Marzocchi, Anna Cantore, Hartmut Kuhn, Silvia Cantara

Subject: Biology And Life Sciences, Endocrinology And Metabolism Keywords: thyroid, Neanderthals, Denisovas, Anatomiccaly modern human, hypothyroidism

Online: 1 April 2024 (10:03:38 CEST)

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Preprint ARTICLE | doi:10.20944/preprints202403.1009.v1

Hepatocyte-Specific PEX16 Abrogation in Mice Leads to Hepatocyte Proliferation, Alteration of Hepatic Lipid Metabolism, and Resistance to High Fat Diet (HFD)-Induced Hepatic Steatosis and Obesity

Xue Chen, Long Wang, Krista L. Denning, Anna Mazur, Yujuan Xu, Kesheng Wang, Logan M. Lawrence, Xiaodong Wang, Yongke Lu

Subject: Biology And Life Sciences, Endocrinology And Metabolism Keywords: peroxisomes; bile acid; fatty acid oxidation

Online: 18 March 2024 (10:29:29 CET)

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Preprint REVIEW | doi:10.20944/preprints202402.1574.v1

Molecular Pathology of Thyroid Tumors: Essential Points to Comprehend the Latest WHO Classification

Tomohiro Chiba

Subject: Biology And Life Sciences, Endocrinology And Metabolism Keywords: thyroid cancer; genomic alterations; pathological diagnosis; WHO classification

Online: 27 February 2024 (15:42:09 CET)

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In 2022, the new WHO Classification of Endocrine and Neuroendocrine Tumors, Fifth Edition (beta version) (WHO 5th) was published. The importance of understanding the molecular genetics of thyroid tumors as revealed by large-scale genomic analyses such as The Cancer Genome Atlas (TCGA). Consequently, the WHO 5th was fundamentally revised, resulting in a systematic classification based on tumor cell-of-origin and clinical risk. This paper outlines following critical points of the WHO 5th. 1. Genetic mutations in follicular cell-derived neoplasms (FDN) highlight the role of mutations in the MAP kinase pathway, including RET, RAS, and BRAF, as drivers of carcinogenesis. Differentiated thyroid cancers such as follicular thyroid carcinoma (FTC) and papillary thyroid carcinoma (PTC) have specific genetic alterations that correlate with morphological classifications: RAS-like tumors (RLTs) and BRAF p.V600E-like tumors (BLTs), respectively. 2. The Framework for benign lesions have revised. The WHO 5th introduces new categories such as "developmental abnormalities" and "thyroid follicular nodular disease" in benign FDN. 3. Low-Risk Tumors include NIFTP, TT-UMP, and HTT. 4. PTC histological variants are reclassified as "subtypes" in the WHO 5th. 5. The concept of high-grade carcinomas is introduced, encompassing poorly differentiated thyroid carcinoma (PDTC), differentiated high-grade thyroid carcinoma (DHGTC), and high-grade medullary thyroid carcinoma (MTC). 6. Squamous cell carcinoma is included in anaplastic thyroid carcinoma (ATC) in the WHO 5th due to shared genetic and prognostic features. 7. Hürthle cell adenoma/carcinoma is renamed oncocytic thyroid adenoma/carcinoma. 8. Other miscellaneous tumors are classified into salivary gland-type carcinomas of the thyroid, thyroid tumours of uncertain histogenesis, thymic tumours within the thyroid, and embryonal thyroid neoplasms. The WHO 5th thus emphasizes the importance of classifying tumors based on genetic abnormalities together with histomorphology, aiding in accurate pathological diagnosis and treatment selection, including molecular-targeted therapies.

Preprint ARTICLE | doi:10.20944/preprints202402.0454.v1

Contribution of Circulating Mfge8 to Human T2DM and Cardiovascular Disease

Madhusmita Rout, Megan W. Malone-Perez, Gilseung Park, Megan R. Lerner, J. Kimble Frazer, Blair Apple, April Vaughan, Marvin Payton, Stavros Stavrakis, Evgeny V. Sidorov, Kar-Ming A. Fung, Dharambir K. Sanghera

Subject: Biology And Life Sciences, Endocrinology And Metabolism Keywords: Circulating Mfge8; Rare Variants; Exosomes; Zebrafish; Cardiometabolic Disease

Online: 7 February 2024 (15:01:06 CET)

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MFGE8 is a major exosome (EV) protein known to mediate inflammation and atherosclerosis in type 2 diabetes mellitus (T2DM) in animal studies. However, its role in the pathophysiology of human T2DM, obesity, and cardiovascular disease has been controversial and less explored. Earlier, we reported a rare Asian Indian population-specific missense variant (rs371227978; Arg148His) in the MFGE8 associated with increased circulating Mfge8 and T2DM. Here, we have further investigated the role of Mfge8 with T2DM risk in additional Asian Indians (n=4917) and Europeans and other multiethnic cohorts from UK Biobank (UKBB) (n= 455,808) and the US (n=1150). We also evaluated the exposure of Mfge8-enriched human EVs (with and without mutation) in zebrafish (ZF) for their impact on the cardiometabolic organ system. Most individual carriers of Arg148His variant not only had high circulating Mfge8 but also showed a positive significant correlation with glucose (r= 0.42; p = 4.9x10-04), while the non-carriers showed a negative correlation of Mfge8 with glucose (r = -0.38; p = 0.001) in Asian Indians. However, the same variant was monomorphic in Europeans and other ethnic groups of UKBB and US cohorts. Even in the absence of Arg148His variant, serum Mfge8 correlated significantly with blood glucose both in Caucasians (r = 0.56; p = 8.4x10-10) and individuals from other ethnicities (African Americans, Hispanics, and others) (r = 0.31; p = 5.8x10-4). Since Mfge8 is an EV marker, the exposure of Mfge8-enriched human EVs to ZF larvae rapidly developed fatty liver disease and heart hypertrophy and exhibited redundant growth with poor muscular architecture with and without the high-fat diet (HFD), while the control group fishes developed fatty liver disease and heart hypertrophy only after the HFD feeding. With strong evidence from animal studies supporting the role of Mfge8 in obesity, insulin resistance, and the development of atherosclerosis in T2DM, the current research suggests that circulating Mfge8 may be a potential marker for preventing or reducing the risk of T2DM and cardiovascular disease.

