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Preprint ARTICLE | doi:10.20944/preprints202311.0027.v1

CNN-Based Facial Expression Recognition with Simultaneous Consideration of Inter-class and Intra-class Variations

Trong-Dong Pham, Minh-Thien Duong, Quoc-Thien Ho, Seongsoo Lee, Min-Cheol Hong

Subject: Engineering, Electrical And Electronic Engineering Keywords: facial expression recognition; convolutional neural networks; loss function; intra-class variations; inter-class variations

Online: 1 November 2023 (09:33:37 CET)

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Preprint ARTICLE | doi:10.20944/preprints202301.0132.v1

Proposal of a Maturity Model for Supply Chain Sustainability

Elisabete Correia, Susana Garrido-Azevedo, Helena Carvalho

Subject: Business, Economics And Management, Business And Management Keywords: Maturity Model; Sustainability assessment; Supply Chain; Intra- and inter-organizational perspec-tive; TBL dimensions

Online: 9 January 2023 (01:27:50 CET)

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Preprint REVIEW | doi:10.20944/preprints201912.0152.v1

Is Amending Section 25 of the South African Constitution an End to the Land Reform Debate?

Joseph Lekunze, Usapfa Luvhengo

Subject: Social Sciences, Geography, Planning And Development Keywords: land expropriation; intra-racial tension; social cohesion; political and traditional elitism; marginalised landless majority

Online: 11 December 2019 (11:38:36 CET)

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Preprint ARTICLE | doi:10.20944/preprints201801.0100.v1

Pressure Distribution during Negative Pressure Wound Therapy of Experimental Abdominal Compartment Syndrome in a Porcine Model

Adrienn Csiszkó, Klaudia Balog, Zoltán Attila Godó, Gyula Juhász, Katalin Pető, Ádám Deák, Mariann Berhés, Norbert Németh, Zsolt Bodnár, Zsolt Szentkereszty

Subject: Medicine And Pharmacology, Clinical Medicine Keywords: intra-abdominal pressure; abdominal compartment syndrome; pressure sensor; negative pressure wound therapy; open abdomen;

Online: 11 January 2018 (09:17:10 CET)

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Preprint REVIEW | doi:10.20944/preprints202306.0057.v1

Oral Mucosa in the Cancer Patient; Putting the Pieces Together. A Narrative Review and New Perspectives.

José Manuel Reuss, Laura Alonso-Gamo, Mariola Garcia-Aranda, Débora Reuss, Manuel Albi, Beatriz Albi, Débora Vilaboa, Beatriz Vilaboa

Subject: Medicine And Pharmacology, Other Keywords: Oral mucositis mucositis; oral mucosa; genitourinary mucosa; microbiome; dysbiosis; saliactive; cancer; PROMs; cancer toxicity; chemotherapy; radiotherapy; pain; olive oil; betaine; trimethylglycine

Online: 1 June 2023 (07:52:02 CEST)

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Preprint ARTICLE | doi:10.20944/preprints202402.1225.v1

Amazon Plume in the Western Tropical North Atlantic

Eugene G. Morozov, Dmitry I. Frey, Pavel A. Salyuk, Maxim V. Budyansky

Subject: Environmental And Earth Sciences, Oceanography Keywords: desalination of the surface layer, intra-annual plume variability, CTD casts, continuous recording, Lagrangian analysis

Online: 21 February 2024 (11:53:03 CET)

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Preprint ARTICLE | doi:10.20944/preprints202310.0709.v1

A Study on the Feasibility of LiFi in an Intra-Vehicular Data Transmission Application

Hongyu Guan, Manolo Dulva Hina

Subject: Engineering, Transportation Science And Technology Keywords: LiFi; Light Fidelity; wireless communication; intra-vehicular data transmission; VLC; intelligent transportation system; LED; optics

Online: 11 October 2023 (09:20:55 CEST)

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Preprint REVIEW | doi:10.20944/preprints202207.0100.v1

From Minor Mutant to Dominance, the Evolution of SARS-CoV-2 Variants

Thomas Caspari

Subject: Biology And Life Sciences, Virology Keywords: omicron; alpha; delta; deltacron; recombination; RNA editing; intra-host variants; tropisms; ox-idative damage; Wuhan

Online: 6 July 2022 (15:27:32 CEST)

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Preprint ARTICLE | doi:10.20944/preprints202311.0483.v1

Loreto Domínguez Senín, David Morales Pancorbo, María Yeray Rodríguez Garcés, María Dolores Santos-Rubio -, Juan Bayo Calero

Subject: Medicine And Pharmacology, Pharmacy Keywords: MRONJ; CDK4/6 inhibitors; metastatic breast cancer; oral epidemiology

Online: 8 November 2023 (08:42:55 CET)

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Preprint ARTICLE | doi:10.20944/preprints202310.2099.v1

Live-Attenuated Salmonella-Based Oral Vaccine Candidates Expressing PCV2d Cap and Rep by Novel Expression Plasmids as a Vaccination Strategy for Mucosal and Systemic Immune Responses against PCV2d

Khristine Kaith Sison Lloren, Chandran Sivasankar, John Hwa Lee

Subject: Medicine And Pharmacology, Veterinary Medicine Keywords: Oral vaccine; Salmonella delivery; porcine circovirus type 2; PCV2d

Online: 31 October 2023 (14:35:37 CET)

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Preprint ARTICLE | doi:10.20944/preprints202310.0290.v1

A Deep Learning Framework with Intermediate Layer using Swarm Intelligence Optimizer for diagnosing Oral Squamous Cell Carcinoma

Bharanidharan Nagarajan, Sannasi Chakravarthy S R, Vinoth Kumar V, Mahesh T R, Surbhi Bhatia Khan

Subject: Engineering, Other Keywords: oral cancer; histopathologic images; CNN; deep learning framework; swarm

Online: 6 October 2023 (04:06:24 CEST)

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Preprint ARTICLE | doi:10.20944/preprints202310.0236.v1

Oral Health Promotion Model Implemented in Primorje-Gorski Kotar County, Croatia

Danko Bakarcic, Nevenka Vlah, Natasa Ivancic Jokic, Suzana Jankovic, Natasa Dragas Zubalj, Sandro Kresina, Silvia Mohoric, Renata Grzic, Helena Glibotic Kresina

Subject: Medicine And Pharmacology, Dentistry And Oral Surgery Keywords: children; dental medicine; health promotion; oral health; preventive medicine

Online: 5 October 2023 (06:43:58 CEST)

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Preprint ARTICLE | doi:10.20944/preprints202309.1915.v1

Endo-Periodontal Lesions ---An Ignored Oral Etiology of Odontogenic Sinusitis

Jianyou Wu, Ming Zheng, Xiangdong Wang, Songlin Wang

Subject: Medicine And Pharmacology, Dentistry And Oral Surgery Keywords: Odontogenic sinusitis; oral etiology; Endo-periodontal lesions; clinical symptoms

Online: 28 September 2023 (09:55:06 CEST)

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Preprint CASE REPORT | doi:10.20944/preprints202309.1501.v1

Prophylaxis Failure and Successful Management of Delayed-onset Malaria with Renal Complications: A Case Report with Oral Artemether-Lumefantrine Treatment

Ilir Tolaj, Gramoz Bunjaku, Murat Mehmeti, Yllka Begolli

Subject: Medicine And Pharmacology, Epidemiology And Infectious Diseases Keywords: severe malaria; Plasmodium falciparum; chemoprophylaxis failure; oral artemether-lumefantrine

Online: 22 September 2023 (02:58:59 CEST)

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Preprint ARTICLE | doi:10.20944/preprints202309.0322.v1

Meat Juice and Oral Fluid as Alternative to Serum for Aujeszky Disease Monitoring in Pigs

Emanuele Carella, Claudio Caruso, Ana Moreno Martin, Alessia Di Blasio, Francesca Oberto, Nicoletta Vitale, Loretta Masoero

Subject: Biology And Life Sciences, Virology Keywords: Meat juice; oral fluid; Aujeszky disease virus; ELISA; pigs

Online: 6 September 2023 (14:54:05 CEST)

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Preprint ARTICLE | doi:10.20944/preprints202308.0948.v1

Prevention Is Better Than Care. Clinical and Economic Implications of Oral Antiviral Agents in COVID 19: A Prospective Study

