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Preprint ARTICLE | doi:10.20944/preprints202308.0053.v1

Evaluation of Equine Fecal Egg Count Tests for Accurate Monitoring of Anthelmintic Resistance

Manigandan Lejeune, Sabine Mann, Holly White, Danielle Maguire, Jaime Hazard, Rebecca Young, Charles Stone, Doug Antczak, Dwight Bowman

Subject: Biology And Life Sciences, Parasitology Keywords: Equine strongyle; Fecal Egg Count; FEC; modified McMaster; Mini-FLOTAC; Wisconsin floatation; sugar 1.33 specific gravity; NaNO3 1.33 specific gravity; NaCl 1.20 specific gravity; ZnSO4 1.18 specific gravity; AAEP; anthelmintic resistance; FEC gold standard

Online: 1 August 2023 (10:32:58 CEST)

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Parasite control strategies such as blanket anthelmintic treatment of all horses in a herd or interval treatment regimen based on egg reappearance remain widely followed practices for the last several decades. These practices have resulted in the fast emergence of resistance in equine strongyles to all major classes of drugs on the market. In this regard, the guidelines set by the American Association of Equine Practitioners advocate evidence-based strongyle control in horses. It recommends targeted treatment of all heavy egg shedders [> 500 eggs per gram (EPG) of feces] while the low shedders (0-200 EPG) are left untreated to maintain susceptible parasite refugia in a herd. As 50-75% of adult horses in a herd are low shedders, preventing them from unnecessary anthelmintic exposure is critical to tackling resistance. There are various fecal egg count (FEC) techniques with many modifications and variations in use, but none is identified as a gold standard and methods comparison studies are lacking. We hypothesized that the diagnostic performance of commonly used quantitation methodologies differs and the FEC methods must be evaluated to determine the gold standard. In this regard, we performed methods comparison studies using polystyrene beads with size and specific gravity comparable to strongyle eggs, as proxy. The linearity of 12 commonly used FEC methodologies (3 techniques with 4 different solutions) was studied using bead standards in the clinically applicable range (63 to 1,000) to determine their suitability for strongyle egg counts. Deming regression analysis identified Mini-FLOTAC with sugar (specific gravity 1.33) as the test with the greatest coefficient of determination. All tests underestimated the true bead count, and we determined a correction factor (CF) for each test to estimate the true count. CF negates the preference for a gold standard test. Finally, we analyzed the validity of CF for 5 tests with R2>0.95 to accurately quantify strongyle eggs from 40 different horses. Overall, this study identified methodologies with the highest diagnostic performance and the limitations to standardizing routine FEC tests to promote uniformity in implementing AAEP parasite control guidelines.

Preprint ARTICLE | doi:10.20944/preprints202307.1948.v1

Progress in Language Abilities Related to Reading Comprehension – Domain Specific Intervention on Executive Functioning

Iveta Kovalčíková, Jochanan Veerbeek, Bart Vogelaar, Martin Klimovič, Eva Gogová

Subject: Social Sciences, Language And Linguistics Keywords: reading comprehension; language; executive functioning; domain-specific cognitive stimulation; low-performing pupil; Exefun-READ

Online: 28 July 2023 (08:26:24 CEST)

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Preprint ARTICLE | doi:10.20944/preprints202307.1417.v1

Phenotypic Differences among Recently Diagnosed Drug-Naïve Patients with Parkinson’s Disease with or without SNCA Polymorphisms

Santiago Pérez-Lloret, Alejandro Enet, Guenson Chevalier, Sofia Bordet, Hanny Barbar, Francisco Capani, Lucas Udovin, Matilde Otero-Losada, Francisco Barrantes

Subject: Medicine And Pharmacology, Neuroscience And Neurology Keywords: single nucleotide polymorphism; Parkinson’s disease; alpha-synuclein; phenotype, pathophysiology; PD-related variants

Online: 20 July 2023 (12:46:20 CEST)

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Preprint ARTICLE | doi:10.20944/preprints202307.1200.v1

Target soybean leaf automatic segmentation based on object detection and interactive segmentation models

Dong Wang, Zetao Huang, Haipeng Yuan, Yun Liang, Shuqin Tu, Cunyi Yang

Subject: Computer Science And Mathematics, Computer Vision And Graphics Keywords: plant phenotype; soybean leaf; image segmentation; object detection

Online: 18 July 2023 (09:14:41 CEST)

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Preprint REVIEW | doi:10.20944/preprints202307.1165.v1

Considerations, Advances, and Challenges Associated with the Use of Specific Emitter Identification in the Security of Internet of Things Deployments: A Survey

Joshua H. Tyler, Mohamed K.M. Fadul, Donald R. Reising

Subject: Engineering, Electrical And Electronic Engineering Keywords: Specific Emitter Identification, Radio Frequency Fingerprinting, Physical Layer Authentication, Physical Layer Security, Internet of Things

Online: 18 July 2023 (07:37:34 CEST)

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Initially introduced almost thirty years ago for the express purpose of providing electronic warfare systems the capabilities to detect, characterize, and identify radar emitters, Specific Emitter Identification (SEI) has recently received a lot of attention within the research community as a physical layer technique for securing Internet of Things (IoT) deployments. This attention is due in large part to SEI’s demonstrated success in passively and uniquely identifying wireless emitters using traditional machine learning and the success of Deep Learning (DL) within the natural language processing and computer vision areas. SEI exploits distinct and unintentional features present within an emitter’s transmitted signals. The existence of these distinctive and unintentional features is attributed to slight manufacturing and assembly variations that exist within and between the components, sub-systems, and systems that comprise an emitter’s Radio Frequency (RF) front end. Although sufficient to facilitate SEI, these features do not hinder normal operations such as detection, channel estimation, timing, and demodulation. However, despite the plethora of SEI publications, it has remained largely a focus of academic endeavors that primarily focus on proof-of-concept demonstration and little to no use in operational networks for various reasons. The focus of this survey is a review of SEI publications from the perspective of its use as a practical, effective, and usable IoT security mechanism, thus we use IoT requirements and constraints (e.g., wireless standard, nature of their deployment) as a lens through which each reviewed paper is analyzed. Previous surveys have not taken such an approach and have only used IoT as motivation, a setting, or a context. In this survey, we consider operating conditions, SEI threats, SEI at scale, publicly available data sets, and SEI considerations that are dictated by the fact that it is to be employed by IoT devices or IoT infrastructure.

Preprint REVIEW | doi:10.20944/preprints202307.1094.v1

Do Vaccines Increase or Decrease Susceptibility to Diseases Other Than Those They Protect Against?

Alberto Rubio-Casillas, Elrashdy M. Redwan, Vladimir N. Uversky, Mikolaj Raszek

Subject: Medicine And Pharmacology, Epidemiology And Infectious Diseases Keywords: non-specific effects of vaccines; tolerance; immune training; excess deaths; IgG4 antibodies.

Online: 17 July 2023 (09:59:57 CEST)

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Preprint ARTICLE | doi:10.20944/preprints202307.0425.v1

Anomalous Ferromagnetic Phase in the Gd1-xErxB4 Series: Crystal Growth, Thermal and Magnetic Properties

Sueli H. Masunaga, V. B. Barbeta, F. Abud, M. S. Torikachvilli, R. F. Jardim

Subject: Physical Sciences, Condensed Matter Physics Keywords: tetraborides; susceptibility; specific heat; geometric magnetic frustration; antiferromagnetism; flux method; Shastry Sutherland

Online: 7 July 2023 (07:40:55 CEST)

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Preprint TECHNICAL NOTE | doi:10.20944/preprints202307.0289.v1

Profitability assessment of precision agriculture applications – a step forward in farm management

Christos Karydas, Myrto Chatziantoniou, Ourania Tremma, Alexandros Milios, Kostas Stamkopoulos, Vangelis Vassiliadis, Spiros Mourelatos

Subject: Environmental And Earth Sciences, Other Keywords: precision agriculture; site-specific fertilization; ifarma; PreFer

Online: 5 July 2023 (11:26:58 CEST)

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Preprint ARTICLE | doi:10.20944/preprints202307.0262.v1

Synthesis, ¹²³I-Radiolabeling Optimization, and Initial Preclinical Evaluation of Novel Urea-Based PSMA Inhibitors with Tributylstannyl Prosthetic Group in Their Structures

Lutfi A. Hasnowo, Maria S. Larkina, Evgenii V. Plotnikov, Vitalina Bodenko, Feruza Yuldasheva, Elena Stasyuk, Stanislav A. Petrov, Nikolai Y. Zyk, Aleksei E. Machulkin, Nikolay I. Vorozhtsov, Elena K. Beloglazkina, Valentine G. Nenajdenko, Vladimir Tolmachev, Anna Orlova, Alexander G. Majouga, Mekhman S. Yusubov

Subject: Medicine And Pharmacology, Pharmacology And Toxicology Keywords: DCL ligand; iodine radioisotopes; radiolabeled pharmaceuticals; targeted delivery; prostatic specific membrane antigen; prostate cancer

