Preprint Article Version 1 Preserved in Portico This version is not peer-reviewed

Neuroprotective Effect of Curcumin on Factors Involved in Neurogenesis and Angiogenesis in Aged Brain

Version 1 : Received: 14 February 2023 / Approved: 17 February 2023 / Online: 17 February 2023 (02:25:34 CET)

How to cite: Habibian, M.; Moosavi, S.J. Neuroprotective Effect of Curcumin on Factors Involved in Neurogenesis and Angiogenesis in Aged Brain. Preprints 2023, 2023020290. https://doi.org/10.20944/preprints202302.0290.v1 Habibian, M.; Moosavi, S.J. Neuroprotective Effect of Curcumin on Factors Involved in Neurogenesis and Angiogenesis in Aged Brain. Preprints 2023, 2023020290. https://doi.org/10.20944/preprints202302.0290.v1

Abstract

Curcumin is a natural dietary polyphenol which that possesses potent anti-aging and neuroprotective properties through various mechanisms and signaling pathways. This study aimed to investigate the effect of curcumin on factors involved in neurogenesis and angiogenesis in the aged brain. Old female Wistar rats were divided into three equal groups (n=7): control, sham, and curcumin (received curcumin, i.p., 30 mg/kg and 5 days/week for 8 weeks) rats. Curcumin treatment caused a significant increase in the vascular endothelial growth factor (VEGF), Brain-derived neurotrophic factor (BDNF) and anti-apoptotic protein BCl-2 in the brains of aging rats but no significant effect on anti-apoptotic Bax protein. Additionally, curcumin attenuated brain lipid peroxidation and decreased transforming growth factor β1 (TGF-β1). These results suggested that curcumin possesses neuroprotective effects against brain aging, which were mediated by improvment in neurogenesis and angiogenesis. Also, curcumin could alleviate brain aging which may be due to attenuating oxidative stress, inhibiting apoptosis and down-regulating TGF-β1, which in turn enhances VEGF and BDNF. Therefore, curcumin has potential therapeutic value in the treatment of neurological apoptosis, neurogenesis and angiogenesis changes caused by brain aging.

Keywords

aging; Apoptosis; Brain-derived neurotrophic factor; transforming growth factor β1; vascular endothelial growth factor

Subject

Medicine and Pharmacology, Medicine and Pharmacology

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