F. Pietrantonio, F. Rosiello, M. Ruggeri, Marco Materazzo, Vincenzo Mirco La Fazia, Nicola Pierucci, Rosa Iodice, G. Granvillano, Lamberto mc Cicerchia, Massimo Maurici, Michela Delli castelli, Fabio Vinci, Angela Ciamei, Marise Sabato, Aurelio Sparta, Davide Acco, Luca Fortunato, Maria sofia Cattaruzza, Antonio Vinci, M. Lordi, Enrica Cipriano

Subject: Medicine And Pharmacology, Internal Medicine Keywords: Molnupiravir; SARS-CoV-2; COVID-19; Nirmatrelvir; oral antiviral

Online: 11 August 2023 (13:23:50 CEST)

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Preprint REVIEW | doi:10.20944/preprints202308.0609.v1

Clinical and Psychosocial Impact of Oral Potentially Malignant Disorders Communication: A Scoping Review

Lady P. A. Arboleda, Thaís C. E. Pereira, Joel B. Epstein, Cesar A. Migliorati, Saman Warnakulasuriya, Márcio Diniz-Freitas, Marcio A. Lopes, Alan R. Santos-Silva

Subject: Medicine And Pharmacology, Dentistry And Oral Surgery Keywords: oral potentially malignant disorders; communication; truth-telling; scoping review

Online: 8 August 2023 (10:56:31 CEST)

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Preprint COMMUNICATION | doi:10.20944/preprints202308.0424.v1

A New Lighting System for Surgical Vision Optimization in Barbed Pharyngoplasty for OSA

Lorenzo Sabatino, Antonio Moffa, Francesco Iafrati, Simone Di Giovanni, Luigi De Benedetto, Lucrezia Giorgi, Peter Baptista, Claudio Vicini, Andrea De Vito, Manuele Casale

Subject: Medicine And Pharmacology, Otolaryngology Keywords: barbed pharyngoplasty; lighting system; surgical vision; oral cavity: klaro

Online: 4 August 2023 (10:18:08 CEST)

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Preprint ARTICLE | doi:10.20944/preprints202307.0623.v1

Oil Pulling and Polyphenols: Treatment of Gingivitis Patients With ‘Itri Extra Virgin Olive Oil’

Giulia Zumbo, Denise Corridore, Samantha Sciscione, Claudio Stamegna, Fabrizio Guerra, Antonella Polimeni, Iole Vozza

Subject: Medicine And Pharmacology, Dentistry And Oral Surgery Keywords: oil pulling; oral health; gingivitis; dentistry; dentistry innovations; polyphenols

Online: 10 July 2023 (11:29:53 CEST)

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Preprint ARTICLE | doi:10.20944/preprints202307.0202.v1

3D Printing of Personalised Carvedilol Tablets Using Selective Laser Sintering

Dennis Douroumis, Atabak Ghanizadeh Tabriz, Quentin Gonot-Munck, Arnaud Baudoux, Vivek Garg, Richard Farnish, Orestis Katsamenis, Hui Ho-Wah, Nathan Boersen, Sandra Roberts, John Jones

Subject: Medicine And Pharmacology, Pharmacy Keywords: 3D printing; selective laser sintering; personalised medicines; oral; carvedilol

Online: 5 July 2023 (02:21:40 CEST)

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Preprint ARTICLE | doi:10.20944/preprints202305.2230.v1

Oral Language Competence in Initial Teacher Education in Catalonia: Activities, Evaluation and Proposals

Marta Gràcia, Andrea Miralda, Sandra Espino, Iris Merino, Verónica Quezada, Fàtima Vega

Subject: Social Sciences, Psychology Keywords: oral language competence; initial teacher education; university teachers; interdisciplinarity

Online: 31 May 2023 (10:57:21 CEST)

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Preprint ARTICLE | doi:10.20944/preprints202305.2082.v1

Characteristics Associated with Major Complications and Refractory Course in Patients with Osteomyelitis of the Jaw: Clinical, Radiological, and Bacteriological Features of 54 Patients

MATHILDE FENELON, Steven Gernandt, Romain Aymon, PAOLO SCOLOZZI

Subject: Medicine And Pharmacology, Dentistry And Oral Surgery Keywords: Bone; Osteomyelitis; Decortication; Treatment Outcome; Oral and Maxillofacial Surgery

Online: 30 May 2023 (08:16:55 CEST)

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Preprint ARTICLE | doi:10.20944/preprints202305.1905.v1

A Novel Anti-CD44 Variant 10 Monoclonal Antibody is Useful for Immunohistochemical Analysis against Oral Squamous cell carcinomas

Kenichiro Ishikawa, Hiroyuki Suzuki, Mika K Kaneko, Yukinari Kato

Subject: Medicine And Pharmacology, Oncology And Oncogenics Keywords: CD44; CD44v10; monoclonal antibody; oral squamous cell carcinoma; immunohistochemistry

Online: 26 May 2023 (09:49:30 CEST)

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Preprint ARTICLE | doi:10.20944/preprints202305.1064.v1

The Influence of Cleaning Solutions on the Retention of Overdenture Attachment Systems

Sofia Monteiro, Pedro Barreiros, Joana Mendes, Carlos Aroso, António Sérgio Silva, José Manuel Mendes

Subject: Medicine And Pharmacology, Dentistry And Oral Surgery Keywords: denture cleanser; attachments; overdenture; oral health; quality of life

Online: 15 May 2023 (16:17:20 CEST)

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Preprint ARTICLE | doi:10.20944/preprints202304.0517.v1

Availability of Primary Closure for Resection of Oral Cavity Cancer

Hyo-Joon Kim, Jun-Seok Choi, Ye-Joon Jo, And Seong-Yong Moon

Subject: Medicine And Pharmacology, Dentistry And Oral Surgery Keywords: Reconstruction; Oral Cancer; Primary closure; Free flap; Local flap

Online: 18 April 2023 (10:39:52 CEST)

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Resection of malignant lesions in the oral and maxillofacial area causes functional and morphological defects. To recover from these defects, reconstruction surgery is needed such as a primary closure or a flap. There are advantages and disadvantages to the method of using the primary closure and the flap, and the choice of procedure is entirely up to a surgeon. The purpose of this study is to evaluate availability of primary closure in patients. For 10 years from January 2010 to May 2020, patients who recovered using flaps after removing malignant lesions from the oral cavity and those who closed the lesion using primary closure were investigated. The investigation was conducted by searching the database of the hospital. There were 85 patients who removed malignant lesions in the oral and maxillofacial area, and among them 16 patients closed the soft tissue defects using primary closure. Operation time, histologic types, stages, wound status, and period of hospitalization according to the patients' medical records were investigated retrospectively. Between the staging and the primary closure, statistically significant differences were observed between stage I and stage II patients in 13 patients using the primary closure. (P=0.046). Statistically significant differences were identified between operation time and primary closure, with an average of 4.02 hours (P=0.015). The average period of hospitality for patients who underwent primary closure was 13.4 days, compared to 26.7 days for those who underwent flap surgery. This difference was statistically significant (P=0.0003). This study evaluated the use of primary closure in patients who underwent resection of malignant lesions in the oral and maxillofacial area. Although the majority of patients underwent reconstruction with flaps, our results showed that primary closure can be a viable option for certain patients with early-stage lesions. Therefore, oral and maxillofacial surgeons should carefully consider various evaluation criteria and select appropriate reconstruction methods to optimize functional and aesthetic outcomes for each patient.

Preprint ARTICLE | doi:10.20944/preprints202301.0170.v1

Self-Micellizing Solid Dispersion of Thymoquinone with Enhanced Biopharmaceutical and Nephroprotective Effects

Shimul Halder, Sanjida Afrose, Manik Chandra Shill, Nahid Sharmin, Patricia Prova Mollick, Madhabi Lata Shuma, Md. Abdul Muhit, S. M. Abdur Rahman

Subject: Medicine And Pharmacology, Pharmacology And Toxicology Keywords: biopharmaceutical; nephroprotective; oral absorption; self-micellizing solid dispersion; thymoquinone.

Online: 10 January 2023 (03:09:17 CET)

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Preprint ARTICLE | doi:10.20944/preprints202211.0372.v1

Self-Micellizing Solid Dispersion of Thymoquinone with Enhanced Biopharmaceutical and Nephroprotective Effects

Shimul Halder, Sanjida Afrose, Manik Chandra Shill, Nahid Sharmin, Patricia Prova Mollick, Madhabi Lata Shuma, S. M. Abdur Rahman

Subject: Biology And Life Sciences, Food Science And Technology Keywords: biopharmaceutical; nephroprotective; oral absorption; self-micellizing solid dispersion; thymoquinone.