Preprint REVIEW | doi:10.20944/preprints202402.0431.v1

Exercise Alleviates Aging of Adipose Tissue through Adipokine Regulation

Dandan Jia, Huijie Zhang, Tiemin Liu, Ru Wang

Subject: Biology And Life Sciences, Endocrinology And Metabolism Keywords: exercise; adipose tissue; aging; adipokines

Online: 7 February 2024 (13:11:12 CET)

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Preprint ARTICLE | doi:10.20944/preprints202401.1810.v1

Flawed Reanalysis Fails to Support the Carbohydrate-Insulin Model of Obesity

Christina Sciarrillo, Juen Guo, Aaron Hengist, Valerie Darcey, Kevin Hall

Subject: Biology And Life Sciences, Endocrinology And Metabolism Keywords: carbohydrate; fat; obesity; insulin

Online: 25 January 2024 (10:41:19 CET)

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Preprint ARTICLE | doi:10.20944/preprints202401.1566.v1

Comprehensive Atlas of Alternative Splicing Reveals NSRP1 Promoting Adipogenesis through CCDC18

Lei Liu, Wei Wang, WeiWei Liu, Xingzheng Li, Guoqiang Yi, Adeyinka Abiola Adetula, Haibo Huang, Zhonglin Tang

Subject: Biology And Life Sciences, Endocrinology And Metabolism Keywords: pigs; alternative splicing; NSRP1; CCDC18; adipose deposition

Online: 23 January 2024 (03:36:53 CET)

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Preprint ARTICLE | doi:10.20944/preprints202401.0856.v1

Proteomic Profiling of Plasma and Gut-Derived Extracellular Vesicles in Obesity

Pedro Baptista Pereira, Estefa Torrejón, Inês Ferreira, Ana Sofia Carvalho, Akiko Teshima, Inês Sousa-Lima, Hans Christian Beck, Bruno Costa-Silva, Rune Matthiesen, Maria Paula Macedo, Rita Machado Oliveria

Subject: Biology And Life Sciences, Endocrinology And Metabolism Keywords: Extracellular Vesicles; Obesity; Prediabetes; Metabolism; Proteomics; Post-Translational Modifications; Acetylation; Glycation

Online: 11 January 2024 (10:08:28 CET)

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Preprint ARTICLE | doi:10.20944/preprints202401.0764.v1

Placental mRNA expression of Neurokinin B is increased in PCOS pregnancies with female offspring.

Georgios K Markantes, Evangelia Panagodimou, Vasiliki Koika, Irene Mamali, Apostolos Kaponis, George Adonakis, Neoklis A Georgopoulos

Subject: Biology And Life Sciences, Endocrinology And Metabolism Keywords: polycystic ovary syndrome (PCOS); placenta; pregnancy; Neurokinin B (NKB); Kisspeptin (KISS1); placental expression

Online: 10 January 2024 (10:02:52 CET)

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Preprint ARTICLE | doi:10.20944/preprints202401.0575.v1

Di(2-Ethylhexyl) Phthalate Induces Osteoblast Cytotoxicity through Alterations in the Oxidant-Antioxidant System

Gautham Chengizkhan, Manju Mohan, Shabana Thabassum Mohammed Rafi, Sridhar Muthusami, Satish Ramalingam, Lurdes Queimado, R. Ileng Kumaran, Srinivasan Narasimhan, Ilangovan Ramachandran

Subject: Biology And Life Sciences, Endocrinology And Metabolism Keywords: Di(2-ethylhexyl) phthalate (DEHP); Endocrine disrupting compound (EDC); sex steroid receptor; Runt-related transcription factor 2 (Runx2); oxidant-antioxidant system; osteoblastic cells; bone

Online: 8 January 2024 (07:14:11 CET)

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Humans are often exposed to various environmental contaminants, among which phthalates are prevalent due to their extensive use as plasticizers in various consumer goods. Di(2-ethylhexyl) phthalate (DEHP), a widely used phthalate, is recognized as an endocrine disruptor chemical (EDC). DEHP is reported to affect various organs. Few studies have addressed the effects of phthalates on bone. However, the effects of DEHP on the bone forming cells (osteoblasts) are obscure. The present study was peformed to determine the cytotoxic effects of DEHP on human osteoblasts in vitro and to delineate the mechansims. In this study, we exposed the human osteo-blastic cell line MG-63 to various concentrations of DEHP (1, 25, 50 and 100 µM) for 24, 48 and 72 h. Cell viability was assessed by MTT assay. Total RNA and protein were collected after 48 h treatment with 1 and 100 µM DEHP and determined for the mRNA and/or protein expression of alkaline phosphatase (ALP), sex steroid receptors (androgen and estrogen receptors), receptor activator of nuclear factor kappa-Β ligand (RANKL), runt-related transcription factor 2 (RUNX2) and peroxisome proliferator-activated receptor alpha (PPARα). The mRNA expression was stud-ied by real-time RT-PCR analysis and the protein expression was determined by western blot analysis. Statistical analyses were done by one-way analysis of variance (ANOVA) followed by the Students–Newman–Keuls (SNK) test. The exposure of MG-63 cells to DEHP caused a signifi-cant decrease in osteoblast viability in all the treatment groups and at all the time points stud-ied. Interestingly, DEHP exposure decreased the mRNA expression of ALP, a bone formation marker. DEHP had differential effects on estrogen receptor alpha (ERα) mRNA and protein ex-pression. However, DEHP treatment downregulated the mRNA and protein expression of ERβ, and androgen receptor (AR). Surprisingly, DEHP downregulated the RANKL mRNA expression. DEHP decreased the protein expression of RUNX2, the key transcription factor and master regu-lator of bone formation. Furthermore, DEHP increased the PPARα protein expression in the os-teoblasts. Importantly, DEHP increased the reactive oxygen species (ROS) molecules and thus oxidative stress in osteoblasts, as observed by increased hydrogen peroxide, hydroxyl radical levels and lipid peroxidation. On the other hand, it decreased the enzymatic and non-enzymatic antioxidant levels namely catalase, superoxide dismutase, glutathione peroxidase activity and reduced glutathione. Our study demonstrated that in vitro exposure to DEHP reduces the osteo-blast viability possibly through alterations in the oxidant-antioxidant system and modulation of the key genes involved in bone formation, highlighting the cytotoxic effects of DEHP on bone forming cells.

