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Preprint ARTICLE | doi:10.20944/preprints202012.0115.v1

Resveratrol Supplementation Attenuates Cognitive and Molecular Alterations Under Maternal High-Fat Diet Intake: Multigenerational Epigenetic Inheritance.

Vanesa Izquierdo, Verónica Palomera-Ávalos, Mercè Pallàs, Christian Griñán-Ferré

Subject: Biology And Life Sciences, Biochemistry And Molecular Biology Keywords: cognitive decline; epigenetics; HFD; aging; SAM0P8; m6A, multigenerational inheritance.

Online: 4 December 2020 (14:54:58 CET)

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Working Paper ARTICLE

Dietary Diversity and Nutritional Adequacy Among an Older Spanish Population with Metabolic Syndrome in the PREDIMED-Plus Study: A Cross-Sectional Analysis

Naomi Cano-Ibáñez, Alfredo Gea, Miguel A. Martínez-González, Jordi Salas-Salvadó, Dolores Corella, M. Dolors Zomeño, Dora Romaguera, Jesús Vioque, Fernando Aros, Julia Wärnberg, J. Alfredo Martínez, Lluis Serra-Majem, Ramón Estruch, Francisco Tinahones, José Lapetra, Xavier Pintó, Josep A. Tur, Antonio García-Ríos, Blanca Riquelme-Gallego, Miguel Delgado-Rodríguez, Pilar Matía, Lidia Daimiel, Vicente Martín, Josep Vidal, Clotilde Vázquez, Emilio Ros, Pilar Buil-Cosiales, Andrés Díaz-López, Rebeca Fernández-Carrión, Montserrat Fitó, Jadwiga Konieczna, Leyre Notario-Barandiaran, Ángel M. Alonso-Gómez, Eugenio Contreras-Fernández, Itziar Abete, Almudena Sánchez-Villegas, Rosa Casas, Araceli Muñoz-Garach, José Manuel Santos-Lozano, Laura Gallardo-Alfaro, Josep Basora, Olga Portoles, Miguel Ángel Muñoz, Manuel Moñino, Salvador Miralles Gisbert, Anai Moreno Rodríguez, Miguel Ruiz-Canela, Antoni Palau Galindo, Karla Alejandra Pérez-Vega, Aurora Bueno-Cavanillas

Subject: Medicine And Pharmacology, Dietetics And Nutrition Keywords: Dietary diversity; nutrient adequacy; metabolic syndrome; aging; PREDIMED-Plus study

Online: 18 March 2019 (09:25:48 CET)

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Preprint ARTICLE | doi:10.20944/preprints202302.0301.v1

Effect of Thermomechanical Aging of Orthodontic Aligners on Force and Torque Generation: An in vitro Study

Tarek Elshazly, Diva Nang, Bijan Golkhani, Hanaa Elattar, Ludger Keilig, Christoph Bourauel

Subject: Medicine And Pharmacology, Dentistry And Oral Surgery Keywords: Dentistry; Orthodontics; Biomechanics; Torque; Force; Tooth Movement; Removable Thermoplastic Appliance; Thermoforming; Aging.

Online: 17 February 2023 (07:07:06 CET)

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Preprint ARTICLE | doi:10.20944/preprints201810.0510.v1

Effect of the Application of an Innovative Program on Prevention of Falls in Seniors

Zbigniew Borysiuk, Paweł Pakosz, Mariusz Konieczny, Krzysztof Kręcisz

Subject: Medicine And Pharmacology, Orthopedics And Sports Medicine Keywords: limits of stability; coactivation; EMG signal; falls; aging

Online: 22 October 2018 (16:07:16 CEST)

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Preprint ARTICLE | doi:10.20944/preprints202002.0457.v1

Influence of Cross Section Thickness and Aspect Ratio on Deformation during Diffusion Bonding and Impact of Metal Diffusion and Evaporation on Temperature Measurement Accuracy

Thomas Gietzelt, Volker Toth, Manfred Kraut, Uta Gerhards, Robin Duerrschnabel

Subject: Engineering, Industrial And Manufacturing Engineering Keywords: diffusion welding; diffusion bonding; cross section width; aspect ratio; material thickness; thermocouple aging

Online: 29 February 2020 (09:01:14 CET)

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Diffusion bonding is often used on pre-machined parts to generate internal cavities, e.g. for cooling injection molding tools close to the mold cavity. Only then, the workpieces are finished to their final dimensions. In the case of micro-process devices, however, it is essential to precisely control the deformation, as otherwise uncontrollable pressure losses will occur with channel cross-sections in the sub-millimeter range. Post-processing is not possible. The most important process parameters for diffusion bonding are temperature, dwell time and contact pressure, with the bonding temperature and contact pressure acting in opposite directions and showing a strong non-linear dependence on deformation. In addition, the deformation is influenced by a number of other factors such as the absolute size of the cross-section and the aspect ratio of the parts, the dimensions and distribution of the internal cross sections and the overall percentage of the cross-section to be bonded. In micro process engineering, small material cross-sections in the range of the materials microstructure can facilitate additional deformation mechanisms such as grain boundary sliding, which are not relevant at all for larger structures. For parts consisting of multiple layers, tolerances in thickness and roughness of multiple surfaces must be levelled, contributing to the percentaged deformation. This makes it difficult, especially in micro process engineering and in single or small series production, to determine suitable joining parameters in advance, which on the one hand do not cause unforeseen large deformations, but on the other hand reliably produce highly vacuum-tight components. Hence, a definition of a fixed percentaged deformation does not work for all kinds of components. This makes it difficult to specify parameters for surely obtain high-vacuum tight parts. For successful diffusion bonding, atoms must diffuse over the bonding planes, forming a monolithic part in which the original layers are no longer visible. Only then, mechanical properties identical to those of the base material, which has been subjected to identical heat treatment, can be achieved. In this paper, the impacts of different material cross section widths as well as of the aspect ratio on deformation were investigated. By accident, it was found that also accuracy of the temperature measurement may have a serious impact in terms of deformation.

Preprint ARTICLE | doi:10.20944/preprints202010.0339.v1

Aging Induces Profound Changes in sncRNA in Rat Sperm and these Changes are Modified by Perinatal Exposure to Environmental Flame Retardant

Alexander Suvorov, Vladimir Naumov, Victoria Shtratnikova, J.Richard Pilsner, Anna Zheludkevich, Evgeny Gerasimov, Maria Logacheva, Oleg Sergeyev

Subject: Biology And Life Sciences, Biochemistry And Molecular Biology Keywords: aging; paternal exposure; sperm; semen; epigenetics; sncRNA; piRNA; miRNA; 2,2′,4,4′-tetrabromodiphenyl ether; PBDE; BDE-47; perinatal; environment.

Online: 16 October 2020 (08:10:16 CEST)

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Preprint ARTICLE | doi:10.20944/preprints202105.0473.v1

Temporal Dynamics of Event-Related Potentials During Inhibitory Control Characterize Age-Related Neural Compensation

Elizabeth R Paitel, Kristy A Nielson

Subject: Social Sciences, Behavior Sciences Keywords: inhibitory control; executive function; event-related potentials; electroencephalography; N200; P300; cognitive aging; neural recruitment

Online: 20 May 2021 (10:18:16 CEST)

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Preprint REVIEW | doi:10.20944/preprints202401.1378.v1

Recent Advance Bakuchiol Application as a Potential Alternative to Retinol in Skincare and Cosmetics

Norisca Aliza Putriana, Patihul Husni, Soraya Ratnawulan Mita

Subject: Medicine And Pharmacology, Pharmacy Keywords: Bakuchiol; anti-aging; anti-hyperpigmentation; anti-oxidant; anti-inflammatory; anti-acne; and anti-melanogenesis

Online: 18 January 2024 (07:23:52 CET)

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Working Paper ARTICLE

Evaluation of Punicalagin Niosomes for Skin Aging

Ebtesam A. Mohamad, Aya A. Aly, Aya A. Khalaf, Mona I. Ahmed, Reham M. Kamel, Sherouk M. Abdelnaby, Yasmine H. Abdelzaher, Marize G. Sedrak, Shaker A. Mousa

Subject: Biology And Life Sciences, Biochemistry And Molecular Biology Keywords: skin aging; punicalagin; niosomes; UV radiation; collagen

Online: 24 March 2021 (17:35:18 CET)

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Preprint ARTICLE | doi:10.20944/preprints202207.0038.v1

Progeria and Aging - Omics Based Comparative Analysis

Aylin Caliskan, Samantha Agnetz Wilhelmine Crouch, Sara Giddins, Thomas Dandekar, Seema Dangwal

Subject: Biology And Life Sciences, Biochemistry And Molecular Biology Keywords: progeria; aging; omics; RNA Sequencing; bioinformatics; sun exposure; HGPS; IGFBP2; ACKR4; WNT

Online: 4 July 2022 (08:10:10 CEST)