Online: 5 July 2023 (04:43:46 CEST)

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Preprint REVIEW | doi:10.20944/preprints202307.0235.v1

Alcohol: Epigenome Alteration and Transgenerational Effect

Nazila Heidari, Arman Hajikarim-Hamedani, Amirhossein Heidari, Yekta Ghane, Mitra-Sadat Sadat-Shirazi, Ghorbangol Ashabi, Mohammad-Reza Zarrindast

Subject: Biology And Life Sciences, Neuroscience And Neurology Keywords: Alcohol; Ethanol; Epigenetics change; phenotype; offspring; Epigenome

Online: 4 July 2023 (13:25:47 CEST)

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Preprint ARTICLE | doi:10.20944/preprints202307.0133.v1

Tumor-Specific Targeting of Polymer Drug Delivery Systems with Recombinant Proteins Bound via Tris(Nitrilotriacetic Acid)

Michal Pechar, Vlastimil Král, Lucie Woldřichová, Ladislav Androvič, Eliška Hrdá, Robert Pola, Sára Pytlíková, Martin Studenovský, Libor Kostka, Vladimír Šubr, Tomáš Etrych, Olga Kočková, Jéssica Mariane Ferreira Mendes, Milan Fábry, Richard Laga

Subject: Chemistry And Materials Science, Medicinal Chemistry Keywords: Hydrophilic polymers; Thermo-responsive polymers; Polymer drug delivery system; Tumor-specific targeting; Recombinant proteins; Non-covalent attachment; Tris(nitrilotriacetic acid) ligation

Online: 4 July 2023 (08:01:27 CEST)

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Preprint ARTICLE | doi:10.20944/preprints202306.2253.v1

Patient-Specific Preictal Pattern-Aware Epileptic Seizure Prediction with Federated Learning

Raghdah Saemaldahr, Mohammad Ilyas

Subject: Computer Science And Mathematics, Artificial Intelligence And Machine Learning Keywords: Epilepsy; Seizure Prediction; Preictal; Federated Learning (FL); Spiking Encoder; Graph Convolutional Neural Network (GCNN); Patient-specific Personalization

Online: 30 June 2023 (14:48:14 CEST)

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Preprint ARTICLE | doi:10.20944/preprints202306.1435.v1

A-DSCNN: Depthwise Separable Convolutional Neural Network Inference Chip Design using an Approximate Multiplier

Jin-Jia Shang, Nicholas Phipps, I-Chyn Wey, Tee Hui Teo

Subject: Engineering, Electrical And Electronic Engineering Keywords: Application-Specific Integrated Circuits; Approximate Multiplier; CMOS; Convolutional Neural Network; Depthwise Separable Convolution; Processing Element

Online: 21 June 2023 (03:49:43 CEST)

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Preprint ARTICLE | doi:10.20944/preprints202306.1450.v1

Oleocanthal Ameliorates Metabolic and Behavior Phenotypes in a Mouse Model of Alzheimer’s Disease

Euitaek Yang, Junwei Wang, Lauren N. Woodie, Michael W. Greene, Amal Kaddoumi

Subject: Medicine And Pharmacology, Neuroscience And Neurology Keywords: Alzheimer’s disease; blood-brain barrier; metabolic phenotype; sleep behavior; Promethion cages; oleocanthal

Online: 20 June 2023 (14:31:29 CEST)

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Preprint REVIEW | doi:10.20944/preprints202306.1133.v1

Tailored Therapy in Severe Asthma: The Importance of Moving beyond a Disease-Centric Approach

Andreas Photiades, Lamprini Vlassi, Chrysoula Kontogianni, Mina Gaga, Eleftherios Zervas

Subject: Medicine And Pharmacology, Pulmonary And Respiratory Medicine Keywords: severe asthma; phenotype; endotype; personalized medicine; targeted therapy; treatment

Online: 15 June 2023 (11:35:43 CEST)

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Preprint REVIEW | doi:10.20944/preprints202306.1013.v1

Agricultural Sciences in the Big Data Era: Genotype and Phenotype Data Standardization, Utilization and Integration

Cecilia H. Deng, Sushma Naithani, Sunita Kumari, Irene Cobo-Simon, Elsa H. Quezada-Rodriguez, Maria Skrabisova, Nick Gladman, Melanie J. Correll, Akeem Babatunde Sikiru, Olusola O. Afuwape, Annarita Marrano, Ines Rebollo, Wentao Zhang, Sook Jung

Subject: Biology And Life Sciences, Agricultural Science And Agronomy Keywords: Genotype; phenotype; sequencing; phenomics; data integration; metadata; standardization

Online: 14 June 2023 (08:30:52 CEST)

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Preprint ARTICLE | doi:10.20944/preprints202306.0605.v1

Synthesis and Evaluation of 99mTc-labeled PSMA-targeted Tracers Based on the Lys-urea-Aad Pharmacophore for Detecting Prostate Cancer with Single Photon Emission Computed Tomography

Kelly Lu, Chengcheng Zhang, Zhengxing Zhang, Hsiou-Ting Kuo, Nadine Colpo, François Bénard, Kuo-Shyan Lin

Subject: Chemistry And Materials Science, Medicinal Chemistry Keywords: prostate-specific membrane antigen (PSMA); technetium-99m; single photon emission computed tomography (SPECT); molecular imaging; HYNIC

Online: 8 June 2023 (08:11:15 CEST)

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Preprint ARTICLE | doi:10.20944/preprints202306.0587.v1

Development of Clause Complexity in Children with Specific Language Impairment/Language Development Disorder. A Longitudinal Study

Claudia Araya, Carmen Julia Coloma, Camilo Quezada, Paula Benavente

Subject: Social Sciences, Language And Linguistics Keywords: Grammar; clause complexity; longitudinal study; Specific Language Impairment (SLI); Developmental Language Disorder (DLD).

Online: 8 June 2023 (04:41:09 CEST)

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Preprint ARTICLE | doi:10.20944/preprints202306.0050.v1

Neuron-Specific Enolase (NSE) as a Biomarker for Autistic Spectrum Disease (ASD)

Felician Stancioiu, Raluca Bogdan, Radu Dumitrescu

Subject: Medicine And Pharmacology, Neuroscience And Neurology Keywords: ASD; autism; autistic spectrum disease; NSE; Neuron-specific enolase; autism biomarker; neuroinflammation; neuronal apoptosis; mTOR

Online: 1 June 2023 (07:30:35 CEST)

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Preprint REVIEW | doi:10.20944/preprints202306.0011.v1

Update on Desensitization Strategies and Drugs on Hyperimmune Patients for Kidney Transplantation

Maurizio Salvadori

Subject: Medicine And Pharmacology, Transplantation Keywords: Desensitization; Donor specific antibodies; HLA system; antibodies identification; B cells; Plasma cells; Complement; New drugs; Desensitization; Donor specific antibodies; HLA system; B cells; Plasma cells; Complemennt; New drugs

Online: 1 June 2023 (03:17:00 CEST)

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Preprint ARTICLE | doi:10.20944/preprints202305.2257.v1

Genetic Diversity and Population Structure of Bursaphelenchus xylophilus in Central China based on SNP Markers

Aixia Yang, Xiaolei Ding, Yuan Feng, Tingting Chen, Jianren Ye

Subject: Biology And Life Sciences, Forestry Keywords: Bursaphelenchus xylophilus; SNP; genetic diversity; population differentiation (List three to ten pertinent keywords specific to the article yet reasonably common within the subject discipline.)

Online: 31 May 2023 (13:23:36 CEST)

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Preprint ARTICLE | doi:10.20944/preprints202305.1836.v3

The Combination of Binding-Avidity of Ovomucoid-Specific IgE Antibody and Specific IgG4 Antibody Can Predict Positive Outcome of Oral Food Challenge during Stepwise Slow Oral Immunotherapy in Children with Hen’s Egg Allergy

Shoichiro Taniuchi, Rika Sakai, Takashi Nishida, Meguru Goma, Masatoshi Mitomori, Aya Imaide, Masahiro Enomoto, Masamitsu Nishino, Yo Okizuka, Hiroshi Kido

Subject: Biology And Life Sciences, Food Science And Technology Keywords: oral immunotherapy; hen’s egg allergy; IgE binding-avidity; ovomucoid specific IgE; ovomucoid specific IgG4; oral food challenge

Online: 31 May 2023 (02:28:20 CEST)

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Preprint ARTICLE | doi:10.20944/preprints202305.2120.v1

Impact of Obesity and Bariatric Surgery on Metabolic Enzymes and P-glycoprotein Activity using Geneva Cocktail Approach

Hengameh Ghasim, Mohammadreza Rouini, Saeed Safari, Farnoosh Larti, Mohammadreza Khoshayand, Kheirollah Gholami, Navid Neyshaburinezhad, Yvonne Gloor, Youssef Daali, Yalda H. Ardakani

