Preprint Article Version 1 Preserved in Portico This version is not peer-reviewed

Preparation and Characterization of a Glycyrrhizic Acid-Based Drug Delivery System for Allergen-Specific Immunotherapy

Ekaterina Pashkina
* ORCID logo ,
Veronika Evseenko
,
Natalya Dumchenko
,
Maxim Zelikman
,
Alina Aktanova
,
Maria Bykova
,
Mikhail Khvostov
,
Aleksandr Dushkin
,
Vladimir Kozlov
Version 1 : Received: 9 December 2021 / Approved: 10 December 2021 / Online: 10 December 2021 (08:50:57 CET)

A peer-reviewed article of this Preprint also exists.

Pashkina, E.; Evseenko, V.; Dumchenko, N.; Zelikman, M.; Aktanova, A.; Bykova, M.; Khvostov, M.; Dushkin, A.; Kozlov, V. Preparation and Characterization of a Glycyrrhizic Acid-Based Drug Delivery System for Allergen-Specific Immunotherapy. Nanomaterials 2022, 12, 148. Pashkina, E.; Evseenko, V.; Dumchenko, N.; Zelikman, M.; Aktanova, A.; Bykova, M.; Khvostov, M.; Dushkin, A.; Kozlov, V. Preparation and Characterization of a Glycyrrhizic Acid-Based Drug Delivery System for Allergen-Specific Immunotherapy. Nanomaterials 2022, 12, 148.

Abstract

The most effective method of treating allergic diseases, aimed not at relieving symptoms, but at eliminating the cause of the disease, is allergen-specific immunotherapy (AIT). To reduce the risk of side effects and improve the delivery of allergens to the mucosa, various delivery systems, such as liposomes, dendrimers, nanoparticles, etc., can be used. To date, there are data on the creation of delivery systems based on glycyrrhizic acid (GA) and its derivatives, but such a delivery system has not been used for allergen-specific therapy until now. At the same time, it is known that GA has an anti-inflammatory effect, shifts the balance towards Th1, and increases the number of Treg cells, which means that in the future it can enhance the anti-allergic effect of AIT and reduce the risk of unwanted side effects. Thus, the study of the immunomodulatory effect of supramolecular complexes (micelles) of GA with extracts of allergens seems to be very promising for the development of new drugs for AIT.

Keywords

drug delivery; allergen; glycyrrhizic acid; allergen-specific immunotherapy

Subject

Medicine and Pharmacology, Immunology and Allergy

Copyright: This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

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