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Preprint REVIEW | doi:10.20944/preprints202012.0079.v1

Mitophagy and the Brain

Natalie Swerdlow, Heather Wilkins

Subject: Medicine And Pharmacology, Immunology And Allergy Keywords: Mitochondria; Alzheimer’s Disease; mitophagy; neurodegeneration; aging

Online: 3 December 2020 (10:36:29 CET)

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Preprint REVIEW | doi:10.20944/preprints202402.0207.v1

The Neuroprotective and Cognitive-Enhancing Effects of Bacopa monnieri: A Systematic Review

Luiz José Valotto Neto, Matheus Reverete, Renato Cesar Moretti Junior, Nathalia Mendes Machado, Rakesh Kumar Joshi, Daiane dos Santos Buglio, Caroline Barbalho Lamas, Rosa Direito, Lucas Fornari Laurindo, Masaru Tanaka, Sandra Maria Barbalho

Subject: Medicine And Pharmacology, Medicine And Pharmacology Keywords: Bacopa monnieri; phytotherapy (plants, medicinal, herbal medicine); neurodegenerative diseases; Alzheimer´; s disease; memory; cognitive functions; aging; neuroprotection; oxidative stress; antioxidants; neuropharmacology

Online: 5 February 2024 (04:02:47 CET)

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Preprint CASE REPORT | doi:10.20944/preprints202002.0280.v1

Novel Morphological Alteration and Neural Pathway of NADPH Diaphorase Positivity in the Spinal Cord with Disc Herniation of Aged Dog: A Case Report

Yinhua Li, Yunge Jia, Wei Hou, Huibing Tan

Subject: Medicine And Pharmacology, Veterinary Medicine Keywords: spinal disc herniation, dog, NADPH diaphorase, the aging-related NADPH diaphorase body, megaloneurite, homogeneous formazan globule, intermedial collateral pathway

Online: 19 February 2020 (11:47:26 CET)

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Preprint ARTICLE | doi:10.20944/preprints202102.0091.v1

Frailty as a Moderator of the Relationship Between Social Isolation and Health Outcomes in Community-Dwelling Older Adults

Fereshteh Mehrabi, François Béland

Subject: Public Health And Healthcare, Public Health And Health Services Keywords: Frailty; Social Isolation; Social Networks; Social Support; Social Participation; Aging

Online: 2 February 2021 (14:32:33 CET)

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Preprint ARTICLE | doi:10.20944/preprints202004.0429.v1

Almond Skin Extracts and Chlorogenic Acid Delay Replicative Aging by Enhanced Oxidative Stress Response Involving SIR2 and SOD2 in Yeast

Duangjai Tungmunnithum, Malika Abid, Ahmed Elamrani, Samantha Drouet, Mohamed Addi, Christophe Hano

Subject: Biology And Life Sciences, Biochemistry And Molecular Biology Keywords: Aging; Almond; Chlorogenic acid; Lipid peroxidation; Mitochondria; 8-Oxo-guanine; Oxidative stress; Protein carbonylation; Sirtuin; Superoxide dismutase; Yeast

Online: 24 April 2020 (08:54:52 CEST)

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Preprint ARTICLE | doi:10.20944/preprints202202.0130.v1

The Real Cause of Differential Aging in the Twin “paradox”

Gordon Liu

Subject: Physical Sciences, Theoretical Physics Keywords: Twin paradox; Relativity; Space-time; Time dilation; Differential aging

Online: 9 February 2022 (10:20:33 CET)

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Preprint ARTICLE | doi:10.20944/preprints202101.0432.v1

Once/Day Provision of Essential Amino Acid Enriched Meal Replacement Improves Body Composition and Physical Function in Obese Elderly

Melynda Coker, Kaylee Ladd, Zeinab Barati, Carl Murphy, Terry Bateman, Bradley Newcomer, Robert Wolfe, Robert Coker

Subject: Medicine And Pharmacology, Immunology And Allergy Keywords: skeletal muscle; adipose tissue; aging

Online: 22 January 2021 (08:40:26 CET)

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Preprint REVIEW | doi:10.20944/preprints202110.0197.v1

Two Opposing Functions of Angiotensin-Converting Enzyme (ACE) That Links Hypertension, Dementia, and Aging

Duc Le, Lindsay Brown, Kundan Malik, Shin Murakami

Subject: Medicine And Pharmacology, Cardiac And Cardiovascular Systems Keywords: AGING; Age-related comorbidities; Angiotensin-Converting Enzyme; Amyloid-degrading enzyme; Alzheimer’s disease; Dementia; Hypertension; Life extension; Stress resistance

Online: 13 October 2021 (11:04:43 CEST)

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Preprint ARTICLE | doi:10.20944/preprints202007.0146.v1

Fenugreek (Trigonellafoenum-graecum L.) Seeds Dietary Supplementation Regulates Liver Antioxidant Defense Systems in Aging Mice

Devesh Tewari, Artur Jóźwik, Małgorzata Łysek-Gładysińska, Weronika Grzybek, Wioletta Adamus-Białek, Jacek Bicki, Nina Strzałkowska, Agnieszka Kamińska, Olaf K. Horbańczuk, Atanas G. Atanasov

Subject: Biology And Life Sciences, Biology And Biotechnology Keywords: fenugreek; aging; liver; antioxidants; mice

Online: 8 July 2020 (11:03:10 CEST)

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Preprint REVIEW | doi:10.20944/preprints202204.0055.v1

Activity-Dependent Induction of Younger Molecular, Cellular and Organism Phenotypes

Thomas Lissek

Subject: Biology And Life Sciences, Biochemistry And Molecular Biology Keywords: cell; biology; aging; medicine; transcription; activity; neurons; brain; immune system; muscle

Online: 7 April 2022 (04:24:23 CEST)

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Working Paper ARTICLE

Circulating MicroRNA-486 and MicroRNA-146a Serve as Potential Biomarkers of Sarcopenia in the Elderly

Huang-Chun Liu, Der-Sheng Han, Chih-Chin Hsu, Jong-Shyan Wang

Subject: Medicine And Pharmacology, Immunology And Allergy Keywords: aging; microRNA; sarcopenia; cytokine

Online: 20 August 2020 (07:39:53 CEST)

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Age-related sarcopenia meaningfully increases the risks of functional limitations and mortality in the elderly. Although circulating microRNAs (c-miRNAs) are associated with aging-related cellular senescence and inflammation, the relationships between c-miRNAs and sarcopenia in the elderly remain unclear. This study investigates whether circulating myo-miRNAs and inflammation-related miRNAs are associated with sarcopenia in the elderly. This study recruited 77 eligible subjects (41 males and 36 females) from 597 community-dwelling older adults, and then divided into normal (n=24), dynapenic (loss of muscular function without mass, n=35), and sarcopenic groups (loss of muscular function with mass, n=18). Moreover, myo-miRNAs (c-miRNA-133a and c-miRNA-486), inflammation-related miRNAs (c-miRNA-21 and c-miRNA-146a), and inflammatory-related cytokine levels in plasma were determined using quantitative polymerase chain reaction and ELISA, respectively. The results demonstrated that sarcopenic group exhibited lesser skeletal muscle mass index (SMI), handgrip strength, and gait speed, as well as, lower c-miR-486 and c-miR-146a levels, compared to those of normal and dynapenic groups. Moreover, c-miR-486 level was positively related to SMI (r=0.334, P=0.003), whereas c-miR-146a level was positively associated with SMI (r=0.240, P=0.035) and handgrip strength (r=0.253, P=0.027). In the receiver operating characteristic analysis for predicting sarcopenia, the area under the curve in c-miR-486 was 0.708 (95% confidence interval: 0.561-0.855, P=0.008) and c-miR-146a was 0.676 (95% CI: 0.551-0.801, P=0.024). However, no significant relationships were observed between SMI/ handgrip strength/gait speed and plasma myeloperoxidase/interleukin-1?/interleukin-6 levels. In conclusion, myo-miRNA (c-miR-486) and inflammation-related miRNA (c-miR-146a) are superior to inflammatory peroxide/cytokines in plasma for serving as critical biomarkers of age-related sarcopenia.

Preprint ARTICLE | doi:10.20944/preprints202304.0394.v1

Performance of Thermal-Oxidative Aging on the Structure and Properties of Ethylene Propylene Diene Monomer (EPDM) Vulcanizates

Hu Quanchao, Chen Qiang, Song Peiru, Gong Xingyu, Chen Junyi, Zhao Yongxian

Subject: Chemistry And Materials Science, Polymers And Plastics Keywords: EPDM vulcanizates; thermal-oxidative aging; thermal decomposition kinetics; antioxidant

Online: 17 April 2023 (04:07:38 CEST)

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Preprint REVIEW | doi:10.20944/preprints202207.0423.v1

Is “Cellular Senescence” a Misnomer?