Preprint ARTICLE | doi:10.20944/preprints202401.0255.v1

Mitigating Diabetes and Gut Dysmotility in Mice: Long-Term Safety and Efficacy of miR-10a/B Treatment with No Indication for Cancer and Inflammation Risks

Rajan Singh, Se Eun Ha, Hahn Sung Park, Sushmita Debnath, Hayeong Cho, Gain Baek, Tae Yang Yu, Seungil Ro

Subject: Biology And Life Sciences, Endocrinology And Metabolism Keywords: miR-10a-5p, miR-10b-5p, diabetes, gastrointestinal dysmotility, cancer, inflammation

Online: 3 January 2024 (15:07:06 CET)

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Preprint ARTICLE | doi:10.20944/preprints202401.0053.v1

Oncostatin M Suppresses Bone Morphogenetic Protein-4-Induced Osteoprotegerin Synthesis in Osteoblasts: Attenuation of p70 S6 Kinase

Tomoyuki Hioki, Junko Tachi, Rie Matsushima-Nishiwaki, Hiroki Iida, Osamu Kozawa, Haruhiko Tokuda

Subject: Biology And Life Sciences, Endocrinology And Metabolism Keywords: oncostatin M; bone morphogenetic protein-4; osteoprotegerin; p70 S6 kinase; osteoblast

Online: 2 January 2024 (09:38:17 CET)

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Preprint ARTICLE | doi:10.20944/preprints202312.1748.v1

Exploratory Metabolomic Analysis for Characterizing the Metabolic Profile of the Urinary Bladder under Estrogen Deprivation

Wei Zhang, Qingbo Yang, Yingying Song, Wenheng Liu, Yao Li

Subject: Biology And Life Sciences, Endocrinology And Metabolism Keywords: estrogen deprivation; bladder dysfunction; metabolomics; biomarkers; amino acid metabolism

Online: 22 December 2023 (11:46:36 CET)

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Preprint ARTICLE | doi:10.20944/preprints202312.1584.v1

17β-Estradiol Effects in Skeletal Muscle: A 31P MR Spectroscopic Imaging (MRSI) Study of Young Females during Early-Follicular (EF) and Peri-ovulation (PO) Phases

Jimin Ren, Luis Rodriguez, Talon Johnson, Anke Henning, Yasin Dhaher

Subject: Biology And Life Sciences, Endocrinology And Metabolism Keywords: phosphocreatine, estrogen, skeletal muscle, metabolism, magnesium, 31P MRS, 7T

Online: 20 December 2023 (21:48:00 CET)

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Preprint ARTICLE | doi:10.20944/preprints202312.1565.v1

A Novel Hemocyte-Derived Peptide and Its Possible Roles in Immune Response of Ciona intestinalis Type A

Shin Matsubara, Rin Iguchi, Michio Ogasawara, Hiroya Nakamura, Tatsuki R. Kataoka, Akira Shiraishi, Tomohiro Osugi, Tsuyoshi Kawada, Honoo Satake

Subject: Biology And Life Sciences, Endocrinology And Metabolism Keywords: ascidian; Ciona; hemocyte; stomach; pharynx; peptide; immune response

Online: 20 December 2023 (15:19:21 CET)

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Preprint ARTICLE | doi:10.20944/preprints202311.1921.v1

Overnutrition during Pregnancy and Lactation Induces Gender-Dependent Dysmetabolism in the Offspring Accompanied by Heightened Stress and Anxiety

Gonçalo M Melo, Adriana M. Capucho, Joana F. Sacramento, José Ponce-de-Leão, Marcos V. Fernandes, Inês F. Almeida, Fátima O. Martins, Silvia V. Conde

Subject: Biology And Life Sciences, Endocrinology And Metabolism Keywords: overnutrition; offspring; dysmetabolism; metabolic diseases; stress; anxiety

Online: 30 November 2023 (04:18:40 CET)

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Preprint REVIEW | doi:10.20944/preprints202311.1531.v1

Sex Differences in Colon Cancer: Genomic and Non‐Genomic Signaling of Estrogen

Brian Joseph Harvey, Harry Myles Harvey

Subject: Biology And Life Sciences, Endocrinology And Metabolism Keywords: colon cancer; estrogen; estrogen receptors, sex differences

Online: 23 November 2023 (13:35:24 CET)

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Preprint REVIEW | doi:10.20944/preprints202311.1333.v1

Is Physical Activity an Efficient Strategy to Control the Adverse Effects of Persistent Organic Pollutants in the Context of Obesity? A Narrative Review

Quentin Alexis Serrano, Sébastien Le Garf, Vincent Martin, Serge Sébastien Colson, Nicolas Chevalier

Subject: Biology And Life Sciences, Endocrinology And Metabolism Keywords: Endocrine disruptors; Inflammation; Insulin resistance; Lipid; Adipogenesis; Microbiota; Bariatric surgery; Adipose tissue

Online: 22 November 2023 (08:25:44 CET)

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Preprint REVIEW | doi:10.20944/preprints202311.1109.v1

The Effects of Intermittent Cold Exposure on Adipose Tissue

Matthew C. Scott, Scott Fuller

Subject: Biology And Life Sciences, Endocrinology And Metabolism Keywords: Intermittent Cold Exposure; ICE; cold exposure; adipose tissue; brown adipose tissue; beiging

Online: 16 November 2023 (13:12:10 CET)

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Preprint ARTICLE | doi:10.20944/preprints202311.0113.v1

Neurosecretory Protein GM-Expressing Neurons Participate in Lipid Storage and Inflammation in Newly Developed Cre Driver Mice

Yuki Narimatsu, Masaki Kato, Eiko Iwakoshi-Ukena, Shogo Moriwaki, Ayano Ogasawara, Megumi Furumitsu, Kazuyoshi Ukena

Subject: Biology And Life Sciences, Endocrinology And Metabolism Keywords: neurosecretory protein GM; hypothalamus; neuropeptide; obesity; chronic inflammation; chemogenetics

Online: 2 November 2023 (07:43:58 CET)

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Preprint REVIEW | doi:10.20944/preprints202310.2022.v1

SREBP Regulation of Lipid Metabolism in Liver Disease, and Therapeutic Strategies

Na Li, Xiaodan Li, Yifu Ding, Xiao Liu, Karin Diggle, Tatiana Kisseleva, David A Brenner

Subject: Biology And Life Sciences, Endocrinology And Metabolism Keywords: SREBPs; NAFLD; NASH; fibrosis; hepatocellular carcinoma (HCC); lipogenesis, endoplasmic reticulum (ER) stress; therapeutic target

Online: 31 October 2023 (09:02:44 CET)