Subject: Medicine And Pharmacology, Endocrinology And Metabolism Keywords: Phenoconversion; Bariatric surgery; CYP450 Phenotype and Genotype; Cocktail; Personalized medicine

Online: 30 May 2023 (10:59:51 CEST)

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Preprint ARTICLE | doi:10.20944/preprints202305.1451.v1

Management’s Discretionary Assessments of Goodwill Impairments—Evidence from STOXX Europe 600

Frode Kjærland, Kristian Forbord, Are Oust, Håkon Stephani

Subject: Business, Economics And Management, Accounting And Taxation Keywords: goodwill impairment; IFRS; earnings management; company-specific factors; fixed effects

Online: 19 May 2023 (16:49:55 CEST)

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Preprint ARTICLE | doi:10.20944/preprints202305.1440.v1

Development of an Accurate Polymerase Chain Reaction (PCR) Assay for Genetic Sex Identification in Lumpfish (Cyclopterus lumpus) based on Male-specific anti-Mullerian Hormone (amh) Gene

Kasidis Chaiyasut, Paul Merviel, Peter Palma, Johanna Perschthaler, Eduardo Jimenez Fernandez, Andrew Davie, Alejandro P. Gutierrez

Subject: Biology And Life Sciences, Animal Science, Veterinary Science And Zoology Keywords: Anti-Müllerian hormone; Cyclopterus lumpus; Male-specific marker; Genetic sex identification

Online: 19 May 2023 (11:36:20 CEST)

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Preprint REVIEW | doi:10.20944/preprints202305.1344.v1

Gray-Zone Lymphoma: A Still Open Issue

Stefano Pileri, Valentina Tabanelli, Chiarle Roberto, Angelica Calleri, Federica Melle, Giovanna Motta, Maria Rosaria Sapienza, Elena Sabattini, Pier Luigi Zinzani, Enrico Derenzini

Subject: Medicine And Pharmacology, Pathology And Pathobiology Keywords: mediastinal gray-zone lymphoma; classical Hodgkin lymphoma; primary mediastinal B-cell lymphoma; diffuse large B-cell lymphoma; NOS; EBV-positive diffuse large B-cell lymphoma; NOS; morphology; phenotype; gene expression profile; mutational landscape

Online: 18 May 2023 (12:25:07 CEST)

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Preprint ARTICLE | doi:10.20944/preprints202305.1251.v1

Length of Stay in Emergency Department by ICD-10 Specific and Non-Specific Diagnoses: A Single-Centre Retrospective Study

Bartosz Miazgowski, Cezary Pakulski, Tomasz Miazgowski

Subject: Medicine And Pharmacology, Emergency Medicine Keywords: length of stay; emergency department; ICD-10 classification; non-specific diagnoses

Online: 17 May 2023 (12:59:54 CEST)

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Preprint ARTICLE | doi:10.20944/preprints202305.0978.v1

Long-Chain Acyl Coenzyme a Dehydrogenase, a Key Player in Metabolic Rewiring/Invasiveness in Experimental Tumors and Human Mesothelioma Cell Lines

Daniel L. Pouliquen, Giacomo Ortone, Letizia Rumiano, Alice Boissard, Cécile Henry, Stéphanie Blandin, Catherine Guette, Chiara Riganti, Joanna Kopecka

Subject: Biology And Life Sciences, Biochemistry And Molecular Biology Keywords: malignant mesothelioma; metabolism; mitochondria; long-chain specific acyl-CoA dehydrogenase; fatty acid β-oxidation, biomarker

Online: 15 May 2023 (05:27:55 CEST)

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Preprint ARTICLE | doi:10.20944/preprints202305.0112.v1

Tracing the Influence of Manure as a Complex Mixture on the Soil Sorption of Pharmaceuticals Back to Selected Chemical Constituents

Sören Thiele-Bruhn, Wei Zhang

Subject: Environmental And Earth Sciences, Soil Science Keywords: Atenolol; caffeine; sulfadiazine; dissolved organic matter; sewage; specific sorption; sorption competition

Online: 3 May 2023 (07:55:31 CEST)

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Preprint REVIEW | doi:10.20944/preprints202305.0031.v1

Mast Cells as a Potential Target of Molecular Hydrogen in Regulating the Local Tissue Microenvironment

Dmitri Atiakshin, Andrey Kostin, Artem Volodkin, Anna Nazarova, Viktoriya Shishkina, Dmitry Esaulenko, Igor Buchwalow, Markus Tiemann, Mami Noda

Subject: Medicine And Pharmacology, Pharmacology And Toxicology Keywords: molecular hydrogen; reactive oxygen intermediates; mast cells; secretome; specific mast cell proteases; local tissue microenvironment; inflammation

Online: 1 May 2023 (11:54:37 CEST)

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Preprint CASE REPORT | doi:10.20944/preprints202305.0013.v1

Renal Mast Cell Specific Proteases in the Pathogenesis of Tubulointerstitial Fibrosis: Case Report

Dmitri Atiakshin, Sergey Morozov, Vladimir Dlin, Andrey Kostin, Michael Ignatyuk, Galina Kuzovleva, Sergey Baiko, Igor Buchwalow, Markus Tiemann

Subject: Medicine And Pharmacology, Gastroenterology And Hepatology Keywords: mast cells; tryptase; carboxypeptidase A3; chymase; fibrogenic niche; kidney fibrosis; specific tissue microenvironment

Online: 1 May 2023 (04:12:22 CEST)

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Kidney fibrosis is a complex polyetiological progressive disease manifesting as an intraorgan proliferation of the connective tissue with the appearance of cicatricial changes. However, pathogenetic mechanisms of renal fibrosis remain poorly understood. The paper highlights features of the protease phenotype and histotopography of mast cells (MCs) found in the kidney, as the key players in extracellular matrix remodeling in nephrofibrosis, detected in a patient diagnosed with "nephrosclerosis with the non-functioning upper pole of the duplex right kidney in the junction of refluxing megaureter of the upper pole of the duplex right kidney". The highest content of MCs was found in the kidney areas with fibrotic changes. MCs were actively involved in the development of inflammatory and fibrotic changes in limited loci of the specific tissue microenvironment of the kidney through targeted secretion of tryptase, chymase, and carboxypeptidase A3 to the vascular endothelium, nephron epithelium, interstitium cells, and components of the intercellular substance. The formation of a profibrotic environment in the kidney interstitium was facilitated by epigenetic effects of tryptase promoting epithelial-mesenchymal transition (EMT) of the nephron epithelium. A selectively increased number and targeted secretory activity of MCs in limited loci of the kidney parenchyma without visible pathological changes evidence a trigger pathogenetic role of specific proteases in the formation of a local microenvironment with a profibrogenic metabolic profile. Thus, MCs are actively involved in the mechanisms of formation and evolution of fibrogenic niches in the kidney; this fact can be used to develop new strategies for therapeutic options of tubulointerstitial fibrosis resulted from chronic kidney injury. Further study of the molecular phenotype of mast cells reveals new fundamental mechanisms of fibrosis pathogenesis being a significant tool for personalized therapy in nephrology.

Preprint REVIEW | doi:10.20944/preprints202304.0989.v1

An Emerging Animal Model for Querying the Role of Whole Genome Duplication in Development, Evolution, and Disease

Mara Schvarzstein, Fatema Alam, Muhammad Toure, Judith L Yanowitz

Subject: Biology And Life Sciences, Cell And Developmental Biology Keywords: Whole genome duplication; tetraploidy; polyploidy; aneuploidy; Caenorhabditis; WGD model (List three to ten pertinent keywords specific to the article yet reasonably common within the subject discipline.)