David Gems, Carina Kern

Subject: Biology And Life Sciences, Cell And Developmental Biology Keywords: Aging; cellular senescence; fibroblast; osteoarthritis; remodeling-associated secretory phenotype (RASP); remodeling activation

Online: 27 July 2022 (13:38:36 CEST)

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Preprint ARTICLE | doi:10.20944/preprints202010.0572.v1

Effects of Tenascin C on the Integrity of Extracellular Matrix and Skin Aging

Young Eun Choi, Min Ji Song, Mari Hara, Kyoko Imanaka-Yoshida, Dong Hun Lee, Jin Ho Chung, Seung-Taek Lee

Subject: Biology And Life Sciences, Biochemistry And Molecular Biology Keywords: aging; collagen; extracellular matrix; fibroblast; skin; tenascin C; TGF-β

Online: 28 October 2020 (08:49:54 CET)

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Preprint ARTICLE | doi:10.20944/preprints202007.0741.v1

Habitual Exercise Attenuates the Aging Associated Muscle Atrophy and Muscle Strength Decline in SAMP8

Kai Aoki, Masaki Konno, Katsunari Honda, Takuya Abe, Takeshi Nagata, Masaaki Takehara, Takehito Sugasawa, Kazuhiro Takekoshi, Hajime Ohmori

Subject: Biology And Life Sciences, Aging Keywords: Aging; Habitual exercise; SAMP8; Sarcopenia

Online: 31 July 2020 (09:55:18 CEST)

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Preprint REVIEW | doi:10.20944/preprints202106.0701.v1

Features of Retinal Neurogenesis as a Key Factor of Age-Related Neurodegeneration: Myth or Reality?

Darya Telegina, Oyuna Kozhevnikova, Anna Antonenko, Nataliya Kolosova

Subject: Biology And Life Sciences, Anatomy And Physiology Keywords: retina; neurodegeneration; AMD; aging; neurogenesis; development; transcription factor

Online: 29 June 2021 (12:41:56 CEST)

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Working Paper ARTICLE

Chronic Effectiveness of Walking With Blood Flow Restriction on the Activation and Strength in Osteoporotic Older Women: A Randomized Clinical Trial

Simoni Teixeira Bittar, Heleodório Honorato Santos, Leonardo Silva Leandro, Leonardo Santos Oliveira, Maria Socorro Cirilo-Sousa

Subject: Medicine And Pharmacology, Immunology And Allergy Keywords: aging; aerobic exercise; vascular occlusion; electromyography

Online: 19 March 2021 (11:11:26 CET)

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Preprint REVIEW | doi:10.20944/preprints202402.0879.v1

Neurodegeneration in Cognitive Impairment and Mood Dis-orders for Experimental, Clinical and Translational Neuropsy-chiatry

Simone Battaglia, Alessio Avenanti, László Vécsei, Masaru Tanaka

Subject: Medicine And Pharmacology, Psychiatry And Mental Health Keywords: Alzheimer’ s disease;
Parkinson’ s disease;
aging decline;
mild cognitive impairment;
multiple sclerosis;
stroke;
psychiatric disorders;
depressive disorder;
bipolar disorder;
post-traumatic stress disorder;
anxiety disorder;
schizophrenia;
somatic symptom disorder;
autism spectrum disorder;
hyperactive attention deficit disorder;
learning disabilities;
acquired brain damage;
altered cognitive processes;
brain functional impairment;
neurocognitive disorders;
cognitive, behavioral, and functional disorders;
acquired trauma;
brain plasticity and connectivity;
non-invasive brain stimulation;
diagnosis and treatment;
functional evidence of altered cognition and connectivity

Online: 16 February 2024 (05:40:14 CET)

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Preprint BRIEF REPORT | doi:10.20944/preprints202107.0075.v1

Accurate Epigenetic Aging in Bottlenose Dolphins (Tursiops Truncatus), an Essential Step in the Conservation of at-Risk Dolphins.

Ashley Barratclough, Cynthia R. Smith, Forrest M. Gomez, Theoni Photopoulou, Ryan Takeshita, Enrico Pirotta, Len Thomas, Abby M. McClain, Celeste Parry, Joseph A Zoller, Steve Horvath, Lori H Schwacke

Subject: Biology And Life Sciences, Anatomy And Physiology Keywords: DNA methylation; epigenetic aging; bottlenose dolphin; chronological age

Online: 5 July 2021 (07:59:15 CEST)

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Preprint REVIEW | doi:10.20944/preprints202111.0043.v1

Managing Skin Ageing as a Modifiable Disorder – The Clinical Application of Nourella® Dual Approach Comprising a Nano-encapsulated Retinoid, Retilex-A® and a Skin Proteoglycan Replacement Therapy, Vercilex®

Jan Wadstein, Israel Sánchez Alvarez, Erling Thom, Lidia Bernal López

Subject: Medicine And Pharmacology, Dermatology Keywords: Skin Aging; Rejuvenation; Skin Cream; Retinoid formulation; RetileX-A; Vercilex

Online: 2 November 2021 (10:55:27 CET)

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Preprint REVIEW | doi:10.20944/preprints202111.0138.v1

Fundamental Clock of Biological Aging: Convergence of Molecular, Neurodegenerative, Cognitive, and Psychiatric Pathways: Non-Equilibrium Thermodynamics Meet Psychology

Victor Vasilyevich Dyakin, Nika Victorovna Dyakina-Fagnano, Laura Beth McIntire, Vladimir Nikolaevich Uversky

Subject: Biology And Life Sciences, Anatomy And Physiology Keywords: spontaneous; non-enzymatic; post translational modifications; racemization; biological clock; natural selection; allostatic load; psychological aging; psychological stress; stress response sys-tem; phase transitions.

Online: 8 November 2021 (13:08:58 CET)

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Preprint REVIEW | doi:10.20944/preprints202211.0255.v3

How Much of Aging Is Simply a Trash Collection Problem?

Michael Renteln

Subject: Biology And Life Sciences, Aging Keywords: Anti-aging therapy; lipofuscin; SENS; oncolytic vector; telomerase; TFEB; intracellular microbe

Online: 22 February 2023 (15:24:21 CET)

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Preprint ARTICLE | doi:10.20944/preprints202012.0683.v1

Effectiveness of tDCS to Improve Recognition and Reduce False Memories in Older Adults

Juan C Melendez, Encarnación Satorres, Alfonso Pitarque, Iraida Delhom, Elena Real, Joaquin Escudero

Subject: Social Sciences, Psychology Keywords: transcranial direct current stimulation; true recognition; false recognition; aging; experiment.

Online: 28 December 2020 (11:15:38 CET)

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Preprint REVIEW | doi:10.20944/preprints202205.0217.v1

Longevity, Aging and Cancer: Thermodynamics and Complexity

J.M. Nieto-Villar, R. Mansilla

Subject: Biology And Life Sciences, Cell And Developmental Biology Keywords: longevity; aging; cancer; complex systems; non-equilibrium thermodynamics; biological phase transition; ferroptosis

Online: 17 May 2022 (03:16:18 CEST)

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Preprint ARTICLE | doi:10.20944/preprints202011.0688.v1

Colour Fixation Strategies on Sustainable Polybutylene Succinate Using Biobased Itaconic Acid

Lidia García-Quiles, Julio Vidal, Debora Puglia, Franco Dominici, Ángel Fernández, Pere Castell

Subject: Chemistry And Materials Science, Biomaterials Keywords: Biopolymers; Biocomposites; Polybutylene succinate; Itaconic Acid; Zirconium oxide; Colourant; Diazo pigment; Extrusion-compounding; Mechanical properties; Hardness; Colour fixing; Gloss; Aging effect; SEM (Scanning Electron Microscopy); Wettability

Online: 27 November 2020 (12:50:24 CET)

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Preprint ARTICLE | doi:10.20944/preprints202005.0074.v1

The Effects of Age, Gender, and Control Device in a Virtual-Reality Driving Simulation

Wen-Te Chang

Subject: Arts And Humanities, Philosophy Keywords: VR; aging effect; gender difference; control device; wayfinding strategy

Online: 5 May 2020 (11:32:12 CEST)

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Preprint ARTICLE | doi:10.20944/preprints202304.1128.v1

Mitochondrial Function-Associated APOE Locus and its Implication in Alzheimer’s Disease and Aging

Eun-Gyung Lee, Lesley Leong, Sunny Chen, Jessica Tulloch, Chang-En Yu

Subject: Biology And Life Sciences, Aging Keywords: APOE locus; TOMM40; APOE; oxidative stress; mitochondrial dysfunction; mitochondrial DNA copy number; gene expression; Alzheimer’s disease; aging

Online: 28 April 2023 (07:08:33 CEST)

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Preprint REVIEW | doi:10.20944/preprints202112.0468.v1