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Preprint REVIEW | doi:10.20944/preprints202310.1747.v1

Local Effects of Steroid Hormones within the Bone Microenvironment

Luca Fatime Sandor, Reka Ragacs, David Sandor Gyori

Subject: Biology And Life Sciences, Endocrinology And Metabolism Keywords: extraglandular steroidogenesis; de novo steroidogenesis; steroid hormones; bone metabolism; osteoclast; osteoblast; osteocyte; bone tumors; bone metastasis; pregnenolone derivates

Online: 26 October 2023 (18:54:46 CEST)

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Preprint ARTICLE | doi:10.20944/preprints202310.0905.v1

Hyponatremia Promotes Cancer Growth in a Murine Xenograft Model of Neuroblastoma

Giada Marroncini, Laura Naldi, Benedetta Fibbi, Alice Errico, Simone Polvani, Marco Brogi, Alessandra Fanelli, Mario Maggi, Alessandro Peri

Subject: Biology And Life Sciences, Endocrinology And Metabolism Keywords: hyponatremia; Syndrome of Inappropriate Antidiuresis; cancer; neuroblastoma; murine xeno-graft

Online: 16 October 2023 (08:36:49 CEST)

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Preprint ARTICLE | doi:10.20944/preprints202310.0542.v1

Pharmacokinetics, Tissue Distribution and Excretion of Desmethylberberine in Rats and Mice, a Metabolite of the Berberine

Yongbin Tong, Chengyu Lu

Subject: Biology And Life Sciences, Endocrinology And Metabolism Keywords: demethyleneberberine; pharmacokinetics; tissue distribution; excretion; rats and mice

Online: 10 October 2023 (03:14:37 CEST)

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Preprint ARTICLE | doi:10.20944/preprints202310.0273.v1

Neutral Sphingomyelinase 2 Inhibition Limits Hepatic Steato-sis and Inflammation

Fatema Al-Rashed, Hossein Arefanian, Ashraf Al Madhoun, Fatemah Bahman, Halemah AlSaeed, Texy Jacob, Reeby Thomas, Areej Al-Roub, Sardar Sindhu, Fawaz Alzaid, Md. Zubbair Malik, Rasheeba Nizam, Thangavel Alphonse Thanaraj, Fahd Al-Mulla, Yusuf A Hannun, Rasheed Ahmad

Subject: Biology And Life Sciences, Endocrinology And Metabolism Keywords: NAFLD; SMPD3; Lipotoxicity; HepG2; TNF-α; sphingomyelin pathway; RNA sequencing; Oil Red O staining; fat accumulation; Obesity

Online: 5 October 2023 (09:27:30 CEST)

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Preprint REVIEW | doi:10.20944/preprints202309.2173.v1

Efficacy of Postprandial Exercise in Mitigating Glycemic Responses in Individuals with Overweight, Obesity, and Type 2 Diabetes – A Systematic Review and Meta-Analysis

Jie Kang, Brian M Fardman, Nicholas A Ratamess, Avery D Faigenbaum, Jill A Bush

Subject: Biology And Life Sciences, Endocrinology And Metabolism Keywords: Glycemic control, Hyperglycemia, Exercise protocols, Exercise timing, Metabolic disorders

Online: 2 October 2023 (11:25:12 CEST)

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Preprint REVIEW | doi:10.20944/preprints202310.0071.v1

Recent Advances in the Development of Bioartificial Pancreas Using 3D Bioprinting for the Treatment of Type 1 Diabetes: A Review

Anushikha Ghosh, Arka Sanyal, Abhik Mallick

Subject: Biology And Life Sciences, Endocrinology And Metabolism Keywords: Biomaterials; 3D bioprinting; pancreas; islets; type 1 diabetes; biofabrication

Online: 2 October 2023 (10:43:08 CEST)

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Preprint ARTICLE | doi:10.20944/preprints202309.2073.v1

Early Castration in Horses Does Not Impact Osteoarticular Metabolism

Marion Rouge, Florence Legendre, Razan Elkhatib, Christelle Delalande, Juliette Cognié, Fabrice Reigner, Philippe Barrière, Stefan Deleuze, Vincent Hanoux, Philippe Galéra, Hélène Bouraïma-Lelong

Subject: Biology And Life Sciences, Endocrinology And Metabolism Keywords: horse; castration; steroid hormones; cartilage; bone; in vivo metabolism

Online: 29 September 2023 (05:25:34 CEST)

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Preprint ARTICLE | doi:10.20944/preprints202309.1891.v1

Myotendinous Thermoregulation in National Level Sprinters after a Unilateral Fatigue Acute Bout. A Descriptive Study

Alessio Cabizosu, Cristian Marín-Pagán, Antonio Martínez-Serrano, Pedro E. Alcaraz, Francisco Javier Martínez-Noguera

Subject: Biology And Life Sciences, Endocrinology And Metabolism Keywords: thermography; tendons; quadriceps muscle; body temperature regulation

Online: 28 September 2023 (03:09:33 CEST)

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Preprint REVIEW | doi:10.20944/preprints202309.1651.v1

Insulin Resistance Develops Due to an Imbalance in the Synthesis of Cyclic AMP and the Natural Cyclic AMP Antagonist Prostaglandyl-Inositol Cyclic Phosphate (Cyclic PIP)

Heinrich K Wasner

Subject: Biology And Life Sciences, Endocrinology And Metabolism Keywords: cyclic AMP; cyclic PIP; insulin resistance; prostaglandylinositol cyclic phosphate; protein phosphorylation; protein kinase A; protein ser/thr phosphatase; type 2 diabetes

Online: 25 September 2023 (11:05:29 CEST)

