Preprint Brief Report Version 1 Preserved in Portico This version is not peer-reviewed

Accurate Epigenetic Aging in Bottlenose Dolphins (Tursiops Truncatus), an Essential Step in the Conservation of at-Risk Dolphins.

Version 1 : Received: 2 July 2021 / Approved: 5 July 2021 / Online: 5 July 2021 (07:59:15 CEST)

How to cite: Barratclough, A.; Smith, C.R.; Gomez, F.M.; Photopoulou, T.; Takeshita, R.; Pirotta, E.; Thomas, L.; McClain, A.M.; Parry, C.; Zoller, J.A.; Horvath, S.; Schwacke, L.H. Accurate Epigenetic Aging in Bottlenose Dolphins (Tursiops Truncatus), an Essential Step in the Conservation of at-Risk Dolphins.. Preprints 2021, 2021070075 (doi: 10.20944/preprints202107.0075.v1). Barratclough, A.; Smith, C.R.; Gomez, F.M.; Photopoulou, T.; Takeshita, R.; Pirotta, E.; Thomas, L.; McClain, A.M.; Parry, C.; Zoller, J.A.; Horvath, S.; Schwacke, L.H. Accurate Epigenetic Aging in Bottlenose Dolphins (Tursiops Truncatus), an Essential Step in the Conservation of at-Risk Dolphins.. Preprints 2021, 2021070075 (doi: 10.20944/preprints202107.0075.v1).

Abstract

Epigenetics, specifically DNA methylation, allows for estimation of animal age from blood or remotely sampled skin. This multi tissue epigenetic aging clock uses 110 longitudinal samples from 34 Navy bottlenose dolphins (Tursiops truncatus), identifying 195 cytosine-phosphate-guanine sites associated with chronological aging via leave-one-individual-out-cross-validation (R2=0.95). With a median absolute error of 2.5 years this clock improves age estimation capacity in wild dolphins, expanding conservation efforts, enabling better understanding of population demographics.

Subject Areas

DNA methylation; epigenetic aging; bottlenose dolphin; chronological age

Comments (0)

We encourage comments and feedback from a broad range of readers. See criteria for comments and our diversity statement.

Leave a public comment
Send a private comment to the author(s)
Views 0
Downloads 0
Comments 0
Metrics 0


×
Alerts
Notify me about updates to this article or when a peer-reviewed version is published.
We use cookies on our website to ensure you get the best experience.
Read more about our cookies here.