Preprint Article Version 1 Preserved in Portico This version is not peer-reviewed

Lactobacillus Acidophilus DDS-1 Modulates the Gut Microbial Co-Occurrence Networks in Aging Mice

Version 1 : Received: 9 February 2022 / Approved: 17 February 2022 / Online: 17 February 2022 (10:59:55 CET)

A peer-reviewed article of this Preprint also exists.

Vemuri, R.; Martoni, C.J.; Kavanagh, K.; Eri, R. Lactobacillus acidophilus DDS-1 Modulates the Gut Microbial Co-Occurrence Networks in Aging Mice. Nutrients 2022, 14, 977. Vemuri, R.; Martoni, C.J.; Kavanagh, K.; Eri, R. Lactobacillus acidophilus DDS-1 Modulates the Gut Microbial Co-Occurrence Networks in Aging Mice. Nutrients 2022, 14, 977.

Journal reference: Nutrients 2022, 14, 977
DOI: 10.3390/nu14050977

Abstract

Age-related alterations in the gut microbiome composition and its impacts on the host’s health have been well described; however, detailed analyses of the gut microbial structure defining ecological microbe-microbe interactions is limited. One of the ways to determine these interactions is by understanding microbial co-occurrence patterns. We previously showed promising abilities of Lactobacillus acidophilus DDS-1 on the aging gut microbiome and immune system. However, the potential of the DDS-1 strain to modulate microbial co-occurrence patterns is unknown. Hence, we aimed to investigate the ability of L. acidophilus DDS-1 to modulate the fecal, mucosal and cecal-related microbial co-occurrence networks in young and aging C57BL/6J mice. Our Kendall’s tau correlation measures of co-occurrence revealed age-related changes in the gut microbiome, which were characterized by reduced number of nodes and associations across sample types when compared to younger mice. After four-week supplementation, L. acidophilus DDS-1 differentially modulated the overall microbial community structure in fecal and mucosal samples as compared to cecal samples. Beneficial bacteria such as Lactobacillus and Akkermansia acted as connectors in aging networks in response to L. acidophilus DDS-1 supplementation. Our findings provided the first evidence of the DDS-1-induced gut microbial ecological interactions revealing the complex structure of microbial ecosystems with age.

Keywords

aging; intestinal microbiota; dysbiosis; probiotics; microbial co-occurrences

Subject

BIOLOGY, Physiology

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