Preprint Review Version 1 Preserved in Portico This version is not peer-reviewed

Mitophagy and the Brain

Version 1 : Received: 2 December 2020 / Approved: 3 December 2020 / Online: 3 December 2020 (10:36:29 CET)

A peer-reviewed article of this Preprint also exists.

Swerdlow, N.S.; Wilkins, H.M. Mitophagy and the Brain. Int. J. Mol. Sci. 2020, 21, 9661. Swerdlow, N.S.; Wilkins, H.M. Mitophagy and the Brain. Int. J. Mol. Sci. 2020, 21, 9661.

Journal reference: Int. J. Mol. Sci. 2020, 21, 9661
DOI: 10.3390/ijms21249661


Stress mechanisms have long been associated with neuronal loss and neurodegenerative diseases. The origin of cell stress and neuronal loss likely stems from multiple pathways. These include (but are not limited to) bioenergetic failure, neuroinflammation, and loss of proteostasis. Cells have adapted compensatory mechanisms to overcome stress and circumvent death. One mechanism is mitophagy. Recent studies have implicated mitophagy in several neurodegenerative diseases and clinical trials are underway which target mitophagy pathways. Here, we review mitophagy pathways, the role of mitophagy in neurodegeneration, potential therapeutics, and the need for further study.


Mitochondria; Alzheimer’s Disease; mitophagy; neurodegeneration; aging



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