PreprintArticleVersion 1Preserved in Portico This version is not peer-reviewed
Observational Study of Trans-Septal Endocardial Left Ventricle Lead Implant for Effective Cardiac Resynchronization Therapy in Patients with Challenging Coronary Sinus Anatomy
Version 1
: Received: 19 July 2023 / Approved: 20 July 2023 / Online: 21 July 2023 (05:19:15 CEST)
How to cite:
Farhangee, A.; Davies, M.J.; Mindrila, I.; Mesina, M. Observational Study of Trans-Septal Endocardial Left Ventricle Lead Implant for Effective Cardiac Resynchronization Therapy in Patients with Challenging Coronary Sinus Anatomy. Preprints2023, 2023071402. https://doi.org/10.20944/preprints202307.1402.v1
Farhangee, A.; Davies, M.J.; Mindrila, I.; Mesina, M. Observational Study of Trans-Septal Endocardial Left Ventricle Lead Implant for Effective Cardiac Resynchronization Therapy in Patients with Challenging Coronary Sinus Anatomy. Preprints 2023, 2023071402. https://doi.org/10.20944/preprints202307.1402.v1
Farhangee, A.; Davies, M.J.; Mindrila, I.; Mesina, M. Observational Study of Trans-Septal Endocardial Left Ventricle Lead Implant for Effective Cardiac Resynchronization Therapy in Patients with Challenging Coronary Sinus Anatomy. Preprints2023, 2023071402. https://doi.org/10.20944/preprints202307.1402.v1
APA Style
Farhangee, A., Davies, M.J., Mindrila, I., & Mesina, M. (2023). Observational Study of Trans-Septal Endocardial Left Ventricle Lead Implant for Effective Cardiac Resynchronization Therapy in Patients with Challenging Coronary Sinus Anatomy. Preprints. https://doi.org/10.20944/preprints202307.1402.v1
Chicago/Turabian Style
Farhangee, A., Ion Mindrila and Mihai Mesina. 2023 "Observational Study of Trans-Septal Endocardial Left Ventricle Lead Implant for Effective Cardiac Resynchronization Therapy in Patients with Challenging Coronary Sinus Anatomy" Preprints. https://doi.org/10.20944/preprints202307.1402.v1
Abstract
Background: Trans-septal endocardial left ventricle lead placement is an alternative technique used capture the left ventricular endocardially but it is use is limited due lack of evidence, practice uptake and clinical trials. we evaluated the efficiency of the procedure, post procedural complication rate, rate of thromboembolic events as well as changes in echocardiographic parameters, brain natriuretic peptide (BNP) level and the New York Heart Association (NYHA) class.
Results: TSLV lead implant is safe, improves ejection fraction, LVEDV, LVESV, LVIDd. Significantly reduces NTproBNP levels and NYHA class. Stroke rate was reported only in one patient (9%), noticeably, this particular patient was on DOAC rather than anti-vitamin K antagonists. In this group, patients, who were on Warfarin , were not reported to have any thrombo-embolic events.
Discussion:
Trans-septal endocardial LV lead implant in patients with a failed CS approach remains a viable alternative however, there is a higher risk of stroke amongst these patients, as well as more procedure related risk of complications compared to conventional CRT.
The data analysis demonstrates that patients undergoing a TSLV lead implant due to a failed trans-venous approach have more advanced heart failure, defined by their higher NYHA class compared to conventional trans-venous CRT implant groups. Their pre TSLV implant, echocardiographic parameters are also worse compared to trans-venous CRT implant group
Keywords
Cardiac resynchronisation therapy; trans-septal LV lead; Heart Failure; Quality of life
Subject
Public Health and Healthcare, Public Health and Health Services
Copyright:
This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
