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Preprint REVIEW | doi:10.20944/preprints202306.2206.v1

New Non‐Invasive Technologies in Cardiac Transplant Follow‐Up: Acquired Evidence and Future Options

Valeria Pergola, Giulia Mattesi, Elena Cozza, Nicola Pradegan, Chiara Tessari, Carlo maria Dellino, Maria Teresa Savo, Filippo Amato, ANNAGRAZIA CECERE, Martina Perazzolo Marra, Francesco Tona, Andrea Igoren Guaricci, Giorgio De Conti, Gino Gerosa, Sabino Iliceto, Raffaella Motta

Subject: Medicine And Pharmacology, Cardiac And Cardiovascular Systems Keywords: heart transplantation; cardiac allograft vasculopathy; plaque analysis; atrial function; strain echocardiography; stress echocardiography; cardiac computed tomography angiography; fraction flow reserve

Online: 30 June 2023 (10:07:10 CEST)

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Preprint ARTICLE | doi:10.20944/preprints202308.1985.v1

Analysis of P(v-a)CO2/C(a-v)O2 Ratio and Other Perfusion Markers in a Population of 98 Pediatric Patients Undergoing Cardiac Surgery

Matteo Taiana, Irene Tomasella, Alessandro Russo, Annalisa Lerose, Marcello ceola Graziadei, Luisa Corubolo, Jacopo Rama, Vittorio Schweiger, A Vignola, Enrico Polati, Giovanni Battista Luciani, Francesco Onorati, Katia Donadello, Leonardo Gottin

Subject: Medicine And Pharmacology, Cardiac And Cardiovascular Systems Keywords: Venoarterial carbon dioxide difference; congenital heart disease; cardiopulmonary bypass; post-operative care; physiologic monitoring, infant

Online: 29 August 2023 (14:20:31 CEST)

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BACKGROUNDː The so-called Low Cardiac Output Syndrome (LCOS) is one of the most common complications in pediatric patients with congenital heart disease undergoing corrective surgery. LCOS requires high concentrations of inotropes to support cardiac contractility and improve cardiac output, allowing for a better systemic perfusion. To date, serum lactate concentrations and central venous oxygen saturation (ScVO2) are the most commonly used perfusion markers, but they are not completely reliable to identify a state of global tissue hypoxia. The study aims to evaluate whether the venoarterial carbon dioxide difference/arterial-venous oxygen difference ratio [P(v-a)CO2/C(a-v)O2] can be a good index to predict the development of LCOS in the aforemen-tioned patients, so as to treat it promptly. METHODSː This study followed a population of 98 children undergoing corrective cardiac surgery from June 2018 to October 2020 at the Department of Cardiac Surgery of University Hospital Inte-grated Trust and their subsequent admission at the Postoperative Cardiothoracic Surgery Intensive Care Unit. During the study, central arterial and venous blood gas analysis were carried out before and after cardiopulmonary bypass (CPB) (pre-CPB and post-CPB), at admission to intensive care unit, before and after extubation and at any time of instability or modification of the patient’s clinical and therapeutic conditions. RESULTSː The data analysis shows that 46.9% of the children developed a LCOS (in line with the current literature) but that there is no statistically significant association between the P(v-a)CO2/C(a-v)O2 ratio and LCOS onset. Despite the limits of statistical significance, however, a 31% increase in the ratio emerged from the pre-CPB phase to the post-CPB phase when LCOS is present. CONCLUSIONSː This study confirms a statistically significant association between the most used markers in adult patients (serum lactate concentration, ScVO2 and oxygen extraction ratio-ERO2) measured in the pre-CPB phase and the incidence of LCOS onset, especially in patients with he-modynamic instability before surgery.

Preprint ARTICLE | doi:10.20944/preprints202304.1076.v1

Motion Artifacts Reduction for Noninvasive Hemodynamic Monitoring of Conscious Patients using Electrical Impedance Tomography

Thi Hang Dang, Geukyung Jang, Kyonghun Lee, Tong In Oh

Subject: Medicine And Pharmacology, Cardiac And Cardiovascular Systems Keywords: Electrical Impedance Tomography; Motion Artifact Detection; Heart Rate; Cardiac Output; Hemodialysis; Source Consistency

Online: 27 April 2023 (10:54:52 CEST)

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Preprint REVIEW | doi:10.20944/preprints202402.1417.v1

Harnessing the Synergy of SGLT2 Inhibitors and Continuous Ketone Monitoring (CKM) in Managing Heart Failure Among Patients with Type 1 Diabetes

Nicola Tecce, Giorgio De Alteriis, Giulia de Alteriis, Ludovica Verde, Mario Felice Tecce, Annamaria Colao, Giovanna Muscogiuri

Subject: Medicine And Pharmacology, Endocrinology And Metabolism Keywords: heart failure; type 1 diabetes; diabetic cardiomyopathy; hospitalization; HFpEF; HFrEF; SGLT2-i; sodium-glucose cotransporter-2 inhibitors; diabetic ketoacidosis; epidemiologic studies; patient education; continuous monitoring of ketone levels; ketonemia

Online: 26 February 2024 (11:54:41 CET)

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Preprint ARTICLE | doi:10.20944/preprints202402.0619.v1

Embodimetrics: A Principal Component Analysis of the Combined Assessment of Cardiac, Cognitive and Mobility Parameters

Andrea Chellini, Katia Salmaso, Michele Di Domenico, Nicola Gerbi, Marco Donati, Marco Iosa

Subject: Biology And Life Sciences, Neuroscience And Neurology Keywords: embodiment; heart rate variability; stroop task; motor control

Online: 12 February 2024 (13:19:53 CET)

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Preprint ARTICLE | doi:10.20944/preprints202309.1743.v1

Aggravation of Health Problems Subsequent to COVID-19 Lockdown

Fatma Nese Efil, Sania Qureshi, Nezihal Gokbulut, Evren Hınçal, Amanullah Soomro

Subject: Computer Science And Mathematics, Mathematical And Computational Biology Keywords: Covid-19; mathematical modeling; cancer; diabetes; heart diseases; sensitivity analysis

Online: 26 September 2023 (10:40:39 CEST)

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Preprint REVIEW | doi:10.20944/preprints202401.0220.v1

The Role of Artificial Intelligence and Machine Learning in Prediction of Right Heart Failure After LVAD Implantation: Comprehensive Review

Ozlem Balcioglu, Cemre Ozgocmen, Dilber Uzun Ozsahin, Tahir Yagdi

Subject: Medicine And Pharmacology, Cardiac And Cardiovascular Systems Keywords: left ventricular assist device; right heart failure; right ventricle failure; artificial intelligence; machine learning

Online: 3 January 2024 (09:44:51 CET)

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Preprint REVIEW | doi:10.20944/preprints202306.2222.v1

Gut Microbiota Composition and Cardiovascular Disease: A Potential New Therapeutic Target?

Martina Belli, Lucy Barone, Susanna Longo, Francesca Romana Prandi, Dalgisio Lecis, Rocco Mollace, Davide Margonato, Saverio Muscoli, Domenico Sergi, Massimo Federici, Francesco Barillà

Subject: Medicine And Pharmacology, Cardiac And Cardiovascular Systems Keywords: Gut microbiota; Cardiovascular diseases; Trimethylamine N-Oxide; Heart failure; Atherosclerosis

Online: 30 June 2023 (11:58:11 CEST)

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Preprint ARTICLE | doi:10.20944/preprints202306.1254.v1

Parkinson's Disease and the Heart: Studying Cardiac Metabolism in the 6-Hydroxydopamine model

Victor Silva da Fonsêca, Valeria de Cassia Gonçalves, Mario Augusto Izidoro, Antônio-Carlos G. de Almeida, Fernando Luiz Affonso Fonseca, Fulvio Alexandre Scorza, Josef Finsterer, Carla Alessandra Scorza

Subject: Medicine And Pharmacology, Neuroscience And Neurology Keywords: Parkinson’s disease; cardiac metabolism; heart; 6-hydroxydopamine; metabolites

Online: 16 June 2023 (14:16:00 CEST)

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Preprint REVIEW | doi:10.20944/preprints202304.1087.v1

Renal Oxygen Demand and Nephron Function: Is Glucose a Friend or Foe?

Edoardo Gronda, Massimo Iacoviello, Alberto Palazzuoli, Manuela Benevenuto, Domenico Gabrielli, Arduino Arduini

Subject: Medicine And Pharmacology, Endocrinology And Metabolism Keywords: glucose transport; SGLT2 inhibitor; diabetic nephropathy; heart failure; chronic kidney disease

Online: 28 April 2023 (03:08:47 CEST)

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Preprint ARTICLE | doi:10.20944/preprints202402.1313.v1

Hearables: In-ear Multimodal Data Fusion for Robust Heart Rate Estimation

Marek Zylinski, Amir Nassibi, Edoardo Occhipinti, Adil Malik, Matteo Bermond, Harry J. Davies, Danilo P. Mandic

Subject: Engineering, Bioengineering Keywords: Data fusion method; Heart rate tracing; Hearables; Wearables

Online: 22 February 2024 (12:21:03 CET)

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Preprint REVIEW | doi:10.20944/preprints202401.1118.v1

Lessons from the Thioredoxin-1 Knockout Mouse Models

Tetiana Shcholok, Eftekhar Eftekharpour

Subject: Biology And Life Sciences, Cell And Developmental Biology Keywords: Redox balance, thiol antioxidants, transgenic models, brain, heart, glutaredoxin, thioredoxin reductase

Online: 15 January 2024 (10:39:50 CET)

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Preprint ARTICLE | doi:10.20944/preprints202305.0784.v1

Clinical, Genetic, and Epidemiological Characteristics of Ar-Rhythmogenic Cardiomyopathy Associated With the Pathogenic Founder Variant NP_00454563.2 (p.Glu259Glyfs*77) in Gene PKP2

Ainhoa Robles-Mezcua, Amalio Ruiz-Salas, Carmen Medina-Palomo, María Robles-Mezcua, Arancha Díaz-Expósito, María Victoria Ortega-Jiménez, Juan Ramón Gimeno-Blanes, Manuel Jiménez-Navarro, José Manuel García-Pinilla

Subject: Medicine And Pharmacology, Cardiac And Cardiovascular Systems Keywords: Arrhythmogenic Cardiomyopathy; PKP2; Founder pathogenic variant; Arrhythmic events; Heart Failure

Online: 11 May 2023 (04:38:37 CEST)

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Introduction and objectives: arrhythmogenic cardiomyopathy (ACM) is a hereditary heart disease defined by the progressive replacement of the ventricular myocardium with fibroadipose tissue, which can act as a substrate for arrhythmias, sudden death, or even give rise to heart failure (HF). Sudden death is frequently the first manifestation of the disease, particularly among young patients. The aim of this study is to describe a new pathogenic variant in the PKP2 gene. Methods: A descriptive observational study that included 8 initially non-interrelated families with a diagnosis of ACM undergoing follow-up at our HF and Familial Cardiomyopathies Unit, who were carriers of the NM_004572.3:c.775_776insG; p. (Glu259Glyfs*77) variant in PKP2 gene. The genetic testing employed next-generation sequencing for the index cases, and the Sanger method for the targeted study with family members. We compiled personal and family histories, demographic and clinical characteristics, data from the additional tests at the time of diagnosis, and arrhythmic events at diagnosis and during follow-up. Results: We included 47 subjects, of whom 8 were index cases (17%). Among the evaluated family members, 16 (34%) were carriers of the genetic variant, 3 of whom also had a diagnosis of ACM. The majority were women (26 patients; 55.3%), with a mean age on diagnosis of 48.9 ± 18.6 years, and a median follow-up of 39 [24-59] months. Worthy of note are the high incidence of arrhythmic events as the form of presentation and in follow-up (21.5% and 20.9% respectively), and the onset of HF in 25% of the sample. The most frequent ventricular involvements were right (4 patients 16.7%) and biventricular (4 patients 16.7%); we found no statistical differences in any of the variables analysed. Conclusions: This variant is a pathogenic variant of gene PKP2 that has not previously been described and is not present in the control groups associated with ACM. It has incomplete penetrance, a highly variable phenotypic expressivity, and was identified in 8 families of our geographical area in Malaga (Andalusia, Spain), where we can establish a founder effect and describe the clinical and risk characteristics.

