Martin, M.; Chen, C.-Y.; McCowan, T.; Wells, S. Differential Development of the Chordae Tendineae and Anterior Leaflet of the Bovine Mitral Valve. J. Cardiovasc. Dev. Dis.2024, 11, 106.
Martin, M.; Chen, C.-Y.; McCowan, T.; Wells, S. Differential Development of the Chordae Tendineae and Anterior Leaflet of the Bovine Mitral Valve. J. Cardiovasc. Dev. Dis. 2024, 11, 106.
Martin, M.; Chen, C.-Y.; McCowan, T.; Wells, S. Differential Development of the Chordae Tendineae and Anterior Leaflet of the Bovine Mitral Valve. J. Cardiovasc. Dev. Dis.2024, 11, 106.
Martin, M.; Chen, C.-Y.; McCowan, T.; Wells, S. Differential Development of the Chordae Tendineae and Anterior Leaflet of the Bovine Mitral Valve. J. Cardiovasc. Dev. Dis. 2024, 11, 106.
Abstract
There is increasing evidence that some adult mitral valve pathologies may have developmental origins involving errors in cell signaling and protein deposition during valvulogenesis. While early and late gestational stages are well-documented in zebrafish and small mammalian models, longitudinal studies in large mammals with a similar gestational period to humans are lacking. Further, the mechanism of chordae tendineae formation and multiplication remains unclear. This current study presents a comprehensive examination of mitral anterior leaflet and chordae tendineae development in a bovine model (with a gestational period of 9 months). Remarkably distinct from small mammals, bovine development displayed early branched chordae, with increasing attachments only until birth, while the anterior leaflet grew both during gestation and postnatally. Chordae also exhibited accelerated collagen deposition, maturation, and crimp development during gestation. These findings suggest that the bovine anterior leaflet and chordae tendineae possess unique compartmentalized processes of development despite being a continuous collagenous structure.
Medicine and Pharmacology, Cardiac and Cardiovascular Systems
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