Online: 26 April 2023 (12:43:20 CEST)

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Preprint REVIEW | doi:10.20944/preprints202304.0903.v1

Leishmaniasis: Immune Cells Crosstalk in Macrophage Polarization

Fernanda Silva Almeida, Shayenne Eduarda Ramos Vanderley, Fernando Cézar Comberlang, Arthur Gomes de Andrade, Luiz Henrique Agra Cavalcante-Silva, Edson dos Santos Silva, Pedro Henrique de Sousa Palmeira, Ian P.G. do Amaral, Tatjana S. L. Keesen

Subject: Biology And Life Sciences, Parasitology Keywords: leishmaniasis; immune response; macrophage phenotype

Online: 25 April 2023 (08:36:54 CEST)

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Preprint ARTICLE | doi:10.20944/preprints202304.0818.v1

Micromagnetic Approach to the Metastability of a Magnetite Nanoparticle and Specific Loss Power As Function of the Easy-Axis Orientation

Nathaly Roa, Johans Restrepo

Subject: Physical Sciences, Other Keywords: dynamic phase transition; alternating magnetic field; magnetic nanoparticle; hyperthermia; specific loss power

Online: 24 April 2023 (04:16:54 CEST)

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Preprint ARTICLE | doi:10.20944/preprints202304.0457.v1

Lateral Flow Biosensor for microRNA Detection Based on Peptide Nucleic Acid Probes

Aodi Liu, Qingjie Xia, Yang Huang, Haoheng Liu, Jin Tian, Kezhou Li

Subject: Biology And Life Sciences, Biology And Biotechnology Keywords: Peptide nucleic acid; microRNA detection; duplex specific nuclease; Early diagnosis of pancreatic cancer; Lateral flow biosensor

Online: 18 April 2023 (02:48:27 CEST)

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Preprint ARTICLE | doi:10.20944/preprints202304.0023.v1

PSI-mediated Vacuolar Sorting is not Disrupted in Arabidopsis leb-2 Mutant

Tatiana Cardoso, Miguel Sampaio, João Neves, Sofia Oliveira, Inês Moura, Ana Séneca, José Pissarra, Susana Pereira, Cláudia Pereira

Subject: Biology And Life Sciences, Plant Sciences Keywords: Arabidopsis; ER-bodies; aspartic proteinases; Plant Specific Insert; Vacuolar sorting; Endomembranes

Online: 3 April 2023 (10:36:29 CEST)

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Preprint ARTICLE | doi:10.20944/preprints202001.0350.v2

An Alternative Model of Gravitational Forces in Nature Using the Combined Effects of Repulsion and Attraction Forces on Gaseous Molecules

Chithra Piyadasa

Subject: Physical Sciences, Atomic And Molecular Physics Keywords: gravitational attraction; gravitational repulsion; intermolecular forces; thermal energy; specific heat; inverse cube law

Online: 21 March 2023 (15:44:21 CET)

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Preprint REVIEW | doi:10.20944/preprints202303.0371.v1

Nuclei on the Rise: When Nuclei-Based Methods Meet Next-Generation Sequencing

Tamer Butto, Kanak Mungikar, Peter Baumann, Jennifer Winter, Beat Lutz, Susanne Gerber

Subject: Medicine And Pharmacology, Hematology Keywords: Nuclei isolation; Next-generation sequencing; Cell-type specific isolation; Epigenetics; Transcriptomics; Single cell sequencing; Single nucleus sequencing

Online: 21 March 2023 (06:40:11 CET)

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Preprint ARTICLE | doi:10.20944/preprints202303.0192.v1

The Human Extracellular Matrix Diseasome Reveals Genotype-Phenotype Associations with Clinical Implications for Age-Related Diseases

Cyril Statzer, Karan Luthria, Arastu Sharma, Maricel G. Kann, Collin Y. Ewald

Subject: Biology And Life Sciences, Anatomy And Physiology Keywords: Phenome; Matrisome; Matreotype; Phenotype; Extracellular Matrix; Data Mining; SNP; PheWAS; GWAS; Electronic Health Records; Drug Repurposing; Precision Medicine; Collagen; Human

Online: 10 March 2023 (09:34:15 CET)

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Preprint ARTICLE | doi:10.20944/preprints202303.0165.v1

Modelling Time–Dependent Flow through Railway Ballast

Raed Alrdadi, Michael H. Meylan

Subject: Engineering, Civil Engineering Keywords: free surface; steady state; unsteady state; railway ballast; fouling ratio; specific yield; finite element method

Online: 9 March 2023 (03:31:03 CET)

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Preprint REVIEW | doi:10.20944/preprints202302.0305.v1

National and Ethnic Mutation Frequency Databases: Cross Comparison and Future Direction

Shumaila Khan, Mehmood Alam, Shahnaz Khan, Wahab Khan, Ihsan Rabbi, Iqbal Qasim

Subject: Computer Science And Mathematics, Information Systems Keywords: genetic databases; mutation disorders; ethnic specific databases

Online: 17 February 2023 (07:59:08 CET)

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Preprint ARTICLE | doi:10.20944/preprints201909.0247.v3

Four‑stage Evolution of Diabetes or Whole‑body Insulin Resistance (WBIR) Driven by Sequential Progression of Tissue‑specific Glycation‑induced Insulin Resistance (GIIR)

Song Jae LEE, Sang Won Shin

Subject: Biology And Life Sciences, Anatomy And Physiology Keywords: obesity; obesity paradox; diabetes; insulin resistance (IR); whole body insulin resistance (WBIR); tissue specific insulin resistance; muscle insulin resistance (MIR); subcutaneous insulin resistance (s AIR); visceral adipose insulin resistance (v AIR); hepatic insulin resistance (HIR); lipid induced insulin resistance (LIIIR); glycation induced insulin resistance (GIIIR); metabolic syndrome

Online: 14 February 2023 (09:38:06 CET)

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Preprint ARTICLE | doi:10.20944/preprints202301.0033.v2

Recent Trends of Antibiotic Resistance in Staphylococcus aureus Causing Clinical Mastitis in Dairy Herds in Abruzzo and Molise Regions, Italy

Franca Rossi, Ilaria Del Matto, Maria Antonietta Saletti, Luciano Ricchiuti, Lucio Marino

Subject: Biology And Life Sciences, Immunology And Microbiology Keywords: Staphylococcus aureus; clinical mastitis; antibiotic resistance (AR) prevalence; AR phenotype; AR genotype; recent trend

Online: 22 January 2023 (06:50:19 CET)

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Preprint ARTICLE | doi:10.20944/preprints202203.0290.v3

New Workflow Predicts Drug Targets Against SARS-CoV-2 via Metabolic Changes in Infected Cells

Nantia Leonidou, Alina Renz, Reihaneh Mostolizadeh, Andreas Dräger

Subject: Biology And Life Sciences, Biology And Biotechnology Keywords: host-virus interactions; tissue-specific model; COVID-19; SARS-CoV-2; antiviral targets; flux balance analysis; flux variability analysis; reaction knockout; host-derived enforcement; metabolic modeling; virus mutations; software engineering; Python

Online: 17 January 2023 (01:50:23 CET)

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Preprint ARTICLE | doi:10.20944/preprints202301.0273.v1

Identifying Patients in Whom the Follow-up Scheme after Robot-assisted Radical Prostatectomy Could be Optimized in the First Year after Surgery: Reducing Healthcare Burden

Hans Veerman, Sophia Van der Graaf, Dennie Meijer, Marinus Jan Hagens, Corinne N. Tillier, Pim J. Van Leeuwen, Henk G. Van der Poel, André N. Vis

Subject: Medicine And Pharmacology, Oncology And Oncogenics Keywords: prostatic neoplasms; prostatectomy; prostate-specific antigen; follow-up; aftercare; recurrence; delivery of healthcare

Online: 16 January 2023 (07:38:27 CET)

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Preprint ARTICLE | doi:10.20944/preprints202103.0088.v2

A Family Based Whole Exome Sequence Study to Identify Modifier Genes for Phenotype Heterogeneity Between Severe and Non-Severe Thalassemia Patients

Dipankar Saha, Debashis Pal, Prosanto Kumar Chowdhury, Kaustav Nayek, Gispati Chakraborty, Surupa Basu, ANUPAM BASU

Subject: Biology And Life Sciences, Biochemistry And Molecular Biology Keywords: WES; Thalassemia; phenotype

Online: 3 January 2023 (08:28:50 CET)

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Preprint ARTICLE | doi:10.20944/preprints202212.0420.v1

Normative scores for CrossFit® Open Workouts: 2011 - 2022

Gerald T. Mangine, Nina Grundlingh, Yuri Feito

Subject: Medicine And Pharmacology, Orthopedics And Sports Medicine Keywords: fitness assessment; sport-specific; athlete classification; high-intensity functional training; sex differences

Online: 22 December 2022 (06:34:53 CET)

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Preprint BRIEF REPORT | doi:10.20944/preprints202212.0219.v1

SARS-CoV-2 Breakthrough Infections after Third Doses Boost IgG Specific Salivary and Blood Antibodies

Maria Noel Badano, Matias Pereson, Florencia Sabbione, Irene Keitelman, Natalia Aloisi, Roberto Chuit, Maria Marta Elizalde de Bracco, Susana Fink, Patricia Bare

Subject: Biology And Life Sciences, Immunology And Microbiology Keywords: SARS-CoV-2 breakthrough infections; vaccines; anti-spike antibody levels; humoral response; IgG specific salivary antibodies

Online: 13 December 2022 (02:28:02 CET)

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Preprint ARTICLE | doi:10.20944/preprints202211.0355.v1

Risk Assessment of Transgender People: Development of Rodent Models Mimicking Gender-Affirming Hormone Therapies and Identification of Sex-Dimorphic Liver Genes as Novel Biomarkers of Sex Transition

Roberta Tassinari, Alessia Tammaro, Gabriele Lori, Sabrina Tait, Andrea Martinelli, Luigia Cangemi, Paolo Frassanito, Francesca Maranghi

Subject: Biology And Life Sciences, Biology And Biotechnology Keywords: testosterone; estrogen; cyprotenone acetate; masculinizing; feminizing; cytochrome P450; sex-specific genes