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Dear Ladies and Gentlemen, I thank you for suggesting to submit the manuscript with the title “Insulin resistance develops due to an imbalance in the synthesis of cyclic AMP and the natural cyclic AMP antagonist prostaglandylinositol cyclic phosphate (cyclic PIP)” to the Editorial Board of the MDPI journal Stresses, and I ask for consideration to publish it in the journal Stresses. It was previously submitted to the MDPI journal Int. J. Mol. Sci. (IJMS-195 6513), but it was found that 1) it would not fit within the scope of this special edition and 2) it would primarily deal with cyclic PIP and would have not enough literature citation on the topic insulin resistance. The present version of the manuscript is improved, but the content is the same. The goal of this review is not to write again a summary on nearly all reports on insulin resistance as this was done by Dr. Petersen and Dr. Shulman, whose review has 961 literature citations. The present manuscript compiles what is known on cyclic PIP in relation to insulin resistance and the reason of writing this manuscript was that the discovered facts on cyclic PIP synthesis allow to suggest how insulin resistance most likely starts. Hitherto, reports on insulin resistance did not come close to this question. I am convinced that the manuscript makes an essential contribution to the question what causes the development of insulin resistance, and I have to say that stress overload is one of the reasons. Unfortunately, I have to mention a topic, about which I do not like to talk. Years ago, research groups postulated with rigor that the mediator of insulin action would be a peptide and then they suggested various, extracellularly synthesized glycans as mediators. They caused confusions and a high degree of disbelief in the matter of mediators of insulin action. In my review on cyclic PIP in IUBMB Life from 2020, I wrote in the introduction that cyclic PIP should not be confused with these mediators. But I cannot write this in the introduction of every report. I am keeping fingers crossed so that the editor in charge will find fair and openminded reviewers. Last not least I confirm that neither the manuscript nor any part of its content is currently under consideration or published in another journal. Kind regards, Henrich Wasner, PhD, BioReg Biopharm, TiLab; University of Illinois at Chicago; 2242 West Harrison St., Ste. 201, Chicago, Il 60612; USA

Preprint ARTICLE | doi:10.20944/preprints202309.1314.v1

Functional Characterization of Novel MC4R Variants Identified in Two Unrelated Patients with Morbid Obesity in Qatar

Idris Mohammed, Senthil Selvaraj, Wesam Ahmed, Tara Al-Barazenji, Ayat Hammad, Hajar Dauleh, Luis R. Saraiva, Mashael Al-Shafai, Khalid Hussain

Subject: Biology And Life Sciences, Endocrinology And Metabolism Keywords: MC4R; Monogenic Obesity; Severe Obesity; childhood obesity; Qatar

Online: 20 September 2023 (08:11:32 CEST)

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The leptin-melanocortin pathway is pivotal in appetite and energy homeostasis. Pathogenic variants in genes involved in this pathway lead to severe early-onset monogenic obesity (MO). The MC4R gene plays a central role in leptin-melanocortin signaling, and variants predominantly heterozygous in this gene are the most common cause of MO. We identified two novel heterozygous variants c,253A>G p.Ser85Gly and c.802T>C p.Tyr268His in the MC4R gene in two unrelated patients with morbid obesity and evaluated the functional impact of these variants. A targeted gene panel consisting of 52 obesity-related genes was undertaken. Variants were analyzed and filtered to identify potential disease-causing and validated using Sanger sequencing. The impact of the variants on the MC4R gene using in silico prediction tools and molecular dynamics simulation was assessed. To further study the pathogenicity of the identified variants, GT1-7 cells were transfected with plasmid DNA encoding either wild-type or mutant MC4R variants. The effects of allelic variations in MC4R gene on cAMP synthesis, MC4R protein level, and activation of ERB and CREB signaling pathways in both stimulated and unstimulated ɑ-MSH paradigms were determined for their functional implications. In-silico analysis suggested that the variants destabilized the MC4R structure and affect the overall dynamics of the MC4R protein, possibly leading to intracellular receptor retention. In-vitro analysis of the functional impact of these variants showed a significant reduction in cell surface receptor expression and impaired extracellular ligand binding activity, leading to reduced cAMP production. In-vitro analysis assays and in silico analysis revealed the pathogenicity of the two novel MC4R variants identified. Our analysis shows that the variants do not affect total protein expression; however, they are predicted to affect the post-translational localization of MC4R protein to the cell surface and impair downstream signaling cascades. This finding might help our patients to benefit from the novel therapeutic advances for monogenic forms of obesity.

Preprint REVIEW | doi:10.20944/preprints202309.1062.v1

Metabolic-Dysfunction Associated Steatotic Liver Disease -Its Pathophysiology, Association with Atherosclerosis and Cardiovascular Disease, and Ideal Treatments

Hidekatsu Yanai, Hiroki Adachi, Mariko Hakoshima, Sakura Iida, Hisayuki Katsuyama

Subject: Biology And Life Sciences, Endocrinology And Metabolism Keywords: cardiovascular disease; fatty acids; insulin resistance; metabolic-dysfunction associated steatotic liver disease; pemafibrate; triglyceride

Online: 18 September 2023 (08:37:02 CEST)

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Preprint ARTICLE | doi:10.20944/preprints202308.1602.v1

Association of Serum Estradiol with PCSK9 Levels and Lipid Profile in Women Undergoing In Vitro Fertilization

Anna Papanikolaou, Georgia Anastasiou, Fotios Barkas, Constantinos Tellis, Konstantinos Zikopoulos, Evangelos Liberopoulos

Subject: Biology And Life Sciences, Endocrinology And Metabolism Keywords: estrogens; proprotein convertase subtilisin/kexin type 9; lipoprotein; low-density lipoprotein cholesterol; cholesterol; lipids; in vitro fertilization

Online: 23 August 2023 (09:18:30 CEST)

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Preprint REVIEW | doi:10.20944/preprints202308.1470.v1

The Exon 3-Deleted Growth Hormone Receptor (d3GHR) Polymorphism - a Favorable Backdoor Mechanism for the GHR Function

Ghadeer Falah, Lital Sharvit, Gil Atzmon

Subject: Biology And Life Sciences, Endocrinology And Metabolism Keywords: Growth hormone receptor (GHR); Human growth hormone; Deletion of exon 3 (d3GHR); Polymorphism; Growth and development; Hormone deficiency

Online: 21 August 2023 (11:59:26 CEST)

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Preprint REVIEW | doi:10.20944/preprints202307.1807.v2

Mitochondrial Dysfunction in PCOS: Insights into Reproductive Organ Pathophysiology

Kyle M. Siemers, Abigail K. Klein, Michelle L. Baack

Subject: Biology And Life Sciences, Endocrinology And Metabolism Keywords: polycystic ovary syndrome (PCOS); ovary; uterus; placenta; mitochondria; biogenesis; mtDNA; metabolism; mitochondrial dynamics; oxidative stress

Online: 21 August 2023 (10:16:55 CEST)

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Preprint ARTICLE | doi:10.20944/preprints202308.0779.v1

Bile Acid Sequestration by Colesevelam Reduces Bile Acid Hydrophobicity and Improves Liver Pathology in Cyp2c70^-/- Mice with a Human-Like Bile Acid Composition

