PreprintArticleVersion 1Preserved in Portico This version is not peer-reviewed
Efficacy and Safety of Phaseolus angularis L for. as Anti-aging Therapy in Healthy Skin: A Single-Center, Randomized, Double-Blind, Placebo-Controlled Study
Version 1
: Received: 19 December 2022 / Approved: 20 December 2022 / Online: 20 December 2022 (09:03:36 CET)
How to cite:
Oh, S.; Jeong, J.; Jin, X.; Kim, M.; Zheng, S.; Yi, T. Efficacy and Safety of Phaseolus angularis L for. as Anti-aging Therapy in Healthy Skin: A Single-Center, Randomized, Double-Blind, Placebo-Controlled Study. Preprints2022, 2022120364. https://doi.org/10.20944/preprints202212.0364.v1
Oh, S.; Jeong, J.; Jin, X.; Kim, M.; Zheng, S.; Yi, T. Efficacy and Safety of Phaseolus angularis L for. as Anti-aging Therapy in Healthy Skin: A Single-Center, Randomized, Double-Blind, Placebo-Controlled Study. Preprints 2022, 2022120364. https://doi.org/10.20944/preprints202212.0364.v1
Oh, S.; Jeong, J.; Jin, X.; Kim, M.; Zheng, S.; Yi, T. Efficacy and Safety of Phaseolus angularis L for. as Anti-aging Therapy in Healthy Skin: A Single-Center, Randomized, Double-Blind, Placebo-Controlled Study. Preprints2022, 2022120364. https://doi.org/10.20944/preprints202212.0364.v1
APA Style
Oh, S., Jeong, J., Jin, X., Kim, M., Zheng, S., & Yi, T. (2022). Efficacy and Safety of Phaseolus angularis L for. as Anti-aging Therapy in Healthy Skin: A Single-Center, Randomized, Double-Blind, Placebo-Controlled Study. Preprints. https://doi.org/10.20944/preprints202212.0364.v1
Chicago/Turabian Style
Oh, S., Shengdao Zheng and Tae-Hoo Yi. 2022 "Efficacy and Safety of Phaseolus angularis L for. as Anti-aging Therapy in Healthy Skin: A Single-Center, Randomized, Double-Blind, Placebo-Controlled Study" Preprints. https://doi.org/10.20944/preprints202212.0364.v1
Abstract
Skin photoaging is caused by prolonged exposure to ultraviolet (UV) radiation from sunlight. UV-exposed skin appears rough, thick, dry, loose, and shows deep wrinkles, and thickening. Our previous research showed that a Phaseolus angularis seed extract (PASE) effectively inhibits photoaging through UVB protection in HaCaT cells. However, its efficacy has not been evaluated in clinical trials so far. In this single-centered, randomized, double-blind study, we investigated the anti-aging effect of PASE in eye wrinkle areas. To these 21 healthy adult women aged 30 to 65, a PASE cream was applied to the right eye wrinkle area and a placebo to the left eye wrinkle area twice a day (morning and evening) for 12 weeks. The change in thick, deep crease wrinkles around the eyes was confirmed by visual evaluation, skin measurements, and a questionnaire. As a result, the R1 (surface roughness), R2 (maximum roughness), R3 (average roughness), R4 (smoothness depth), and R5 (arithmetic mean roughness) values in the group using the PASE cream all decreased. Particularly, R1, R4, and R5 significantly decreased by 18.1%, 18.6%, and 25.0%. In addition, no participants reported side effects. Our study showed that PASE led to clinically significant levels of wrinkle improvement. In conclusion, as PASE is a natural food, safe, and with few side effects, it can be a good resource for natural anti-wrinkle cosmetics in the future.
Keywords
Phaseolus angularis seed extract (PASE); anti-aging; health skin, cosmetic products
Subject
Medicine and Pharmacology, Dermatology
Copyright:
This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