Preprint ARTICLE | doi:10.20944/preprints202306.2226.v1

Red Blood Cells and Endothelium Derived Circulating Extracellular Vesicles in Health and Chronic Heart Failure: A Focus on Phosphatidylserine Dynamics in Vesiculation

Rosa Suades, Alba Vilella-Figuerola, Teresa Padró, Sonia Mirabet, Lina Badimon

Subject: Medicine And Pharmacology, Cardiac And Cardiovascular Systems Keywords: annexin V; connexin 43; endothelial cells; extracellular vesicles; heart failure; leukocytes; microvesicles; phosphatidylserine; platelets; red blood cells

Online: 30 June 2023 (10:49:27 CEST)

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Preprint ARTICLE | doi:10.20944/preprints202308.0895.v1

Ubiquitin Proteasome System Role in Diabetes-Induced Cardiomyopathy

Ortal Nahum-Ankonina, Efrat Kurtzwald-Josefson, Aaron Ciechanover, Maayan Waldman, Orna Schwartz Rohaker, Edith Hochhauser, Sam j Meyer, Dan Aravot, Moshe Philip, Yaron D. Barac

Subject: Biology And Life Sciences, Cell And Developmental Biology Keywords: UPS; T2DM; Heart

Online: 11 August 2023 (08:07:50 CEST)

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Preprint ARTICLE | doi:10.20944/preprints202308.2138.v1

Cardiac Autonomic Function and Functional Capacity in Post-COVID-19 Individuals with Systemic Arterial Hypertension

Edelvita Fernanda Duarte Cunha, Matheus Sobral Silveira, Juliana Cristina Milan-Mattos, Heitor Fernandes Silveira Cavalini, Ádrya Aryelle Ferreira, Joice de Souza Batista, Lara Cazé Uzumak, João Paulo Coelho Guimarães, Pedro Igor Lustosa Roriz, Fabianne Maisa de Novaes Assis Dantas, Arto J. Hautala, Raphael Martins De Abreu, Aparecida Maria Catai, Paulo Adriano Schwingel, Victor Ribeiro Neves

Subject: Public Health And Healthcare, Physical Therapy, Sports Therapy And Rehabilitation Keywords: hypertension; SARS-CoV-2; post-COVID conditions; physical functional performance; autonomic nervous system diseases; heart rate control.

Online: 31 August 2023 (09:55:39 CEST)

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Preprint ARTICLE | doi:10.20944/preprints202403.0386.v1

Advanced Detection of Cardiac Beat Intervals in Functional Near-Infrared Spectroscopy(fNIRS) through Signal Integration Reconstruction

Kyoung soo Kim, Taehoon Kim, Jihyun Cha

Subject: Computer Science And Mathematics, Signal Processing Keywords: Heartbeat; fNIRS; RR-interval; heart rate; HRV; Cardiac beat interval; algorithm

Online: 8 March 2024 (01:52:57 CET)

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Preprint ARTICLE | doi:10.20944/preprints202312.1675.v1

Personality Traits, Machiavellianism Intelligence, Irrational Beliefs among Chronically Ill Older People and COVID-19 Outbreak

Kanwal Shahbaz, David Lim, Ayesha Shahbaz

Subject: Public Health And Healthcare, Health Policy And Services Keywords: personality characteristics; Machiavellian intelligence; irrational belief; chronically ill older people; systemic lu-pus erythematosus; complicated diabetes; glomerulonephritis and chronic heart failure; Covid-19

Online: 21 December 2023 (15:29:52 CET)

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Preprint ARTICLE | doi:10.20944/preprints202402.1757.v1

Use of a Simple Stair-Climbing Test to Assess Cardiopulmonary Fitness in Clinical Practice. An Overview of the Published Liter-Ature Aiming for a Future Goal

Johanna Wander, Maurice Pablo Mall, Anne Lentz, Meike Schrader, Nikolaus Alexander Haas, Simone Katrin Dold

Subject: Medicine And Pharmacology, Cardiac And Cardiovascular Systems Keywords: Stair Climbing Test; Cardiorespiratory Fitness; Exercise Test, Children; Congenital Heart Disease

Online: 29 February 2024 (14:34:53 CET)

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Preprint REVIEW | doi:10.20944/preprints202403.1067.v1

Effects of Stress and Anxiety on Pregnant Women's Cardiovascular Health: A Narrative Review

Brenda-Cristiana Bernad, Mirela-Cleopatra Tomescu, Lavinia Hogea, Dana Emilia Velimirovici, Minodora Andor, Diana Lungeanu, Virgil Enătescu, Adina-Ioana Bucur, Ana Lascu, Rata Andreea Luciana, Elena Silvia Bernad, Vlad Nicoraș, Diana-Aurora Arnautu

Subject: Medicine And Pharmacology, Obstetrics And Gynaecology Keywords: pregnancy; fetus; stress; anxiety; cardiovascular diseases; heart disease risk factors; psychological; mental health

Online: 19 March 2024 (05:10:48 CET)

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Preprint ARTICLE | doi:10.20944/preprints202306.0310.v1

Aerobic Exercise Training Improves Calcium Handling and Cardiac Function in Rats with Heart Failure Resulting from Aortic Stenosis

Vitor Loureiro Da Silva, Gustavo Augusto Ferreira Mota, Sérgio Luiz Borges De Souza, Dijon Henrique Salomé De Campos, Alexandre Barroso Melo, Danielle Fernandes Vileigas, Priscila Murucci Coelho, Paula Grippa Sant’Ana, Carlos Padovani, Ana Paula Lima-Leopoldo, Silméia Garcia Zanati Bazan, Andre Soares Leopoldo, Antonio Carlos Cicogna

Subject: Biology And Life Sciences, Life Sciences Keywords: exercise training; aortic stenosis; heart failure; isolated papillary muscle; isolated cardiomyocyte; calcium handling.

Online: 5 June 2023 (10:47:28 CEST)

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Aerobic exercise training (AET) has been used in the management of heart disease. AET may, totally or partially, restore the activity and/or expression of proteins that regulate calcium (Ca2+) handling, optimize intracellular Ca2+ flow, and attenuate cardiac functional impairment in failing hearts. However, the literature presents conflicting data regarding the effects of AET on Ca2+ transit and cardiac function in rats with heart failure resulting from aortic stenosis. The objective of this study was to evaluate the effects of AET on calcium handling and cardiac function in rats with heart failure due to aortic stenosis. Wistar rats were distributed into two groups: control (Sham; n= 61) and aortic stenosis (AoS; n= 44). After 18 weeks, the groups were redistributed into: non-exposed to exercise training (Sham, n = 28 and AoS, n = 22) and trained (Sham-ET, n = 33 and AoS-ET, n = 22) for 10 weeks. Treadmill exercise training was performed with a velocity equivalent to the lactate threshold. Echocardiogram, isolated papillary muscle, and isolated cardiomyocyte analyzed cardiac function. During isolated papillary muscle assay and isolated cardimyocyte was evaluated Ca2+. The expression of regulatory proteins of diastolic Ca2+ was analyzed via Western Blot. AET attenuated the diastolic dysfunction and benefited the systolic function. AoS-ET animals presented better response to post-rest contraction, and SERCA2a and L-type Ca2+ channels blocked than the AoS. Furthermore, AET was able to improve aspects of the mechanical function and the responsiveness of the myofilaments to the Ca2+ of the AoS-ET animals. AoS animals presented alteration in the protein expression of the SERCA2a and NCX, and AET restored SERCA2a and NCX levels near normal values. Therefore, AET increased SERCA2a activity, improved the cellular Ca2+ influx mechanism, and increased myofilament responsiveness to Ca2+, attenuating cardiac dysfunction at cellular, tissue, and chamber levels in animals with aortic stenosis and heart failure.

Preprint ARTICLE | doi:10.20944/preprints202305.0713.v1

ECG Recordings as Predictors of Very Early Autism Likelihood: A Machine Learning Approach

Deepa Tilwani, Jessica Bradshaw, Amit P. Sheth, Christian O'Reilly

Subject: Computer Science And Mathematics, Artificial Intelligence And Machine Learning Keywords: Autism Spectrum Disorder, Biomarker, Electrocardiograms, Machine Learning, Heart rate variability.