Online: 21 November 2022 (04:43:27 CET)

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Preprint ARTICLE | doi:10.20944/preprints202211.0308.v1

Versertality of Bacteriome Dominated by Rothia mucilaginosa in a Group of Sri Lankan Oral Fibro Epithelial Polyp Male Patient: A Pilot Study

Manosha Perera, Irosha Perera

Subject: Medicine And Pharmacology, Dentistry And Oral Surgery Keywords: Xenobiotic; Drug; Oral fibro epithelial polyps; Rothia mucilaginosa; Bacteriome

Online: 16 November 2022 (12:45:26 CET)

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Preprint ARTICLE | doi:10.20944/preprints202109.0351.v1

A Parallel Tracking of Salivary and Gut Microbiota Profiles Can Reveal Maturation and Interplay of Early Life Microbial Communities in Healthy Infants

Sofia Reddel, Giuseppe Rubens Pascucci, Silvia Foligno, Federica Del Chierico, Pamela Vernocchi, Alessandra Marzullo, Maria Grazia Pattumelli, Paolo Palma, Guglielmo Salvatori, Lorenza Putignani

Subject: Biology And Life Sciences, Immunology And Microbiology Keywords: oral microbiota; gut microbiota; networks analysis; ecological niche; newborns

Online: 21 September 2021 (09:13:34 CEST)

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Preprint ARTICLE | doi:10.20944/preprints202102.0436.v1

Antimicrobial Effect of Nano-Silver Against Oral Streptococci: Implications in Containment of Bacterial Biofilm on Orthodontal Appliances

Saba Farheen, Abdul Mateen Oanz, Nazoora Khan, Mohd Saad Umar, Fauzia Jamal, Mohammad Kashif, Ansam Wadia Alshameri, Saba Khan, Mohammad Owais

Subject: Biology And Life Sciences, Biochemistry And Molecular Biology Keywords: silver nanoparticles; biofilm; orthodontic wire; drug resistance; oral-Streptococcus

Online: 19 February 2021 (12:23:26 CET)

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Preprint ARTICLE | doi:10.20944/preprints202008.0165.v1

A Novel Oral Syringe for Dosing and Administration of Multiparticulate Formulations: Acceptability Study in Preschool and School Children

Justyna Hofmanová, Joanne Bennett, Alastair Coupe, Jeremy Bartlett, Andrew Monahan, Hannah Katharine Batchelor

Subject: Medicine And Pharmacology, Pediatrics, Perinatology And Child Health Keywords: multiparticulates, administration device, acceptability, paediatric formulation, mouthfeel, oral syringe

Online: 6 August 2020 (12:00:05 CEST)

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Working Paper ARTICLE

COVID-19: Pediatric Oral Health During and After the Pandemics

Valeria Luzzi, Gaetano Ierardo, Maurizio Bossù, Antonella Polimeni

Subject: Medicine And Pharmacology, Dentistry And Oral Surgery Keywords: COVID-19; pandemics; pediatric dentistry; oral health prevention; coronavirus

Online: 16 May 2020 (18:11:49 CEST)

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Preprint REVIEW | doi:10.20944/preprints202004.0357.v1

Overview of Trans-National Recommendations for COVID-19 Transmission Control in Dental Care Settings

Mohamed Jamal, Maanas Shah, Sameeha Husain Almarzooqi, Hend Aber, Summayah Khawaja, Rashid El Abed, Zuhair Alkhatib, Lakshman Perera Samaranayake

Subject: Medicine And Pharmacology, Dentistry And Oral Surgery Keywords: coronavirus; COVID-19; SARS-CoV2; dentistry; oral health; transmission

Online: 20 April 2020 (02:14:36 CEST)

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Preprint REVIEW | doi:10.20944/preprints202004.0100.v1

Formulation Strategies to Improve Oral Bioavailability of Ellagic Acid

Guendalina Zuccari, Sara Baldassari, Giorgia Ailuno, Federica Turrini, Silvana Alfei, Gabriele Caviglioli

Subject: Biology And Life Sciences, Food Science And Technology Keywords: ellagic acid; oral administration; bioavailability; microformulations; nanoformulations; solubility enhancement

Online: 7 April 2020 (12:02:54 CEST)

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Working Paper ARTICLE

Promoter Hypermethylation of Tumor Suppressor Genes, p16^INK4a, RASSF1A, TIMP3 and PCQAP/MED15, in Salivary DNA as a Quadruple Biomarker Panel for Early Detection of Oral and Oropharyngeal Cancers

Chamikara Liyanage, Asanga Wathupola, Sanjayan Muraleetharan, Kanthi Perera, Chamindie Punyadeera, Preethi Udagama

Subject: Medicine And Pharmacology, Oncology And Oncogenics Keywords: Oral cancer; Oropharyngeal cancer; Tumor-suppressor genes; Promoter hypermethylation

Online: 19 March 2019 (12:56:24 CET)

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Preprint ARTICLE | doi:10.20944/preprints201803.0044.v1

Alcohol-containing Mouthwashes and Oral Cancer: A Mechanistic Explanation

José Manuel Calderón-Montaño, Julio José Jiménez-Alonso, Emilio Guillén-Mancina, Estefanía Burgos-Morón, Miguel Lopez-Lazaro

Subject: Medicine And Pharmacology, Oncology And Oncogenics Keywords: cancer prevention; carcinogenesis; oral cancer; pharynx cancer; mouthrinses; ethanol.

Online: 6 March 2018 (14:28:22 CET)

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Preprint REVIEW | doi:10.20944/preprints202312.1683.v1

Illustrative Case Series and Narrative Review of Intra-abdominal Abscesses:A Radiological Perspective.

Shirom Rajeev Siriwardana, Pramesha Dilhari Anjula

Subject: Biology And Life Sciences, Other Keywords: Intra-abdominal abscesses, Tubo-ovarian abscess, Appendicular abscess, diverticular abscess, Infected walled-off pancreatic necrosis. ;

Online: 21 December 2023 (23:27:26 CET)

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Preprint ARTICLE | doi:10.20944/preprints202004.0030.v1

Intra-Cystic (In Situ) Mucoepidermoid Carcinoma: A Clinico-Pathological Study of 14 Cases

Saverio Capodiferro, Giuseppe Ingravallo, Luisa Limongelli, Mauro Giuseppe Mastropasqua, Angela Tempesta, Gianfranco Favia, Eugenio Maiorano

Subject: Medicine And Pharmacology, Pathology And Pathobiology Keywords: salivary glands, minor salivary glands, salivary gland carcinoma, mucoepidermoid carcinoma, in situ carcinoma, intra-cystic carcinoma

Online: 8 April 2020 (14:46:41 CEST)

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Aims: To report on the clinico-pathological features of a series of 12 intra-oral mucoepidermoid carcinomas showing exclusive intra-cystic growth. Methods and methods: All mucoepidermoid carcinomas diagnosed in the period 1990-2012 were retrieved, the original histological preparations were reviewed to confirm the diagnosis, and from selected cases, showing exclusive intra-cystic neoplastic component, additional sections were cut at 3 subsequent 200m intervals and stained with Hematoxylin-Eosin, PAS and Alcian Blue, to possibly identify tumor invasion of the adjacent tissues, which could have been overlooked in the original histological preparations. Also, pertinent findings collected from the clinical charts and follow-up data were analyzed. Results: We identified 14 intraoral mucoepidermoid carcinomas treated by conservative surgery and with a minimum follow up of 5 years. The neosplasm were located in the hard palate (9 cases), the soft palate (2), the cheeck (2) and the retromolar trigone (1). In all instances histological examination was revealed the presence of a single cystic space, containing clusters of columnar, intermediate, epidermoid, clear and mucous-producing cells, the latter exhibiting distinct intra-cytoplasmic mucin production, as confirmed by PAS and Alcian Blue stains. The cysts were entirely circumscribed by fibrous connective tissue and no solid areas or infiltrating tumour clusters were detected. Conservative surgical resection was performed in all cases and no recurrences or nodal metastases were observed during the follow up period. Conclusions: Mucoepidermoid carcinomas showing prominent (>20%) intra-cystic proliferation currently are considered low-grade tumours. In addition, we also unveil the possibility that mucoepidermoid carcinomas, at least in their early growth phase, may display an exclusive intra-cystic fashion and might be considered as in situ carcinomas, unable to infiltrate adjacent tissues or metastasize.

