Preprint Brief Report Version 1 Preserved in Portico This version is not peer-reviewed

SARS-CoV-2 Breakthrough Infections after Third Doses Boost IgG Specific Salivary and Blood Antibodies

Maria Noel Badano
* ORCID logo ,
Matias Pereson
,
Florencia Sabbione
,
Irene Keitelman
ORCID logo ,
Natalia Aloisi
,
Roberto Chuit
,
Maria Marta Elizalde de Bracco
,
Susana Fink
,
Patricia Bare
Version 1 : Received: 9 December 2022 / Approved: 13 December 2022 / Online: 13 December 2022 (02:28:02 CET)

A peer-reviewed article of this Preprint also exists.

Badano, M.N.; Pereson, M.J.; Sabbione, F.; Keitelman, I.; Aloisi, N.; Chuit, R.; de Bracco, M.M.E.; Fink, S.; Baré, P. SARS-CoV-2 Breakthrough Infections after Third Doses Boost IgG Specific Salivary and Blood Antibodies. Vaccines 2023, 11, 534. Badano, M.N.; Pereson, M.J.; Sabbione, F.; Keitelman, I.; Aloisi, N.; Chuit, R.; de Bracco, M.M.E.; Fink, S.; Baré, P. SARS-CoV-2 Breakthrough Infections after Third Doses Boost IgG Specific Salivary and Blood Antibodies. Vaccines 2023, 11, 534.

Abstract

SARS-CoV-2 breakthrough infections, associated with waning immunity, increase systemic antibody levels. In this study, we analyzed the impact of the infection timing on the magnitude of the systemic humoral response and whether breakthrough infections also boost antibody levels in the salivary compartment. We observed that the combination of infection plus vaccination, regardless of infection timing, produced a sharp increase of systemic antibodies, being higher in subjects infected after third doses. Moreover, despite high systemic antibody levels, breakthrough infections after dose 3 occurred and boosted antibody levels in the salivary compartment. These results lead to rethink the current vaccination strategies against COVID-19 and the use of salivary anti-SARS-CoV-2 antibodies for disease surveillance and vaccination follow-up.

Keywords

SARS-CoV-2 breakthrough infections; vaccines; anti-spike antibody levels; humoral response; IgG specific salivary antibodies

Subject

Biology and Life Sciences, Immunology and Microbiology

Copyright: This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

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