Preprint Article Version 1 Preserved in Portico This version is not peer-reviewed

Risk Factors and Outcomes of Children with Congenital Heart Disease on Extracorporeal Membrane Oxygenation, a 10-Year Single-Center Report

Antonio Amodeo
* ORCID logo ,
Milena Stojanovic
,
Tugba Erdil
,
Hitendu Dave
,
Robert A. Cesnjevar
ORCID logo ,
Sebastian Paal
,
Oliver Kretschmar
,
Martin Schweiger
ORCID logo
Version 1 : Received: 29 June 2023 / Approved: 29 June 2023 / Online: 30 June 2023 (03:41:18 CEST)

A peer-reviewed article of this Preprint also exists.

Amodeo, A.; Stojanovic, M.; Erdil, T.; Dave, H.; Cesnjevar, R.; Paal, S.; Kretschmar, O.; Schweiger, M. Risk Factors and Outcomes of Children with Congenital Heart Disease on Extracorporeal Membrane Oxygenation—A Ten-Year Single-Center Report. Life 2023, 13, 1582. Amodeo, A.; Stojanovic, M.; Erdil, T.; Dave, H.; Cesnjevar, R.; Paal, S.; Kretschmar, O.; Schweiger, M. Risk Factors and Outcomes of Children with Congenital Heart Disease on Extracorporeal Membrane Oxygenation—A Ten-Year Single-Center Report. Life 2023, 13, 1582.

Abstract

For children born with congenital heart defects (CHD), extracorporeal life support may be necessary. This study aimed to investigate the outcomes of children on extracorporeal membrane oxygenation (ECMO), focusing on various risk factors, including the type of CHD. The study was conducted as a retrospective single-center analysis at the Children's Hospital Zurich. All patients with CHD who required ECMO (veno-arterial or veno-venous) between 2009 and 2019 were included. Among the 88 patients, 36 (41%) had a single ventricle heart defect while 52 (59%) had a biventricular heart defect. Out of the total patients, 25 (28%) survived, with 7 (8%) having a single ventricle heart defect and 18 (20%) having a biventricular heart defect. Statistical analysis with a p-value of 0.19 revealed no significant difference in survival rates between the two groups. At the one-year follow-up, all children who survived to discharge were still alive. The rate of complications on ECMO was higher in children with a single ventricle (odds ratio [OR] 1.57, 95% confidence interval [CI] 0.67 - 3.7). The occurrence of a second ECMO run was more frequent in patients with a single ventricle compared to those with a biventricular physiology (22% vs. 9.6%). Although the study did not identify a significant difference in survival rates, it did indicate that patients with a single ventricle faced a higher risk of complications during ECMO and a greater likelihood of requiring a second ECMO run.

Keywords

ongenital heart disease; extracorporeal life support; ECMO; single ventricle; complications; risk factors; mortality

Subject

Medicine and Pharmacology, Cardiac and Cardiovascular Systems

Copyright: This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

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