Preprint ARTICLE | doi:10.20944/preprints201909.0145.v1

A Clustered, Decentralized Approach to Urban Water Management

Seneshaw Tsegaye, Thomas M. Missimer, Jong-Yeop Kim, Jason Hock

Subject: Engineering, Civil Engineering Keywords: decentralized water systems; cluster approach; intra-cluster homogeneity; Water Supply Systems (WSS); Urban Water Systems (UWS)

Online: 14 September 2019 (19:33:09 CEST)

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Preprint ARTICLE | doi:10.20944/preprints202403.1746.v1

The Development of an Oral Health Nursing Tool in Patients with a Psychotic Disorder: A Human-Centered Design with a Feasibility Test

Sonja Kuipers, Stynke Castelein, Linda Kronenberg, Job van ’t Veer, Nynke Boonstra

Subject: Social Sciences, Other Keywords: oral health; nursing; mental health; psychotic disorder; human-centered design

Online: 28 March 2024 (15:37:34 CET)

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Patients with a psychotic disorder frequently report oral health problems, while mental health nurses (MHNs) seem not to be fully aware of these problems and the risk factors. Therefore, this study aims to develop supportive tools for MHNs regarding oral health to increase sensitization among MHNs and to provide MHNs with knowledge to recognize (potential) oral health problems in patients with a psychotic disorder. We used a human-centered design in which the user, MHNs as well as experts by experience, were placed in the centre of the research process. Problems and needs in MHNs working with patients with a psychotic disorder were addressed. To identify key issues of problem as well as the needs in terms of resources, we started with focus groups (n = 9). We analysed the data thematically based on context of patients and MHNs in practice regarding oral health, preferred oral health tools focused on MHN, and intended outcomes of tools. A Multi Criteria Decision Matrix was developed and analysed (n = 9) to identify the most optimal and viable solution based on established criteria and issues that are prevalent in the work of MHNs. Most promising result was the development of a brochure with an awareness screener. The brochure with awareness screener was developed as a low-fidelity prototype for MHNs regarding oral health in patients with a psychotic disorder, based on the latest scientific evidence. After testing it, the feasibility was tested through semi-structured interviews (n=19). MHNs and experts by experience were satisfied with the tool and provided recommendations for adjustments to the content. Significant augmentations to the brochure include a clinical lesson and a toothbrush with toothpaste for patients. We can conclude that a brochure with an awareness screener is feasible for MHNs. Future steps aiming to further refine and optimize care processes for oral health tools in MHNs, should take refining eligibility criteria for psychiatric populations and the language level of the target group of a tool into account.

Preprint CASE REPORT | doi:10.20944/preprints202403.0377.v1

Personalized and Complex Esthetic Oral Rehabilitation in a Case of Non-syndromic Oligodontia

Silvia Izabella Pop, Ana Procopciuc, Mihai Mitariu, Loredana Mițariu, Radu Vasile Pop

Subject: Medicine And Pharmacology, Dentistry And Oral Surgery Keywords: anodontia; oligodontia; oral rehabilitation; dental implants; esthetic dentistry; crowns; ceramics.

Online: 6 March 2024 (23:53:32 CET)

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Preprint ARTICLE | doi:10.20944/preprints202402.1199.v1

Validated Lc-Ms/Ms Assay for the Quantitative Determination of Fenretinide in Plasma and Tumor and Its Application to Pharmacokinetic Study in Mice of a Novel Oral Nanoformulation of Fenretinide

Cristina Matteo, Isabella Orienti, Adriana Eramo, Ann Zeuner, Mariella Ferrari, Alice Passoni, Renzo Bagnati, Marianna Ponzo, Ezia Bello, Massimo Zucchetti, Roberta Frapolli

Subject: Biology And Life Sciences, Life Sciences Keywords: Fenretinide; 4-HPR; oral formulation; pharmacokinetics; tumour distribution; analytical chemistry

Online: 22 February 2024 (01:40:14 CET)

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Preprint ARTICLE | doi:10.20944/preprints202308.1631.v1

Biaxial Flexural Strength of 3D-Printed Splint Materials

Johann Wulff, Angelika Rauch, Michael Schmidt, Martin Rosentritt

Subject: Chemistry And Materials Science, Biomaterials Keywords: 3D-printing; oral splint; biaxial flexural strength; TMD; PMMA; DLP

Online: 23 August 2023 (09:17:16 CEST)

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Preprint ARTICLE | doi:10.20944/preprints202306.0718.v3

3D Analysis of the Upper and Lower Arches Using Digital Technology: Measurement of the Index of Bolton and Correspondence between Arch Shape and Orthodontic Arches

Marco Pasini, Elisabetta Carli, Federico Giambastiani, Maria Rita Giuca, Domenico Tripodi

Subject: Medicine And Pharmacology, Dentistry And Oral Surgery Keywords: digital models; Bolton index; orthodontics CAD Software; extra-oral scanner

Online: 23 June 2023 (12:51:27 CEST)

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Preprint ARTICLE | doi:10.20944/preprints202304.0834.v1

Antifungal Susceptibility of Oral Candida Isolates From Mother-Infant Dyads to Nystatin, Fluconazole, and Caspofungin.

Naemah A Alkhars, Anthony Gaca, Yan Zeng, Nisreen Al-Jallad, Elena Rustchenko, Tong Tong Wu, Eli Eliav, Jin Xiao

Subject: Biology And Life Sciences, Immunology And Microbiology Keywords: Antifungal agent; in vitro susceptibility; oral Candida; nystatin; fluconazole; caspofungin

Online: 24 April 2023 (07:49:36 CEST)

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Preprint REVIEW | doi:10.20944/preprints202304.0798.v1

Attempts to Understand Oral Mucositis in Head and Neck Cancer Patients Through Omics Studies

Cielito C. Reyes-Gibby, Erin Marie D. San Valentin, Sai-ching J Yeung

Subject: Biology And Life Sciences, Biochemistry And Molecular Biology Keywords: Head and neck cancer; oral mucositis; pain; genomics; transcriptomics; microbiomics

Online: 23 April 2023 (12:29:17 CEST)

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Preprint ARTICLE | doi:10.20944/preprints202304.0562.v1

Glucose Levels of the Oral Glucose Tolerance Test (oGTT) Can Predict Adverse Pregnancy Outcomes in Women with Gestational Diabetes (GDM)

Selina Balke, Petra Weid, Laura Fangmann, Paul Rostin, Wolfgang Henrich, Josefine Theresia Koenigbauer

Subject: Medicine And Pharmacology, Endocrinology And Metabolism Keywords: oGTT, oral glucose tolerance test, gestational diabetes, GDM, cesarean section

Online: 19 April 2023 (07:38:14 CEST)

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Objectives and Background: Gestational diabetes (GDM) is a common pregnancy complication, defined as a glucose intolerance diagnosis during pregnancy. GDM is strongly associated with adverse fetal and maternal outcomes. In Germany, to screen and diagnose GDM we use a 1-hour 50g oGCT (oral glucose challenge test) followed by a 2-hour 75g oGTT if the first was pathological. This analysis examines the correlation of 75g oGTT glucose levels and fetomaternal outcome. Methods: Data of 1664 patients from a gestational diabetes consultation clinic at the Charité University hospital in Berlin, Germany, were analyzed retrospectively from 2015 until 2022. The 75g oGTT blood glucose levels were categorized into isolated fasting hyperglycemia (GDM-IFH), isolated post-load hyperglycemia (GDM-IPH) and combined hyperglycemia (GDM-CH), using the levels of the fasting, 1-hour and 2-hour values after glucose application. These subtypes were compared regarding baseline characteristics as well as fetal and maternal outcome. Results: GDM-IFH and GDM-CH women displayed higher preconceptional BMI and required insulin therapy more frequently (p<0,001). The GDM-IFH group was at higher risk of having a primary cesarean section (p=0,047), while GDM-IPH women were significantly more likely to have an emergent cesarean section (p=0,013). The offspring of GDM-IFH and GDM-CH women were born with a significantly higher mean birthweight (p<0,001) and birth weight percentiles (p<0,001) and were at increased risk of being large for gestational age (LGA) (p=0,004). Women from the GDM-IPH group delivered significantly more neonates who were small for gestational age (p=0,027) or with low fetal weight <30th percentile (p=0,003). Conclusion: This analysis shows a strong association between glucose response pattern in the 75g oGTT and adverse perinatal fetomaternal outcome. The differences among the subgroups, specifically concerning insulin therapy, mode of delivery and fetal growth, suggest an individualized approach in prenatal care after a GDM diagnosis.

