Shin, J.H.; Song, M.J.; Kim, J.H. Acute Effect of Positive Airway Pressure on Heart Rate Variability in Obstructive Sleep Apnea. J. Clin. Med.2023, 12, 7606.
Shin, J.H.; Song, M.J.; Kim, J.H. Acute Effect of Positive Airway Pressure on Heart Rate Variability in Obstructive Sleep Apnea. J. Clin. Med. 2023, 12, 7606.
Shin, J.H.; Song, M.J.; Kim, J.H. Acute Effect of Positive Airway Pressure on Heart Rate Variability in Obstructive Sleep Apnea. J. Clin. Med.2023, 12, 7606.
Shin, J.H.; Song, M.J.; Kim, J.H. Acute Effect of Positive Airway Pressure on Heart Rate Variability in Obstructive Sleep Apnea. J. Clin. Med. 2023, 12, 7606.
Abstract
Autonomic dysregulation is associated with cardiovascular consequences in obstructive sleep apnea (OSA). This study aimed to investigate the effect of acute continuous positive airway pressure (CPAP) treatment on autonomic activity and to identify factors contributing to the heart rate variability (HRV) changes in OSA. Frequency domain HRV parameters were calculated and compared between the baseline polysomnography and during the CPAP titration in 402 patients with moderate to severe OSA. There were significant reductions in total power, very low-frequency band power, low-frequency band power, and high-frequency band power during the CPAP titration as compared to the baseline polysomnography. This tendency was more pronounced in men than in women, and in patients with severe OSA than those with moderate OSA. Multivariate analysis found that changes in apnea-hypopnea index and oxygen saturation were significantly associated with changes in sympathetic and parasympathetic activity, respectively. This study demonstrated that HRV parameters significantly changed during the CPAP titration, indicating a beneficial effect of CPAP in restoration of sympathetic and parasympathetic hyperactivity in OSA. Prospective longitudinal studies should determine whether long-term CPAP treatment aids in maintaining the long-lasting improvement of the autonomic functions, thereby contributing to the prevention of cardiovascular and cerebrovascular diseases in patients with OSA.
Medicine and Pharmacology, Neuroscience and Neurology
Copyright:
This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