Opioids in the Elderly Patients with Cognitive Impairment: A Narrative Review

Martina Rekatsina, Antonella Paladini, Dariusz Myrcik, Omar Viswanath, Ivan Urits, Joseph Pergolizzi, Frank Breve, Giustino Varrassi

Subject: Medicine And Pharmacology, Anesthesiology And Pain Medicine Keywords: aging; elderly; pain; opioids; dementia; cognitive impairment

Online: 29 December 2021 (13:42:02 CET)

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Preprint REVIEW | doi:10.20944/preprints202309.0059.v1

Enhancing Skin Anti-Aging Through Healthy Lifestyle Factors

Helen Knaggs, Edwin D Lephart

Subject: Medicine And Pharmacology, Dermatology Keywords: Skin; Anti-aging; Health, Lifestyle Factors, Diet, Sleep, Exercise, Social interactions, Polyphenols, Vitamins

Online: 1 September 2023 (10:30:06 CEST)

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Preprint ARTICLE | doi:10.20944/preprints202112.0120.v1

Metabolomic Profiles of Mice Tissues Reveals an Interplay Between Aging and Energy Metabolism

Qishun Zhou, Jakob Kerbl-Knapp, Fangrong Zhang, Melanie Korbelius, Katharina Barbara Kuentzel, Nemanja Vujic, Alena Akhmetshina, Gerd Hörl, Margret Paar, Ernst Steyrer, Dagmar Kratky, Tobias Madl

Subject: Biology And Life Sciences, Endocrinology And Metabolism Keywords: aging; NMR spectroscopy; mice; energy metabolism; fat; intestine; metabolomics

Online: 8 December 2021 (12:03:07 CET)

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Preprint ARTICLE | doi:10.20944/preprints202111.0082.v1

Heat Shock Factor 1 Directly Regulates Postsynaptic Scaffolding PSD-95 in Aging and Huntington’s Disease and Influences Striatal Synaptic Density

Nicole Zarate, Taylor A Intihar, Dahyun Yu, Jacob Sawyer, Wei Tsai, Maha Syed, Luke Carlson, Rocio Gomez-Pastor

Subject: Biology And Life Sciences, Biochemistry And Molecular Biology Keywords: HSF1; PSD-95; aging; Huntington’s disease

Online: 3 November 2021 (14:08:46 CET)

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Preprint ARTICLE | doi:10.20944/preprints202112.0026.v2

Telomere Shortening linked to Disability and Mitochondrial DNA Copy Number in Patients with Relapsing-Remitting Multiple Sclerosis

José Alfonso Cruz-Ramos, Gabriela del Carmen López-Armas, Eduardo Ignacio Díaz-Barba, Mónica Navarro-Meza, Miguel Ángel Macías-Islas, Ana Miriam Saldaña-Cruz, Abraham Zepeda-Moreno, Héctor Raúl Pérez-Gómez, Alejandra Martínez-Hernández, Martha Eloísa Ramos-Márquez

Subject: Medicine And Pharmacology, Neuroscience And Neurology Keywords: Leukocyte telomere length; Mitochondrial DNA; Relapsing- Remittent Multiple Sclerosis; Disability; Aging

Online: 7 December 2021 (12:35:12 CET)

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Preprint REVIEW | doi:10.20944/preprints202111.0458.v1

Age-Dependent Decline of NAD+ - Universal Truth or Confounded Consensus?

Augusto Peluso, Mads Vargas Damgaard, Marcelo Alves Mori, Jonas Thue Treebak

Subject: Biology And Life Sciences, Anatomy And Physiology Keywords: NAD+; aging; yeast; C. elegans; mouse; rat; monkey; human

Online: 24 November 2021 (13:10:22 CET)

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Preprint ARTICLE | doi:10.20944/preprints202211.0342.v1

Burying and Burrowing Behavior in Male and Female Normal and 3xTg-AD Mice: A New Comprehensive Study Based on the Two-Zone Configuration.

Mikel Santana-Santana, Jose R. Bayascas, Lydia Giménez-Llort

Subject: Social Sciences, Behavior Sciences Keywords: neuroethology; methodology; sexual differences; aging; Alzheimer’s disease; marble burying test; burrowing test; repetitive behavior

Online: 18 November 2022 (01:08:33 CET)

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Preprint REVIEW | doi:10.20944/preprints202307.1412.v1

Hydrogen Assisted Aging to Storage & Sealing Materials: A Comprehensive Review

A.K.M. Ahsanul Habib, Ahmed Nazmus Sakib, Zarin Tasnim Mona, Md Monjur Hossain Bhuiyan, Pejman Kazempoor, Zahed Siddique

Subject: Engineering, Chemical Engineering Keywords: hydrogen; aging; polymer; storage and sealing materials; sustainability; pipeline; leak

Online: 20 July 2023 (10:11:53 CEST)

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Preprint ARTICLE | doi:10.20944/preprints202008.0485.v1

Analysis of Age-Based Bone Mineral Density in the Koran Adult population using Dual Energy X-ray Absorptiometry

Jung Chul Lee, Hee-Joo Lee, Jaeyong Park

Subject: Biology And Life Sciences, Aging Keywords: DEXA; BMD; BMC; Osteoporosis; BMI; Aging

Online: 21 August 2020 (11:29:10 CEST)

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Preprint ARTICLE | doi:10.20944/preprints202212.0282.v1

A Two-step FE Model Updating Approach for System and Damage Identification of Full-Scale Prestressed Bridge Girders

Niloofar Malekghaini, S. Farid Ghahari, Hamed Ebrahimian, Matthew Bowers, Eric Ahlberg, Ertugrul Taciroglu

Subject: Engineering, Civil Engineering Keywords: Modal-based model updating, Bayesian model updating, System identification, Damage identification, Operational health monitoring, I-girder, Bridge, Aging.

Online: 15 December 2022 (10:10:39 CET)

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Working Paper ARTICLE

Assessment of Cognitive Aging Using an SSVEP-Based Brain Computer Interface System

Saraswati Sridhar, Vidya Manian

Subject: Medicine And Pharmacology, Other Keywords: brain-computer Interface; cognitive aging; steady-state visual evoked potential, neural network; detection accuracy; band power

Online: 13 May 2019 (08:32:23 CEST)

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Preprint ARTICLE | doi:10.20944/preprints202007.0672.v1

Mathematical Connection Between Short Telomere Induced Senescence Calculation and Mortality Rate Data

Jerry B. Torrance, Steve Goldband

Subject: Biology And Life Sciences, Aging Keywords: aging; telomeres; senescence; mortality; disease

Online: 28 July 2020 (10:07:22 CEST)

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Preprint ARTICLE | doi:10.20944/preprints202107.0128.v1

Characterization and Thermal Aging Tests of Cr Based Multilayer for Unconcentrated Solar Thermal Applications

Antonio Caldarelli, Carmine D'Alessandro, Davide De Maio, Daniela De Luca, Eliana Gaudino, Marilena Musto, Emiliano Di Gennaro, Roberto Russo

Subject: Chemistry And Materials Science, Biomaterials Keywords: Spectrally selective coating; Optical properties; Thermal stability; High temperature emissivity; Energy activation; Prediction of lifetime test; Thermal aging.

Online: 6 July 2021 (09:29:09 CEST)

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Preprint REVIEW | doi:10.20944/preprints202210.0248.v1

Resolving Darwin’s Dilemma over Natural Selection, Individual Benefit and Aging-on the Natural Selection of Organismal Aging

Richard Walker

Subject: Biology And Life Sciences, Aging Keywords: Trade-off of survival for reproduction; natural selection of aging; regulatory redundancy; aging’s individual benefit; regulatory molecular biology; Darwin’s dilemma; aging-reproduction trade-off; aging declines force of selection; master gene; holistic regulatory mechanism

Online: 18 October 2022 (04:36:09 CEST)

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Preprint REVIEW | doi:10.20944/preprints202305.1990.v1

The Central Role of the Kynurenine Pathway of Tryptophan Metabolism in the Pathophysiology of Frailty, Sarcopenia and Osteoporosis

Juan Ballesteros, Daniel Rivas, Gustavo Duque

Subject: Biology And Life Sciences, Aging Keywords: Tryptophan; Kynurenine pathway; Aging; older adults; Inflammation; Osteoporosis; Sarcopenia; Frailty; Biomarkers; Osteosarcopenia

Online: 29 May 2023 (07:32:17 CEST)

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Preprint ARTICLE | doi:10.20944/preprints202201.0263.v1

Novel ABC Transporter Associated with Fluconazole Resistance in Aging of Cryptococcus neoformans

Natalia Kronbauer Oliveira, Somanon Bhattacharya, Rina Gambhir, Manav Joshi, Bettina C Fries

Subject: Biology And Life Sciences, Immunology And Microbiology Keywords: drug resistance; ABC transporter; efflux pump; cryptococcosis; aging

Online: 18 January 2022 (15:56:02 CET)