Preprint COMMUNICATION | doi:10.20944/preprints202210.0351.v1

Machine Learning Heuristics on Gingivobuccal Cancer Gene Datasets Reveals Key Candidate Attributes for Prognosis

Tanvi Singh, Girik Malik, Saloni Someshwar, Hien Thi Thu Le, Rathnagiri Polavarapu, Laxmi Chavali, Jayaraman K. Valadi, Vijayaraghava Seshadri Sundararajan, Nidheesh M, Kavi Kishor PB, Prashanth N Suravajhala

Subject: Biology And Life Sciences, Biochemistry And Molecular Biology Keywords: oral cancer; machine learning; gene prioritization; genomic datasets; data mining

Online: 24 October 2022 (07:10:08 CEST)

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Preprint REVIEW | doi:10.20944/preprints202106.0249.v1

Do Mouthwashes Reduce Covid-19 Viral Load during Dental Procedures and Oropharyngeal Examinations? A Systematic Review

Simin Z. Mohebbi, Tayebe Ebrahimi, Ahmad Reza Shamshiri

Subject: Medicine And Pharmacology, Immunology And Allergy Keywords: mouthwash; mouth rinse; oral rinse; covid19; SARS-COV-2; coronavirus

Online: 9 June 2021 (09:10:08 CEST)

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Preprint ARTICLE | doi:10.20944/preprints202010.0162.v1

Enterococcus faecalis Enhances Candida albicans Mediated Tissue Destruction in a Strain-Dependent Manner

Akshaya Lakshmi Krishnamoorthy, Alex A Lemus, Adline Princy Solomon, Alex M Valm, Prasanna Neelakantan

Subject: Medicine And Pharmacology, Immunology And Allergy Keywords: biofilm; Candida albicans; E-cadherin; Enterococcus faecalis; FISH; oral mucosa.

Online: 8 October 2020 (08:20:36 CEST)

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Preprint ARTICLE | doi:10.20944/preprints202010.0145.v1

Causal Association between Periodontitis and Parkinson's Disease: A Bidirectional Mendelian Randomization Study

João Botelho, Vanessa Machado, José João Mendes, Paulo Mascarenhas

Subject: Medicine And Pharmacology, Immunology And Allergy Keywords: Parkinson’s disease; Periodontitis; Periodontal disease; Mendelian Randomization; Bioinformatics; Oral Health

Online: 7 October 2020 (08:26:14 CEST)

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Preprint ARTICLE | doi:10.20944/preprints202005.0016.v1

Interest of Proton Pump Inhibitors in Reducing the Occurrence of COVID-19: A Case-Control Study

Frederic Blanc, Cedric Waechter, Thomas Vogel, Benoît Schorr, Catherine Demuynck, Catherine Martin-Hunyadi, Maxence Meyer, Denata Mutelica, Nadjiba Bougaa, Samira Fafi-Kremer, Lidia Calabrese, Elise Schmitt, Delphine Imperiale, Catherine Jehl, Alexandre Boussuge, Carmen Suna, François Weill, Alexia Matzinger, Candice Muller, Patrick Karcher, Georges Kaltenbach, Erik Sauleau

Subject: Medicine And Pharmacology, Epidemiology And Infectious Diseases Keywords: COVID-19; elderly; proton pump inhibitors; antipsychotics; metformin; oral antidiabetics

Online: 2 May 2020 (15:48:33 CEST)

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Background: COVID-19 is a disease of the elderly as 95% of deaths related to COVID-19 occur in people over 60 years of age. Despite the urgent need for a preventive treatment there are currently no serious leads, other than the vaccination. Objective: To find a preventive treatment of COVID-19 in elderly patients. Design: Retrospective case-control study. Setting: Robertsau Geriatric Hospital of the University Hospitals of Strasbourg, France. Patients: 179 elderly patients who had been in contact with the SARS-CoV-2, of whom 89 had tested RT-PCR-positive (COVID-pos) for the virus and 90 had tested RT-PCR-negative (COVID-neg). Measurements: Treatments within 15 days prior to RT-PCR (including antihypertensive drugs, antipsychotics, antibiotics, nonsteroidal anti-inflammatory drugs, proton pump inhibitors (PPIs), paracetamol, anticoagulant, oral antidiabetics (OADs), corticosteroids, immunosuppressants), comorbidities, symptoms, laboratory values, and clinical outcome were all collected using the electronic patient record. Results: COVID-pos patients more frequently had a history of diabetes (P=.016) and alcoholism (P=.023), a lower leukocyte count (P=.014) and a higher mortality rate– 29.2% versus 14.4% – (P=.014) when compared to COVID-neg patients. Patients on PPIs were 2.3 times less likely (odds ratio [OR] = 0.4381, 95% confidence interval [CI] [0.2331, 0.8175], P=.0053) to develop COVID-19 infection, compared to those not on PPIs. No other treatment decreased or increased this risk. COVID-19 patients on antipsychotics (P=.0013) and OADs (P=.0166) were less likely to die. Limitations: retrospective study. Conclusion: PPIs treatment lowered the risk of development of COVID-19 infection, and antipsychotics and OADs decreased the risk of mortality in geriatric patients. If further studies confirm this finding, PPIs could be used preventatively in the elderly in this pandemic context. Moreover, OADS and antipsychotics should be tested in clinical trials.

Preprint ARTICLE | doi:10.20944/preprints201907.0079.v1

The Depletion of the “Don’t-Eat-Me” Signal CD47 Increases Radiosensitivity through Phenotypical Attenuation of Cancer Stem Cell and EMT Properties in Oral Squamous Cell Carcinoma Cells

Shin Pai, Oluwaseun Adebayo Bamodu, Yen-Kuang Lin, Chun-Shu Lin, Pei-Yi Chu, Ming-Hsien Chien, Liang-Shun Wang, Michael Hsiao, Chi-Tai Yeh, Jo-Ting Tsai

Subject: Biology And Life Sciences, Anatomy And Physiology Keywords: Keywords: Chemoradiation; Oral Cancer Stem cells; CD47; Radiotherapy techniques; Radioresistance

Online: 4 July 2019 (13:13:40 CEST)

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Preprint ARTICLE | doi:10.20944/preprints201808.0273.v1

Oral Lubrication Matters: Effects on Satiety

Emma Krop, Marion Hetherington, Sophie Miquel, Anwesha Sarkar

Subject: Social Sciences, Psychology Keywords: satiety; oral processing; lubrication; mastication; snack; appetite; chewing; food intake

Online: 15 August 2018 (14:59:00 CEST)

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Preprint COMMUNICATION | doi:10.20944/preprints202312.0894.v1

Assessing Antibiotic Safety: A Comparative Study of Four Promising Candidates Using pKCSM Database

IVAN VITO FERRARI

Subject: Medicine And Pharmacology, Pharmacology And Toxicology Keywords: Antibiotics,pkCSM, Max.tolerated dose (human),Oral Rat Chronic Toxicity,Oral Rat Acute Toxicity ;

Online: 12 December 2023 (12:55:56 CET)

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Preprint ARTICLE | doi:10.20944/preprints202401.1678.v1

Deciphering the Role of Post-translational Modifications and Cellular Location of HDV Antigens in HDV-Mediated Liver Damage in Mice

Sheila Maestro, Carla Usai, Nahia Gomez-Echarte, Gracian Camps, Cristina Olagüe, Africa Vales, Rafael Aldabe, Gloria Gonzalez-Aseguinolaza

Subject: Biology And Life Sciences, Virology Keywords: HDV; HDAg post-translational modification; isoprenylation; phosphorylation; ribozyme; intra-cellular localization: cell and mouse models; liver damage

Online: 23 January 2024 (09:49:03 CET)

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Preprint INTERESTING IMAGES | doi:10.20944/preprints202308.1196.v1

Intra-Arterial Contrast-Enhanced Ultrasonography Using Sonazoid for Hepatocellular Carcinoma: Case Reports

Kazue Shiozawa, Takahiro Murakami, Takashi Matsui, Ken Ito, Manabu Watanabe

Subject: Medicine And Pharmacology, Gastroenterology And Hepatology Keywords: hepatocellular carcinoma; contrast-enhanced ultrasonography; intra-arterial contrast-enhanced ultrasonography; transarterial chemoembolization; extrahepatic metastasis; hepatocellular carcinoma rupture

Online: 16 August 2023 (10:48:38 CEST)

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Preprint ARTICLE | doi:10.20944/preprints202208.0301.v1

Simultaneous Motor and Visual Intraoperative Neuromonitoring in Asleep Parietal Lobe Surgery: Dual Strip Technique

