Preprint Article Version 1 Preserved in Portico This version is not peer-reviewed

Habitual Exercise Attenuates the Aging Associated Muscle Atrophy and Muscle Strength Decline in SAMP8

Version 1 : Received: 30 July 2020 / Approved: 31 July 2020 / Online: 31 July 2020 (09:55:18 CEST)

A peer-reviewed article of this Preprint also exists.

Aoki, K.; Konno, M.; Honda, K.; Abe, T.; Nagata, T.; Takehara, M.; Sugasawa, T.; Takekoshi, K.; Ohmori, H. Habitual Aerobic Exercise Diminishes the Effects of Sarcopenia in Senescence-Accelerated Mice Prone8 Model. Geriatrics 2020, 5, 48. Aoki, K.; Konno, M.; Honda, K.; Abe, T.; Nagata, T.; Takehara, M.; Sugasawa, T.; Takekoshi, K.; Ohmori, H. Habitual Aerobic Exercise Diminishes the Effects of Sarcopenia in Senescence-Accelerated Mice Prone8 Model. Geriatrics 2020, 5, 48.

Journal reference: Geriatrics 2020, 5, 48
DOI: 10.3390/geriatrics5030048

Abstract

Loss of muscle mass and strength are progressing with aging. Exercise is a beneficial method to prevent physical disfunction and habitual exercise improve the muscle quality. Therefore, we evaluated the effects of a long-term habitual exercise on the senescence-accelerated mice prone8 (SAMP8). 27wk SAMP8 were used in this study. Mice were classified into 28 (28w) and 44 weeks old. The 44-week group was divided into the sedentary group (44w) and a group exercising for 16 weeks (44w+Ex). The 44w+Ex performed habitual exercise from 28 to 44 weeks. Additionally, grip strength tests were performed with mice aged 28 and 44 weeks. Mice were dissected and collected muscle samples and measured muscle weight at 44w. Gastrocnemius was decreased in 44w but were unchanged in 44w+Ex. Grip strength in 44w was lower trend, but there was no change in 44w+Ex. The phosphorylation levels of Akt and p70S6K as a protein synthesis marker were decreased in 44w. Cytochrome c oxidase subunit IV(COXIV) mRNA and protein levels decreased in 44w. These results suggested that long-term habitual exercise attenuated muscle mass and strength decline through improving muscle protein synthesis and mitochondrial function. In conclusion, long-term habitual exercise attenuated muscle mass and strength decline.

Subject Areas

Aging; Habitual exercise; SAMP8; Sarcopenia

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