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Preprint ARTICLE | doi:10.20944/preprints202107.0158.v1

Maria Casagrande, Francesca Agostini, Francesca Favieri, Giuseppe Forte, Jasmine Giovannoli, Angela Guarino, Andrea Marotta, Fabrizio Doricchi, Diana Martella

Subject: Social Sciences, Psychology Keywords: Attention; Attentional Networks; Alerting; Orienting; Executive Control; Aging; Lateralization

Online: 6 July 2021 (14:52:33 CEST)

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Preprint ARTICLE | doi:10.20944/preprints202207.0027.v1

Influence of Environmental Parameters and Fiber Orientation on Dissolution Kinetics of Glass Fibers in Polymer Composites

Andrey E. Krauklis, Hani Amir Aouissi, Selma Bencedira, Juris Burlakovs, Ivar Zekker, Irina Bute, Maris Klavins

Subject: Chemistry And Materials Science, Polymers And Plastics Keywords: glass fibers; composites; environmental aging; modeling; kinetics; water; pH; temperature; orientation; durability

Online: 4 July 2022 (03:44:24 CEST)

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Preprint TECHNICAL NOTE | doi:10.20944/preprints202009.0168.v1

Prediction of Lung Function in Adolescence Using Epigenetic Aging: A Machine Learning Approach

Md. Adnan Arefeen, Sumaiya Tabassum Nimi, M. Sohel Rahman, S. Hasan Arshad, John W. Holloway, Faisal I. Rezwan

Subject: Computer Science And Mathematics, Computer Science Keywords: lung function; epigenetic aging; machine learning; feature selection; hyperparamter tuning

Online: 8 September 2020 (03:15:28 CEST)

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Preprint REVIEW | doi:10.20944/preprints202309.2093.v1

The Hidden Dangers of Excess Folate, Uncovering the Molecular Mechanisms

ALI M FARDOUS, Ahmad R Heydari

Subject: Biology And Life Sciences, Biochemistry And Molecular Biology Keywords: Unmetabolized folic acid (UMFA); folic acid; one-carbon cycle; Methylation; epigenetic; carcinogenesis; aging; neurodevelopment; embryogenesis; folate

Online: 29 September 2023 (10:39:29 CEST)

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Preprint REVIEW | doi:10.20944/preprints202309.1932.v1

DNA damage response & senescence-associated secretory phenotype pathway: Emerging targets for anti-aging

Jawad Nadeem, Amna Parveen, Sun Yeou Kim

Subject: Medicine And Pharmacology, Medicine And Pharmacology Keywords: Anti-aging, DNA damage response, senescence-associated secretory phenotype

Online: 28 September 2023 (04:56:53 CEST)

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Preprint ARTICLE | doi:10.20944/preprints202310.0053.v1

On the Origin of Aging by Means of Natural Selection

Richard Francis Walker

Subject: Biology And Life Sciences, Aging Keywords: aging vs survival; DNA damage; double-stranded breaks; Gompertz-Makeham Law; developmental regulatory redundancy; tradeoffs vs emergent properties; fecundity; reproductive fitness; redundancy reliabiiity; programmed aging

Online: 2 October 2023 (08:08:57 CEST)

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Preprint ARTICLE | doi:10.20944/preprints202112.0360.v2

Rice Husk Shredding as a Means of Increasing the Long-Term Mechanical Properties of Earthen Mixtures for 3D Printing

Elena Ferretti, Massimo Moretti, Alberto Chiusoli, Lapo Naldoni, Francesco De Fabritiis, Massimo Visonà

Subject: Engineering, Civil Engineering Keywords: earthen buildings; 3D printing; sustainability; biocomposites; aging; mechanical properties; lime carbonation; vulcanization

Online: 11 January 2022 (12:14:21 CET)

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Preprint ARTICLE | doi:10.20944/preprints202311.0853.v1

Stress-Granules, P-bodies, and Cell Aging: A Bioinformatics Study

Yakov I. Mokin, Nikolay S. Ilyinsky, Semen V. Nesterov, Eugene Y. Smirnov, Olga S. Sergeeva, Anna E. Romanovich, Irina M. Kuznetsova, Konstantin K. Turoverov, Vladimir N. Uversky, Alexander V. Fonin

Subject: Biology And Life Sciences, Life Sciences Keywords: liquid-liquid phase separation; membrane-less organelles; stress granules; P-bodies; intrinsically disordered proteins; intrinsically disordered regions; aging; senescence; protein aggregation; nucleic acids; RNA-binding protein; DNA-binding protein

Online: 14 November 2023 (16:38:59 CET)

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At the molecular level, aging is often accompanied by dysfunction of stress-induced membrane-less organelles (MLOs) and changes in their material state. In this work, we analyzed the proteins included in the proteome of stress granules (SGs) and P-bodies for their tendency to transform the material state of these MLOs. Particular attention was paid to proteins whose gene expression changes during replicative aging. It was shown that the proteome of the studied MLOs practically does not differ in the analyzed characteristics and consists of completely or partially intrinsically disordered proteins, 30 - 40% of which are potentially capable of liquid-liquid phase separation (LLPS). At the same time, the proportion of proteins capable of spontaneous LLPS is relatively small, which indicates the leading role of nucleic acids in the biogenesis of these membrane-less organelles. Proteins whose gene expression changes during the transition of human cells to a senescent state make up about 20% of the studied proteomes. There is a statistically significant increase in the number of positively charged proteins in both datasets studied compared to the complete proteomes of these organelles. An increase in the relative content of DNA-, but not RNA-binding proteins, was also found in the stress-granules dataset with senescence-related processes. Among SG proteins potentially involved in senescent processes, there is an increase in the abundance of potentially amyloidogenic proteins compared to the whole proteome. The hnRPDL protein has the highest degree of disorder and highest propensity for LLPS among such proteins, which allows us to consider it as “potentially dangerous.” Proteins common to SGs and P bodies, potentially involved in processes associated with senescence, form clusters of interacting proteins. The largest cluster is represented by RNA-binding proteins involved in RNA processing and translation regulation. These data indicate that SG proteins, but not proteins of P-bodies, are more likely to transform the material state of MLOs. Furthermore, these MLOs can participate in processes associated with aging in a coordinated manner.

Preprint ARTICLE | doi:10.20944/preprints202301.0374.v1

Very Low and High Levels of Vitamin D are Associated with Shorter Leukocyte Telomere Length in 148,321 UK Biobank Participants

Chia-Ling Kuo, Ben Kirk, Meiruo Xiang, Luke C. Pilling, George A. Kuchel, Richard Kremer, Gustavo Duque

Subject: Medicine And Pharmacology, Medicine And Pharmacology Keywords: Telomerase; leukocyte telomere length; vitamin D; aging; serum levels; geroscience

Online: 22 January 2023 (03:36:34 CET)

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Preprint ARTICLE | doi:10.20944/preprints202308.1309.v1

Healthy Aging: Impact of Social Interaction on Psychological Well-Being in Older Adults— Longitudinal Study

Erika Ruperti-Lucero, Caridad López-Granero, Angel Barrasa

Subject: Social Sciences, Psychology Keywords: healthy aging; group dynamics; psychological well-being; older adult

Online: 18 August 2023 (09:18:38 CEST)

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Preprint ARTICLE | doi:10.20944/preprints202209.0377.v1

Calibrating A Comprehensive Immune Age Metric to Analyze the Cross Sectional Age-Related Decline in Cardiorespiratory Fitness

Peter Bröde, Maren Claus, Patrick D. Gajewski, Stephan Getzmann, Klaus Golka, Jan G. Hengstler, Edmund Wascher, Carsten Watzl

Subject: Biology And Life Sciences, Anatomy And Physiology Keywords: aging; immunosenescence; physical fitness; physical activity; obesity; sex

Online: 26 September 2022 (05:00:15 CEST)

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Preprint ARTICLE | doi:10.20944/preprints202306.1701.v1

Evaluating Sarcopenia Using Bioelectrical Impedance Vector Analysis and Phase Angle

Saizhao Tang, Fang Lin Jiang, Seon-Ho Eom, Jae-Young Lee, Ji Heon Chae, Chul-Hyun Kim

Subject: Public Health And Healthcare, Primary Health Care Keywords: bioelectrical impedance vector analysis; phase angle; aging; diagnosis; noninvasive

Online: 25 June 2023 (03:09:52 CEST)