Devika Rajashekar, José Pedro Lavrador, Prajwal Ghimire, Hannah Keeble, Lauren Harris, Noemia Pereira, Sabina Patel, Ahmad Beyh, Richard Gullan, Keyoumars Ashkan, Ranjeev Bhangoo, Francesco Vergani

Subject: Medicine And Pharmacology, Oncology And Oncogenics Keywords: corticospinal tract; optic radiations; tractography; transcranial magnetic stimulation; subdural strip electrodes; intra-operative neuro-monitoring; parietal lobe

Online: 17 August 2022 (05:08:09 CEST)

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Background: The role played by the non-dominant parietal lobe in motor cognition, attention and spatial awareness networks has potentiated the use of awake surgery. When this is not feasible, asleep monitoring and mapping techniques should be used to achieve an onco-functional balance. Objective: This study aims to assess the feasibility of a dual-strip method to obtain direct cortical stimulation for continuous real-time cortical monitoring and subcortical mapping of motor and visual pathways simultaneously in parietal lobe tumour surgery. Methods: Single-centre prospective study between May’19-November’20 of patients with intrinsic non-dominant parietal-lobe tumours. Two subdural strips were used to simultaneously map and monitor motor and visual pathways. Results: Fifteen patients were included. With regards to motor function, a large proportion of patients had abnormal interhemispheric resting motor threshold ratio (iRMTr) (71.4%), abnormal Cortical Excitability Score (CES) (85.7%), close distance to the corticospinal tract – Lesion-To-Tract Distance (LTD) – 4.2mm, Cavity-To-Tract Distance (CTD) – 7mm and intraoperative subcortical distance - 6.4mm. Concerning visual function, the LTD and CTD for optic radiations (OR) were 0.5mm and 3.4mm, respectively; the mean intensity for positive subcortical stimulation of OR was 12mA±2.3mA and 5/6 patients with deterioration of VEPs>50% had persistent hemianopia and transgression of ORs. 12 patients remained stable, one patient had a de-novo transitory hemiparesis, and two showed improvements in motor symptoms. A higher iRMTr for lower limbs was related with a worse motor outcome (p=0.013) and a longer CTD to OR was directly related with a better visual outcome (p=0.041). At 2 weeks after hospital discharge, all patients were ambulatory at home and all proceeded to have oncological treatment. Conclusion: We propose motor and visual function boundaries for asleep surgery of intrinsic non-dominant parietal tumours. Pre-operative abnormal cortical excitability of the motor cortex, deterioration of the VEP recordings and CTD<2mm from the OR were related to poorer outcomes.

Preprint ARTICLE | doi:10.20944/preprints202404.0735.v1

Preparation and Evaluation of Niosomal Formulation for Solubility Enhancement of Anti-fungal Agent for the Treatment of Oral Candidiasis

Yogesh Chaudhari, Manisha Chaudhari, Shikha Prasad

Subject: Medicine And Pharmacology, Pharmacy Keywords: Candida albicans; Oral thrush; Anti-fungal; Subgingival film; Niosomes

Online: 11 April 2024 (04:02:09 CEST)

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Preprint REVIEW | doi:10.20944/preprints202312.0263.v1

Cancer‐Associated Fibroblast Heterogeneity in Oral Cancer

Julia Arebro, Che-Min Lee, Kevin L Bennewith, Cathie Garnis

Subject: Medicine And Pharmacology, Oncology And Oncogenics Keywords: Cancer‐associated fibroblast, CAF subtype, oral squamous cell carcinoma, tumor microenvironment

Online: 5 December 2023 (11:11:14 CET)

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Preprint ARTICLE | doi:10.20944/preprints202310.0507.v1

Effect of alpha-linolenic acid on human oral squamous cell carcinoma metastasis and apoptotic cell death

Ching-Chyuan Su, Cheng-Chia Yu, Yi-Wen Shih, Kai-Li Liu, Haw-Wen Chen, Chih-Chung Wu, Ya-Chen Yang, En-Ling Yeh, Chien-Chun Li

Subject: Medicine And Pharmacology, Oncology And Oncogenics Keywords: α-linolenic acid; epithelial-mesenchymal transition; metastasis; apoptosis; oral cancer; OSCC

Online: 9 October 2023 (14:46:21 CEST)

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Preprint ARTICLE | doi:10.20944/preprints202309.1537.v1

Safety Evaluation of N-((3S,4S)-4-(3,4-Difluorophenyl)piperidin-3-yl)-2-fluoro-4-(1-methyl-1H-pyrazol-5-yl) benzamide (Hu7691) by a Repeated Dose 14-Day Oral Exposure Toxicity Study in Rats

Renhua Gai, Chao Chen, Wei Zhang, Ma Jian, Xiaomeng Wang, Xiaoqing Chi, Guangxing Li

Subject: Medicine And Pharmacology, Pharmacology And Toxicology Keywords: Hu7691; 14-day exposure; Oral toxicity study; SD rats; Formulation; Histopathology

Online: 22 September 2023 (07:38:10 CEST)

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Preprint ARTICLE | doi:10.20944/preprints202308.1352.v1

Oral Iron Absorption of Ferric Citrate Hydrate and Hepcidin-25 in Hemodialysis Patients: A Prospective, Multicenter, Observational Riona-Oral Iron Absorption Trial

Naohisa Tomosugi, Yoshitaka Koshino, Chie Ogawa, Kunimi Maeda, Noriaki Shimada, Kimio Tomita, Shoichiro Daimon, Tsutomu Shikano, Kazuyuki Ryu, Toru Takatani, Kazuya Sakamoto, Satonori Ueyama, Daisuke Nagasaku, Masato Nakamura, Shibun Ra, Masataka Nishimura, Chieko Takagi, Yoji Ishii, Noritoshi Kudo, Shinsuke Takechi, Takashi Ishizu, Takamoto Yanagawa, Masamichi Fukuda, Yutaka Nitta, Takayuki Yamaoka, Taku Saito, Suzuko Imayoshi, Momoyo Omata, Joji Oshima, Akira Onozaki, Hiroaki Ichihashi, Yasuhisa Matsushima, Hisahito Takae, Ryoichi Nakazawa, Koichi Ikeda, Masato Tsuboi, Keiko Konishi, Shouzaburo Kato, Maki Ooura, Masaki Koyama, Tsukasa Naganuma, Makoto Ogi, Shigeyuki Katayama, Toshiaki Okumura, Shigemi Kameda, Sayuri Shirai

Subject: Medicine And Pharmacology, Urology And Nephrology Keywords: oral iron absorption; ferric citrate hydrate; hemodialysis; hepcidin-25; iron shift

Online: 18 August 2023 (11:20:29 CEST)

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Preprint REVIEW | doi:10.20944/preprints202307.0945.v1

Biomechanical Implications of Mandibular Flexion on Implant-Supported Full-Arch Rehabilitations: A Systematic Literature Review

Mario Caggiano, Francesco D'Ambrosio, Alfonso Acerra, David Giudice, Francesco Giordano

Subject: Medicine And Pharmacology, Dentistry And Oral Surgery Keywords: mandibular flexure; mandibular deformation; fixed oral rehabilitation; implant-supported full-arch

Online: 14 July 2023 (09:51:56 CEST)

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Preprint ARTICLE | doi:10.20944/preprints202307.0650.v1

Association between Salivary Cortisol and α-amylase with the Psychological Profile of Patients with Oral Lichen Planus and Burning Mouth Syndrome: A Cross-Sectional Study

Ana Glavina, Liborija Lugović-Mihić, Dinko Martinović, Livia Cigić, Ledia Tandara, Marino Lukenda, Dolores Biočina-Lukenda, Daniela Šupe-Domić

Subject: Medicine And Pharmacology, Dentistry And Oral Surgery Keywords: Alpha-Amylase; Biomarkers; Burning Mouth Syndrome; Cortisol; Oral Lichen Planus; Saliva.