Anna Palmiotti, Hilde D. De Vries, Milaine V. Hovingh, Martijn Koehorst, Niels L. Mulder, Esther Verkade, Melany K. Veentjer, Theo H. Van Dijk, Vincent W. Bloks, Rick Havinga, Henkjan J. Verkade, Jan Freark De Boer, Folkert Kuipers

Subject: Biology And Life Sciences, Endocrinology And Metabolism Keywords: bile acids; colesevelam; enterohepatic circulation; liver; humanized mouse model

Online: 10 August 2023 (04:16:37 CEST)

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Preprint REVIEW | doi:10.20944/preprints202308.0710.v1

Mitochondrial Dynamics and Insulin Secretion

Uma D. Kabra, Martin Jastroch

Subject: Biology And Life Sciences, Endocrinology And Metabolism Keywords: diabetes; mitochondrial dynamics; glucose-stimulated insulin secretion; pancreatic beta cell; fusion; fission

Online: 9 August 2023 (08:22:26 CEST)

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Preprint ARTICLE | doi:10.20944/preprints202308.0640.v1

Understanding Type 2 Diabetes Mellitus Risk Parameters Through Intermittent Fasting: A Machine Learning Approach Shula Shazman 1,2,*

Shula Shazman

Subject: Biology And Life Sciences, Endocrinology And Metabolism Keywords: Type 2 Diabetes Mellitus (T2DM); Intermittent Fasting; Machine Learning

Online: 8 August 2023 (11:54:50 CEST)

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Preprint ARTICLE | doi:10.20944/preprints202308.0610.v1

The Effect of High-Intensity Interval Exercise on Short-Term Glycaemic Control, Serum Level of Key Mediator in Hypoxia and Pro-Inflammatory Cytokines in Patients with Type 1 Diabetes

Barbara Hall, Aleksandra Żebrowska, Marcin Sikora, Szymon Siatkowski, Anna Robins

Subject: Biology And Life Sciences, Endocrinology And Metabolism Keywords: type 1 diabetes; high-intensity interval exercise; glycaemic control; hypoxia; inflammation

Online: 8 August 2023 (10:18:30 CEST)

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Preprint REVIEW | doi:10.20944/preprints202307.1807.v1

Mitochondrial Dysfunction in PCOS: Insights into Reproductive Organ Pathophysiology

Kyle M. Siemers, Abigail K. Klein, Michelle L. Baack

Subject: Biology And Life Sciences, Endocrinology And Metabolism Keywords: polycystic ovary syndrome (PCOS); ovary; uterus; placenta; mitochondria; biogenesis; mtDNA; metabolism; mitochondrial dynamics; oxidative stress

Online: 26 July 2023 (11:29:11 CEST)

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Preprint REVIEW | doi:10.20944/preprints202307.1451.v1

Comprehensive Strategy for Identifying Extracellular Vesicle Surface Proteins as Biomarkers for Non-alcoholic Fatty Liver Disease

Nahuel Aquiles García, Maiken Mellergaard, Hernán González-King, Carlos Salomon Gallo, Aase Handberg

Subject: Biology And Life Sciences, Endocrinology And Metabolism Keywords: Non-alcoholic fatty liver; Extracellular vesicles; Biomarkers; Surface proteins

Online: 21 July 2023 (10:05:15 CEST)

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Preprint ARTICLE | doi:10.20944/preprints202307.1077.v1

Fructose-Induced Insulin Resistance in Adult Rats and Moderate-Intensity Training during Peri-Pubertal Period Improves Metabolic Dysfunction

Sandra da Silva Silveira, Veridiana Mota Moreira, Maria Natália Chimirri Peres, Lucas Paulo Jacinto Saavedra, Laize Peron Tófolo, Flávio Andrade Andrade, Tatiane Aparecida Ribeiro Domingos, Claudinéia Conationi Da Silva Franco, Christian Moreira Mendes, Ananda Malta, Douglas Lopes Almeida, Paulo Cezar de Freitas Mathias

Subject: Biology And Life Sciences, Endocrinology And Metabolism Keywords: aerobic exercise training; metabolic programming; DOHaD; adolescence

Online: 17 July 2023 (10:58:52 CEST)

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Preprint REVIEW | doi:10.20944/preprints202307.0959.v1

The heterogeneity of diabetes, a silent pandemic: the essence of one health approach and precision medicine in the fight against diabetes

Kenneth Marshall, Su Bu

Subject: Biology And Life Sciences, Endocrinology And Metabolism Keywords: Diabetes mellitus; silent pandemic; existential risk; heterogeneity; Insulin gene; health, genetic; anthropogenics; hyperglycemia

Online: 14 July 2023 (09:55:58 CEST)

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Preprint REVIEW | doi:10.20944/preprints202306.1724.v1

Metabolic Alterations in Canine Mammary Tumors

Guilherme Henrique Tamarindo, Adriana Alonso Novais, Luiz Gustavo De Almeida Chuffa, Debora Aparecida Pires de Campos Zuccari

Subject: Biology And Life Sciences, Endocrinology And Metabolism Keywords: canine mammary tumors; metabolism, cancer; mitochondria; metabolic reprogramming; glucose; amino acids; lipids

Online: 25 June 2023 (08:00:35 CEST)

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Preprint REVIEW | doi:10.20944/preprints202306.1390.v1

VLDL Biogenesis and Secretion: It Takes a Village

Willemien van Zwol, Bart van de Sluis, Henry Ginsberg, Jan Albert Kuivenhoven

Subject: Biology And Life Sciences, Endocrinology And Metabolism Keywords: Very low density lipoproteins; biogenesis; dyslipidemia

Online: 20 June 2023 (05:24:45 CEST)

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Preprint ARTICLE | doi:10.20944/preprints202306.1340.v1

A Methionine Portioning-Based Medical Nutrition Therapy With Relaxed Fruit and Vegetable Consumption in Patients With Pyri-Doxine Nonresponsive Cystathionine-β-Synthase Deficiency

Esma Uygur, Cigdem Aktuglu-Zeybek, Mirsaid Aghalarov, Mehmet Serif Cansever, Ertugrul Kıykım, Tanyel Zubarioglu

Subject: Biology And Life Sciences, Endocrinology And Metabolism Keywords: CBS deficiency; homocystinuria; homocysteine; simplified diet; methionine portioning; fruits, vegetables

Online: 19 June 2023 (09:45:30 CEST)

