Preprint Article Version 1 Preserved in Portico This version is not peer-reviewed

Soft Biomimetic Approach for the Development of Calcinosis-Resistant Glutaraldehyde-Fixed Biomaterials for Cardiovascular Surgery

Alyona I. Zvyagina
,
Vladislav V. Minaychev
,
Margarita I. Kobyakova
,
Yana V. Lomovskaya
ORCID logo ,
Anatoliy S. Senotov
ORCID logo ,
Kira V. Pyatina
,
Vladimir S. Akatov
ORCID logo ,
Roman S. Fadeev
,
Irina S. Fadeeva
* ORCID logo
Version 1 : Received: 25 July 2023 / Approved: 26 July 2023 / Online: 26 July 2023 (07:20:56 CEST)

A peer-reviewed article of this Preprint also exists.

Zvyagina, A.I.; Minaychev, V.V.; Kobyakova, M.I.; Lomovskaya, Y.V.; Senotov, A.S.; Pyatina, K.V.; Akatov, V.S.; Fadeev, R.S.; Fadeeva, I.S. Soft Biomimetic Approach for the Development of Calcinosis-Resistant Glutaraldehyde-Fixed Biomaterials for Cardiovascular Surgery. Biomimetics 2023, 8, 357. Zvyagina, A.I.; Minaychev, V.V.; Kobyakova, M.I.; Lomovskaya, Y.V.; Senotov, A.S.; Pyatina, K.V.; Akatov, V.S.; Fadeev, R.S.; Fadeeva, I.S. Soft Biomimetic Approach for the Development of Calcinosis-Resistant Glutaraldehyde-Fixed Biomaterials for Cardiovascular Surgery. Biomimetics 2023, 8, 357.

Abstract

Pathological aseptic calcification is the most common form of structural valvular degeneration (SVD), leading to premature failure of heart valve bioprostheses (BHVs). The processing methods used to obtain GA-fixed pericardium-based biomaterials determine the hemodynamic characteristics and durability of BHVs. This article presents a comparative study of the effects of several processing methods on the degree of damage to the ECM of GA-fixed pericardium-based biomaterials as well as on their biostability, biocompatibility, and resistance to calcification. Based on the assumption that preservation of the native ECM structure will enable the creation of calcinosis-resistant materials, this study provides a soft biomimetic approach for the manufacture of GA-fixed biomaterials using gentle decellularization and washing methods. It has been shown that the use of soft methods for preimplantation processing of materials, ensuring maximum preservation of the intactness of the pericardial ECM, radically increases the resistance of biomaterials to calcification. The data obtained are of interest for the development of new calcinosis-resistant biomaterials for the manufacture of BHVs.

Keywords

structural valve degeneration; matrix damage; glutaraldehyde-fixed biomaterials; pericardium; immunogenicity; calcification; calcinosis-resistant biomaterials; heart valve bioprosthesis

Subject

Biology and Life Sciences, Biology and Biotechnology

Copyright: This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

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