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Sarcopenia becomes more common with age, being most prevalent among elderly individuals. According to the EWGSOP, muscle mass is one of the criteria for the evaluation of sarcopenia. The main methods for evaluating muscle mass are CT, MRI, and DXA, but these methods are difficult to apply in the field due to equipment costs, radioactivity, and lack of portability. BIVA and PhA are alternative approaches for assessing somatic cell mass and volume and do not require predictive equations. These variables are clinically relevant parameters that indicate cell health, especially cell membrane integrity and cell function. This study in sarcopenic and nonsarcopenic elderly volunteers aimed to determine the BIVA distribution pattern among individual sarcopenia patients; to evaluate the relationship between PhA and muscle strength, muscle quality, and physical function; and to find any correlates of PhA. The sample comprised 134 free-living elderly individuals of both sexes aged 69–91 years. Anthropometric parameters, grip strength, DXA findings, BIA results, and physical performance (the 6-meter walk test) were measured. Impedance vector distributions were evaluated in sarcopenia patients and healthy elderly individuals using BIVA. According to the AWGS criteria, sarcopenia was diagnosed according to DXA findings, grip strength and physical performance test results. Group differences were evaluated using the t test, Mann‒Whitney U test, and Hotelling's T2 test. Correlation analysis was performed to identify variables significantly associated with PhA. Linear regression analysis was performed to determine whether PhA was associated with muscle strength, muscle quality and physical function. BIVA detected a significant difference between the sarcopenia and non-sarcopenia groups (both sexes) due to higher R/H values and lower phase angles in a few individuals, whereas Xc/Ht values did not differ between the two groups. The sarcopenia group had a significantly lower PhA than the non-sarcopenia group among both males (p<0.01) and females (p<0.05). PhA was significantly correlated with age, ASM, HGS, and muscle quality in both sexes and significantly correlated with ASM/Ht2 and physical performance in males. PhA was a significant indicator of muscle strength in both males (β = 2.6; p<0.01) and females (β = 3.4; p<0.01), a significant indicator of muscle quality in both males (β = 0.07; p<0.05) and females (β = 0.17; p<0.01), and a significant indicator of physical performance in males (β = 0.3; p<0.01). BIVA can detect changes in muscle mass in individuals with sarcopenia and is a practical method for the assessment of sarcopenia in the field. PhA is a good indicator of muscle strength, muscle quality and physical performance (in males). These methods can help diagnose sarcopenia in elderly individuals with reduced mobility.

Preprint HYPOTHESIS | doi:10.20944/preprints202108.0267.v1

From Oncological Paradigms to Non-Communicable Disease Pandemic. The Need of Recovery Human Biology Evolution

Elia Biganzoli, Romano Demicheli

Subject: Medicine And Pharmacology, Oncology And Oncogenics Keywords: Cancer dormancy; Low-grade chronic inflammation; Healthy aging; Physical exercise

Online: 11 August 2021 (17:57:09 CEST)

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Preprint REVIEW | doi:10.20944/preprints202312.1823.v1

Eternal Youth: A Comprehensive Exploration of Gene, Cellular, and Pharmacological Anti-aging Strategies

Kristina V. Kitaeva, Valeriya V. Solovyeva, Nataliya L. Blatt, Albert A. Rizvanov

Subject: Biology And Life Sciences, Aging Keywords: aging; senolytic; senescent cells; AAV; anti-aging therapy; cell therapy; gene therapy

Online: 25 December 2023 (16:20:43 CET)

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Preprint ARTICLE | doi:10.20944/preprints202202.0208.v1

Lactobacillus Acidophilus DDS-1 Modulates the Gut Microbial Co-Occurrence Networks in Aging Mice

Ravichandra Vemuri, Christopher J. Martoni, Kylie Kavanagh, Rajaraman Eri

Subject: Biology And Life Sciences, Anatomy And Physiology Keywords: aging; intestinal microbiota; dysbiosis; probiotics; microbial co-occurrences

Online: 17 February 2022 (10:59:55 CET)

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Preprint ARTICLE | doi:10.20944/preprints202307.1589.v1

Replicative Senescence in Vascular Smooth Muscle Cells: PURPL and NEAT1 Long Non-Coding RNAs as New Senescence-Associated Biomarkers

Clara Rossi, Marco Venturin, Jakub Gubala, Angelisa Frasca, Alberto Corsini, Cristina Battaglia, Stefano Bellosta

Subject: Biology And Life Sciences, Cell And Developmental Biology Keywords: aging; biomarkers; lncRNA; NEAT1; PURPL; RRAD; senescence; smooth muscle cells

Online: 24 July 2023 (10:02:09 CEST)

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Preprint ARTICLE | doi:10.20944/preprints202304.0351.v1

Low-Temperature Aged Synthesis of CeO₂-coated Li-rich Oxide as Cathode for Low Cost High Energy Density Li-ion Batteries

Yanlin Liu, Bin Li, Min Chen, Weishan Li

Subject: Chemistry And Materials Science, Electrochemistry Keywords: Li-rich oxide; surface coating; cerium oxide; low temperature aging; lithium-ion battery

Online: 14 April 2023 (04:47:33 CEST)

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Preprint ARTICLE | doi:10.20944/preprints202305.0655.v1

Cognitive Aging in Older Breast Cancer Survivors

James C Root, Yuelin Li, Elizabeth Schofield, Irene Orlow, Elizabeth Ryan, Tiffany Traina, Sunita Patel, Tim A Ahles

Subject: Biology And Life Sciences, Aging Keywords: cancer; cognition; aging; deficit accumulation

Online: 9 May 2023 (12:37:24 CEST)

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Preprint ARTICLE | doi:10.20944/preprints202306.1184.v1

Diagnosing Alzheimer's Disease Levels Using Machine Learning and MRI: A Novel Approach

Reza Bahadori, Ali Akbar Kiaei, Hourieh Malek Zadeh, Mahnaz Boush, Sadegh Abadijou, Danial Safaei, Amir Hossein Mehdikhani

Subject: Public Health And Healthcare, Public Health And Health Services Keywords: Alzheimer's disease; neurological illness; dementia; machine learning; Magnetic Resonance Im-aging

Online: 16 June 2023 (07:28:28 CEST)

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Preprint REVIEW | doi:10.20944/preprints202311.1218.v1

Immunosenescence and Cytomegalovirus: Exploring Their Connection in the Context of Aging, Health, and Disease

Ludmila Müller, Svetlana Di Benedetto

Subject: Biology And Life Sciences, Immunology And Microbiology Keywords: aging; immunosenescence; cytomegalovirus; inflammaging; CMV latency; COVID-19; SARS-CoV-2; long COVID; age-related diseases

Online: 20 November 2023 (05:14:11 CET)

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Preprint HYPOTHESIS | doi:10.20944/preprints202204.0124.v1

Revisiting Epithelial Carcinogenesis

Luis Fernando Méndez-López

Subject: Biology And Life Sciences, Biochemistry And Molecular Biology Keywords: Senescence; EMT; NF-κB; Inflammation; Epigenetics; Aging

Online: 13 April 2022 (10:22:37 CEST)

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Preprint REVIEW | doi:10.20944/preprints202302.0516.v1

The Confound of Hemodynamic Response Function Variability in Resting-State Functional MRI Studies

D Rangaprakash, Robert Barry, Gopikrishna Deshpande

Subject: Biology And Life Sciences, Biophysics Keywords: BOLD fMRI; HRF; resting state connectivity; aging; sex differences; confound

Online: 28 February 2023 (09:32:04 CET)

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Preprint REVIEW | doi:10.20944/preprints202402.0378.v1

Targeting the Hallmarks of Aging with Vitamin D: Starting to Decode the Myth

Carmelinda Ruggiero, Laura Tafaro, Luisella Cianferotti, Flavia Tramontana, Ilaria Giovanna Macchione, Carla Caffarelli, Agostino Virdis, Marika Ferracci, Giuseppe Rinonapoli, Patrizia Mecocci, Nicola Napoli, Valeria Calsolaro

Subject: Medicine And Pharmacology, Other Keywords: aging; hallmarks of aging; vitamin D; clinical studies

Online: 6 February 2024 (15:25:32 CET)

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Preprint ARTICLE | doi:10.20944/preprints202208.0424.v1

Portuguese Version of the Aging Attitudes Questionnaire (AAQ): Validation of the Psychometric Properties

Margarida Pedroso de Lima, Paulo Martins, António-José Gonzalez

Subject: Social Sciences, Psychology Keywords: Aging; Attitudes; Subjective Well-being; Ageism; Psychometric Validation

Online: 25 August 2022 (03:17:06 CEST)

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Preprint ARTICLE | doi:10.20944/preprints202212.0364.v1

Efﬁcacy and Safety of Phaseolus angularis L for. as Anti-aging Therapy in Healthy Skin: A Single-Center, Randomized, Double-Blind, Placebo-Controlled Study

Sarang Oh, Jeehaeng Jeong, Xiangji Jin, Myeongju Kim, Shengdao Zheng, Tae-Hoo Yi

Subject: Medicine And Pharmacology, Dermatology Keywords: Phaseolus angularis seed extract (PASE); anti-aging; health skin, cosmetic products

Online: 20 December 2022 (09:03:36 CET)

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Preprint ARTICLE | doi:10.20944/preprints202209.0091.v1

Sex Specific Differences in Response to Calorie Restriction in Skeletal Muscle of Young Rats