Online: 10 May 2023 (08:42:42 CEST)

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Preprint ARTICLE | doi:10.20944/preprints202402.1504.v1

The Development and Testing of the Hippocratic Heart Failure Self-care Scale

Hero Brokalaki, ANASTASIA A CHATZIEFSTRATIOU, Nikolaos V. Fotos, Athina Patelarou, Konstantinos Giakoumidakis

Subject: Public Health And Healthcare, Primary Health Care Keywords: self-care; self-management; heart failure; validation; scale development

Online: 27 February 2024 (12:39:05 CET)

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Preprint REVIEW | doi:10.20944/preprints202311.1143.v1

Coronary Microvascular Dysfunction and Hypertension: A Bond More Important Than We Think

Marija Zdravkovic, Viseslav Popadic, Slobodan Klasnja, Andrea Klasnja, Tatjana Ivankovic, Ratko Lasica, Dragan Lovic, Drasko Gostiljac, Zorana Vasiljevic

Subject: Medicine And Pharmacology, Cardiac And Cardiovascular Systems Keywords: coronary microvascular dysfunction; hypertension; hypertensive heart disease; myocardial fibrosis; heart failure

Online: 17 November 2023 (15:28:27 CET)

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Preprint ARTICLE | doi:10.20944/preprints202307.0603.v1

Pharmacological Screening of Kv7.1 and Kv7.1/KCNE1 Activators as Potential Antiarrhythmic Drugs in Zebrafish Heart

Alicia De la Cruz, Xiaoan Wu, Quinn Carroll Rainer, Irene Hiniesto-Iñigo, Marta Elena Perez, Isak Edler, Sara Inga Liin, Hans Peter Larsson

Subject: Biology And Life Sciences, Biophysics Keywords: IKs; Long QT Syndrome; polyunsaturated fatty acids; zebrafish heart; ML-277

Online: 10 July 2023 (10:15:56 CEST)

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Preprint ARTICLE | doi:10.20944/preprints202312.1152.v1

A Technical Comparative Heart Disease Prediction Framework Using Boosting Ensemble Techniques

Najmu Nissa, Sanjay Jamwal, Mehdi Neshat

Subject: Computer Science And Mathematics, Artificial Intelligence And Machine Learning Keywords: Heart Disease; Diagnosis, Machine Learning; Boosting; Ensemble learning; Comparative framework

Online: 18 December 2023 (02:45:49 CET)

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Preprint REVIEW | doi:10.20944/preprints202307.0090.v1

Sacubitril-Valsartan and Its Results for the Treatment of Heart Failure with Preserved and Mildly Reduced Ejection Fraction

Luiz Claudio Danzmann, Francisco Forestiero, Raphael Fernandes Catucci, Nivia Tosetto

Subject: Public Health And Healthcare, Public Health And Health Services Keywords: Sacubitril-valsartan; heart failure; ejection fraction and cardiovascular disease

Online: 3 July 2023 (13:25:11 CEST)

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Preprint ARTICLE | doi:10.20944/preprints202312.0273.v1

Optimized Cuffless Blood Pressure Measurement Using ECG, PPG and Linear Regression

Francesca Boschi, Valeria Figini, Guido Pagana, Monica Visintin

Subject: Engineering, Bioengineering Keywords: ECG; PPG; Pulse transit Time; Heart rate; Blood pressure; Denoising; Regression analysis

Online: 5 December 2023 (14:23:23 CET)

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Preprint ARTICLE | doi:10.20944/preprints202305.2160.v1

Wavelet Analysis of Respiratory Muscle sEMG Signals During the Physiological Breakpoint of Static Dry End-Expiratory Breath-Holding in Naive Apneists: A Pilot Study

Nataša Ž. Mišić, Mirko Ostojić, Saša Cvetković, Petar Miodragović, Zdravko Aničić, Anita Popović, Đorđe Stefanović

Subject: Engineering, Electrical And Electronic Engineering Keywords: breath-holding; hypoxia; hypercapnia; involuntary breathing movement; muscle fiber subtypes; heart rate variability; wavelet analysis; multiresolution analysis

Online: 31 May 2023 (02:41:15 CEST)

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Preprint REVIEW | doi:10.20944/preprints202403.0867.v1

Missed or Delayed Diagnosis of Heart Disease by the General Pediatrician

Ageliki A Karatza, Sotirios Fouzas, Despoina Gkentzi, Eirini Kostopoulou, Nikoleta Oikonomou, Gabriel Dimitriou, Xenophon Sinopidis

Subject: Medicine And Pharmacology, Pediatrics, Perinatology And Child Health Keywords: congenital heart disease; acquired heart disease; children; diagnostic errors; missed diagnosis; delayed diagnosis; primary care pediatrician

Online: 17 March 2024 (16:01:57 CET)

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Preprint REVIEW | doi:10.20944/preprints202307.1818.v3

Is modern medicine in need of an overhydration marker in kidney failure? The accuracy of available fluid overload markers and the potential of the new ones.

Barbara Emilia Nikitiuk, Alicja Rydzewska-Rosołowska, Katarzyna Kakareko, Irena Głowińska, Tomasz Hryszko

Subject: Medicine And Pharmacology, Internal Medicine Keywords: fluid status; overhydration; hydration status; renal failure; kidney failure; heart failure; Ca-125; NT-pro-BNP; VEXUS; BIS

Online: 5 October 2023 (14:28:42 CEST)

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Preprint ARTICLE | doi:10.20944/preprints202212.0376.v2

A Fresh View at Sports PSM-Systems

Vladimir Savostyanov, Alexander Kobelev

Subject: Biology And Life Sciences, Anatomy And Physiology Keywords: Sport; Heart Rate; Breathe Rate; Monitoring; Functional Athlete Readiness; Impedance; Rheography

Online: 6 January 2023 (02:04:00 CET)

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Preprint ARTICLE | doi:10.20944/preprints202306.0014.v1

Empagliflozin Reduces Interleukin-6 Levels in Patients With Heart Failure

Michael Gotzmann, Pauline Henk, Ulrik Stervbo, Arturo Blázquez-Navarro, Andreas Mügge, Nina Babel, Timm H. Westhoff

Subject: Medicine And Pharmacology, Cardiac And Cardiovascular Systems Keywords: SGLT2 inhibition; empagliflozin; heart failure; interleukin 6

Online: 1 June 2023 (03:33:38 CEST)

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Preprint ARTICLE | doi:10.20944/preprints202307.1058.v1

SGLT2 Inhibitors Introduction and Changes of the Other Disease Modifiers’ Drugs in Heart Failure Patients: A Single Center Real World Experience

Erika Tabella, Michele Correale, Gianmarco Alcidi, Rosanna Pugliese, Sara Ioannoni, Matteo Romano, Gianpaolo Palmieri, Matteo Di Biase, Natale Daniele Brunetti, Massimo Iacoviello

Subject: Medicine And Pharmacology, Cardiac And Cardiovascular Systems Keywords: Heart Failure; Therapy; type-2 sodium-glucose cotransporters inhibitors; angiotensin receptor neprylisin inhibitors

Online: 17 July 2023 (15:07:48 CEST)

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Preprint REVIEW | doi:10.20944/preprints202307.1285.v1

Extracellular Vesicle microRNAs in Heart Failure: Pathophysiological Mediators and Therapeutic Targets

Changhai Tian, Jessica N. Ziegler, Irving Zucker

Subject: Biology And Life Sciences, Life Sciences Keywords: Extracellular vesicles; MicroRNAs; Sorting mechanism; Biomarkers; Heart failure

Online: 20 July 2023 (02:49:03 CEST)

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Preprint ARTICLE | doi:10.20944/preprints202307.0408.v1

An Intelligent Physiological Control Method Using Sliding Mode Neural Network for Left Ventricular Assist Device

Mohsen Bakouri

Subject: Engineering, Bioengineering Keywords: pole placement; sliding mode control; left ventricular assist devices; cardiovascular system; heart failure

Online: 6 July 2023 (10:15:31 CEST)

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Preprint ARTICLE | doi:10.20944/preprints202306.0800.v1

The Role of Right Ventriculo-Arterial Coupling in Symptoms Presentation of Patients With Hypertrophic Cardiomyopathy

Andreas Angelopoulos, Evangelos Oikonomou, Alexios S. Antonopoulos, Panagiotis Theofilis, Konstantinos Kalogeras, Paraskevi Papanikolaou, George Lazaros, Gerasimos Siasos, Dimitris Tousoulis, Konstantinos Tsioufis, Charalambos Vlachopoulos

Subject: Medicine And Pharmacology, Cardiac And Cardiovascular Systems Keywords: hypertrophic cardiomyopathy; cardiomyopathies; heart failure

Online: 12 June 2023 (08:41:43 CEST)

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Preprint ARTICLE | doi:10.20944/preprints202308.1669.v1

Anticoagulation Status and Left Atrial Appendage Occlusion Indications in Hospitalized Cardiology Patients with Atrial Fibrillation: A Hellenic Cardiorenal Morbidity Snapshot (HECMOS) Sub-Study

Dimitris Tsiachris, Panteleimon E. Papakonstantinou, Ioannis Doundoulakis, Panagiotis Tsioufis, Michail Botis, Kyriakos Dimitriadis, Ioannis Leontsinis, Athanasios Kordalis, Christos-Konstantinos Antoniou, Emmanouil Mantzouranis, Panagiotis Iliakis, Panayotis Vlachakis, Konstantinos A Gatzoulis, Konstantinos Tsioufis

Subject: Medicine And Pharmacology, Cardiac And Cardiovascular Systems Keywords: atrial fibrillation; heart failure; rhythm strategy; catheter ablation; snapshot

Online: 25 August 2023 (02:48:47 CEST)

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Background and Objectives: Proper use of oral anticoagulants is crucial in the management of non-valvular atrial fibrillation (AF) patients. Left atrial appendage closure (LAAC) may be considered for stroke prevention in patients with AF and contraindications for long-term anticoagulant treatment. We aimed to assess the anticoagulation status and LAAC indications in patients with AF from HECMOS (Hellenic Cardiorenal Morbidity Snapshot) survey. Materials and Methods: HECMOS was a nationwide snapshot survey of cardiorenal morbidity in hospitalized cardiology patients. HECMOS used an electronic platform to collect demographic and clinically relevant information from all patients hospitalized on March 3, 2022, in 55 different cardiology departments. In this substudy, we included patients with known AF without mechanical prosthetic valves and moderate to severe mitral valve stenosis. Patients with prior stroke, previous major bleeding, poor adherence to anticoagulants, and end-stage renal disease were considered candidates for LAAC. Results: Two hundred fifty-six patients (mean age 76.6±11.7, 148 males) were included in our analysis. Most of them (n=159; 62%) suffered from persistent AF. Mean CHA2DS2-VASc score was 4.28±1.7, while mean HAS-BLED score was 1.47±0.9. Three out of 3 patients with a CHA2DS2-VASc 0 or 1 (female) received improperly anticoagulants. Sixteen out of 18 patients with a CHA2DS2-VASc 1 or 2 (female) received anticoagulants. Thirty-three out of 235 patients with a CHA2DS2-VASc > 1 or 2 (for female) did not receive improperly anticoagulants. Among 221 under anticoagulant therapy, 191 (86.4%) received non-vitamin K antagonist oral anticoagulants (NOACs) and 30 (13.6%) received vitamin K antagonists. Relative indications for LAAC were present in 64 patients with NVAF (60 had only one risk factor and 2 had two concurrent risk factors). In detail, 36 had a prior stroke, 17 patients had a history of major bleeding, 15 patients reported poor or no adherence to the anticoagulant therapy and 5 had eGFR< 15 ml/min/1.73m2. Moreover, 33 had a HAS-BLED score ≥3. No LAAC treatment was recorded. Conclusions: Anticoagulation status was nearly optimal in a high thromboembolic risk population of cardiology patients, mainly treated with NOACs. One out of four AF patients should be screened for LAAC.

Preprint CASE REPORT | doi:10.20944/preprints202402.1065.v1

Cardiac Arrest and Complete Heart Block: Complications after Electrical Cardioversion for Unstable Supraventricular Tachycardia in the Emergency Department

Adina Maria Marza, Claudiu Barsac, Dumitru Sutoi, Alexandru Cristian Cindrea, Alexandra Herlo, Cosmin Iosif Trebuian, Alina Petrica

Subject: Medicine And Pharmacology, Emergency Medicine Keywords: supraventricular tachycardia, cardioversion, unstable patient, complete heart block, ineffective pacing, cardiac arrest, advanced life support.

