Preprint Article Version 1 Preserved in Portico This version is not peer-reviewed

Clinical Significance of Velamentous Cord Insertion Prenatally Diagnosed in Twin Pregnancy

Version 1 : Received: 18 December 2020 / Approved: 21 December 2020 / Online: 21 December 2020 (10:14:02 CET)

How to cite: Lee, H.; Lee, S.; Park, M.; Han, Y.J.; Kim, M.Y.; Boo, H.Y.; Chung, J.H. Clinical Significance of Velamentous Cord Insertion Prenatally Diagnosed in Twin Pregnancy. Preprints 2020, 2020120489 (doi: 10.20944/preprints202012.0489.v1). Lee, H.; Lee, S.; Park, M.; Han, Y.J.; Kim, M.Y.; Boo, H.Y.; Chung, J.H. Clinical Significance of Velamentous Cord Insertion Prenatally Diagnosed in Twin Pregnancy. Preprints 2020, 2020120489 (doi: 10.20944/preprints202012.0489.v1).

Abstract

Background The purpose of this study was to evaluate the prevalence of velamentous cord insertion (VCI) and the actual association between pathologically confirmed VCI and perinatal outcomes in twins based on the chorionicity. Methods All twin pregnancies who received prenatal care at a specialty clinic for multiple pregnancies, from less than 12weeks of gestation until delivery in a single institution between 2015 and 2018 were included in this retrospective cohort study. Results A total of the 941 twins were included in the study. The prevalence of VCI in dichorionic (DC) twins and monochorionic diamniotic (MCDA) twins was 5.8% and 7.8%, respectively (p=0.251). In all study population, the prevalence of vasa previa and placenta accreta were higher in VCI group compared to that of non-VCI group (p=0.008 and 0.022). In MCDA twins with VCI, birth weight, 1 and 5-minute Apgar score were lower compared to DC twins with VCI (p=0.010, 0.002 and 0.000). There was no significant association between VCI and selective fetal growth restriction (p=0.708), twin-to-twin transfusion syndrome (p=0.400) and birth-weight discordance (>20% and >25%) (p= 0.378 and 0.161) in MCDA twins. Conclusion VCI in twins was not a risk factor for adverse perinatal outcomes and twin-specific complications.

Subject Areas

Velamentous cord insertion; Twin; Perinatal outcomes; Pregnancy outcomes; Chorionicity; Twin specific complications

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