Online: 18 November 2022 (10:10:00 CET)

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Preprint REVIEW | doi:10.20944/preprints202209.0487.v2

Innate Immunity in Cardiovascular Diseases – Identification of Novel Molecular Players and Targets

Wolfgang Poller, Bettina Heidecker, Enrico Ammirati, Andreas W Kuss, Ana Tzvetkova, Wolfram C Poller, Carsten Skurk, Arash Haghikia

Subject: Medicine And Pharmacology, Cardiac And Cardiovascular Systems Keywords: Immunology; innate immunity; immunogenetics; noncoding genome; tRNA biology; evolutionary genetics (list 3-10 specific to the article yet reasonably common within the subject discipline)

Online: 1 November 2022 (09:55:10 CET)

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Preprint REVIEW | doi:10.20944/preprints202207.0160.v2

NIH SenNet Consortium: Mapping Senescent Cells in the Human Body to Understand Health and Disease

Patty J Lee, Philip Blood, Katy Börner, Judith Campisi, Feng Chen, Heike Daldrup-Link, Phil De Jager, Li Ding, Francesca E. Duncan, Oliver Eickelberg, Rong Fan, Toren Finkel, Vesna Garovic, Nils Gehlenborg, Carolyn Glass, Ziv Bar-Joseph, Pragati Katiyar, So-Jin Kim, Melanie Königshoff, George Kuchel, Haesung Lee, Jun H. Lee, Jian Ma, Qin Ma, Simon Melov, Kay Metis, Ana L. Mora, Nicolas Musi, Nicola Neretti, João F. Passos, Irfan Rahman, Juan Carlos Rivera-Mulia, Paul Robson, Mauricio Rojas, Ananda L. Roy, Birgit Schilling, Pixu Shi, Jonathan Silverstein, Vidyani Suryadevera, Jichun Xie, Jinhua Wang, An-Kwok Ian Wong, Laura Niedernhofer

Subject: Biology And Life Sciences, Cell And Developmental Biology Keywords: Cellular Senescence Network; Normal Aging; Senescence; Senescence-associated secretory phenotype; SenNet

Online: 15 September 2022 (12:52:05 CEST)

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Preprint ARTICLE | doi:10.20944/preprints202208.0488.v1

Primary Chemoradiotherapy Treatment (PCRT) for HER2+ and Triple Negative Breast Cancer Patients: A Feasible Combination

Raquel Ciérvide, Angel Montero Luis, Eduardo García-Rico, Mariola Garcia-Aranda, Mercedes Herrero, Jessica Skaarup, Leticia Benasi, Maria Jose Barrera, Estela Vega, Beatriz Rojas, Raquel Bratos, Ana Luna, Manuela Parras, Maria Lopez, Ana Delgado, Paloma Quevedo, Silvia Castilla, Margarita Feyjoo, Ana Higueras, Mario Prieto, Ana Suarez-Gauthier, Lina Garcia-Cañamaque, Nieves Escolán, Beatriz Alvarez, Xin Chen, Rosa Alonso, Mercedes Lopez, Ovidio Hernando, Jeannette Valero, Emilio Sánchez Sahugar, Eva Ciruelos, Carmen Rubio

Subject: Medicine And Pharmacology, Oncology And Oncogenics Keywords: chemoradiation; preoperative; neoadjuvant; TN/HER-2+ phenotype; pathological response; breast cancer

Online: 29 August 2022 (10:47:34 CEST)

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Preprint ARTICLE | doi:10.20944/preprints202208.0378.v1

Frequency and Antibiotic Susceptibility Patterns of Streptococcus Agalactiae Strains Isolated from Women in Yaounde, Cameroon

Cécile Ingrid Djuikoue, Paule Dana Djouela Djoulako, Rodrigue Kamga Wouambo, Rosine Yemetio Foutsa, Dorine Ekeu, Teke Apalata

Subject: Medicine And Pharmacology, Pathology And Pathobiology Keywords: Antibiotic resistance; Colonization; Prevalence; GBS; Resistance phenotype

Online: 22 August 2022 (08:04:16 CEST)

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Group B Streptococcus (GBS), a commensal in the body, causes a wide range of infectious diseases. The colonisation levels of GBS and its resistance profile to antibiotics provide important information useful for orienting prevention strategies. There is little data available on the subject with determination of resistance phenotypes in Cameroon. We therefore aimed to determine the prevalence of colonization, antibiotic resistance, including patterns of inducible resistance to clindamycin of GBS in Yaounde. To achieve this goal, a prospective cross-sectional study with an analytical component was carried out from the 28th June to the 29th August 2020 at the BIOSANTE laboratory and the Yaounde Gynaeco-Obstetrics and Paediatrics hospital. Vaginal swabs and urine were collected on 163 women. This samples were analysed using 5% defibrinated sheep blood agar and chocolate plus polyvitex agar. The isolates were identified using the morphology of the colony, Gram staining, haemolysis, catalase test and latex grouping test. Antibiotic susceptibility testing was done by disk diffusion method following the recommendations of the ACFSM 2019. The double disk diffusion method was used to identify isolates with clindamycin inducible resistance. Our data was analysed by the software SPSS version 2.1. The results obtained showed that the global prevalence of colonization by GBS was 37% (57/163), 40.35% in non-pregnant women and 59.65% in pregnant women. Pregnancy (P-value = 0.019) and gestational age (P-value = 0.025) constituted the risk factors of maternal colonization by GBS. In addition, the strains of GBS were resistant to all antibiotics tested. A D test showcased that 64.7% of GBS were resistant in a constitutive manner to clindamycin. We also note the presence of M phenotypes. As a whole, our results demonstrate that the rate of GBS colonization in this study was similar or higher than those in the previous report in Cameroon. All this indicates that attention should be paid to this bacterium in the monitoring of antimicrobial resistance and in the care of pregnant women and newborns.

Preprint REVIEW | doi:10.20944/preprints202208.0316.v1

Type of ANCA may be Superior to Clinical Phenotype in Distinguishing Different Clinical Entities in ANCA-associated Vasculitis

Afroditi Maria Konstantouli, Georgios Lioulios, Asimina Fylaktou, Maria Stangou

Subject: Medicine And Pharmacology, Clinical Medicine Keywords: ANCA-associated vasculitis; Proteinase 3; Myeloperoxidase; Clinical Phenotype; Outcome

Online: 17 August 2022 (09:58:51 CEST)

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Preprint REVIEW | doi:10.20944/preprints202208.0220.v1

Promoting Oncolytic Vector Replication With Switches That Detect Ubiquitous Mutations

Michael Renteln

Subject: Medicine And Pharmacology, Oncology And Oncogenics Keywords: Molecular switches; oncolytic vectors; patient-specific ubiquitous mutations; targeted therapy; multi-region sequencing; molecular biology

Online: 11 August 2022 (11:50:12 CEST)

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Preprint ARTICLE | doi:10.20944/preprints202207.0426.v1

Predicting the Cross-Coordinated Immune Response Dynamics in Sars-Cov-2 Infection: Implications for Disease Pathogenesis

Dmitry Grebennikov, Antonina Karsonova, Marina Loginova, Valentina Casella, Andreas Meyerhans, Gennady Bocharov

Subject: Computer Science And Mathematics, Applied Mathematics Keywords: SARS-CoV-2 infection; innate immune response; antigen-specific immune response; kinetic coordination; mathematical model; pathogenesis, long COVID-19

Online: 27 July 2022 (15:11:44 CEST)

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Preprint REVIEW | doi:10.20944/preprints202207.0423.v1

Is “Cellular Senescence” a Misnomer?

David Gems, Carina Kern

Subject: Biology And Life Sciences, Cell And Developmental Biology Keywords: Aging; cellular senescence; fibroblast; osteoarthritis; remodeling-associated secretory phenotype (RASP); remodeling activation

Online: 27 July 2022 (13:38:36 CEST)

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Preprint ARTICLE | doi:10.20944/preprints202207.0372.v1

Cell Compartment-specific Folding of Ty1 Long Terminal Repeat Retrotransposon RNA Genome

Małgorzata Zawadzka, Angelika Andrzejewska-Romanowska, Julita Gumna, David J. Garfinkel, Katarzyna Pachulska-Wieczorek

Subject: Biology And Life Sciences, Virology Keywords: RNA genome; RNA structure; Cell compartment-specific folding; LTR-retrotransposon; gRNA dimerization; gRNA cyclization; tRNA annealing; Ty1; Gag.

Online: 25 July 2022 (10:07:00 CEST)

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Preprint REVIEW | doi:10.20944/preprints202207.0281.v1

Software-Defined Networks for Optical Networks using Flexible Orchestration : Advances, Challenges and Opportunities

Kenneth Nsafoa-Yeboah, Eric Tchao, Bright Yeboah-Akowuah, Benjamin Kommey, Andrew Selasi Agbemenu, Eliel Keelson, Mohammad Monirujjaman Khan

Subject: Computer Science And Mathematics, Computer Networks And Communications Keywords: Optical networks; software-defined networks; fifth-generation wireless network(5G); network service orchestrators; customer- specific requirements; Quality of service, flexibility.