Online: 19 February 2024 (14:52:55 CET)

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Preprint CASE REPORT | doi:10.20944/preprints202307.0438.v1

Exercise-Induced Arrhythmia or Munchhausen Syndrome in a Marathon Runner?

Robert Gajda, Wojciech Drygas, Jacek Gajda, Pawel Kiper, Beat Knechtle, Magdalena Kwaśniewska, Maciej Sterliński, Elżbieta Katarzyna Biernacka

Subject: Medicine And Pharmacology, Cardiac And Cardiovascular Systems Keywords: heart rate monitor; endurance running; arrhythmia, tachycardia; artifacts; exertion rhythm disorders; Munchhausen syndrome; athlete's heart

Online: 7 July 2023 (07:41:51 CEST)

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Preprint ARTICLE | doi:10.20944/preprints202305.1056.v1

Impact on Accessibility to Care and Outcomes of a Clinician-to-Clinician Electronic Consultation Program in Heart Failure Patients with Previous Hospital Admissions: Implications for Heart Failure Care

David García-Vega, Pilar Mazon-Ramos, Manuel Portela-Romero, Moisés Rodríguez-Mañero, Daniel Rey-Aldana, Manuela Sestayo-Fernandez, Sergio Cinza-Sanjurjo, Jose Ramon González-Juanatey

Subject: Medicine And Pharmacology, Cardiac And Cardiovascular Systems Keywords: heart failure; hospitalization; cardiovascular outcomes; electronic consultation

Online: 15 May 2023 (15:30:16 CEST)

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(1) Objectives. Patients with heart failure (HF) who experience hospitalizations for worsening HF (HFH) are at high risk of subsequent events. We aimed to evaluate the impact of an outpatient care management program that includes a clinician-to-clinician e-consultation using an integrated electronic medical record in a healthcare area with a widely dispersed population on delay time in care, hospital admissions, and mortality in a high-risk group of patients with HF and previous episodes of HFH. (2) Methods. We selected 6,444 HF patients who visited the cardiology service at least once between 2010 and 2021. Of these, 4,851 were attended in e-consult, and 2,008 in one-time in-person consultations. In 2,230 HF patients, there was documentation of a previous episode of HFH. Using an interrupted time series regression model, we analysed the impact of incorporating e-consult into the health care model in the group of patients with HFH and evaluated the elapsed time to cardiology care, heart failure (HF), cardiovascular (CV), and all-cause hospital admissions and mortality, calculating the incidence relative risk (iRR). (3) Results. In the group of patients with previous HF hospitalizations, the introduction of e-consult substantially decreased waiting times to cardiology care. The time elapsed to care after e-consult implementation was significantly reduced compared with the previous in-person period (8.6 [8.7] vs 55.4 [79.9] days, p<0.001). In that group of patients, after e-consult implantation, hospital admissions for HF were reduced (iRR [CI95%]: 0,837 [0,840-0,833]), 0,900 [0,862-0,949] for CV and 0,699 [0,678-0,726] for all-cause hospitalizations. There was also lower mortality (iRR [CI95%]: 0.715 [0.657-0.798] due to HF, 0,737 [0.764-0.706] for CV and 0,687 [0.652-0,718] for all-cause). The improved outcomes after e-consultation implementation were significantly higher in the group of patients with previous HFH and were independent of the patient’s clinical characteristics managed during the in-person or e-consultation periods. (4) Conclusions. In HF patients with previous HFH, an outpatient care program that includes an e-consult significantly reduced waiting times to cardiology care and was safe, with a lower rate of hospital admissions and mortality in the first year.

Preprint ARTICLE | doi:10.20944/preprints202304.0797.v1

Nutritional Supplementation and Exercise – Essential Allies in the Treatment of Chronic Heart Failure: The Metabolic and Molecular Bases.

Evasio Pasini, Giovanni Corsetti, Francesco Saverio Dioguardi

Subject: Biology And Life Sciences, Life Sciences Keywords: Heart failure; Malnutrition; Exercise; Amino-acids; mTOR; Deptor

Online: 23 April 2023 (08:45:26 CEST)

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Preprint ARTICLE | doi:10.20944/preprints202402.1067.v1

Non‐Invasive Heart Failure Evaluation with Wearable Signals and Machine Learning Algorithms

Odeh Adeyi Victor, Yifan Chen, Wenyan Wang, Xiaorong Ding

Subject: Engineering, Bioengineering Keywords: Heart Failure, Photoplethysmogram, Echocardiogram, Machine Learning

Online: 19 February 2024 (12:55:23 CET)

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Preprint REVIEW | doi:10.20944/preprints202403.0531.v1

Challenges in Echocardiography for the Diagnosis and Prognosis of Non-ischemic Hypertensive Heart Disease

Nikolaos PE Kadoglou, Angeliki Mouzarou, Nikoleta Hadjigeorgiou, Ioannis Korakianitis, Michael Myrianthefs

Subject: Medicine And Pharmacology, Cardiac And Cardiovascular Systems Keywords: Hypertensive heart disease; echocardiography; prognosis; speckle tracking

Online: 8 March 2024 (16:49:26 CET)

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Preprint REVIEW | doi:10.20944/preprints202401.0731.v1

Multimodality Imaging in Right Heart Tumors: A Practical Algorithm towards an Appropriate Diagnosis

Mariana Floria, Alexandru Burlacu, Paula Cristina Morariu, Alexandru-Florinel Oancea, Diana Elena Iov, Genoveva Livia Baroi, Celina Silvia Stafie, Viorel Scripcariu, Daniela Maria Tanase

Subject: Medicine And Pharmacology, Cardiac And Cardiovascular Systems Keywords: right heart; tumor; multimodality; imaging; echocardiography; computer-tomography; cardiac magnetic resonance; positron emission tomography

Online: 10 January 2024 (04:23:37 CET)

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Preprint ARTICLE | doi:10.20944/preprints202310.0971.v1

Cardiac Abnormalities in a Predictive Mouse Model of Chagas Disease

Amanda Fortes Francisco, Giovane R. Sousa, Mhairi Vaughan, Harry Langston, Archie Khan, Shiromani Jayawardhana, Martin C. Taylor, Michael D. Lewis, John M. Kelly

Subject: Biology And Life Sciences, Parasitology Keywords: Trypanosoma cruzi; electrocardiography (ECG); Chronic Chagas Cardiomyopathy; Chagas heart disease

Online: 16 October 2023 (12:36:35 CEST)

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Preprint REVIEW | doi:10.20944/preprints202311.0836.v1

Congestion in Heart Failure: From the Secret of a Mummy to Today's Novel Diagnostic and Therapeutic Approaches. A Comprehensive Review

Ioannis Alevroudis, Serafeim-Chrysovalantis Kotoulas, Stergios Tzikas, Vassilios Vassilikos

Subject: Medicine And Pharmacology, Cardiac And Cardiovascular Systems Keywords: Acute Decompensated Heart failure; fluid overload; loop diuretics; diuretic resistance; mineralocorticoid; SGLT2 inhibitors; ultrafiltration; Carbonic Anhydrase Inhibitor

Online: 14 November 2023 (07:52:29 CET)

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Preprint ARTICLE | doi:10.20944/preprints202308.0088.v1

Kinetic, Physiological and Fatigue Level Differences Depending on the Menstrual Cycle Phase and Running Intensity

Carolina Domínguez-Muñoz, Juan Del Campo, Alberto García, José Guzmán, Rafael Martínez-Gallego, Jesús Ramón-Llin

Subject: Social Sciences, Tourism, Leisure, Sport And Hospitality Keywords: menstrual cycle; running; kinetic variables; lactate concentration; heart rate; level of fatigue

Online: 2 August 2023 (02:28:34 CEST)

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Preprint REVIEW | doi:10.20944/preprints202310.0293.v1

A Systematic Review of Individualized Heart Surgery with a Personalized Prosthesis

Faizus Sazzad, KR Ramanathan, Irwan Shah Moideen, Abdulrahman El Gohary, John C Stevens, Theo Kofidis

Subject: Medicine And Pharmacology, Cardiac And Cardiovascular Systems Keywords: personalized; individualized; open heart surgery; implantation; systematic review

Online: 5 October 2023 (13:45:08 CEST)

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Preprint ARTICLE | doi:10.20944/preprints202306.0179.v1

Analysis of the Heart Rate of Operators of Forwarding Machines during Timber Forwarding and the Dependence of Its Values on the Performed Work Activities

David Sláma, Václav Mergl, Eva Abramuszkinová Pavlíková

Subject: Engineering, Other Keywords: operator; forwarder; tractor with a timber trailer; ergonomics; heart rate; physical load

Online: 2 June 2023 (10:21:50 CEST)

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Preprint ARTICLE | doi:10.20944/preprints202401.1181.v1

Hemodialysis Efficiency Predictor in End Stage Kidney Disease Using Real-Time Heart Rate Variability

Sung Il Im, Ye Na Kim, Hyun Su Kim, Soo Jin Kim, Su Hyun Bae, Bong Joon Kim, Jung Ho Heo, YeonSoon Jung, Hark Rim, Sung Pil Cho, Jung Hwan Park, Ho Sik Shin

Subject: Medicine And Pharmacology, Cardiac And Cardiovascular Systems Keywords: predictors of hemodialysis; heart rate variability

Online: 16 January 2024 (13:55:36 CET)

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Preprint REVIEW | doi:10.20944/preprints202402.0456.v1

The Potential Use of Soluble TREM Like Transcript – 1, a Platelet-Specific Receptor, for Early Detection of Anthracyclines Induced Congestive Heart Failure (CHF) in Leukemia Patients

Siobhan Branfield, Susan LaGrand, Ian Cleary, Angelia Gibson, Anthony Valance Washington

Subject: Medicine And Pharmacology, Cardiac And Cardiovascular Systems Keywords: Keywords: keyword triggering receptor expressed in myeloid cells-like transcript (TLT-1); blood platelets; cardiovascular diseases; left ventricular ejection fraction (LVEF); biomarker; anthracyclines, Troponin I, cardiotoxicity, congestive heart failure (CHF)

Online: 7 February 2024 (17:08:39 CET)

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Preprint ARTICLE | doi:10.20944/preprints202306.1359.v1

Acute changes on atrial function during progressive exercise in patients with heart failure with mildly-reduced ejection fraction. A case-control study

Ferdinando Iellamo, Giuseppe Caminiti, Marco Alfonso Perrone, Valentino D'Antoni, Alessandro Gismondi, Deborah Di Biasio, Sara Vadala, Giuseppe Marazzi, Valentina Morsella, Maurizio Volterrani

