PreprintReviewVersion 1Preserved in Portico This version is not peer-reviewed
Combined Pharmacological Modulation of Translational and Transcriptional Activity Signaling Pathways as a Promising Therapeutic Approach in Children With Myocardial Changes
Version 1
: Received: 20 February 2024 / Approved: 21 February 2024 / Online: 21 February 2024 (04:42:02 CET)
How to cite:
Kamenshchyk, A.; Belenuchev, I.; Oksenych, V.; Kamyshnyi, O. Combined Pharmacological Modulation of Translational and Transcriptional Activity Signaling Pathways as a Promising Therapeutic Approach in Children With Myocardial Changes. Preprints2024, 2024021191. https://doi.org/10.20944/preprints202402.1191.v1
Kamenshchyk, A.; Belenuchev, I.; Oksenych, V.; Kamyshnyi, O. Combined Pharmacological Modulation of Translational and Transcriptional Activity Signaling Pathways as a Promising Therapeutic Approach in Children With Myocardial Changes. Preprints 2024, 2024021191. https://doi.org/10.20944/preprints202402.1191.v1
Kamenshchyk, A.; Belenuchev, I.; Oksenych, V.; Kamyshnyi, O. Combined Pharmacological Modulation of Translational and Transcriptional Activity Signaling Pathways as a Promising Therapeutic Approach in Children With Myocardial Changes. Preprints2024, 2024021191. https://doi.org/10.20944/preprints202402.1191.v1
APA Style
Kamenshchyk, A., Belenuchev, I., Oksenych, V., & Kamyshnyi, O. (2024). Combined Pharmacological Modulation of Translational and Transcriptional Activity Signaling Pathways as a Promising Therapeutic Approach in Children With Myocardial Changes. Preprints. https://doi.org/10.20944/preprints202402.1191.v1
Chicago/Turabian Style
Kamenshchyk, A., Valentyn Oksenych and Oleksandr Kamyshnyi. 2024 "Combined Pharmacological Modulation of Translational and Transcriptional Activity Signaling Pathways as a Promising Therapeutic Approach in Children With Myocardial Changes" Preprints. https://doi.org/10.20944/preprints202402.1191.v1
Abstract
Myocardial hypertrophy is the most common condition that accompanies heart changings in children. Transcriptional pathways regulating gene expression playing a critical role both in cardiac embryogenesis and in the pathogenesis of congenital hypertrophic cardiomyopathy, neonatal posthypoxic myocardial hypertrophy and congenital heart diseases. This paper describes the state of cardiac gene expression and potential pharmacological modulators at different transcriptional levels. An experimental model of perinatal cardiac hypoxia showed downregulated expression of genes responsible for cardiac muscle integrity and overexpressed genes associated with energy metabolism and apoptosis, which may provide a basis for a therapeutic approach. Current evidence suggests that RNA drugs, theaflavin, neuraminidase, proton pump and histone deacetylase inhibitors are promising pharmacological agents in progressive cardiac hypertrophy. The different points of application of the above drugs makes combined use possible, potentiating the effects of inhibition in specific signaling pathways. The special role of N-acetyl cysteine in both the inhibition of several signaling pathways and the reduction of oxidative stress was emphasized.
Copyright:
This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