Margalida Torrens-Mas, Cayetano Navas-Enamorado, Devin Wahl, Andres Sanchez-Polo, Anna Picca, Jordi Oliver, Pilar Roca, Marta Gonzalez-Freire

Subject: Biology And Life Sciences, Biochemistry And Molecular Biology Keywords: calorie restriction; aging; inflammation; autophagy; senescence.; skeletal muscle

Online: 6 September 2022 (11:01:40 CEST)

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Preprint ARTICLE | doi:10.20944/preprints202212.0332.v1

Effect of Aging of Orthodontic Aligners in Different Storage Media on Force and Torque Generation: An in vitro Study

Tarek Elshazly, Diva Nang, Bijan Golkhani, Hanaa Elattar, Christoph Bourauel

Subject: Chemistry And Materials Science, Biomaterials Keywords: Biomechanics; Orthodontic force; Torque; Tooth Movement; Removable Thermoplastic Appliance; Aging; Aligners

Online: 19 December 2022 (09:10:51 CET)

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Working Paper REVIEW

Appropriate Technologies to Accompany Sunscreens in the Battle Against Ultraviolet, Superoxide and Singlet Oxygen

Paolo Giacomoni

Subject: Biology And Life Sciences, Biochemistry And Molecular Biology Keywords: Ultraviolet; superoxide; singlet Oxygen; cell blebbing; skin aging; peroxidative cascade; antioxidants

Online: 21 October 2020 (10:32:55 CEST)

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Preprint ARTICLE | doi:10.20944/preprints202302.0290.v1

Neuroprotective Effect of Curcumin on Factors Involved in Neurogenesis and Angiogenesis in Aged Brain

Masoumeh Habibian, Seyyed Jafar Moosavi

Subject: Medicine And Pharmacology, Medicine And Pharmacology Keywords: aging; Apoptosis; Brain-derived neurotrophic factor; transforming growth factor β1; vascular endothelial growth factor

Online: 17 February 2023 (02:25:34 CET)

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Preprint ARTICLE | doi:10.20944/preprints202202.0153.v2

Trends in Excess Winter Mortality (EWM) From 1900/01 to 2019/20—Evidence for a Complex System of Multiple Long-Term Trends

Rodney P. Jones, Andrey Ponomarenko

Subject: Medicine And Pharmacology, Epidemiology And Infectious Diseases Keywords: winter mortality; trends; season; estimated influenza mortality; pandemic influenza; aging

Online: 25 February 2022 (14:24:30 CET)

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Preprint CASE REPORT | doi:10.20944/preprints202303.0017.v1

Characteristics of Sleep and Autonomic Activity in Active Older Adults Based on Metabolic Age: A Case Report

Miki Sato, Ryuichi Tanioka, Feni Betriana, Kyoko Osaka, Yueren Zhao, Tetsuya Tanioka, Akira Takahashi

Subject: Medicine And Pharmacology, Neuroscience And Neurology Keywords: healthy aging; autonomic nervous activities; heart rate variability; sleep status; well-being

Online: 1 March 2023 (09:12:46 CET)

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Preprint ARTICLE | doi:10.20944/preprints202212.0250.v1

Studying the Geroprotective Properties of YAP/TAZ Signaling Inhibitors on Drosophila melanogaster Model

Denis A. Golubev, Nadezhda V. Zemskaya, Anastasia A. Gorbunova, Daria V. Kukuman, Alexey A. Moskalev, Mikhail V. Shaposhnikov

Subject: Biology And Life Sciences, Biochemistry And Molecular Biology Keywords: YAP/TAZ, Drosophila, Aging, Geroprotector

Online: 14 December 2022 (06:51:24 CET)

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Preprint ARTICLE | doi:10.20944/preprints202304.0078.v1

Personalizing Digital Health: Adapting Health Technology Systems to Meet the Needs of Different Older Populations

Jennifer Jimenez, Alberto del Rio, Arianna N. Berman, Miriam Grande

Subject: Public Health And Healthcare, Public Health And Health Services Keywords: aging population; healthcare systems; healthcare system evaluation; chronic illness; digital healthcare; personalization; healthcare usability; healthcare satisfaction

Online: 6 April 2023 (08:48:56 CEST)

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Preprint ARTICLE | doi:10.20944/preprints202303.0145.v1

Factors Affecting the Vitamin C Dose-Concentration Relationship: Implications for Global Vitamin C Dietary Recommendations

Anitra C. Carr, Jens Lykkesfeldt

Subject: Medicine And Pharmacology, Dietetics And Nutrition Keywords: vitamin C; ascorbic acid; vitamin C requirements; vitamin C recommendations; body weight; obesity; smoking; aging; socioeconomic status; NHANES

Online: 8 March 2023 (03:47:32 CET)

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Vitamin C status is known to be associated with several demographic and lifestyle factors. These include gender, age, ethnicity, pregnancy/lactation, body weight, smoking status and dietary habits. In the present study, our aim was to interrogate the National Health and Nutrition Examination Survey (NHANES) 2017-2018 datasets to assess the impact of these factors on vitamin C dose-concentration relationships to establish if there are higher requirements for vitamin C in certain subpopulations and the possible extent of these additional requirements. The relevant data were extracted from the NHANES 2017-2018 datasets, the final cohort of which comprised 2828 non-supplementing adult males and females (aged 18 – 80+ years) with both vitamin C serum concentrations and dietary intake data available. The data was subsequently stratified by gender, age tertiles (≤36, 37-58, ≥59 years), ethnicity (non-Hispanic white, non-Hispanic black, and total Hispanic), socioeconomic tertiles (poverty income ratios: >3.0, 1.36 – 3.0, ≤1.35), weight tertiles (≤72, 72-91, ≥91 kg), BMI tertiles (≤26, 26-32, ≥32 kg/m2) and smoking status. Sigmoidal (four parameter logistic) curves with asymmetrical 95% confidence intervals were fitted to the dose-concentration data. We found that males required vitamin C intakes ~1.2-fold higher than females to reach ‘adequate’ serum concentrations of 50 µmol/L. Males had both higher body weight and a higher prevalence of smoking than females. Smokers required vitamin C intakes ~2.0-fold higher than non-smokers to reach adequate vitamin C concentrations. Relative to adults in the lighter weight tertile, adults in the heaver weight tertile required ~2.0-fold higher dietary intakes of vitamin C to reach adequate serum concentrations. We did not observe any impact of ethnicity or socioeconomic status on the vitamin C dose-concentration relationship, and although no significant difference between younger and older adults was observed at vitamin C intakes > 75 mg/day, at intakes < 75 mg/day, older adults had an attenuated serum response to vitamin C intake. In conclusion, certain demographic and lifestyle factors, specifically gender, smoking and body weight, have a significant impact on vitamin C requirements. Overall, the data indicate that the general population must consume ~110 mg/day of vitamin C to attain adequate serum concentrations, smokers require ~165 mg/day relative to non-smokers, and heavier people (100+ kg) require ~155 mg/day to reach the same vitamin C concentrations. These findings have important implications for global vitamin C dietary recommendations.

Preprint REVIEW | doi:10.20944/preprints202305.0598.v1

Aging Disrupts Circadian Rhythms in Mouse Liver Mitochondria

Wei Xu, Xiaodong Li

Subject: Biology And Life Sciences, Aging Keywords: circadian rhythms; aging; suprachiasmatic nucleus; peripheral clock; inflammatory response

Online: 9 May 2023 (08:19:43 CEST)

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Preprint ARTICLE | doi:10.20944/preprints202305.0538.v1

Genetic Targeting of the dTORC1 Inhibitor, dSAMTOR, during Drosophila Aging: A Tissue-specific Pathology

Stamatia A. Katarachia, Sophia P. Markaki, Athanassios D. Velentzas, Dimitrios J. Stravopodis

Subject: Biology And Life Sciences, Cell And Developmental Biology Keywords: Aging; Betaine; dBHMT; Drosophila; dSAMTOR; dTORC1; Kinase; Methionine; SAM

Online: 8 May 2023 (12:06:37 CEST)