Online: 11 July 2023 (09:24:41 CEST)

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Preprint CASE REPORT | doi:10.20944/preprints202306.1182.v1

Leiomyoma With Uncommon Localization – Incisive Papilla and Palatal Fibromucosa: A Case Report

Marina Rakitovan, Adrian Nicoara, Raluca Maria Closca, Nicolae Constantin Balica, Stefanescu Horatiu Eugen, Flavia Baderca

Subject: Public Health And Healthcare, Public Health And Health Services Keywords: oral pathology; leiomyoma; incisive papilla; palatal fibromucosa; surgical excision; immunohistochemical staining

Online: 16 June 2023 (07:24:23 CEST)

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Preprint ARTICLE | doi:10.20944/preprints202306.0847.v1

A Novel UHPLC-MS/MS Based Bioanalytical Method Used for S-Allyl Cysteine Comparative Pharmacokinetic Study

Niyaz Ahmad, Mohd Faiyaz Khan, Faisal K Alkholifi, Zabih Ullah, Sadaf Farooqui, Dr. Nazia Khan, Mohammed Saifuddin Khalid, Mir Naiman Ali, Hajera Tabassum

Subject: Medicine And Pharmacology, Pharmacy Keywords: S-Allyl Cysteine; Oral Bioavailability; PLGA NPs; LC–MS/MS; Pharmacokinetics

Online: 12 June 2023 (14:09:39 CEST)

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Preprint COMMUNICATION | doi:10.20944/preprints202305.1734.v1

Prevalence of Enterococci and Vancomycin Resistance in the Throat of Non-Hospitalized Individuals Randomly Selected in Central Italy

Annalisa Palmieri, Marcella Martinelli, Agnese Pellati, Francesco Carinci, Dorina Lauritano, Claudio Arcuri, Luigi Baggi, Roberto Gatto, Luca Scapoli

Subject: Public Health And Healthcare, Public Health And Health Services Keywords: Enterococcus faecalis; Enterococcus faecium; vancomycin; prevalence; resistance; antibiotics; oral cavity; screening

Online: 25 May 2023 (04:29:13 CEST)

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Preprint ARTICLE | doi:10.20944/preprints202305.1237.v1

Comparison Between Cultivated Oral Mucosa and Ocular Surface Epithelia for COMET Patients Follow-up.

Eustachio Attico, Giulia Galaverni, Andrea Torello, Elisa Bianchi, Susanna Bonacorsi, Lorena Losi, Rossella Manfredini, Alessandro Lambiase, Paolo Rama, Graziella Pellegrini

Subject: Biology And Life Sciences, Biochemistry And Molecular Biology Keywords: aniridia; biomarker; COMET; cornea; LSCD; neovascularization; oral mucosa; PITX2; ocular surface

Online: 17 May 2023 (10:45:28 CEST)

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Preprint ARTICLE | doi:10.20944/preprints202304.0569.v1

Development and Evaluation of Self-Microemulsifying Drug Delivery System for Improving Oral Absorption of Poorly Water-soluble Olaparib

Yong-Han Kim, Seong-Bo Kim, Se-Hui Choi, Thi-Thao-Linh Nguyen, Sung-Hoon Ahn, Kyung-Sun Moon, Kwan Hyung Cho, Taeyong Sim, Eun-Ji Heo, Sungtae Kim, Han-Gon Choi, Dong-Jin Jang

Subject: Medicine And Pharmacology, Medicine And Pharmacology Keywords: Olaparib; self-microemulsifying drug delivery system; microemulsion; solubility; dissolution; oral absorption

Online: 19 April 2023 (08:16:05 CEST)

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The purpose of this study is to develop and evaluate a self-microemulsifying drug delivery system (SMEDDS) to improve the oral absorption of poorly water-soluble Olaparib. Through the solubility test of Olaparib in various oils, surfactants and co-surfactants, pharmaceutical excipients for use in SMEDDS manufacturing were selected. Self-emulsifying regions were identified by mixing the selected materials at various ratios, and a pseudoternary phase diagram was constructed by synthesizing these results. Various physicochemical properties of microemulsion incorporating Olaparib were confirmed by investigating the particle morphology, particle size, zeta potential, drug content and stability. In addition, the improved dissolution and oral absorption of Olaparib were also confirmed through a dissolution test and a pharmacokinetic study. An optimal microemulsion was generated in the formulation of Capmul MCM EP/NF 10%, Labrasol 80% and PEG 400 10%. Fabricated nano-sized microemulsions were well-dispersed in aqueous solutions, and it was also confirmed that it was maintained well without any problems of either physical or chemical stability. The 5 min initial dissolution of Olaparib in fabricated formulations was improved by 10.6 times (pH1.2), 14.8 times (pH6.8) and 14.8 times (distilled water) compared to the values of Olaparib powder. The dissolution at 120min was 45.4±4.0%(pH1.2), 53.5±1.1% (pH6.8) and 58.1±1.00% (distilled water) in Olaparib powder but has been significantly improved by 1.7 times (74.8±1.9%), 1.6 times (84.2±0.3%) and 1.5 times (81.2±0.7%) in SMEDDS. Associated with the high dissolutions of Olaparib in fabricated microemulsions, the pharmacokinetic parameters were also greatly improved. The Cmax and AUCinf of Olaparib in the prepared microemulsion were increased 4.2- and 3.2-fold, respectively, compared to powder. Taken together with the results mentioned above, the microemulsion system could be an effective tool as an oral delivery formulation for Olaparib. Additionally, our results demonstrate that the SMEDDS systems comprising Capmul MCM, Labrasol and PEG 400 could be a useful option for improvement of several other poorly water-soluble drugs with physico-chemical properties similar to Olaparib.

Preprint ARTICLE | doi:10.20944/preprints202108.0398.v1

Direct Oral Anticoagulants in Patients with Nonvalvular Atrial Fibrillation: A Real-World Experience from a Single Spanish Regional Hospital

Enrique Rodilla, Maria Isabel Orts-Martinez, Miguel Angel Sanz-Caballer, María Teresa Gimeno-Brosel, Maria Jesús Arilla-Morel, Isabel Navarro-Gonzalo, Inmaculada Castillo-Valero, Inmaculada Salvador-Mercader, Ana Carral-Tatay

Subject: Medicine And Pharmacology, Clinical Medicine Keywords: Direct oral anticoagulants (DOACs); Nonvalvular atrial fibrillation (NVAF); Real-world experience

Online: 19 August 2021 (10:32:56 CEST)

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The aim is to evaluate a program for direct oral anticoagulants (DOACs) management in nonvalvular atrial fibrillation (NVAF) patients, according to patient profiles, appropriateness of dosing, patterns of crossover, effectiveness and safety. This is an observational and longitudinal retrospective study in a cohort of patients attended in daily clinical practice in a single regional hospital in Spain with a systematic follow-up plan for up to 3 years for patients initiating dabigatran, rivaroxaban or apixaban between JAN/2012-DEC/2016. We analyzed 490 episodes of treatment (apixaban 2.5 mg: 9.4%, apixaban 5 mg: 21.4%, dabigatran 75 mg: 0.6%, dabigatran 110 mg: 12,4%, dabigatran 150 mg: 19.8%, rivaroxaban 15 mg: 17.8% and rivaroxaban 20 mg: 18.6%) in 445 patients. 13.6% of patients on dabigatran, 9.7% on rivaroxaban, and 3.9% on apixaban, switched to other DOACs or changed dosing. Apixaban was the most frequent DOAC switched to. The most frequent reasons for switching were toxicity (23.8%), bleeding (21.4%) and renal deterioration (16.7%). Inappropriateness of dose was found in 23.8% of episodes. Patients taking apixaban 2.5 mg were older, had higher CHA2DS2VASc score and lower creatinine clearance. Patients taking dabigatran 150 mg and rivaroxaban 20 mg were younger, had lower CHA2DS2VASc and higher creatinine clearance. Rates of stroke/transient ischemic attack (TIA) were 1.64/0.54 events/100 patients-years, while rates of major, clinically relevant non-major (CRNM) bleeding and intracranial bleeding where 2.4, 5, and 0.5 events/100 patients-years. Gastrointestinal and genitourinary bleeding were the most common type of bleeding events (BE). On multivariable analysis, prior stroke (RR: 4.2; CI: 1.5-11.8; p=0.006) and age (RR: 1.2; CI: 1.1-1.4; p=0.006) were independent predictors of stroke/TIA. Concurrent platelet inhibitors (RR: 7.1; CI: 2.3-21.8; p=0.001), male gender (RR: 2.1; CI: 1.2-3.7; p=0.0012) and age (RR: 1.1; CI: 1.02-1.13; p=0.005) were independent predictors of BE. This study complements the scant data available on the use of DOACs in NVAF patients in Spain, confirming a good safety and effectiveness profile

Preprint ARTICLE | doi:10.20944/preprints202105.0497.v1

Metal(loids) Bioaccessibility in Road Dusts from the Surrounding Villages of an Active Mine

Carla Candeias, Paula F. Ávila, Eduardo Ferreira da Silva, Fernando Rocha

Subject: Environmental And Earth Sciences, Atmospheric Science And Meteorology Keywords: road dusts; active mine; metal(loids); oral bioaccessibility; human health risk

