Carbohydrate Antigen 125 (CA 125): Novel Biomarker in Acute Heart Failure

Mihai Cristian Marinescu; Violeta Diana Oprea; Sorina Nicoleta Munteanu; Aurel Nechita; Dana Tutunaru; Luiza-Camelia Nechita; Aurelia Romila

doi:10.20944/preprints202403.0391.v1

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preprints.org > medicine and pharmacology > cardiac and cardiovascular systems > doi: 10.20944/preprints202403.0391.v1

Preprint Review Version 1 Preserved in Portico This version is not peer-reviewed

Carbohydrate Antigen 125 (CA 125): Novel Biomarker in Acute Heart Failure

Mihai Cristian Marinescu

^* ,

Violeta Diana Oprea

^* ,

Sorina Nicoleta Munteanu

Aurel Nechita

Dana Tutunaru

Luiza-Camelia Nechita

Aurelia Romila

Version 1 : Received: 6 March 2024 / Approved: 7 March 2024 / Online: 8 March 2024 (01:55:07 CET)

A peer-reviewed article of this Preprint also exists.

Marinescu, M.C.; Oprea, V.D.; Munteanu, S.N.; Nechita, A.; Tutunaru, D.; Nechita, L.C.; Romila, A. Carbohydrate Antigen 125 (CA 125): A Novel Biomarker in Acute Heart Failure. Diagnostics 2024, 14, 795. Marinescu, M.C.; Oprea, V.D.; Munteanu, S.N.; Nechita, A.; Tutunaru, D.; Nechita, L.C.; Romila, A. Carbohydrate Antigen 125 (CA 125): A Novel Biomarker in Acute Heart Failure. Diagnostics 2024, 14, 795.

Abstract

Heart failure is a global major healthcare problem with millions of hospitalizations annually and with a very high mortality. There is an increased interest in finding new and reliable biomarkers for the diagnostication, prognostication and therapeutical guidance of patients hospitalized for acute heart failure. There is data to sustain the role of CA 125, a worldwide used marker of ovarian cancer, in patients with heart failure. Several studies have shown links between CA 125 levels and congestion seen in acute heart failure, high mortality and readmission rates at 6 months follow up after discharge from acute heart failure and also a role of CA 125 in the guidance of heart failure therapy. There are also clinical trials that showed that several particularities of CA 125 make it even better than NTpro BNP ( a classical and more utilised marker of heart failure) in several scenarios of acute heart failure.

Keywords

acute heart failure; CA 125; NTpro BNP

Subject

Medicine and Pharmacology, Cardiac and Cardiovascular Systems

Copyright: This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

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