Subject: Medicine And Pharmacology, Cardiac And Cardiovascular Systems Keywords: left atrial function, heart failure; stepwise exercise

Online: 19 June 2023 (12:59:37 CEST)

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Preprint ARTICLE | doi:10.20944/preprints202311.0477.v1

Clinical Impact of Digitalis Therapy in a Large Multicenter Cohort of CRT‐Recipients

Julia W Erath, Nikolett Vigh, Balázs Muk, Carsten W Israel, Badder Kattih, Dávid Pilecky, Gabor Z Duray, Mate Vamos

Subject: Medicine And Pharmacology, Clinical Medicine Keywords: digitalis; digoxin; digitoxin; cardiac‐resynchronization‐therapy; CRT‐D; defibrillator; congestive heart failure; mortality; CRT response

Online: 7 November 2023 (14:18:16 CET)

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Preprint ARTICLE | doi:10.20944/preprints202306.2009.v1

Sex Differences in Prognosis of Heart Failure Due to Ischemic and Nonischemic Cardiomyopathy

Antonio Padua Mansur, Antonio Carlos Pereira-Barretto, Carlo Henrique Del Carlo, Solange Desirée Avakian, Naomi Kondo Nakagawa, Luiz Antonio Machado Cesar, Edimar Alcides Bocchi

Subject: Medicine And Pharmacology, Cardiac And Cardiovascular Systems Keywords: heart failure; cardiomyopathy; ischemic heart disease; prognosis; women; men

Online: 29 June 2023 (07:27:12 CEST)

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Preprint ARTICLE | doi:10.20944/preprints202306.2247.v1

Experimental One Side Choppers Relating Neuro-Muscular Human Abilities to Heart Rates and Technological Evolution

Igor Parra, Maria Luisa Morales, Francisco Javier Mar, Eudald Carbonell

Subject: Arts And Humanities, Archaeology Keywords: hominins; chopper; human evolution; heart rate; piano playing; technome

Online: 30 June 2023 (11:47:16 CEST)

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Preprint ARTICLE | doi:10.20944/preprints202306.2112.v1

Risk Factors and Outcomes of Children with Congenital Heart Disease on Extracorporeal Membrane Oxygenation, a 10-Year Single-Center Report

Antonio Amodeo, Milena Stojanovic, Tugba Erdil, Hitendu Dave, Robert A. Cesnjevar, Sebastian Paal, Oliver Kretschmar, Martin Schweiger

Subject: Medicine And Pharmacology, Cardiac And Cardiovascular Systems Keywords: ongenital heart disease; extracorporeal life support; ECMO; single ventricle; complications; risk factors; mortality

Online: 30 June 2023 (03:41:18 CEST)

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Preprint REVIEW | doi:10.20944/preprints202312.2128.v1

The Structure of the Cardiac Mitochondria Respirasome Is Adapted for the β‐Oxidation of Fatty Acids

Alexander V. Panov

Subject: Biology And Life Sciences, Biochemistry And Molecular Biology Keywords: heart mitochondria; β -oxidation of fatty acids; respiratory chain; respirasome; ubiquinone; ubiquinol; oxidative phosphorylation; tricarboxylic acid cycle

Online: 28 December 2023 (07:14:56 CET)

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Preprint ARTICLE | doi:10.20944/preprints202308.1262.v1

Gender-Based Clinical, Therapeutic Strategies and Prognosis Differences in Atrial Fibrillation

Aurelio Quesada, Javier Quesada-Ocete, Blanca Quesada-Ocete, Victor Del Moral-Ronda, Javier Jiménez-Bello, Ricardo Rubini-Costa, Carl J. Lavie, Daniel P. Morin, Fernando De la Guía-Galipienso, Ricardo Rubini-Puig, Fabian Sanchis-Gomar

Subject: Medicine And Pharmacology, Cardiac And Cardiovascular Systems Keywords: atrial fibrillation; gender; electrical cardioversion; heart failure; mortality

Online: 17 August 2023 (07:15:22 CEST)

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Preprint ARTICLE | doi:10.20944/preprints202401.0941.v1

Prediction of Stress in Radiation Therapy: Integrating Artificial Intelligence with Biological Signals

Sangwoon Jeong, Hongryull Pyo, Won Park, Youngyih Han

Subject: Medicine And Pharmacology, Other Keywords: radiation oncology; artificial intelligence; biological signals; physiological stress; heart rate variability; machine learning

Online: 11 January 2024 (14:52:37 CET)

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Preprint ARTICLE | doi:10.20944/preprints202307.1402.v1

Observational Study of Trans-Septal Endocardial Left Ventricle Lead Implant for Effective Cardiac Resynchronization Therapy in Patients with Challenging Coronary Sinus Anatomy

Arsalan Farhangee, Marke J Davies, Ion Mindrila, Mihai Mesina

Subject: Public Health And Healthcare, Public Health And Health Services Keywords: Cardiac resynchronisation therapy; trans-septal LV lead; Heart Failure; Quality of life

Online: 21 July 2023 (05:19:15 CEST)

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Preprint ARTICLE | doi:10.20944/preprints202311.0971.v1

Modelling and Simulation of the Combined Use of IABP and Impella as a Rescue Procedure in Cardiogenic Shock. An Alternative for non-Transplant Centres?

Beatrice De Lazzari, Massimo Capoccia, Roberto Badagliacca, Claudio De Lazzari

Subject: Medicine And Pharmacology, Cardiac And Cardiovascular Systems Keywords: Lumped-parameter model, CARDIOSIM©; IABP; Impella; cardiovascular system; heart failure; clinician; numerical simulator; e-learning

Online: 15 November 2023 (07:09:06 CET)

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Preprint ARTICLE | doi:10.20944/preprints202309.1483.v1

Radiation Exposure Assessment in Coronary Angiography CT Scan: Establishing Diagnostic Reference Level for Northeast Assam Population

Arnabjyoti Deva Sarma, Jibon Sharma, Manash Pratim Sarma, Mrinal Kanti Singha

Subject: Medicine And Pharmacology, Clinical Medicine Keywords: radiology; computed tomography; coronary angiography; phantom; heart

Online: 22 September 2023 (05:16:02 CEST)

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Preprint REVIEW | doi:10.20944/preprints202306.2095.v1

Can Nutrition Contribute to a Reduction in Sarcopenia, Frailty, and Comorbidities in a Super-Aged Society?

Sadao Yoshida, Ryo Shiraishi, Yuki Nakayama, Yasuko Taira

Subject: Medicine And Pharmacology, Clinical Medicine Keywords: sarcopenia; frailty; comorbidity; diabetes; chronic kidney disease (CKD); heart failure; dementia; vitamin D; oral nutritional supplement (ONS); elderly people

Online: 29 June 2023 (11:05:54 CEST)

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Preprint ARTICLE | doi:10.20944/preprints202403.0671.v1

Subclinical Echocardiographic Parameters and Biomarker Approach to Characterise the Pathophysiology of Carcinoid Syndrome

Ileana Nitu, Ionela Baciu, Simona Găloiu, Iulia Burcea, Catalina Poiana

Subject: Medicine And Pharmacology, Cardiac And Cardiovascular Systems Keywords: carcinoid heart disease; global longitudinal strain; systolic velocities, NT-proBNP; serotonin, 5- hydroxyindolacetic acid

Online: 12 March 2024 (10:17:17 CET)

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Preprint ARTICLE | doi:10.20944/preprints202312.0633.v1

A Complete Pipeline for Heart Rate Extraction from Infant ECG

Harry T. Mason, Astrid Priscilla Martinez-Cedillo, Quoc C. Vuong, M. Carmen Garcia-de-Soria, Stephen Smith, Elena Geangu, Marina I. Knight

Subject: Computer Science And Mathematics, Signal Processing Keywords: ECG; Infant ECG; Heart Rate; R-Peaks; Open-Source; Naturalistic; Longform

Online: 8 December 2023 (14:39:00 CET)

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Preprint REVIEW | doi:10.20944/preprints202312.0329.v1

Clinical Review of Hypertensive Acute Heart Failure

Ratko Lasica, Lazar Djukanovic, Jovanka Vukmirovic, Marija Zdravkovic, Arsen Ristic, Milika Asanin, Dragan Simic

Subject: Medicine And Pharmacology, Cardiac And Cardiovascular Systems Keywords: hypertension; acute heart failure; congestion; diagnosis; modern therapy

Online: 6 December 2023 (07:06:50 CET)

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Preprint ARTICLE | doi:10.20944/preprints202311.0661.v1

Survival and Recurrence of Endocarditis Following Mechanical vs. Biological Aortic Valve Replacement in Patients Aged 40 to 65 Years: Data from the INFECT-REGISTRY

Antonio Salsano, Michele Di Mauro, Laura Labate, Alessandro Della Corte, Federica Lo Presti, Michele De Bonis, Cinzia Trumello, Mauro Rinaldi, Erik Cura Stura, Guglielmo Actis Dato, Giuseppe Punta, Francesco Nicolini, Davide Carino, Carlo De Vincentiis, Andrea Garatti, Giangiuseppe Cappabianca, Andrea M Musazzi, Diego Cugola, Maurizio Merlo, Davide Pacini, Gianluca Folesani, Sandro Sponga, Igor Vendramin, Alberto Pilozzi Casado, Francesco Rosato, Elisa Mikus, Carlo Savini, Francesco Onorati, Giovanni Battista Luciani, Roberto Scrofani, Francesco Epifani, Francesco Musumeci, Antonio Lio, Andrea Colli, Giosuè Falcetta, Salvatore Nicolardi, Salvatore Zaccaria, Enrico Vizzardi, Antonio Pantaleo, Giuseppe Minniti, Emmanuel Villa, Margherita Dalla Tomba, Francesco Pollari, Fabio Barili, Alessandro Parolari, Roberto Lorusso, Francesco Santini

Subject: Medicine And Pharmacology, Cardiac And Cardiovascular Systems Keywords: endocarditis; aortic valve replacement; prosthetic heart valve.

