Preprint Article Version 1 Preserved in Portico This version is not peer-reviewed

Once/Day Provision of Essential Amino Acid Enriched Meal Replacement Improves Body Composition and Physical Function in Obese Elderly

Version 1 : Received: 21 January 2021 / Approved: 22 January 2021 / Online: 22 January 2021 (08:40:26 CET)

How to cite: Coker, M.; Ladd, K.; Barati, Z.; Murphy, C.; Bateman, T.; Newcomer, B.; Wolfe, R.; Coker, R. Once/Day Provision of Essential Amino Acid Enriched Meal Replacement Improves Body Composition and Physical Function in Obese Elderly. Preprints 2021, 2021010432 (doi: 10.20944/preprints202101.0432.v1). Coker, M.; Ladd, K.; Barati, Z.; Murphy, C.; Bateman, T.; Newcomer, B.; Wolfe, R.; Coker, R. Once/Day Provision of Essential Amino Acid Enriched Meal Replacement Improves Body Composition and Physical Function in Obese Elderly. Preprints 2021, 2021010432 (doi: 10.20944/preprints202101.0432.v1).

Abstract

We have previously demonstrated that the acute ingestion of essential amino acids may augment net protein balance in the elderly. Using a double blind, randomized controlled trial, our objective was to compare an experimental meal replacement enriched with essential amino acids (EMR) compared to a commercial meal replacement (Optifast®) provided once/day (q.d.) for four weeks on body composition and physical function in older, obese participants. Twenty-seven individuals (69±5 yrs; body mass index of 32±4 kg/m2) were randomly assigned to EMR (n=13) or Optifast® (n=15) supplementation. Measurements of body composition, skeletal muscle cross-sectional area (CSA), intrahepatic lipid and physical function were completed pre- and post-supplementation. Body mass, fat mass, and visceral fat mass were reduced with EMR but not altered with Optifast®. Thigh muscle CSA increased ( 4.1 ± 1.9 cm2, P = 0.03) with EMR but not Optifast®. There was a significant increase in the distance covered during the six-minute walk test with EMR ( 21±26 m) but no change in Optifast® ( 22±54 m). Improvements in body composition and physical function support the efficacious use of EMR-based meal replacements in the obese elderly.

Keywords

skeletal muscle; adipose tissue; aging

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