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Aging Disrupts Circadian Rhythms in Mouse Liver Mitochondria
Version 1
: Received: 8 May 2023 / Approved: 9 May 2023 / Online: 9 May 2023 (08:19:43 CEST)
A peer-reviewed article of this Preprint also exists.
Xu, W.; Li, X. Aging Disrupts Circadian Rhythms in Mouse Liver Mitochondria. Molecules 2023, 28, 4432. Xu, W.; Li, X. Aging Disrupts Circadian Rhythms in Mouse Liver Mitochondria. Molecules 2023, 28, 4432.
Abstract
The circadian clock regulates daily changes in behavioral, endocrine and metabolic activities in mammals. Circadian rhythms in cellular physiology are significantly affected by aging. In particular, we previously found that aging has profound impact on daily rhythms in mitochondrial functions, leading to increased oxidative stress. However, this is unlikely due to malfunction of molecular clocks in the suprachiasmatic nucleus or peripheral tissues, as robust clock oscillations are observed therein in old animals. Nonetheless, aging induces changes in gene expression levels and rhythms in various peripheral and probably central tissues. In this article, we review findings on the roles of the circadian clock and aging in regulating mitochondrial rhythms and redox homeostasis. Chronic sterile inflammation is implicated in mitochondrial dysfunction and increased oxidative stress during aging. In particular, upregulation of CD38 by inflammatory response can disturb mitochondrial functions in multiple ways.
Keywords
circadian rhythms; aging; suprachiasmatic nucleus; peripheral clock; inflammatory response
Subject
Biology and Life Sciences, Aging
Copyright: This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
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