Preprint Article Version 1 Preserved in Portico This version is not peer-reviewed

Preparation and Characterization of a Glycyrrhizic Acid-Based Drug Delivery System for Allergen-Specific Immunotherapy

Version 1 : Received: 9 December 2021 / Approved: 10 December 2021 / Online: 10 December 2021 (08:50:57 CET)

A peer-reviewed article of this Preprint also exists.

Pashkina, E.; Evseenko, V.; Dumchenko, N.; Zelikman, M.; Aktanova, A.; Bykova, M.; Khvostov, M.; Dushkin, A.; Kozlov, V. Preparation and Characterization of a Glycyrrhizic Acid-Based Drug Delivery System for Allergen-Specific Immunotherapy. Nanomaterials 2022, 12, 148. Pashkina, E.; Evseenko, V.; Dumchenko, N.; Zelikman, M.; Aktanova, A.; Bykova, M.; Khvostov, M.; Dushkin, A.; Kozlov, V. Preparation and Characterization of a Glycyrrhizic Acid-Based Drug Delivery System for Allergen-Specific Immunotherapy. Nanomaterials 2022, 12, 148.

Journal reference: Nanomaterials 2021, 12, 148
DOI: 10.3390/nano12010148

Abstract

The most effective method of treating allergic diseases, aimed not at relieving symptoms, but at eliminating the cause of the disease, is allergen-specific immunotherapy (AIT). To reduce the risk of side effects and improve the delivery of allergens to the mucosa, various delivery systems, such as liposomes, dendrimers, nanoparticles, etc., can be used. To date, there are data on the creation of delivery systems based on glycyrrhizic acid (GA) and its derivatives, but such a delivery system has not been used for allergen-specific therapy until now. At the same time, it is known that GA has an anti-inflammatory effect, shifts the balance towards Th1, and increases the number of Treg cells, which means that in the future it can enhance the anti-allergic effect of AIT and reduce the risk of unwanted side effects. Thus, the study of the immunomodulatory effect of supramolecular complexes (micelles) of GA with extracts of allergens seems to be very promising for the development of new drugs for AIT.

Keywords

drug delivery; allergen; glycyrrhizic acid; allergen-specific immunotherapy

Subject

MEDICINE & PHARMACOLOGY, Allergology

Comments (0)

We encourage comments and feedback from a broad range of readers. See criteria for comments and our diversity statement.

Leave a public comment
Send a private comment to the author(s)
Views 0
Downloads 0
Comments 0
Metrics 0


×
Alerts
Notify me about updates to this article or when a peer-reviewed version is published.
We use cookies on our website to ensure you get the best experience.
Read more about our cookies here.