Online: 9 November 2023 (15:01:57 CET)

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Preprint ARTICLE | doi:10.20944/preprints202306.1354.v1

Change in Number of Repetitions, Heart Rate, and Heart Rate Recovery Rate(%) According to Rest Interval Between Sets on 65%1RM Bench Press Exercise

Chul Yoon, Byung-Min Kim

Subject: Public Health And Healthcare, Other Keywords: 65%1RM bench press; Rest interval; Number of repetition (volume load); Heart rate recovery rate

Online: 19 June 2023 (12:36:16 CEST)

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(1)Background:The purpose of the study was conducted to investigate the recovery of heart rate according to the performance level and rest interval conditions during 65%1RM bench press exercise;(2)Methods:The subjects of this study were eight healthy male college studentsin their 20 (years) attending University C. 1RM was measured before theexperiment, and the exercise sequence of six rest intervals (30sec, 1, 2, 3, 4,5min) was randomly selected and cross-distribution experiment. The experimental measurement was conducted a total of six times according to the rest interval condition (six conditions) once every 3 days to minimize the learning effect. The data was verified with repeated measures Two-way ANOVA and Contrast's repeated method was applied for post-comparison;(3)Results: First, the amount of exercise and the number of repetitions statistically substantially dropped (p<.001) as the number of sets rose, and a greater decline was shown when the rest periods got shorter. Second, the heart rate after exercise was increased significantly (p<.01) as the set progressed in the long rest interval conditions (4, 5min), and the heart rate after rest was increased statistically significantly (p<,05) as the set progressed in the short rest interval conditions (30sec, 1min). Third, the heart rate recovery rate (%) was able to perform more repetitions than in the short rest interval condition due to the relatively high physiological recovery of the neuromuscular and circulatory system under the long rest interval condition;(4)Conclusions: Therefore, according to the rest conditionduring the 65%1RM bench press exercise conducted in this study, the restinterval condition of 2~3min may be effective in improving muscular endurance,and the rest interval condition of 4~5min may be effective in improving muscular hypertrophy. As a result of this study, there was a significant difference in exercise performance (repetition) and physiological recovery depending on the rest interval condition according to the set progress during the same intensity resistance exercise. Through this, it is judged that it is possible to adjust the amount of exercise appropriate for the purpose of training by adjusting not only the intensity during resistance exercise but also the rest interval between sets.

Preprint ARTICLE | doi:10.20944/preprints202403.0277.v1

Compartmentalized Development of the Chordae Tendineae and Anterior Leaflet of the Bovine Mitral Valve

Meghan Martin, Chih-Ying Chen, Timothy McCowan, Sarah Wells

Subject: Medicine And Pharmacology, Cardiac And Cardiovascular Systems Keywords: heart valves; extracellular matrix; remodeling; elastin; cardiac development; collagen; valvulogenesis

Online: 5 March 2024 (15:05:04 CET)

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Preprint REVIEW | doi:10.20944/preprints202306.2123.v1

Can Nutrition Contribute to a Reduction in Sarcopenia, Frailty, and Comorbidities in a Super-Aged Society?

Sadao Yoshida, Ryo Shiraishi, Yuki Nakayama, Yasuko Taira

Subject: Medicine And Pharmacology, Clinical Medicine Keywords: sarcopenia; frailty; comorbidity; diabetes; chronic kidney disease (CKD); heart failure; dementia; vitamin D; oral nutritional supplement (ONS); elderly people

Online: 29 June 2023 (13:14:19 CEST)

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Preprint CASE REPORT | doi:10.20944/preprints202309.0330.v1

Right to Left Shunt Evaluation in Cardiac Patent Foramen Ovale Using Bubble Contrast Transcranial Color Coded Doppler: Focused on Cryptogenic Stroke Case

Myeong-Hoon Ji, Youl-Hun Seoung

Subject: Public Health And Healthcare, Public Health And Health Services Keywords: Heart; Patent foramen ovale; Right to left shunt; Bubble contrast; Transcranial color coded doppler

Online: 5 September 2023 (14:49:24 CEST)

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Preprint ARTICLE | doi:10.20944/preprints202305.0097.v1

Prognostic Implications of Physical Activity on Mortality from Ischaemic Heart Disease: Longitudinal Cohort Study Data

Dalia Luksiene, Vilma Jasiukaitiene, Ricardas Radisauskas, Abdonas Tamosiunas, Martin Bobak

Subject: Public Health And Healthcare, Physical Therapy, Sports Therapy And Rehabilitation Keywords: physical activity; mortality risk; ischaemic heart disease; longitudinal cohort study

Online: 3 May 2023 (04:52:51 CEST)

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Preprint REVIEW | doi:10.20944/preprints202402.1191.v1

Combined Pharmacological Modulation of Translational and Transcriptional Activity Signaling Pathways as a Promising Therapeutic Approach in Children With Myocardial Changes

Andrii Kamenshchyk, Igor Belenuchev, Valentyn Oksenych, Oleksandr Kamyshnyi

Subject: Biology And Life Sciences, Anatomy And Physiology Keywords: myocardial hypertrophy; children; gene expression signaling pathways; pharmacological modulation; heart

Online: 21 February 2024 (04:42:02 CET)

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Preprint REVIEW | doi:10.20944/preprints202307.0002.v1

Heart Failure with Reduced Ejection Fraction: The Role of Cardiovascular and Lung Ultrasound Beyond Ejection Fraction

Syuzanna Shahnazaryan, Sergey Pepoyan, Hamayak Sisakian

Subject: Medicine And Pharmacology, Cardiac And Cardiovascular Systems Keywords: heart failure with reduced ejection fraction; echocardiography; outpatient monitoring; left ventricular filling pressure; lung ultrasound; inferior vena cava

Online: 3 July 2023 (03:31:39 CEST)

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Preprint ARTICLE | doi:10.20944/preprints202311.0159.v1

Utility of Point-of-Care Ultrasound in Predicting Acute Heart Failure In-Hospital Worsening in Acutely Decompensated Oldest-Old Patients

Tessa Mazzarone, Virginia Morelli, Andrea Giusti, Maria Giovanna Bianco, Lorenzo Maccioni, Cristina Cargiolli, Daniela Guarino, Agostino Virdis, Chukwuma Okoye

Subject: Medicine And Pharmacology, Emergency Medicine Keywords: Heart Failure; older adults; ultrasound; outcomes; pleural effusion

Online: 2 November 2023 (10:31:43 CET)

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Preprint REVIEW | doi:10.20944/preprints202312.1697.v1

Interplay of Angiotensin Peptides, Vasopressin and Insulin in the Heart: Altered Interactions in Obesity and Diabetes Mellitus

Ewa Szczepańska-Sadowska

Subject: Medicine And Pharmacology, Cardiac And Cardiovascular Systems Keywords: Angiotensin; diabetes mellitus; heart failure; hypertension; hypoxia; insulin; obesity; vasopressin

Online: 22 December 2023 (08:12:34 CET)

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Preprint REVIEW | doi:10.20944/preprints202401.1295.v1

Autonomic Function in Obese Children and Adolescents: Systematic Review and Meta-Analysis

Georgios E. Papadopoulos, Foteini Balomenou, Xenofon M Sakellariou, Christos Tassopoulos, Dimitrios N Nikas, Vasileios Giapros, Theofilos M Kolettis

Subject: Medicine And Pharmacology, Clinical Medicine Keywords: obesity; heart rate variability; autonomic nervous system; sympathetic activity; vagal activity; children; adolescents

Online: 17 January 2024 (10:16:30 CET)

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Preprint ARTICLE | doi:10.20944/preprints202401.1618.v1

Improving Estimation of Heart Rate and Heart Variability with Real-Time Palm Images Based on Independent Component Analysis and Particle Swarm Optimization

Te-Jen Su, Jui-Chuan Cheng, Wei-Hong Lin, Wen-Rong Yang, Ya-Chung Hung, Shih-Ming Wang, Li-chin Tseng

Subject: Computer Science And Mathematics, Artificial Intelligence And Machine Learning Keywords: Independent Component Analysis; Heart Rate Variability; Heart Rate; Particle Swarm Optimization Algorithm

Online: 23 January 2024 (09:30:41 CET)

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Preprint REVIEW | doi:10.20944/preprints202403.1790.v1

Novel Medical Treatments and Devices for the Management of Heart Failure with Reduced Ejection Fraction

Michele Alfieri, Filippo Bruscoli, Luca Di Vito, Federico Di Giusto, Giancarla Scalone, Procolo Marchese, Domenico Delfino, Simona Silenzi, Milena Martoni, Federico Guerra, Pierfrancesco Grossi

Subject: Public Health And Healthcare, Public Health And Health Services Keywords: heart failure; reduced ejection fraction; SGLT2 inhibitors; vericiguat; CardioMEMS; Cardiac Contractility Modulation; Left bundle branch area pacing; Wearable cardioverter defibrillators; Ultrafiltration

Online: 28 March 2024 (17:15:23 CET)

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Preprint ARTICLE | doi:10.20944/preprints202312.1507.v1

Clinical Utility of Baseline Brain Natriuretic Peptide Levels on Health Status Outcomes after Catheter Ablation for Atrial Fibrillation in Individuals without Heart Failure

Shin Kashimura, Nobuhiro Ikemura, Shun Kohsaka, Yoshinori Katsumata, Takehiro Kimura, Daisuke Shinmura, Kotaro Fukumoto, Koji Negishi, Ikuko Ueda, Seiji Takatsuki, Masaki Ieda

Subject: Medicine And Pharmacology, Cardiac And Cardiovascular Systems Keywords: atrial fibrillation; brain natriuretic peptide; catheter ablation; non–heart failure; quality of life

Online: 20 December 2023 (10:56:19 CET)

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Preprint CASE REPORT | doi:10.20944/preprints202401.1490.v1

Liver-Kidney-Heart Axis – A Clinical Challenge

Dina Fernandes Neto, Iago Blanco, María Melendo Viu, David Dobarro Perez, Andrés Iñiguez Romo

Subject: Medicine And Pharmacology, Internal Medicine Keywords: type-5 cardio-renal syndrome; heart failure; cirrhosis; Liver-Kidney-Heart axis

Online: 19 January 2024 (13:11:37 CET)

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Cirrhosis is a chronic disease with multiple etiologies, multiple manifestations, and multi-organ involvement. Affects about 200 million people worldwide. Its main complication is Portal hypertension (PHT). Cirrhotic cardiomyopathy is a consequence of PHT, with heart failure (HF) being the main manifestation. On the other hand, for people with cardiopathy due to other reasons beyond cirrhosis, the presence of the last could act as a trigger to acute HF. Finally, when HF and cirrhosis coexist, the renal system suffers the most, originating from type-5 cardio-renal syndrome, a complex entity with many challenges in diagnosis and treatment. This entity was recently defined and there is a lack of data on the epidemiology of this syndrome. A 77-year-old woman, with cardiovascular risk factors; heart failure with reduced ejection fraction (HFrEF), secondary ischemic and valvular cardiopathy, chronic Kidney disease (CKD), and stable decompensated cirrhosis, went to the emergency department after progressive abdominal perimeter augmentation, legs’ edema and hematochezia. It was assumed acute decompensated cirrhosis and acute decompensated chronic kidney disease, had triggered digestive bleeding and the patient stayed hospitalized. Intravenous diuretic therapy was started but, the ascites and kidney function got worse, the Nt pro-BNP grew until 1125000 pg/ml, and a transthoracic echocardiography showed important signs of congestion, isolated right ventricular dysfunction, with normal cardiac output. After teamwork’s discussion, a type-5 cardio-renal syndrome was assumed deciding not to act on tricuspid regurgitation due to the maladaptive RV remodeling. Hepatorenal syndrome treatment was begun (oral terlipressin and intravenous albumin), followed by decongestion therapy, resulting in a marked improvement in clinical presentation. The kidney, heart, and liver recovered to these basal states. With this clinical case, the authors want to show how multidisciplinary management is important to face tricuspid regurgitation and right ventricular dysfunction.