Online: 19 July 2022 (07:44:11 CEST)

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Preprint ARTICLE | doi:10.20944/preprints202206.0401.v1

Assessing Loss of Regulatory Divergence, Genome–Transcriptome Incongruence, and Preferential Expression Switching in Abaca/ Banana Backcrosses

Nelzo C. Ereful, Antonio G. Lalusin, Antonio C. Laurena

Subject: Biology And Life Sciences, Plant Sciences Keywords: abaca (Musa textilis); allelic imbalance; regulatory divergence; banana (M. balbisiana); allele-specific expression

Online: 29 June 2022 (09:34:03 CEST)

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Preprint ARTICLE | doi:10.20944/preprints202203.0286.v1

Classical-Relativistic Variability of Inertia of Photon Displacement Mass in the Matter and the Specific Vacuum Temperature

Daniel Souza Cardoso, José Rafael Bordin

Subject: Physical Sciences, Optics And Photonics Keywords: photon inertia; inertia momenta; photon inertia variability; photon inertia momenta variability; specific vacuum temperature; Abraham momenta; Minkowski momenta; relativistic energy wave; translational inertia; rotational inertia; photon displacement mass

Online: 21 March 2022 (11:21:56 CET)

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Preprint REVIEW | doi:10.20944/preprints202201.0280.v1

Roles of Podoplanin in Malignant Progression of Tumor

Hiroyuki Suzuki, Mika K Kaneko, Yukinari Kato

Subject: Medicine And Pharmacology, Oncology And Oncogenics Keywords: podoplanin, PDPN, tumor malignancy, tumor marker, antibody therapy, cancer-specific monoclonal antibody, CasMab

Online: 19 January 2022 (16:05:50 CET)

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Preprint ARTICLE | doi:10.20944/preprints202201.0101.v1

Line × tester Study in Bread Wheat (Triticum aestivum L.) for Important Biochemical and Morphological Traits

Anand Kumar, Lokendra Singh, Prashant Kaushik

Subject: Biology And Life Sciences, Biochemistry And Molecular Biology Keywords: Bread wheat; general combining ability; specific combining ability; heritability; genetic advance

Online: 10 January 2022 (11:30:43 CET)

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Preprint ARTICLE | doi:10.20944/preprints202112.0167.v1

Preparation and Characterization of a Glycyrrhizic Acid-Based Drug Delivery System for Allergen-Specific Immunotherapy

Ekaterina Pashkina, Veronika Evseenko, Natalya Dumchenko, Maxim Zelikman, Alina Aktanova, Maria Bykova, Mikhail Khvostov, Aleksandr Dushkin, Vladimir Kozlov

Subject: Medicine And Pharmacology, Immunology And Allergy Keywords: drug delivery; allergen; glycyrrhizic acid; allergen-specific immunotherapy

Online: 10 December 2021 (08:50:57 CET)

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Preprint ARTICLE | doi:10.20944/preprints202111.0369.v1

Domain-Specific Languages for Workflows.A Systematic Literature Review

Akif Quddus Khan

Subject: Computer Science And Mathematics, Information Systems Keywords: WorkflowDSL, DSL, Domain-Specific Language, Workflow.

Online: 19 November 2021 (15:08:02 CET)

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Preprint ARTICLE | doi:10.20944/preprints202111.0237.v1

Incidence and Risk Factors for Cerebrovascular-Specific Mortality in Patients with Colorectal Cancer: A Registry-Based Cohort Study Involving 563298 Patients

Wei Huang, Ming Tang, Yun-Liang Chen, Tao-Lan Zhang, Tao Hong, Jing Li, Guo-Hua Lv, Yiguo Yan, Zhi-Hua Ouyang, Mingxiang Zou

Subject: Medicine And Pharmacology, Oncology And Oncogenics Keywords: Colorectal cancer; Cerebrovascular-specific mortality; Cerebrovascular-specific diseases; Incidence; Risk factors

Online: 12 November 2021 (16:47:45 CET)

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Preprint ARTICLE | doi:10.20944/preprints202111.0074.v1

Isochoric Specific Heat in the Dual Model of Liquids

Fabio Peluso

Subject: Physical Sciences, Condensed Matter Physics Keywords: Liquid model; Phonons in liquids; Instantaneous Normal Modes; Mesoscopic model of liquids; Phonon – particle interaction; Specific heat

Online: 3 November 2021 (09:14:38 CET)

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Preprint ARTICLE | doi:10.20944/preprints202110.0050.v2

Enthalpies of Adduct Formation between Boron Trifluoride and Selected Organic Bases in Solution: Toward an Accurate Theoretical Entry to Lewis Basicity

Jean-François Gal, Pierre-Charles Maria, Manuel Yáñez, Otilia Mó

Subject: Chemistry And Materials Science, Physical Chemistry Keywords: BF3 enthalpies; Lewis basicity; Specific solvation; High-level ab initio calculations; Dichloromethane; Boron trifluoride.

Online: 2 November 2021 (10:38:18 CET)

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Preprint ARTICLE | doi:10.20944/preprints202109.0335.v1

Personalization of a Human Body Model Using Subject-Specific Clothing Industry Dimensions

Luděk Hynčík, Hana Čechová, Tomasz Bońkowski, Gabriela Kavalířová, Petra Špottová, Viola Hampejsová, Hong Meng

Subject: Engineering, Other Keywords: human body; anthropometric dimensions; personalization; subject-specific model; biofidelity

Online: 20 September 2021 (14:15:24 CEST)

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Working Paper HYPOTHESIS

Competitive Coherence Generates Qualia in Bacteria and Other Living Systems

Vic Norris

Subject: Biology And Life Sciences, Immunology And Microbiology Keywords: consciousness; qualia; network; bacteria; learning; phenotype

Online: 15 September 2021 (15:58:51 CEST)

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Preprint ARTICLE | doi:10.20944/preprints202109.0226.v1

Minimum-Fuel Planar Earth-to-Mars Low-Thrust Trajectories Using Bang-Bang Control

Daero Lee

Subject: Engineering, Energy And Fuel Technology Keywords: Low-thrust trajectories; bang-bang control; electric propulsion; constant specific impulse; indirect method; direct method

Online: 14 September 2021 (09:48:25 CEST)

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Preprint ARTICLE | doi:10.20944/preprints202109.0110.v1

Effects of Sex and 17β-Estradiol on Cardiac Fibroblast Morphology and Signaling Activities in vitro

Kelsey Watts, Will Richardson

Subject: Biology And Life Sciences, Biochemistry And Molecular Biology Keywords: cardiac fibroblasts; sex-specific; estrogen; fibrosis; heart failure

Online: 6 September 2021 (17:24:51 CEST)

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Preprint REVIEW | doi:10.20944/preprints202109.0094.v1

Barriers and Challenges Going From Conventional to Cryogenic Superconducting Propulsion for Hybrid and All-Electric Aircrafts

F. Ferreira da Silva, João F. P. Fernandes, P. J. da Costa Branco

Subject: Engineering, Electrical And Electronic Engineering Keywords: Review; Electrical Machines; Superconducting Machines; Hybrid-Electric Aircraft; Propulsion Design; All-Electric Aircraft; Specific Power

Online: 6 September 2021 (13:04:15 CEST)

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Preprint ARTICLE | doi:10.20944/preprints202108.0368.v1

An Investigation of Point Mutations Discovers Novel Genes and Their Corresponding Motifs in Pancreatic Cancer

Amin Ghareyazi, Amir Mohseni, Hamed Dashti, Abdollah Dehzangi, Hamid R. Rabiee, Hamid Alinejad-Rokny

Subject: Biology And Life Sciences, Biochemistry And Molecular Biology Keywords: pancreatic cancer; cancer subtype identification; somatic point mutations; genotype and phenotype characterization; therapeutic targets; personalized medicine

Online: 17 August 2021 (22:24:57 CEST)

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Preprint REVIEW | doi:10.20944/preprints202107.0635.v1

Genetic and Epigenetic Factors of Takotsubo Syndrome: a Systematic Review

Valentina Ferradini, Davide Vacca, Beatrice Belmonte, Ruggiero Mango, Giuseppe Novelli, Carmela Rita Balistreri, Federica Carla Sangiuolo

Subject: Medicine And Pharmacology, Immunology And Allergy Keywords: Takotsubo cardiomyopathy (TTS); biomarkers; specific and effective treatments; TTS management; genetic and epigenetic factors; systematic review

Online: 28 July 2021 (17:07:01 CEST)

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Working Paper ARTICLE

Comparative Transcriptomics of Non-Embryogenic and Embryogenic Callus in Semi-Recalcitrant and Non-Recalcitrant Upland Cotton Lines