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Preprint ARTICLE | doi:10.20944/preprints202306.0420.v1

Anaerobic Exercise Significantly Increased Glut4 Gene Expression in Muscle Tissue of Diabetic Rats

Sezgin Hepsert, Semih Dalkilic, Lutfiye Kadioglu Dalkilic, Fatih Mehmet Ugurlu, Dilek Arslan Atessahin, Ragip Pala, Yakup Kilic

Subject: Biology And Life Sciences, Endocrinology And Metabolism Keywords: diabetes; anaerobic exercise; glut4 gene expression; streptozocin

Online: 6 June 2023 (08:52:56 CEST)

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Preprint REVIEW | doi:10.20944/preprints202305.1788.v1

Type II Transmembrane Serine Proteases as Modulators in Adipose Tissue Phenotype and Function

Qingyu Wu, Shuo Li, Xianrui Zhang, Ningzheng Dong

Subject: Biology And Life Sciences, Endocrinology And Metabolism Keywords: adipose tissue; corin; hepsin; matriptase-2; type II transmembrane serine protease; thermogenesis

Online: 25 May 2023 (09:51:58 CEST)

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Preprint ARTICLE | doi:10.20944/preprints202305.1481.v1

20(S)-Protopanaxatriol Improves Atherosclerosis by Inhibiting Low-Density Lipoprotein Receptor Degradation in ApoE KO Mice

Meng Zhang, Fang Luo, Li-tian Wang, Weng-Luer Meng, Dan-dan Hu, Jin-bo Yang, Ye-Wei Huang, Jun Sheng, Xuan-jun Wang

Subject: Biology And Life Sciences, Endocrinology And Metabolism Keywords: atherosclerosis; 20(S)-PPT; PCSK9; LDLR; Panax notoginseng

Online: 22 May 2023 (09:02:18 CEST)

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Preprint ARTICLE | doi:10.20944/preprints202305.1240.v1

Diabetic Neuropathic Pain: Pathophysiology & Treatment

Johannes Geeso, Cinthya Galan

Subject: Biology And Life Sciences, Endocrinology And Metabolism Keywords: DNP; PNS; Diabetic neuropathic pain; Peripheral pain; Distal symmetric polyneuropathy; diabetic neuropathy; diabetes mellitus; DM; T1D; T2D; DPN; DPNP; Diabetic peripheral neuropathic pain; Diabetic peripheral neuropathy

Online: 17 May 2023 (10:55:11 CEST)

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Preprint ARTICLE | doi:10.20944/preprints202305.0685.v1

Association of Metabolic Syndrome Components with Kidney Cancer in Young Adult Population : A Nationwide Population-Based Cohort Study in Korea

Hee Yeon Lee, Kyung-Do Han, In Sook Woo, Hyuk-Sang Kwon

Subject: Biology And Life Sciences, Endocrinology And Metabolism Keywords: Kidney cancer; Metabolic syndrome; Age; Young adults

Online: 10 May 2023 (04:38:19 CEST)

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Preprint REVIEW | doi:10.20944/preprints202305.0130.v1

Neurochemical Basis of Energy Homeostasis in Health and Obesity

Dhanush Haspula, Zhenzhong Cui

Subject: Biology And Life Sciences, Endocrinology And Metabolism Keywords: Obesity; hypothalamus; appetite; glucose homeostasis; weight-loss drugs; AGRP; POMC; NTS; incretins

Online: 3 May 2023 (10:22:49 CEST)

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Preprint REVIEW | doi:10.20944/preprints202305.0041.v1

A Significance of an Amelioration of Endothelial Dysfunction by Sodium-Glucose Cotransporter 2 Inhibitors for an Improvement of Heart Failure and Chronic Kidney Disease

Hidekatsu Yanai, Hiroki Adachi, Mariko Hakoshima, Hisayuki Katsuyama

Subject: Biology And Life Sciences, Endocrinology And Metabolism Keywords: endothelial dysfunction; chronic kidney disease; heart failure; sodium-glucose cotransporter 2 inhibitors

Online: 2 May 2023 (02:18:51 CEST)

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Preprint REVIEW | doi:10.20944/preprints202304.1189.v1

Metabolic Role of GABA in the Secretory Function of Pancreatic β-Cells. Its Hypothetical Implication in β-Cell Degradation in Type 2 Diabetes

Jorge Tamarit-Rodriguez

Subject: Biology And Life Sciences, Endocrinology And Metabolism Keywords: Functional role of GABA in insulin secretion stimulation; GABA metabolism in pancreatic islets; GABA and insulin secretion; interaction of glucose and GABA metabolism in pancreatic islets; GABA shunt

Online: 29 April 2023 (02:51:09 CEST)

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The stimulus-secretion coupling of glucose-induced release is generally attributed to the metabolism of the hexose in the β-cells in the glycolytic pathway and the citric acid cycle. Glucose metabolism generates an increased cytosolic concentration of ATP and of the ATP/ADP ratio that closes the ATP-dependent K+-channel at the plasma membrane by the interaction of ATP with the regulatory Kir6.2 channel subunit The resultant depolarization of the β-cells opens voltage-dependent Ca2+-channels at the plasma membrane that allow an increase of the cytosolic cation concentration that triggers the exocytosis of insulin secretory granules. The resultant secretory response evolves in time as a biphasic secretion with a first and transient peak of approximately 10 minutes duration followed by a sustained phase of secretion lasting as long as the stimulus. Whereas the first transient peak can be reproduced by a simple depolarization of β-cells with high extracellular KCl maintaining the KATP-channels open with diazoxide, the sustained phase is agreed to depend on the participation of some metabolic signal that remains to be determined Our group has been investigating for several years the participation of β-cell GABA metabolism, together with that of glucose (the β-cell “specific” nutrient secretagogue) and some other “metabolic” secretagogues (branched-chain alpha-ketoacids and a mixture of L-Leucine + L-glutamine, at supraphysiological concentrations) in their mechanism of stimulation of insulin secretion. All three types of stimuli promote the flux in the GABA shunt of rat islets by different metabolic pathways that end in the production of α-ketoglutarate. This citric acid cycle intermediary is preferentially derived to the GABA shunt instead of its continuous oxidation in the citric acid cycle. Islet content of GABA is significantly suppressed by all the stimuli and blocking the GABA shunt with gabaculine, or ϒ-vinyl-GABA (GABAT inhibitors), diminish the insulin secretory responses as well as total ATP and the ATP/ADP ratio. It is concluded that GABA metabolism is increased in parallel to glucose metabolism and is significantly contributing to the magnitude of the insulin secretory response. Its possible implication in β-cells degradation in type-2 (perhaps also in type 1) diabetes is suggested.

