Version 1
: Received: 13 June 2023 / Approved: 14 June 2023 / Online: 14 June 2023 (09:00:00 CEST)
How to cite:
Ivashchenko, A.; Akhmetova, K.; Zhanuzakov, M.; Niyazova, T.; Tauassarova, M.; Akimniyazova, A.; Salimgerei, A. piRNAs and miRNAs Can Bind to mRNA of KLOTHO and FGF23 Genes. Preprints2023, 2023061021. https://doi.org/10.20944/preprints202306.1021.v1
Ivashchenko, A.; Akhmetova, K.; Zhanuzakov, M.; Niyazova, T.; Tauassarova, M.; Akimniyazova, A.; Salimgerei, A. piRNAs and miRNAs Can Bind to mRNA of KLOTHO and FGF23 Genes. Preprints 2023, 2023061021. https://doi.org/10.20944/preprints202306.1021.v1
Ivashchenko, A.; Akhmetova, K.; Zhanuzakov, M.; Niyazova, T.; Tauassarova, M.; Akimniyazova, A.; Salimgerei, A. piRNAs and miRNAs Can Bind to mRNA of KLOTHO and FGF23 Genes. Preprints2023, 2023061021. https://doi.org/10.20944/preprints202306.1021.v1
APA Style
Ivashchenko, A., Akhmetova, K., Zhanuzakov, M., Niyazova, T., Tauassarova, M., Akimniyazova, A., & Salimgerei, A. (2023). piRNAs and miRNAs Can Bind to mRNA of <i>KLOTHO</i> and <i>FGF23</i> Genes. Preprints. https://doi.org/10.20944/preprints202306.1021.v1
Chicago/Turabian Style
Ivashchenko, A., Aigul Akimniyazova and Aron Salimgerei. 2023 "piRNAs and miRNAs Can Bind to mRNA of <i>KLOTHO</i> and <i>FGF23</i> Genes" Preprints. https://doi.org/10.20944/preprints202306.1021.v1
Abstract
The problem of increasing life expectancy is solved with the help of many medical and social areas. It has been established that piRNAs and miRNAs can significantly modify the expression of protein-coding genes by suppressing the translation process. The aim of this work was to establish the possibility of binding piRNAs and miRNAs with mRNA of the KLOTHO and FGF23 genes, which promote health and increase life expectancy through participation in key metabolic processes. We used the MirTarget program, which determines the quantitative characteristics of complementary interactions of all piRNAs and miRNAs nucleotides with mRNA of the genes. piR-44682, piR-1940042, piR-3008660, piR-3215034, piR-6885965, piR-7980636 and one miRNA (ID00756.3p-miR) binding to the mRNA of the KLOTHO gene were found in one cluster of binding sites (BSs). piRNA-6890096 interacted with the mRNA of KLOTHO gene in a fully complementary manner using only canonical nucleotides. Among 17494 human genes, target genes interacting with five piRNAs that bind to the mRNA of KLOTHO gene were identified. mRNA of the AFF2, BCL2L11, CPT1A, DAZAP1, NDRG3, SKIDA1, WBP4, ZIC5, ZSWIM6 genes interacted with piR-3215034 and piR-6885965, which formed clusters of BSs located in 5'UTR, CDS and 3'UTR. The piR-576442, piR-1501557, piR-1845735, piR-2069834, and piR-3029987 had BSs in the mRNAs of the FGF23 gene, located only in the 3'UTR. It is proposed to use piRNAs and miRNAs as regulators of the expression of KLOTHO and FGF23 anti-aging genes.
Biology and Life Sciences, Biochemistry and Molecular Biology
Copyright:
This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
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