Sonika Kumar, Ashleigh Ruggles, Sam Logan, Alora Mazarakis, Tyson Thomas, Matthew Bates, Dave Reed, Clayton Grosse, Zhigang Li, Jane Grimwood, Jeremy Schmutz, Christopher A Saski

Subject: Biology And Life Sciences, Plant Sciences Keywords: callus; genotype-specific recalcitrance; reprogramming; somatic embryogenesis; transcriptomics; upland cotton

Online: 20 July 2021 (15:30:47 CEST)

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Working Paper ARTICLE

Comparison of BSGI and MRI as Approaches to Evaluating Residual Tumor Status After Neoadjuvant Chemotherapy in Chinese Women With Breast Cancer

Hongbiao Liu, Hongwei Zhan, Ying Zhang, Gangqiang He, Hui Wang, Qiaoxia Zhang, Lili Zheng

Subject: Medicine And Pharmacology, Immunology And Allergy Keywords: breast-specific gamma imaging (BSGI); neoadjuvant chemotherapy (NAC); breast cancer; Magnetic resonance imaging (MRI); residual tumor size

Online: 6 July 2021 (12:40:31 CEST)

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Preprint ARTICLE | doi:10.20944/preprints202107.0110.v1

A Multi-Criteria Assessment Strategy for 3d Printed Porous Polyetheretherketone (Peek) Patient-Specific Implants for Orbital Wall Reconstruction

Neha Sharma, Dennis Welker, Soheila Aghlmandi, Michaela Maintz, Hans-Florian Zeilhofer, Philipp Honigmann, Thomas Seifert, Florian M. Thieringer

Subject: Medicine And Pharmacology, Immunology And Allergy Keywords: blow-out; biocompatible materials; computer-aided design; finite element analysis; orbit; implant; orbital fracture; patient-specific modeling; printing; three-dimensional.

Online: 5 July 2021 (15:37:53 CEST)

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Preprint ARTICLE | doi:10.20944/preprints202106.0602.v1

Design and Performance Test of the Coffee Bean Classifier

Ansar Ansar, Sukmawaty Sukmawaty, Murad Murad, Surya Abdul Muttalib, Riyan Hadi Putra, Abdurrahim Abdurrahim

Subject: Engineering, Automotive Engineering Keywords: classifier; coffee beans; efficiency; specific energy; sieves

Online: 24 June 2021 (11:22:48 CEST)

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Preprint ARTICLE | doi:10.20944/preprints202105.0781.v1

Alternative Exhibition Spaces. Multi-criteria Method of Comparative Analysis

Joanna Stefańska, Paulina Kowalczyk, Agata Gawlak

Subject: Social Sciences, Anthropology Keywords: white cube; exhibition space; space; work; architecture; site specific; interaction

Online: 31 May 2021 (13:53:59 CEST)

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The aim of this article is to make a multi-criteria analysis of various exhibition spaces of an originally non-exhibition character and to determine how these spaces affect the selection of works and the exhibition concept. The analysis is based on the exhibitions of art objects at collective exhibitions in unconventional architectural spaces: commercial, i.e. the modern office building of PBG Gallery Skalar Office Centre in Poznań, post-industrial i.e. in the former Zakłady Przemysłu Ziemniaczanego Lubanta S.A. and in the historic interior of the "U Jezuitów" Gallery of the Cultural Integration Centre in Poznań. The multi-criteria comparative analysis shows a variety of features of the studied spaces as well as the relationship between architecture and art and their mutual interaction. The participatory role of the non-exhibition space in the process of creating an exhibition and selecting works has been proven. It has also been confirmed that the presentation of works of art in originally non-exhibition spaces creates a new quality of the artwork. Unconventional architectural space, when used for the exhibition of works of art, expands and strengthens the area of their influence through the interaction between the work and the architectural space. The specificity of the space adapted for exhibition needs, the presence and type of architectural details in the interior, the quantity and quality of light and its distribution in space, the volume and colour of the interior determine the exhibition space and influence the shape of the exhibitions organised and the reception of the artworks. The only condition for the change of the original function of an architectural space into that of an exhibition space is a coherent artistic vision of the creator. This should take into account the appropriate selection of the exhibited objects, where the process of searching for the relationship between architecture and art determines the features of the architectural space as integral components influencing the realisation of the exhibition .

Preprint ARTICLE | doi:10.20944/preprints202105.0677.v1

Supervised Analysis for Phenotype Identification: The Case of Heart Failure Ejection Fraction Class

Cristina Lopez, Jose Luis Holgado, Raquel Cortes, Inma Sauri, Antonio Fernandez, Jose Miguel Calderon, Julio Nuñez, Josep Redon

Subject: Medicine And Pharmacology, Immunology And Allergy Keywords: heart failure, phenotype, left ventricular ejection fraction, primary care, artificial intelligence, supervised analysis

Online: 27 May 2021 (14:08:53 CEST)

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Working Paper ARTICLE

Domain-Specific Stimulation of Executive Functioning in Low-Preforming Students with a Roma Background: Cognitive Potential Of Mathematics

Iveta Kovalčíková, Jochanan Veerbeek, Bart Vogelaar, Alena Prídavková, Ján Ferjenčík, Edita Šimčíková, Blanka Tomková

Subject: Business, Economics And Management, Accounting And Taxation Keywords: executive functioning; domain-specific cognitive stimulation; math; low-performing student; Roma ethnic group.

Online: 13 May 2021 (13:06:47 CEST)

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Preprint ARTICLE | doi:10.20944/preprints202105.0243.v1

Action and Entropy in Heat Engines: An Action Revision of the Carnot Cycle

Ivan Robert Kennedy, Migdat Hodzic

Subject: Physical Sciences, Quantum Science And Technology Keywords: Carnot cycle; Caloric; specific heat; entropy; Gibbs potential; vortical entropy; reversible cycle; working fluid, quantum field, relative action, heat engine

Online: 11 May 2021 (11:18:39 CEST)

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Despite the remarkable success of Carnot’s heat engine cycle in founding the discipline of thermodynamics two centuries ago, false viewpoints of his use of the caloric theory in the cycle still linger, limiting his legacy. An action revision of the Carnot cycle can correct this, showing that the heat flow powering external mechanical work is compensated internally with configurational changes in the thermodynamic or Gibbs potential of the working fluid, differing in each stage of the cycle quantified by Carnot as caloric. Action (@) is a property of state having the same physical dimensions as angular momentum (mrv=mr2ω). However, this property is scalar rather than vectorial, including a dimensionless phase angle (@=mr2ωδφ). We have recently confirmed with atmospheric gases that their entropy is a logarithmic function of the relative vibrational, rotational and translational action ratios with Planck’s quantum of action ħ. The Carnot principle shows that the maximum rate of work (puissance motrice) possible from the reversible cycle is controlled by the difference in temperature of the hot source and the cold sink, the colder the better. This temperature difference between the source and the sink also controls the isothermal variations of the Gibbs potential of the working fluid, that Carnot identified as reversible temperature-dependent but unequal exchanges in caloric. Importantly, the engine’s inertia ensures that heat from work performed adiabatically in the expansion phase is all restored to the working fluid during the adiabatic recompression, less the net work performed. This allows both the energy and the thermodynamic potential to return to the same values at the beginning of each cycle, a point strongly emphasized by Carnot. Our action revision equates Carnot’s calorique, or the non-sensible heat later described by Clausius as ‘work-heat’ exclusively to negative Gibbs energy (-G) or quantum field energy. This action field complements the sensible energy or vis-viva heat as molecular kinetic motion and its recognition should have significance for designing more efficient heat engines or better understanding of the heat engine powering the Earth’s climates.

Preprint BRIEF REPORT | doi:10.20944/preprints202104.0658.v1

SCA Medium: A New Culture Medium for the Isolation of all Candida auris Clade

Ahmad Ibrahim, Lucie Peyclit, Rim Abdallah, Saber Khelaifia, Amanda Chamieh, Jean-Marc Rolain, Fadi Bittar

Subject: Biology And Life Sciences, Biochemistry And Molecular Biology Keywords: Candida; Candida auris; Culture; Emerging fungus; Isolation; Specific medium

Online: 26 April 2021 (11:06:41 CEST)

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Preprint ARTICLE | doi:10.20944/preprints202104.0583.v1

Free Energies of Hydrated Halide Anions: High throughput Computations on Clusters to Treat Rough Energy-Landscapes

Diego Gomez, Lawrence Pratt, David Rogers, Susan Rempe

Subject: Physical Sciences, Acoustics Keywords: ion hydration; physical cluster theory; halides; Hofmeister series; specific ion effects

Online: 21 April 2021 (13:36:47 CEST)

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Preprint REVIEW | doi:10.20944/preprints202104.0244.v1

Curating and Comparing 114 Strain-Specific Genome-Scale Metabolic Models of Staphylococcus aureus

Alina Renz, Andreas Dräger

Subject: Biology And Life Sciences, Biochemistry And Molecular Biology Keywords: Staphylococcus aureus; MRSA; genome-scale metabolic models; model-driven discovery; strain-specific models