Preprint ARTICLE | doi:10.20944/preprints202304.1133.v1

Plasma Amino Acids in NAFLD Patients With Obesity Are Associated With Steatosis and Fibrosis; Results From the MAST4HEALTH Study

Athina I. Amanatidou, Eleni V Mikropoulou, Charalampia Amerikanou, Maja Milanović, Stefan Stojanoski, Mladen Bjelan, Lucia Cesarini, Jonica Campolo, Anastasia Thanopoulou, Rajarshi Banerjee, Mary Jo Kurth, Nataša Milić, Milica Medic-Stojanoska, Maria Giovanna Trivella, Amalia Gastaldelli, Maria Halabalaki, Andriana C. Kaliora, George V Dedoussis

Subject: Biology And Life Sciences, Endocrinology And Metabolism Keywords: Non-alcoholic fatty liver disease; magnetic resonance imaging; amino acids; metabolomics; inflammation

Online: 28 April 2023 (07:20:14 CEST)

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Preprint REVIEW | doi:10.20944/preprints202304.1102.v1

Sex Specificities of Human Placental Adaptive Changes: The Influence of Maternal Obesity

Esther Dos Santos, Marta Hita Hernandez, Valérie Sérazin, François Vialard, Marie-Noëlle Dieudonné

Subject: Biology And Life Sciences, Endocrinology And Metabolism Keywords: Maternal obesity; placenta; environmental adaptation; sex specificities; reproduction

Online: 28 April 2023 (04:06:35 CEST)

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Preprint ARTICLE | doi:10.20944/preprints202304.0602.v1

Thyroid Hormone Transporters MCT8 and OATP1C1 are Expressed in Projection Neurons and Interneurons of Basal Ganglia and Motor Thalamus in the Adult Human and Macaque Brain

Ting Wang, Yu Wang, Ana Montero-Pedrazuela, Lucía Prensa, Ana Guadaño-Ferraz, Estrella Rausell

Subject: Biology And Life Sciences, Endocrinology And Metabolism Keywords: Thyroid hormones; thyroid hormone transporters; MCT8; OATP1C1; human; monkey; basal ganglia; motor thalamus; MSN cells; nucleus basalis of Meynert

Online: 20 April 2023 (03:25:07 CEST)

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Preprint ARTICLE | doi:10.20944/preprints202304.0208.v1

Supplement of Succinate Reduces Lipid Deposition and Improves Metabolic Function in Obese Mice

Tengteng Ji, Bing Fang, Ming Zhang, Yaqiong Liu

Subject: Biology And Life Sciences, Endocrinology And Metabolism Keywords: Obesity, Succinate, Glucose Tolerance, Lipolysis, Lipogenesis, High-Fat Diet

Online: 11 April 2023 (08:03:02 CEST)

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Preprint ARTICLE | doi:10.20944/preprints202212.0045.v8

The Imaginary Universe

Szymon Łukaszyk

Subject: Biology And Life Sciences, Endocrinology And Metabolism Keywords: emergent dimensionality; imaginary dimensions; Planck units; fine-structure constant; black holes; neutron stars; white dwarfs; complex energy; complex force; Buchdahl's theorem; photon sphere; holographic principle; mathematical physics

Online: 20 March 2023 (09:55:20 CET)

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Preprint REVIEW | doi:10.20944/preprints202303.0211.v1

Progress on Understanding Metabolic Syndrome, and Knowledge of Its Complex Pathophysiology

Birendra Kumar Jha, Mohammad Imran, Yousuf Mohammed, Laxmi Akhileshwar Jha, Keshav Raj Paudel, Saurav Kumar Jha

Subject: Biology And Life Sciences, Endocrinology And Metabolism Keywords: metabolic syndrome; glucose tolerance; pathophysiology; hyperglycemia; diet

Online: 13 March 2023 (03:58:55 CET)

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Preprint REVIEW | doi:10.20944/preprints202303.0004.v1

Fecal Metagenomics and Metabolomics Identifying Microbial Signatures in Non-Alcoholic Fatty Liver Disease

Satu Pekkala

Subject: Biology And Life Sciences, Endocrinology And Metabolism Keywords: gut microbiota; metabolomics; metagenomics; liver fat; NAFLD; diet; metabolic pathways

Online: 1 March 2023 (02:40:16 CET)

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Preprint REVIEW | doi:10.20944/preprints202302.0482.v1

Reproductive System Abnormalities Accompanied By Environmental Factors Alterations in Rat Model

Muhammad Aslam, Mubashir Abbas

Subject: Biology And Life Sciences, Endocrinology And Metabolism Keywords: Rats; Biological research; Environmental conditions; Stress; Handling

Online: 28 February 2023 (02:04:49 CET)

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Preprint REVIEW | doi:10.20944/preprints202302.0223.v1

Premier Obesogenic Factors: Overeating and Food Addiction

Muhammad Aslam, Mubashir Abbas

Subject: Biology And Life Sciences, Endocrinology And Metabolism Keywords: Obesity; Hyperpalatability; Adipose tissue; Hormonal imbalance

Online: 14 February 2023 (02:17:02 CET)

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Preprint REVIEW | doi:10.20944/preprints202302.0015.v1

Mitochondrial Bioenergy in Neural Disease: Huntington and Parkinson

Annalisa Tassone, Maria Meringolo, Paola Bonsi, Tommaso Schirinzi, Giuseppina Martella

Subject: Biology And Life Sciences, Endocrinology And Metabolism Keywords: movement disorders; mitochondria; energy metabolism; synaptic plasticity; basal ganglia; calcium

Online: 1 February 2023 (11:53:47 CET)

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Preprint ARTICLE | doi:10.20944/preprints202212.0578.v1

“One and a Half Years of Things We Could Have Done”: Multi-Method Analysis of the Narratives of Adolescents with T1D during the COVID-19 Pandemic

Marta Tremolada, Maria Cusinato, Alessia D’Agnillo, Arianna Negri, Elena Righetto, Carlo Moretti

Subject: Biology And Life Sciences, Endocrinology And Metabolism Keywords: Type 1 diabetes; mental-health; COVID-19; adolescents; qualitative research; narratives; NVivo

Online: 30 December 2022 (09:16:21 CET)

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