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mTORC1 regulates mammalian cell metabolism and growth, in response to diverse environmental stimuli. Nutrient signals control the localization of mTORC1 onto lysosome-surface scaffolds that are critically implicated in its amino acid-dependent activation. Arginine, Leucine and S-Adenosyl-Methionine (SAM) can serve as major mTORC1-signaling activators, with SAM binding to SAMTOR (SAM + TOR), a fundamental SAM sensor, abolishing protein’s (SAMTOR’s) inhibitory action(s) against mTORC1, thereby releasing its (mTORC1) kinase activity. Given the lack of knowledge regarding the role of SAMTOR in invertebrates, we have, in silico, identified the Drosophila SAMTOR homologue (dSAMTOR) and have, herein, genetically targeted it, through utilization of the GAL4/UAS transgenic tool. Survival profiles and negative geotaxis patterns were examined both in control and dSAMTOR-downregulated adult flies, during aging. One of the two gene-targeted schemes resulted in lethal phenotypes, whereas the other one caused rather moderate pathologies in most tissues. Screening of head-specific kinase activities, via PamGene technology application, unveiled the significant upregulation of several kinases, including the dTORC1 characteristic substrate, dp70S6K, in dSAMTOR-downregulated flies, thus strongly supporting the inhibitory dSAMTOR function(s) upon dTORC1/dp70S6K signaling axis in Drosophila-brain settings. Importantly, genetic targeting of the Drosophila BHMT -bioinformatics- counterpart (dBHMT), an enzyme that catabolizes Betaine to produce Methionine (the SAM precursor), led to severe compromises in fly longevities, with glia-, motor neuron- and muscle-specific dBHMT downregulations exhibiting the strongest effects. Abnormalities in wing-vein architectures were also detected in dBHMT-targeted flies, thereby justifying their notably reduced negative geotaxis capacities, herein, observed, mainly in the brain-(mid)gut axis. In vivo adult-fly exposure to clinically relevant doses of Methionine revealed the mechanistic synergism of decreased dSAMTOR and increased Methionine levels in pathogenic longevity, thus rendering (d)SAMTOR an important component in Methionine-associated disorders, including Homocystinuria(s).

Preprint ARTICLE | doi:10.20944/preprints202203.0319.v1

Unveiling the Mechanisms of High-temperature 1/2[111] Screw Dislocation Glide in Iron--Carbon Alloys

Ivaylo Hristov Katzarov, Ljudmil Borisov Drenchev

Subject: Chemistry And Materials Science, Metals, Alloys And Metallurgy Keywords: dislocations; diffusion; FeC; Dynamic strain aging

Online: 24 March 2022 (02:20:36 CET)

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Preprint ARTICLE | doi:10.20944/preprints202208.0159.v1

Phosphatidylethanolamine N-methyltransferase Knockout Modulates Metabolic Changes in Aging Mice

Qishun Zhou, Fangrong Zhang, Jakob Kerbl-Knapp, Melanie Korbelius, Katharina B. Kuentzel, Nemanja Vujic, Alena Akhmetshina, Gerd Hörl, Margret Paar, Ernst Steyrer, Dagmar Kratky, Tobias Madl

Subject: Biology And Life Sciences, Endocrinology And Metabolism Keywords: metabolomics; NMR; PEMT; knockout; aging; mice; liver; intestine; white/brown adipose tissue

Online: 8 August 2022 (13:36:04 CEST)

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Preprint ARTICLE | doi:10.20944/preprints202307.1220.v1

PGC-1α Regulates the Interplay between Oxidative Stress, Senescence and Autophagy in the Aging Retina Important in Age-Related Macular Degeneration

Iswariyaraja Sridevi Gurubaran, Cezary Watala, Joanna Kostanek, Joanna Szczepanska, Elzbieta Pawlowska, Kai Kaarniranta, Janusz Blasiak

Subject: Biology And Life Sciences, Life Sciences Keywords: age-related macular degeneration; aging retina; peroxisome proliferator-activated receptor gamma coactivator 1-alpha; PGC-1 AMD; cellular senescence; autophagy; oxidative stress

Online: 18 July 2023 (11:09:42 CEST)

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Preprint ARTICLE | doi:10.20944/preprints202111.0387.v1

Balance Differences between North and South American Older Adults: A Cross-Sectional, Age and Sex Matched Study

Matheus Almeida Souza, Daniel Goble, Paige Arney, Edgar Ramos Vieira, Gabriela Silveira-Nunes, Leonardo Intelangelo, Michelle Almeida Barbosa, Alexandre Carvalho Barbosa

Subject: Medicine And Pharmacology, Orthopedics And Sports Medicine Keywords: Aging; Accidental Falls; Frail Elderly; Postural Balance

Online: 22 November 2021 (11:50:39 CET)

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Preprint ARTICLE | doi:10.20944/preprints202309.2114.v1

Prolonging Human Lifespan by Consciousness Integration or Brain Integration

Yaohua Xie

Subject: Biology And Life Sciences, Aging Keywords: Human; lifespan; aging; consciousness; brain; integration

Online: 30 September 2023 (17:55:59 CEST)

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Preprint BRIEF REPORT | doi:10.20944/preprints202303.0207.v2

Sex Age Annotated Omics Data: Enabling Powerful Omics Studies

Pietro Hiram Guzzi, Francesca Cortese, Raffaele Giancotti, Ugo Lomoio, Barbara Puccio, Patrizia Vizza, Giuseppe Tradigo, Pierangelo Veltri

Subject: Computer Science And Mathematics, Mathematical And Computational Biology Keywords: Annotation; Biological Databases; Aging Analysis

Online: 15 March 2023 (02:00:02 CET)

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Preprint ARTICLE | doi:10.20944/preprints202306.1021.v1

piRNAs and miRNAs Can Bind to mRNA of KLOTHO and FGF23 Genes

Anatoliy Ivashchenko, Kyrmyzy Akhmetova, Murat Zhanuzakov, Togzhan Niyazova, Makpal Tauassarova, Aigul Akimniyazova, Aron Salimgerei

Subject: Biology And Life Sciences, Biochemistry And Molecular Biology Keywords: piRNA; miRNA; KLOTHO gene; FGF23 gene; anti-aging gene

Online: 14 June 2023 (09:00:00 CEST)

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Preprint REVIEW | doi:10.20944/preprints202306.1948.v1

The Reduction of Mitochondrial Membrane Potential in Aging: The Role of the Mitochondria Permeability Transition Pore

Hagai Rottenberg

Subject: Biology And Life Sciences, Aging Keywords: Aging, mitochondria, membrane potential, permeability transition pore, C. elegans

Online: 28 June 2023 (07:06:20 CEST)

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Preprint COMMUNICATION | doi:10.20944/preprints202204.0299.v3

A Simplistic and Cost-Effective Design for Real-World Development of an Ambient Assisted Living System for Fall Detection and Indoor Localization: Proof of Concept

Nirmalya Thakur, Chia Y. Han

Subject: Computer Science And Mathematics, Information Systems Keywords: elderly; aging population; ambient intelligence; fall detection; indoor localization; real-world implementation; sensors; activities of daily living; assisted living

Online: 21 July 2022 (10:46:08 CEST)

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Falls, highly common in the constantly increasing global aging population, can have a variety of negative effects on their health, well-being, and quality of life, including restricting their capabilities to conduct Activities of Daily Living (ADLs), which are crucial for one’s sustenance. Timely assistance during falls is highly necessary, which involves tracking the indoor location of the elderly during their diverse navigational patterns associated with ADLs to detect the precise location of a fall. With the decreasing caregiver population on a global scale, it is important that the future of intelligent living environments can detect falls during ADL.s while being able to track the indoor location of the elderly in the real world. Prior works in these fields have several limitations, such as – the lack of functionalities to detect both falls and indoor locations, high cost of implementation, complicated design, the requirement of multiple hardware components for deployment, and the necessity to develop new hardware for implementation, which make the wide-scale deployment of such technologies challenging. To address these challenges, this work proposes a cost-effective and simplistic design paradigm for an Ambient Assisted Living system that can capture multimodal components of user behaviors during ADLs that are necessary for performing fall detection and indoor localization in a simultaneous manner in the real world. Proof of concept results from real-world experiments are presented to uphold the effective working of the system. The findings from two comparison studies with prior works in this field are also presented to uphold the novelty of this work. The first comparison study shows how the proposed system outperforms prior works in the areas of indoor localization and fall detection in terms of the effectiveness of its software design and hardware design. The second comparison study shows that the cost for the development of this system is the least as compared to prior works in these fields, which involved real-world development of the underlining systems, thereby upholding its cost-effective nature.

Preprint REVIEW | doi:10.20944/preprints202305.0028.v1

The Role of Oxidative Stress and Antioxidants in Cardiovascular Comorbidities in COPD

Zsuzsanna Miklós, Ildikó Horváth

Subject: Medicine And Pharmacology, Clinical Medicine Keywords: antioxidants; arterial aging; airway inflammation; -Klotho; ROS; hydrogen peroxide; SOD; heart rate variability

Online: 1 May 2023 (11:23:19 CEST)

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Preprint ARTICLE | doi:10.20944/preprints202304.0287.v1

Influences of Cold Rolling and Aging on Microstructure and Property of CuCrSn Alloy

Tao Chen, Qingke Zhang, Feng Liu, Xiaolong Feng, Cheng Xu, Zhenlun Song

Subject: Chemistry And Materials Science, Metals, Alloys And Metallurgy Keywords: CuCrSn alloy; Cold rolling; Aging; Tensile strength; Conductivity.

Online: 13 April 2023 (03:24:33 CEST)

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