Preprint Article Version 1 Preserved in Portico This version is not peer-reviewed

Incidence and Risk Factors for Cerebrovascular-Specific Mortality in Patients with Colorectal Cancer: A Registry-Based Cohort Study Involving 563298 Patients

Version 1 : Received: 10 November 2021 / Approved: 12 November 2021 / Online: 12 November 2021 (16:47:45 CET)

How to cite: Huang, W.; Tang, M.; Chen, Y.; Zhang, T.; Hong, T.; Li, J.; Lv, G.; Yan, Y.; Ouyang, Z.; Zou, M. Incidence and Risk Factors for Cerebrovascular-Specific Mortality in Patients with Colorectal Cancer: A Registry-Based Cohort Study Involving 563298 Patients. Preprints 2021, 2021110237 (doi: 10.20944/preprints202111.0237.v1). Huang, W.; Tang, M.; Chen, Y.; Zhang, T.; Hong, T.; Li, J.; Lv, G.; Yan, Y.; Ouyang, Z.; Zou, M. Incidence and Risk Factors for Cerebrovascular-Specific Mortality in Patients with Colorectal Cancer: A Registry-Based Cohort Study Involving 563298 Patients. Preprints 2021, 2021110237 (doi: 10.20944/preprints202111.0237.v1).

Abstract

Background: Colorectal cancer (CRC) is one of the most prevalent diseases and the second leading cause of death worldwide. However, the relationship between CRC and cerebrovascular-specific mortality (CVSM) remains elusive and less is known about the influencing factors associated with CVSM in CRC. Here, we aimed to analyze the incidence as well as the risk factors of CVSM in CRC. Methods: Patients with a primary CRC diagnosed between 1973 and 2015 were identified from Surveillance Epidemiology and End Results database with follow-up data available until 31 December 2016. Conditional standardized mortality ratios were calculated to compare the incidence of CVSM between CRC patients and the general US population. Univariate and multivariate survival analyses with a competing risk model were used to interrogate the risk factors for CVSM. Results: A total of 563298 CRC individuals were included. The CVSM in CRC patients was significantly higher than the general population in all age subgroups. Among competing causes of death in patients, the cumulative mortality caused by cerebrovascular-specific diseases steadily increased during study period. While age and surgery positively influenced CVSM on both univariate and multivariate analyses, male patients and those who had radiotherapy, chemotherapy, more recent year (2001-2015) of diagnosis as well as multiple primary or distant tumors experienced a lower risk of CVSM. Interpretation: Our data suggest a potential role for CRC in the incidence of CVSM and also identify several significant predictors of CVSM, which may be helpful for risk stratification and therapeutic optimization of cerebrovascular-specific diseases in CRC patients.

Keywords

Colorectal cancer; Cerebrovascular-specific mortality; Cerebrovascular-specific diseases; Incidence; Risk factors

Subject

MEDICINE & PHARMACOLOGY, Oncology & Oncogenics

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