Kitaeva, K.V.; Solovyeva, V.V.; Blatt, N.L.; Rizvanov, A.A. Eternal Youth: A Comprehensive Exploration of Gene, Cellular, and Pharmacological Anti-Aging Strategies. Int. J. Mol. Sci.2024, 25, 643.
Kitaeva, K.V.; Solovyeva, V.V.; Blatt, N.L.; Rizvanov, A.A. Eternal Youth: A Comprehensive Exploration of Gene, Cellular, and Pharmacological Anti-Aging Strategies. Int. J. Mol. Sci. 2024, 25, 643.
Kitaeva, K.V.; Solovyeva, V.V.; Blatt, N.L.; Rizvanov, A.A. Eternal Youth: A Comprehensive Exploration of Gene, Cellular, and Pharmacological Anti-Aging Strategies. Int. J. Mol. Sci.2024, 25, 643.
Kitaeva, K.V.; Solovyeva, V.V.; Blatt, N.L.; Rizvanov, A.A. Eternal Youth: A Comprehensive Exploration of Gene, Cellular, and Pharmacological Anti-Aging Strategies. Int. J. Mol. Sci. 2024, 25, 643.
Abstract
The enhancement of human living conditions has resulted in an increase in average life expectancy, giving rise to a novel social and medical challenge: aging, which diminishes the overall quality of human life. The aging process of the body begins through the activation of effector signaling pathways of aging in cells, loss of their normal functions and deleterious effects on the microenvironment, which leads to chronic inflammation and similar transformation of neighboring cells. The cumulative retention of these senescent cells over a prolonged period results in the deterioration of tissues and organs, ultimately leading to a reduced quality of life and an elevated mortality risk. Among the most encouraging methods for addressing aging and age-related illnesses are pharmacological, genetic, and cellular therapies. Elevating the activity of aging-suppressing genes, employing specific groups of native and genetically modified cells, and utilizing senolytic medications may offer the potential to delay aging and age-related ailments over the long term. The review explores the strategies and advancements in the field of anti-aging therapies that are currently under investigation, with a particular emphasis on gene therapy involving adeno-associated vectors and cell-based therapeutic approaches.
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