Preprint Review Version 1 Preserved in Portico This version is not peer-reviewed

Novel Medical Treatments and Devices for the Management of Heart Failure with Reduced Ejection Fraction

Michele Alfieri
ORCID logo ,
Filippo Bruscoli
,
Luca Di Vito
* ORCID logo ,
Federico Di Giusto
,
Giancarla Scalone
,
Procolo Marchese
ORCID logo ,
Domenico Delfino
,
Simona Silenzi
,
Milena Martoni
,
Federico Guerra
,
Pierfrancesco Grossi
Version 1 : Received: 27 March 2024 / Approved: 27 March 2024 / Online: 28 March 2024 (17:15:23 CET)

A peer-reviewed article of this Preprint also exists.

Alfieri, M.; Bruscoli, F.; Di Vito, L.; Di Giusto, F.; Scalone, G.; Marchese, P.; Delfino, D.; Silenzi, S.; Martoni, M.; Guerra, F.; Grossi, P. Novel Medical Treatments and Devices for the Management of Heart Failure with Reduced Ejection Fraction. J. Cardiovasc. Dev. Dis. 2024, 11, 125. Alfieri, M.; Bruscoli, F.; Di Vito, L.; Di Giusto, F.; Scalone, G.; Marchese, P.; Delfino, D.; Silenzi, S.; Martoni, M.; Guerra, F.; Grossi, P. Novel Medical Treatments and Devices for the Management of Heart Failure with Reduced Ejection Fraction. J. Cardiovasc. Dev. Dis. 2024, 11, 125.

Abstract

Heart failure (HF) is a growing issue in developed countries and most patients present with a reduced ejection fraction. This condition significantly impairs quality of life and represents a threat not only for patients, but also for the entire healthcare system due to its high management cost. In the last decade, new medical treatments and devices have been developed to reduce HF hospitalizations and improve prognosis, while reducing the overall mortality rate. Medical therapy does not achieve the same results in all patients and, whenever it fails, technology comes in handy: novel devices for the management of HF have reduced symptoms. They have also improved the treatment of fluid retention and life threatening arrhythmias. The present review article gives to the readers a comprehensive overview of the most recent and important findings that need to be considered in HF with reduced ejection fraction patients. Both novel medical treatments and devices have been presented and discussed.

Keywords

heart failure; reduced ejection fraction; SGLT2 inhibitors; vericiguat; CardioMEMS; Cardiac Contractility Modulation; Left bundle branch area pacing; Wearable cardioverter defibrillators; Ultrafiltration

Subject

Public Health and Healthcare, Public Health and Health Services

Copyright: This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

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