Preprint ARTICLE | doi:10.20944/preprints202310.0466.v1

Prevalence and Intensity of Sarcocystis Infections in Alpine Chamois (Rupicapra r. rupicapra) in Germany

Steffen Rehbein, Martin Visser

Subject: Biology And Life Sciences, Parasitology Keywords: Sarcocystis; chamois; heart; diaphragm; Germany

Online: 9 October 2023 (07:36:37 CEST)

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Chamois are mountain ungulates (Subfamily Caprinae) which inhabit several medium and high altitude mountain ranges from southern Europe to the Near East. The first findings of Sarcocystis cysts in the musculature of chamois were reported in the 1970s. However, only limited work on the epidemiology of sarcocystosis and identification of the species of Sarcocystis in chamois has been done in the past. The present work was part of a comprehensive study on the parasites of chamois in Germany aiming to provide, for the first time, data on the prevalence and intensity of Sarcocystis infection in native Alpine chamois using histology examination of heart and/or diaphragm tissue samples collected from 216 chamois (40 kids and 176 chamois ranging of one up to 18 years of age). Sarcocysts were detected in either heart or diaphragm of 167/216 chamois (77.3%) with 131 of 183 heart samples and 127 of 215 diaphragm samples testing sarcocyst positive. Of the 181 chamois with both heart and diaphragm available (34 kids and animals up to 18 years of age), sarcocysts were detected in heart and/or diaphragm of 142 animals translating in an overall 78.5% prevalence of Sarcocystis infection (95%CI 72.5% - 84.4%). Sarcocysts were more frequently recorded in heart vs. diaphragm (72.4% vs. 56.4%; p=0.0021), and diaphragm positivity was associated with heart positivity (p=0.0001). Sarcocyst positivity (heart and/or diaphragm) was significantly (p<0.001) lower in kids than in the older chamois (27.1% vs. 88.6%, respectively) but prevalence did not differ between the sexes, regardless of the chamois’ age (p>0.3). Intensity of infection was generally low (<10 sarcocysts per cm² muscle cut) in both heart positive and diaphragm positive animals (94.7% and 93.7%, respectively) with heart yielding higher sarcocyst counts than diaphragm (p<0.001). Both heart and diaphragm sarcocyst counts were significantly (p<0.001) lower in kids than in the older chamois. Sarcocystis infection was demonstrated to be prevalent in chamois in Germany but intensity is apparently low. Further studies are desired to identify the species of Sarcocystis parasitizing the chamois using both phenotypic and molecular characteristics.

Preprint ARTICLE | doi:10.20944/preprints202311.0744.v1

Comparative Analysis of Frailty Identification Criteria on Continuous Non-invasive Neurocardiovascular Signals during an Active Stand Test in the Irish Longitudinal Study on Ageing (TILDA)

Feng Xue, Silvin P. Knight, Emma Connolly, Aisling M. O’Halloran, Morgana Afonso Shirsath, Louise Newman, Eoin Duggan, Rose Anne Kenny, Roman Romero-Ortuno

Subject: Engineering, Bioengineering Keywords: NIRS; Frailty; active stand; Frailty Phenotype; Frailty Index; Clinical Frailty Scale; cardiovascular; cerebrovascular; neurocardiovascular; statistical parametric mapping; SPM; blood pressure; heart rate; brain oxygenation; TSI

Online: 13 November 2023 (10:50:07 CET)

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Preprint REVIEW | doi:10.20944/preprints202403.0391.v1

Carbohydrate Antigen 125 (CA 125): Novel Biomarker in Acute Heart Failure

Mihai Cristian Marinescu, Violeta Diana Oprea, Sorina Nicoleta Munteanu, Aurel Nechita, Dana Tutunaru, Luiza-Camelia Nechita, Aurelia Romila

Subject: Medicine And Pharmacology, Cardiac And Cardiovascular Systems Keywords: acute heart failure; CA 125; NTpro BNP

Online: 8 March 2024 (01:55:07 CET)

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Preprint ARTICLE | doi:10.20944/preprints202311.1913.v1

Hand-Held Echocardiography by Advanced Practice Providers in Patients with Congestive Heart Failure

Maria-Cecilia Tagle-Cornell, Barbara S. Novais, Songnan Wen, Justin Shipman, Deepa Mandale, Drew Flom, Sandeep Sahnan, Lindsey Kriz, Michelle Alland, Christen Bird, Tasneem Z. Naqvi

Subject: Medicine And Pharmacology, Cardiac And Cardiovascular Systems Keywords: Congestive heart failure; echocardiography; hand-held echocardiogram; heart failure; images, advanced practice providers

Online: 29 November 2023 (23:04:44 CET)

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Preprint ARTICLE | doi:10.20944/preprints202401.1004.v1

Predicting Long-Term Childhood Survival of Newborns with Congenital Heart Defects: A Population-Based, Prospective Cohort Study (EPICARD)

Makan Rahshenas, Nathalie Lelong, Damien BONNET, Lucile Houyel, Babak Choodari-Oskooei, Mithat Gonen, Francois Goffinet, Babak KHOSHNOOD

Subject: Medicine And Pharmacology, Cardiac And Cardiovascular Systems Keywords: congenital heart defects; mortality; prediction; long-term; childhood

Online: 12 January 2024 (11:37:40 CET)

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Introduction: Congenital heart defects (CHD) are the most frequent group of major congenital anomalies, accounting for almost 1% of all births. They comprise a very heterogeneous group of birth defects in terms of their severity, clinical management, epidemiology and embryologic origins. Taking this heterogeneity into account is an important imperative to provide reliable prognostic information to patients and their caregivers, as well as to compare results between centers or to assess alternative diagnostic and treatment strategies. The Anatomic and Clinical Classification of CHD (ACC-CHD) aims to facilitate both the CHD coding process and data analysis in clinical and epidemiological studies. Objectives: 1) To describe the long-term childhood survival of newborns with CHD and 2) To develop and validate predictive models of infant mortality based on the ACC-CHD. Materials and Methods: This study is based on data from a population-based, prospective cohort study: Epidemiological Study of Children with Congenital Heart Defects (EPICARD). The final study population comprised 1881 newborns with CHD after excluding cases that were associated with chromosomal and other anomalies. Statistical analysis included non-parametric survival analysis and flexible parametric survival models. The predictive performance of models was assessed by Harrell’s C index and the Royston-Sauerbrei R2 with internal validation by bootstrap. Results: The overall 8-year survival rate for newborns with isolated CHD was 0.96 [0.93- 0.95]. There was a substantial difference between the survival rate of the categories of ACC-CHD. The highest and lowest 8-year survival rates were 0.995 [0.989-0.997] and 0.34 [0.21-0.50] for “interatrial communication abnormalities and ventricular septal defects” and "functionally univentricular heart", respectively. Model discrimination as measured by Harrell’s C was 87% and 89% for the model with ACC-CHD alone and the full model, which included other known predictors of infant mortality, respectively. The predictive performance as measured by R2 was 45% and 50%, for the ACC-CHD alone and the full model. These measures were essentially the same after internal validation by bootstrap. Conclusion: The ACC-CHD classification provided the basis of a highly discriminant survival model with good predictive ability for the 8-year survival of newborns with CHD. Prediction of individual outcomes remains an important clinical and statistical challenge.

Preprint ARTICLE | doi:10.20944/preprints202308.2126.v1

Echocardiographic-Fluoroscopic Fusion Imaging Improves Interventionalists´ Learning Curve for Percutaneous Left Atrial Appendage Closure

Dominika Anna Kanschik, Houtan Heidari, Kathrin Klein, Amin Polzin, Verena Veulemans, Jürgen Leick, Malte Kelm, Christian Jung, Tobias Zeus, Shazia Samreen Afzal

Subject: Medicine And Pharmacology, Internal Medicine Keywords: structural heart disease; left atrial appendage closure; fusion imaging; learning curve

Online: 31 August 2023 (10:36:53 CEST)

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Preprint ARTICLE | doi:10.20944/preprints202307.2058.v1

What Are the Causes of Death Among Patients Admitted to a Contemporary Tertiary Level Cardiology Department? An Analysis of 10 Years of Morbidity & Mortality Meetings

Chun Shing Kwok, Jacopo Tafuro, Chun Wai Wong, Sadie Bennett, Donah Zachariah, Diane Barker, Adrian Morley-Davies, Duwarakan Satchithananda, Mark Gunning, Josip Andelo Borovac

Subject: Medicine And Pharmacology, Cardiac And Cardiovascular Systems Keywords: death; acute myocardial infarction; heart failure; cardiac arrest; cardiovascular departments; sepsis; causes of death; outcomes; medical ward

Online: 31 July 2023 (09:46:01 CEST)

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Preprint ARTICLE | doi:10.20944/preprints202403.1090.v1

Influence of desert dust on the development of premature coronary disease

Alberto Dominguez-Rodriguez, Néstor Báez-Ferrer, Pablo Avanzas, Sergio Rodríguez, Pedro Abreu-González, Elisa Trujillo-Martin, Guillermo Burillo-Putze, Daniel Hernández-Vaquero

Subject: Medicine And Pharmacology, Cardiac And Cardiovascular Systems Keywords: Desert dust; acute coronary syndrome; premature coronary heart disease; air pollution

Online: 19 March 2024 (05:20:15 CET)

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Preprint ARTICLE | doi:10.20944/preprints202306.0476.v2

Diurnal Variation of and Optimal Time To Measure Holter-Based Late Potentials To Predict Lethal Arrhythmia After Myocardial In-Farction

Kenichi Hashimoto, Naomi Harada, Motohiro Kimata, Yusuke Kawamura, Naoya Fujita, Akinori Sekizawa, Yosuke Ono, Yasuhiro Obuchi, Tadateru Takayama, Yuji Kasamaki, Yuji Tanaka

Subject: Medicine And Pharmacology, Cardiac And Cardiovascular Systems Keywords: Late potentials; signal-averaged electrocardiogrhy; heart rate variability; fatal arrhyrthmia; sudden cardiac death

Online: 8 June 2023 (03:37:05 CEST)

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Abstract: Background and Objectives: Holter-based late potentials (LPs) are useful for predicting lethal arrhythmias in organic cardiac diseases. Although Holter-based LPs exhibit diurnal varia-tion, no studies have evaluated the optimal timing of LP measurement over 24 h for predicting lethal arrhythmia that leads to sudden cardiac death. Thus, this study aimed to validate the most effective timing for Holter-based LP testing and to explore factors influencing diurnal variability of LP parameters. Materials and Methods: We retrospectively analyzed 126 patients with post-myocardial infarction (MI) status and 60 control participants who underwent high-resolution Holter electrocardiography. Among the 126 post-MI patients, 23 developed sustained ventricular tachycardia (VT) (the MI-VT group), while 103 did not (the MI-non-VT group) during the obser-vation period. Holter-based LPs were measured at 0:00, 4:00, 8:00, 12:00, 16:00, and 20:00, and heart rate variability analysis was simultaneously performed to investigate factors influencing diurnal variability of LP parameters. Results: Holter-based LP parameters showed diurnal variation with significant deterioration at night and improvement during the day. Assessment at the time with the longest duration of low-amplitude signals <40 μV in the filtered QRS complex terminus (LAS40) gave the highest receiver operating characteristics curve (area under the curve, 0.659) and the highest odds ratio (3.75; 95% confidence interval, 1.45–9.71; p=0.006) for predicting VT. In the multiple regression analysis, heart rate and noise were significant factors affecting LP parameters in the MI-VT and control groups. In the non-VT group, LP parameters were significantly influenced by noise and parasympathetic heart rate variability parameters such as logPNN50. Conclusions: For Holter-based LP measurements, test accuracy was higher when LP was measured at the time of the highest or worst value of LAS40. Changes in autonomic nervous system activity, including heart rate and noise levels, were factors influencing diurnal variability.

