Working Paper Review Version 1 This version is not peer-reviewed

Appropriate Technologies to Accompany Sunscreens in the Battle Against Ultraviolet, Superoxide and Singlet Oxygen

Version 1 : Received: 19 October 2020 / Approved: 21 October 2020 / Online: 21 October 2020 (10:32:55 CEST)

A peer-reviewed article of this Preprint also exists.

Giacomoni, P.U. Appropriate Technologies to Accompany Sunscreens in the Battle Against Ultraviolet, Superoxide, and Singlet Oxygen. Antioxidants 2020, 9, 1091. Giacomoni, P.U. Appropriate Technologies to Accompany Sunscreens in the Battle Against Ultraviolet, Superoxide, and Singlet Oxygen. Antioxidants 2020, 9, 1091.

Journal reference: Antioxidants 2020, 9, 1091
DOI: 10.3390/antiox9111091

Abstract

The interaction of ultraviolet radiation with biological matter results in direct damage such as pyrimidine dimers in DNA. It also results in indirect damage provoked by the production of Reactive Oxygen Species (ROS) catalyzed by photo-sensitizers. Photosensitizers can be endogenous (e.g. Tryptophan) or exogenous (e.g. TiO2 and other photo-stable UVA sunscreens). Direct damage triggers an inflammatory response and the oxidative and proteolytic bursts that characterize its onset. The inflammatory reaction multiplies the effects of one single photon. Indirect damage, such as the peroxidative cascade in membrane lipids, can extend to thousands of molecular modifications per absorbed photon. Sunscreens should therefore be formulated in the presence of appropriate anti-oxidants. Superoxide and Singlet Oxygen are the main ROS that need to be tackled: this review describes some of the molecular, biochemical, cellular and clinical consequences of exposure to UV radiation as well as some results associated with scavengers and quenchers of Superoxide and Singlet Oxygen, as well as with inhibitors of singlet Oxygen production.

Subject Areas

Ultraviolet; superoxide; singlet Oxygen; cell blebbing; skin aging; peroxidative cascade; antioxidants

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