Caliskan, A.; Crouch, S.A.W.; Giddins, S.; Dandekar, T.; Dangwal, S. Progeria and Aging—Omics Based Comparative Analysis. Biomedicines2022, 10, 2440.
Caliskan, A.; Crouch, S.A.W.; Giddins, S.; Dandekar, T.; Dangwal, S. Progeria and Aging—Omics Based Comparative Analysis. Biomedicines 2022, 10, 2440.
Caliskan, A.; Crouch, S.A.W.; Giddins, S.; Dandekar, T.; Dangwal, S. Progeria and Aging—Omics Based Comparative Analysis. Biomedicines2022, 10, 2440.
Caliskan, A.; Crouch, S.A.W.; Giddins, S.; Dandekar, T.; Dangwal, S. Progeria and Aging—Omics Based Comparative Analysis. Biomedicines 2022, 10, 2440.
Abstract
Abstract: Since ancient times aging has also been regarded as a disease, and humankind has always strived to extend the natural lifespan. Analyzing the genes involved in aging and disease allows for finding important indicators and biological markers for pathologies and possible therapeutic targets. An example of the use of omics technologies is the research regarding aging and the rare and fatal premature aging syndrome progeria (Hutchinson-Gilford progeria syndrome, HGPS). In our study, we focused on the in silico analysis of differentially expressed genes (DEGs) in progeria and aging, using a publicly available RNA Seq dataset (GEO dataset GSE113957) and a variety of bioinformatics tools. We identified several genes that appear to be involved both in natural aging and progeria (KRT8, KRT18, ACKR4, CCL2, UCP2, ADAMTS15, ACTN4P1, WNT16, IGFBP2). Further analyzing these genes and the pathways involved confirmed their possible roles in aging, suggesting the need for further in vitro and in vivo research. The graphical abstract illustrates the analysis workflow we used and will introduce in the following as an example to demonstrate the power of omics and bioinformatics.
Biology and Life Sciences, Biochemistry and Molecular Biology
Copyright:
This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
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