Preprint Article Version 1 Preserved in Portico This version is not peer-reviewed

Fenugreek (Trigonellafoenum-graecum L.) Seeds Dietary Supplementation Regulates Liver Antioxidant Defense Systems in Aging Mice

Version 1 : Received: 6 July 2020 / Approved: 8 July 2020 / Online: 8 July 2020 (11:03:10 CEST)

A peer-reviewed article of this Preprint also exists.

Tewari, D.; Jóźwik, A.; Łysek-Gładysińska, M.; Grzybek, W.; Adamus-Białek, W.; Bicki, J.; Strzałkowska, N.; Kamińska, A.; Horbańczuk, O.K.; Atanasov, A.G. Fenugreek (Trigonella foenum-graecum L.) Seeds Dietary Supplementation Regulates Liver Antioxidant Defense Systems in Aging Mice. Nutrients 2020, 12, 2552. Tewari, D.; Jóźwik, A.; Łysek-Gładysińska, M.; Grzybek, W.; Adamus-Białek, W.; Bicki, J.; Strzałkowska, N.; Kamińska, A.; Horbańczuk, O.K.; Atanasov, A.G. Fenugreek (Trigonella foenum-graecum L.) Seeds Dietary Supplementation Regulates Liver Antioxidant Defense Systems in Aging Mice. Nutrients 2020, 12, 2552.

Journal reference: Nutrients 2020, 12, 2552
DOI: 10.3390/nu12092552

Abstract

Fenugreek seeds are widely used in Asia and other places of the world for their nutritive and medicinal properties. In Asia, Fenugreek seeds are also widely recommended for the geriatric populations. Here, we evaluated for the first time the effect of fenugreek seed feed supplementation on the liver antioxidant defense systems in aging mice. The study was conducted on 12 months aged mice which were given fenugreek seed dietary supplement. We have evaluated the activities of various antioxidant defense enzymes like superoxide dismutase (SOD), glutathione reductase (GR), and glutathione peroxidase (GPx), and estimated the phenolics and free radical scavenging properties in mice liver upon fenugreek supplementation. The estimation of SOD, GPx and GR activities in aged mice liver revealed a significant (P<0.01) difference among all the liver enzymes. Overall, this study reveals that fenugreek seed dietary supplementation has a positive effect in on the activities of the hepatic antioxidant defense enzymes in the aged mice.

Subject Areas

fenugreek; aging; liver; antioxidants; mice

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