Online: 8 April 2021 (14:25:31 CEST)

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Preprint ARTICLE | doi:10.20944/preprints202103.0606.v1

Eleni Bonti, Afroditi Kamari, Maria Sofologi, Sofia Giannoglou, Georgia-Nektaria Porfyri, Paraskevi Tatsiopoulou, Georgios Kougioumtzis, Maria Efstratopoulou, Ioannis Diakogiannis

Subject: Biology And Life Sciences, Biochemistry And Molecular Biology Keywords: adolescence; SLD; SLI; specific learning disabilities in mathematics; learning profiles; neurodevelopmental disorders

Online: 24 March 2021 (17:03:48 CET)

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Preprint ARTICLE | doi:10.20944/preprints202103.0328.v1

Epitope Mapping of the Diphtheria Toxin and Development of an ELISA-Specific Diagnostic Assay

Salvatore Giovanni De-Simone, Larissa Rodrigues Gomes, Paloma Napoleão-Pêgo, Guilherme Curty Lechuga, Jorge Soares de Pina, Flavio Rocha Silva

Subject: Biology And Life Sciences, Biochemistry And Molecular Biology Keywords: Diphtheria toxin; B epitopes; epitope mapping; bi-specific peptides; ELISA; diagnostic performance

Online: 11 March 2021 (16:43:02 CET)

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Preprint ARTICLE | doi:10.20944/preprints202103.0242.v1

Genomic Fabric Remodeling in Prostate Cancer

Sanda Iacobas, Dumitru A. Iacobas

Subject: Biology And Life Sciences, Biochemistry And Molecular Biology Keywords: apoptosis; evading apoptosis; expression variability; cancer functional pathway; prostate cancer phenotype; immortality; proliferation; P53 signaling; transcriptomic network

Online: 9 March 2021 (08:44:15 CET)

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Preprint ARTICLE | doi:10.20944/preprints202103.0160.v1

99mTc-Sestamibi Bioaccumulation Can Induce the Apoptosis in Breast Cancer Cells: Molecular and Clinical Perspectives

Nicoletta Urbano, Manuel Scimeca, Rita Bonfiglio, Alessandro Mauriello, Elena Bonanno, Orazio Schillaci

Subject: Medicine And Pharmacology, Immunology And Allergy Keywords: 99mTc-Sestamibi; Breast Specific Gamma Imaging; Breast Cancer; Apoptosis; Theragnostic

Online: 4 March 2021 (14:00:05 CET)

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Preprint ARTICLE | doi:10.20944/preprints202102.0215.v1

Insect-Specific Flavivirus Replication in Mammalian Cells is Inhibited by Physiological Temperature and the Zinc-Finger Antiviral Protein

Agathe M.G. Colmant, Jody Hobson-Peters, Teun A.P. Slijkerman, Jessica J. Harrison, Gorben P. Pijlman, Monique M. van Oers, Peter Simmonds, Roy A. Hall, Jelke J. Fros

Subject: Biology And Life Sciences, Biochemistry And Molecular Biology Keywords: Insect-specific flavivirus; CpG; Dinucleotides; Innate immunity; Zinc-finger antiviral protein

Online: 8 February 2021 (15:46:14 CET)

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Preprint REVIEW | doi:10.20944/preprints202101.0304.v1

The Proteolytic Activation of Vascular Endothelial Growth Factors

Jaana Künnapuu, Hanieh Bokharaie, Michael Jeltsch

Subject: Biology And Life Sciences, Biochemistry And Molecular Biology Keywords: Vascular Endothelial Growth Factors (VEGFs); VEGF-A; PlGF; VEGF-B; VEGF-C; VEGF-D; angiogenesis; lymphangiogenesis; CCBE1; proteases; ADAMTS3; plasmin; cathepsin D; KLK3; prostate-specific antigen (PSA); thrombin; wound healing; metastasis; proteolytic activation; vascular biology

Online: 18 January 2021 (09:05:58 CET)

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Preprint CONCEPT PAPER | doi:10.20944/preprints202005.0321.v2

Proposed O-GalNAc/Gal Gycosylation Pathways in Blood Group O and Non-O Blood Group Phenotypes During Plasmodium falciparum Infections Driving Evolution

Peter Arend

Subject: Biology And Life Sciences, Biochemistry And Molecular Biology Keywords: trans-species O-glycosylation; trans-species functional bridge; phenotype-specific plasma glycosylation; glycosidic exclusion; ontogenetic Tn formation

Online: 12 January 2021 (12:33:29 CET)

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Preprint ARTICLE | doi:10.20944/preprints202012.0489.v1

Clinical Significance of Velamentous Cord Insertion Prenatally Diagnosed in Twin Pregnancy

Hyun-mi Lee, SiWon Lee, Min-Kyung Park, You Jung Han, Moon Young Kim, Hye Yeon Boo, Jin Hoon Chung

Subject: Medicine And Pharmacology, Immunology And Allergy Keywords: Velamentous cord insertion; Twin; Perinatal outcomes; Pregnancy outcomes; Chorionicity; Twin specific complications

Online: 21 December 2020 (10:14:02 CET)

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Preprint CONCEPT PAPER | doi:10.20944/preprints202008.0574.v2

An Engineering Theory of Evolution

Simeon Castle, Claire Grierson, Thomas Gorochowski

Subject: Biology And Life Sciences, Biology And Biotechnology Keywords: evolution; evotype; engineering theory; genotype-phenotype maps; directed evolution; selection; synthetic biology; bioengineering; evolvability; self-adaptive systems

Online: 9 December 2020 (10:51:51 CET)

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Preprint ARTICLE | doi:10.20944/preprints202011.0549.v1

Topology Optimization of Microstructures to Reduce Structural Oscillations

Georgios Stylianos Zymvragakis, Panagiotis Koutsianitis, Georgios E. Stavroulakis

Subject: Engineering, Automotive Engineering Keywords: vibration suppression; topology optimization; band gaps; Bloch theory; finite element analysis (List three to ten pertinent keywords specific to the article; yet reasonably common within the subject discipline.)

Online: 20 November 2020 (16:35:21 CET)

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Preprint ARTICLE | doi:10.20944/preprints202010.0449.v1

Comparative Genomics Reveals Novel Target Genes Towards Specific Control of Plant-Parasitic Nematodes

Priscila Grynberg, Roberto Coiti Togawa, Leticia Dias de Freitas, Jose Dijair Antonino, Corinne Rancurel, Marcos Mota do Carmo Costa, Maria Fátima Grossi-de-Sa, Robert Neil Gerard Miller, Ana Cristina Miranda Brasileiro, Patricia Messenberg Guimaraes, Etienne G. J. Danchin

Subject: Biology And Life Sciences, Anatomy And Physiology Keywords: comparative genomics; plant-parasitic nematodes; phylogenomics; parasite-specific genes; pest control; de novo gene birth; horizontal gene transfers

Online: 22 October 2020 (09:01:30 CEST)

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Preprint ARTICLE | doi:10.20944/preprints202010.0187.v1

The Impact of Water Loss by Evaporation and Calcite Precipitation on the Sodium Adsorption Ratio (SAR) and an Alternative Method of Estimating the SAR of Irrigation Drainage Water

Qiyu Zhou, William Bleam, Douglas Soldat

Subject: Environmental And Earth Sciences, Water Science And Technology Keywords: sodium adsorption ratio; SAR; CROSS, electrical conductivity; specific conductivity; salinity; irrigation; groundwater; water quality

Online: 9 October 2020 (08:45:56 CEST)

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Preprint REVIEW | doi:10.20944/preprints202010.0118.v1

From FAANG to Fork: Application of Highly Annotated Genomes to Improve Farmed Animal Production

Emily L Clark, Alan L Archibald, Hans D Daetwyler, Martien AM Groenen, Peter W Harrison, Ross D Houston, Christa Kuehn, Sigbjorn Lien, Daniel J Macqueen, James M Reecy, Diego Robledo, Mick Watson, Christopher K Tuggle, Elisabetta Giuffra

Subject: Biology And Life Sciences, Animal Science, Veterinary Science And Zoology Keywords: FAANG; farmed animal; genomics; genotype-to-phenotype

Online: 6 October 2020 (10:53:17 CEST)

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Preprint ARTICLE | doi:10.20944/preprints202010.0052.v1

Predicting SARS-CoV-2 Weather-Induced Seasonal Virulence from Atmospheric Air Enthalpy

Angelo Spena, Leonardo Palombi, Massimo Corcione, Alessandro Quintino, Mariachiara Carestia, Vincenzo Andrea Spena

Subject: Biology And Life Sciences, Biochemistry And Molecular Biology Keywords: weather-related SARS-CoV-2 virulence; specific enthalpy of atmospheric moist air; temperature and humidity effects on COVID-19 outbreak; correlating equation; COVID-19 spread prediction risk scale

Online: 5 October 2020 (08:10:08 CEST)

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