Preprint ARTICLE | doi:10.20944/preprints202307.1770.v1

Soft Biomimetic Approach for the Development of Calcinosis-Resistant Glutaraldehyde-Fixed Biomaterials for Cardiovascular Surgery

Alyona I. Zvyagina, Vladislav V. Minaychev, Margarita I. Kobyakova, Yana V. Lomovskaya, Anatoliy S. Senotov, Kira V. Pyatina, Vladimir S. Akatov, Roman S. Fadeev, Irina S. Fadeeva

Subject: Biology And Life Sciences, Biology And Biotechnology Keywords: structural valve degeneration; matrix damage; glutaraldehyde-fixed biomaterials; pericardium; immunogenicity; calcification; calcinosis-resistant biomaterials; heart valve bioprosthesis

Online: 26 July 2023 (07:20:56 CEST)

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Preprint ARTICLE | doi:10.20944/preprints202310.1332.v1

Hippo Signaling Mediates TGFβ-Dependent Transcriptional In-Puts in Cardiac Cushion Mesenchymal Cells to Regulate Extracel-Lular Matrix Remodeling

Mrinmay Chakrabarti, Ahad Chattha, Abhijith Nair, Kai Jiao, Jay D Potts, Lianming Wang, Scotty Branch, Shea Harrelson, Saeed Khan, Mohamad Azhar

Subject: Medicine And Pharmacology, Cardiac And Cardiovascular Systems Keywords: Transforming growth factor beta; YAP; SMAD3; Heart Valve; Extracellular matrix

Online: 20 October 2023 (12:22:01 CEST)

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Abstract: The transforming growth factor beta (TGFβ) and Hippo signaling pathways are evolutionarily conserved pathways that play a critical role in cardiac fibroblasts during embryonic development, tissue repair, and fibrosis. TGFβ and Hippo signaling is also important for cardiac cushion remodeling and septation during embryonic development. Loss of TGFβ2 in mice causes cardiac cushion remodeling defects resulting in congenital heart disease. In this study, we used in vitro molecular and pharmacologic approaches in the cushion mesenchymal cell line (tsA58-AVM) and investigated if Hippo pathway acts as a mediator of TGFβ2 signaling. Immunofluorescence staining showed that TGFβ2 induced nuclear translocation of activated SMAD3 in the cushion mesenchymal cells. In addition, the results indicated increased nuclear localization of Yes associated protein 1 (YAP1) following a similar treatment of TGFβ2. In collagen lattice formation assays, TGFβ2 treatment of cushion cells resulted in an enhanced collagen contraction compared to the untreated cushion cells. Interestingly, verteporfin, a YAP1 inhibitor, significantly blocked the ability of cushion cells to contract collagen gel in absence or presence of by exogenously added TGFβ2. To confirm the molecular mechanisms of verteporfin induced inhibition of TGFβ2-dependent extra-cellular matrix (ECM) reorganization we performed gene expression analysis of key mesenchymal genes involved in ECM remodeling in heart development and disease. Our results confirmed that verteporfin significantly decreased the expression of α-smooth muscle actin (Acta2), collagen 1a1 (Col1a1), Ccn1 (i.e., Cyr61), and Ccn2 (i.e., Ctgf). Western blot analysis indicated that verteporfin treatment significantly blocked TGFβ2-induced activation of SMAD2/3 in cushion mesenchymal cells. Collectively, these results indicate that TGFβ2 regulation of cushion mesenchymal cell be-havior and ECM remodeling is mediated by YAP1. Thus, TGFβ2 and Hippo pathway integration represents an important step in understanding the etiology of congenital heart disease.

Preprint ARTICLE | doi:10.20944/preprints202311.0576.v1

Acute Effect of Positive Airway Pressure on Heart Rate Variability in Obstructive Sleep Apnea

Ji Hye Shin, Min Ji Song, Ji Hyun Kim

Subject: Medicine And Pharmacology, Neuroscience And Neurology Keywords: Obstructive sleep apnea; heart rate variability; continuous positive airway pressure

Online: 9 November 2023 (09:13:15 CET)

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Preprint ARTICLE | doi:10.20944/preprints202312.0458.v2

The Influence of Pericardial Fat on Left Ventricular Diastolic Function

Hugo Duarte, Carlos Alcafache, Patricia Coelho, Francisco Rodrigues

Subject: Medicine And Pharmacology, Cardiac And Cardiovascular Systems Keywords: Pericardium [A07.541.795]; Echocardiography [E01.370.350.130.750]; Ventricular Dysfunction, Left [C14.280.945.900]; Heart Failure, Diastolic [C14.280.434.611]; Abdominal Circumference [SP6.270.233.111.178].

Online: 7 February 2024 (14:52:16 CET)

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Preprint REVIEW | doi:10.20944/preprints202403.1376.v1

Prognostic significance of Lung ultrasound for Heart Failure Patient Management in Primary Care. A Systematic Review

Anna Panisello-Tafalla, Marcos Haro Montoya, Rosa Caballol-Angelats, Maylin Montelongo-Sol, Yoenia Rodriguez-Carralero, Jorgina Lucas-Noll, Josep Lluis Clua-Espuny

Subject: Public Health And Healthcare, Primary Health Care Keywords: Lung ultrasound; Heart Failure; B-lines; prognosis; mortality; hospital admissions; Primary care.

Online: 22 March 2024 (11:38:10 CET)

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Preprint ARTICLE | doi:10.20944/preprints202312.1407.v1

Cardiomyocyte Differentiation from Mouse Embryonic Stem Cells by WNT Switch Method

Isaiah K Mensah, Martin L Emerson, Hern J Tan, Humaira Gowher

Subject: Biology And Life Sciences, Cell And Developmental Biology Keywords: cardiomyocytes; mesoderm; mouse embryonic stem cells; heart; in vitro differentiation; wnt signaling

Online: 19 December 2023 (07:09:23 CET)

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Preprint ARTICLE | doi:10.20944/preprints202309.0396.v1

Cardiac Laterality: Surgical Results of Right Atrial Isomerism

Diego B. Ortega-Zhindón, Nonanzit Pérez-Hernández, José Manuel Rodríguez-Pérez, José A. García-Montes, Juan Calderón-Colmenero, Jorge L. Cervantes-Salazar

Subject: Medicine And Pharmacology, Anatomy And Physiology Keywords: heterotaxy syndrome; atrial isomerism; heart surgery; congenital heart disease.

Online: 7 September 2023 (03:33:23 CEST)

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Preprint REVIEW | doi:10.20944/preprints202311.1314.v1

Cardiac Targeting Peptide: From Discovery to Applications

Daniella Sahagun, Maliha Zahid

Subject: Medicine And Pharmacology, Cardiac And Cardiovascular Systems Keywords: cell penetrating peptides; protein transduction domains; cardiac targeting peptide; heart failure; atrial fibrillation

Online: 21 November 2023 (10:43:05 CET)

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Preprint ARTICLE | doi:10.20944/preprints202310.1359.v1

Recipient Pericardial Apolipoprotein Levels Might Be an Indicator of Worse Outcomes after Orthotopic Heart Transplantation

Székely Andrea MD PhD, Pállinger Éva MD PhD, Töreki Evelin MD, Ifju Mandula, Barta Bálint András MD, Szécsi Balázs MD, Losoncz Eszter MD, Dohy Zsófia MD, Barabás Imre János MD PhD, Kosztin Annamária MD PhD, Buzas I Edit MD PhD, Radovits Tamás MD PhD, Merkely Béla MD PhD

Subject: Medicine And Pharmacology, Cardiac And Cardiovascular Systems Keywords: organ recipient; heart transplantation; primary graft dysfunction; interleukin; apolipoprotein

Online: 20 October 2023 (13:40:14 CEST)

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End-stage heart failure (ESHF) leads to hypoperfusion and edema formation in the whole body and is accompanied by neurohormonal and immunological alterations. Orthotopic heart transplantation (HTX) has been used as a beneficial option for ESHF. Due to the shortage of donor hearts, the ideal matching and timing of donors and recipients has become more important. Our aim was to explore the relationship between the clinical outcome of HTX and the cytokine and apolipoprotein profiles of the recipient pericardial fluid obtained at transplantation after opening the pericardial sac. The clinical data and the interleukin, adipokine and lipoprotein levels in the pericardial fluid of twenty recipients were investigated. Outcome variables included primer graft dysfunction (PGD), need for posttransplantation mechanical cardiac support (MCS), International Society for Heart and Lung Transplantation grade ≥ 2R rejection and mortality. Recipient risk scores were also investigated. Leptin levels were significantly lower in patients with PGD than in those without PGD (median: 6.36 [IQR: 5.55-6.62]; versus 7.54 [IQR=6.71-10.44]; p = 0.029). Higher ApoCII levels (median: 14.91 [IQR: 11.55-21.30] versus 10.31 [IQR=10.02-13.07]; p = 0.042) and ApoCIII levels (median: 60.32 [IQR: 43.00-81.66] versus 22.84 [IQR=15.84-33.39]; p=0.005) were found in patients (n=5) who died in the first 5 years after HTX. In patients who had rejection (n=4) in the first month after transplantation, the levels of adiponectin (median: 74.48 [IQR: 35.51-131.70] versus 29.96 [IQR: 19.86-42.28]; p=0.039), ApoCII (median: 20.11 [IQR: 13.06-23.54] versus 10.32 [IQR: 10.02-12.84]; p=0.007) and ApoCIII (median: 70.97 [IQR: 34.72-82.22] versus 26.33 [IQR: 17.18-40.17; p=0.029) were higher than those in the nonrejection group. Moreover, the pericardial thyroxine (T4) levels (median: 3.96 [IQR: 3.49-4.46] versus 4.69 [IQR: 4.23-5.77]; p=0.022) were lower in patients with rejection than in patients who did not develop rejection. Our results indicate that apolipoproteins can facilitate the monitoring of rejection and could be a useful tool in the forecast of early and late complications.

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