Preprint Article Version 1 Preserved in Portico This version is not peer-reviewed

Parkinson's Disease and the Heart: Studying Cardiac Metabolism in the 6-Hydroxydopamine model

Victor Silva da Fonsêca
,
Valeria de Cassia Gonçalves
ORCID logo ,
Mario Augusto Izidoro
,
Antônio-Carlos G. de Almeida
ORCID logo ,
Fernando Luiz Affonso Fonseca
ORCID logo ,
Fulvio Alexandre Scorza
,
Josef Finsterer
ORCID logo ,
Carla Alessandra Scorza
*
Version 1 : Received: 13 June 2023 / Approved: 16 June 2023 / Online: 16 June 2023 (14:16:00 CEST)

A peer-reviewed article of this Preprint also exists.

Silva da Fonsêca, V.; Goncalves, V.C.; Augusto Izidoro, M.; Guimarães de Almeida, A.-C.; Luiz Affonso Fonseca, F.; Alexandre Scorza, F.; Finsterer, J.; Scorza, C.A. Parkinson’s Disease and the Heart: Studying Cardiac Metabolism in the 6-Hydroxydopamine Model. Int. J. Mol. Sci. 2023, 24, 12202. Silva da Fonsêca, V.; Goncalves, V.C.; Augusto Izidoro, M.; Guimarães de Almeida, A.-C.; Luiz Affonso Fonseca, F.; Alexandre Scorza, F.; Finsterer, J.; Scorza, C.A. Parkinson’s Disease and the Heart: Studying Cardiac Metabolism in the 6-Hydroxydopamine Model. Int. J. Mol. Sci. 2023, 24, 12202.

Abstract

Parkinson’s-disease (PD) is an incurable age-related neurodegenerative disease and its global prevalence of disability and death has increased exponentially. Although motor symptoms are the characteristic manifestations of PD, the clinical spectrum also contains a wide variety of non-motor symptoms, which are the main cause of disability and determinants of the decrease in a patient's quality of life. Noteworthy in this regard is the stress on the cardiac system that is often observed in the course of PD, however its effects have not yet been adequately researched. Here, an untargeted metabolomics approach was used to assess changes in cardiac metabolism in the 6-hydroxydopamine model of PD. Beta-sitosterol, campesterol, cholesterol, monoacylglycerol, α-tocopherol, stearic acid, beta-glycerophosphoric acid, o-phosphoethanolamine, myo-inositol-1-phosphate, alanine, valine and allothreonine, are the metabolites that significantly discriminate Parkinsonian rats from sham counterparts. Upon analysis of the metabolic pathways with the aim of uncovering the main biological pathways involved in concentration patterns of cardiac metabolites, biosynthesis of both phosphatidylethanolamine and phosphatidylcholine, glucose-alanine cycle, the glutathione metabolism and plasmalogen synthesis most adequately differentiated sham and Parkinsonian rats. Our results reveal that both lipid and energy metabolism are particularly involved in changes in cardiac metabolism in PD. These results provide insight into cardiac metabolic signatures in PD and indicate potential targets for further investigation.

Keywords

Parkinson’s disease; cardiac metabolism; heart; 6-hydroxydopamine; metabolites

Subject

Medicine and Pharmacology, Neuroscience and Neurology

Copyright: This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

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