Preprint Review Version 1 Preserved in Portico This version is not peer-reviewed

Mast Cells as a Potential Target of Molecular Hydrogen in Regulating the Local Tissue Microenvironment

Dmitri Atiakshin
ORCID logo ,
Andrey Kostin
,
Artem Volodkin
,
Anna Nazarova
,
Viktoriya Shishkina
ORCID logo ,
Dmitry Esaulenko
,
Igor Buchwalow
* ORCID logo ,
Markus Tiemann
,
Mami Noda
Version 1 : Received: 30 April 2023 / Approved: 1 May 2023 / Online: 1 May 2023 (11:54:37 CEST)

A peer-reviewed article of this Preprint also exists.

Atiakshin, D.; Kostin, A.; Volodkin, A.; Nazarova, A.; Shishkina, V.; Esaulenko, D.; Buchwalow, I.; Tiemann, M.; Noda, M. Mast Cells as a Potential Target of Molecular Hydrogen in Regulating the Local Tissue Microenvironment. Pharmaceuticals 2023, 16, 817. Atiakshin, D.; Kostin, A.; Volodkin, A.; Nazarova, A.; Shishkina, V.; Esaulenko, D.; Buchwalow, I.; Tiemann, M.; Noda, M. Mast Cells as a Potential Target of Molecular Hydrogen in Regulating the Local Tissue Microenvironment. Pharmaceuticals 2023, 16, 817.

Abstract

Knowledge of the biological effects of molecular hydrogen (H2), hydrogen gas, is constantly expanding giving a reason for optimism for several healthcare practitioners regarding management of multiple diseases, including socially significant ones. However, mechanisms underlying the biological effects of H2 are still being actively argued. In this review, we focus on mast cells as a potential target for H2 at the level of a specific tissue microenvironment. H2 regulates processing of pro-inflammatory components of the mast cell secretome and their entry into the extracellular matrix; this can significantly affect the state of the integrated-buffer metabolic environment and the structure of the immune landscape of the local tissue microenvironment. The analysis performed highlights several potential mechanisms for developing the biological effects of H2 and offers great opportunities for translating the obtained findings into clinical practice.

Keywords

molecular hydrogen; reactive oxygen intermediates; mast cells; secretome; specific mast cell proteases; local tissue microenvironment; inflammation

Subject

Medicine and Pharmacology, Pharmacology and Toxicology

Copyright: This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

Download PDF

Comments (0)

We encourage comments and feedback from a broad range of readers. See criteria for comments and our Diversity statement.

Leave a public comment
Send a private comment to the author(s)
* All users must log in before leaving a comment
Views 0
Downloads 0
Comments 0
Metrics 0
Get PDF Cite Share 0
Bookmark BibSonomy Mendeley Reddit Delicious
×
Alerts
Notify me about updates to this article or when a peer-reviewed version is published.
We use cookies on our website to ensure you get the best experience.
Read more about our cookies here.