Online: 21 May 2021 (07:44:30 CEST)

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Preprint ARTICLE | doi:10.20944/preprints202011.0455.v1

Association Between Dietary Inflammatory Index and Periodontitis: A Cross-Sectional and Mediation Analysis

Vanessa Machado, João Botelho, João Viana, Paula Pereira, Luísa Lopes, Luís Proença, Ana Sintra Delgado, José João Mendes

Subject: Medicine And Pharmacology, Immunology And Allergy Keywords: NHANES; periodontal diseases; periodontitis; tooth loss; inflammation; diet; nutrition; oral health

Online: 17 November 2020 (14:44:20 CET)

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Preprint CASE REPORT | doi:10.20944/preprints202006.0363.v1

Linear Oral Lichen Planus: A Rare Presentation

Prashanth Panta, David Felix, Dimitrios Andreadis, Mukund Seshadri

Subject: Medicine And Pharmacology, Dentistry And Oral Surgery Keywords: Oral lichen planus; Koebner phenomenon; mechanical trauma; dental cusps; psychological distress

Online: 30 June 2020 (10:09:06 CEST)

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Preprint ARTICLE | doi:10.20944/preprints202005.0135.v1

Special Precautions in Oral and Maxillofacial Surgeries Regarding COVID-19 Transmission

Matheus Francisco Barros Rodrigues, Layla Louise de Amorim Rocha, Rodrigo da Franca Acioly, Dennis Dinelly de Souza, Daniel do Carmo Carvalho, Rimsky Coelho Lopes da Rocha, Cristofe Coelho Lopes da Rocha

Subject: Biology And Life Sciences, Virology Keywords: Coronavirus disease 2019 (COVID-19); Oral and maxillofacial; Urgency and emergency;

Online: 7 May 2020 (15:29:53 CEST)

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Working Paper ARTICLE

Transcriptome and Metabolome Analysis Reveal Oral Secretions from Two Lepidoptera Species Induced Defense Response in Cotton

Huan Si, Hongling Liu, Yiwen Sun, Zhongping Xu, Sijia Liang, Bo LI, Xiao Ding, Jianying Li, Qiongqiong Wang, Lin Sun, Shuangxia Jin

Subject: Biology And Life Sciences, Animal Science, Veterinary Science And Zoology Keywords: Oral secretions; H. armigera; S. litura; Cotton; Suppression; Host plant defense

Online: 27 August 2019 (10:06:32 CEST)

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Preprint ARTICLE | doi:10.20944/preprints202310.1755.v1

Investigating Transportation Needs in Clinical Nursing – Observational Task Assessment in Rural Clinics

Domenic Sommer, Jakob Kasbauer, Dietmar Jakob, Sebastian Schmidt, Florian Wahl

Subject: Public Health And Healthcare, Nursing Keywords: assistive robots; clinic logistics; nursing task classification; nursing workload; intra-hospital transfers; time and motion studies; healthcare; Germany

Online: 27 October 2023 (05:11:52 CEST)

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Preprint ARTICLE | doi:10.20944/preprints202101.0361.v1

Granites and Pegmatites of the Collisional and Intra-Plate Magmatism of the Baikal Area: Age, Mineralogical and Geochemical Types and Genesis Peculiarities

Viktor Antipin, Natalya Sheptyakova, Larisa Kushch, Valentina Makrygina

Subject: Environmental And Earth Sciences, Atmospheric Science And Meteorology Keywords: Paleozoic granitoids; pegmatites; age; collisional; intra-plate; magmatism; mineralogical and geochemical types; mineralization; minerals; post-collisinal; amazonite; genesis

Online: 18 January 2021 (16:14:03 CET)

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The paper presents new data on mineralogical-geochemical peculiarities of the granites and pegmatites of the Baikal area (Olkhon Region) with implications for the age, generation conditions and geodynamic settings of magmatism. The early Paleozoic granitoids of the Olkhon region are syncollisional formations produced from the gneiss-schistose substratum of the Olkhon metamorphic sequences. Pegmatoid granites and pegmatites of the Region were generated within a wide age range (458-390 Ma) and include different mineralogical and geochemical types. Amongst the Early Paleozoic granitoids, pegmatoid rocks are products of the collisional magmatism evolution and are similar to granites in terms of the mineral composition and distribution patterns of rare and rare earth elements. On the Olkhon island (Baikal lake) the pegmatite of the Tashkiney vein belong to the Be-Nb-Ta mineralogical-geochemical type demonstrating high contents of W, Sn U, Th and very low concentrations of Li and volatile components (F, B). In the Pryolkhonye area, vein pegmatite Iliksin is with Li, Be, Nb, Ta mineralization (lepidolite, vorobyevite, samarskite et al). The studied pegmatite veins are similar both by the profound negative Ba, Sr, Eu, and Zr anomalies. The zircons from the Tashkiney vein (390±5.0 Ma) and of the Iliksin vein (430.1±2.2 Ma, U-Pb isotope LA ICP MS metod) indicate the formation of pegmatite at the late post-collisional stage of magmatism in the Olkhon Region. As regard to mineralogical and geochemical characteristics, vein pegmatites with amazonite (Ainsky and Ulan-Nur) belong to the Li-F type. The tantalum mineralization, represented by microlites and minerals of the columbite-tantalite group is associated with the Ainsky amazonite pegmatite. As opposed to the Early Paleozoic syncollisional granitoids and pegmatoid formations, the middle Paleozoic vein bodies of pegmatites (Tashkiney, Iliksin, Ainsky, Ulan-Nur) are regarded as rare-metal pegmatites. In terms of geochemical characteristics, they are similar to the rare-metal pegmatoid granites and pegmatites of the intra-plate setting widespread in Mongolia and Transbaikalia. The rare-metal mineralization in the Olkhon region may be genetically related to the evolution of Be-Nb-Ta and Li-F types of the post-collisional granites and pegmatites.

Preprint ARTICLE | doi:10.20944/preprints201910.0235.v1

Climate Change and Fading Genetic Resources of Parkia biglobosa (Jacq.) in Nigeria Based on SSR Markers

Jacob Popoola, James Agbolade, Abiodun Ajiboye, Omotolani Akinola, Francis Lewu, Joseph Kioko, Conrad Omonhinmin

Subject: Biology And Life Sciences, Biochemistry And Molecular Biology Keywords: African locust bean; climate change; cluster analysis; genetic intra-specific diversity; polymorphic information content; food and nutrition security

Online: 20 October 2019 (16:01:21 CEST)

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African locust bean (Parkia biglobosa (Jacq.) is a multi-purpose economic tree with genetic potentials in sub-Saharan Africa. Its cultivation and production is declining with increased aging and genetically threatened throughout its natural ranges. Research efforts are needed to change the present scenario to sustainable cultivation and utilization, hence this present study. This study was aimed at evaluating genetic diversity and geographical spread relationships of twenty landraces collected from different ecological zones of Nigeria using simple sequence repeat (SSR) markers. Ten SSR markers were screened and five primers (PbL02, PbL03, PbL04, PbL05 and PbL09) were selected based on clear amplification products and reproducible scorable bands. The SSR primers detected a total of 55 alleles ranged from 10 to 14 alleles with a mean of 11. The percentage polymorphisms were high and ranged from 68.75 % in PbL04 to 84.21 % in PbL05 with a mean of 74.16 %. The polymorphic information content (PIC) was in the range of 0.31 in PbL02 to 0.37 in PbL09. The genetic diversity and heterozygosity values ranged from 0.39 to 0.50 and 0.00 to 0.68 while the average genetic distance for all pair wise comparisons was 0.31.The first five Principal Component (PC) accounted for 70.20 % of the total variation out of which PC1 (31.50%) and PC2 (19.20%) extracted 49.70% molecular similarity. The dendrogram resulted in separation of the 19 landraces into three major clusters based on unweighted pair group method with arithmetic average. Cluster I comprised of five landraces: ABNo130 and BENo023; OYNo11, KANo125 and NiNo262 while cluster II had only one (BANo116). Cluster III was diverse comprising 13 landraces: ZANo188, KNNo162, KENo220, GMNo076 and EbNo260, ADNo64, EdNo164, KANo137, KENo217, KwNo270, NiNo241, OsNo206 and PLNo120. The homogeneity of alleles among the studied landraces suggested suspicion of loss of genetic intra-specific variation among the landraces of P. biglobosa which calls for concerted efforts toward better cultivation, conservation, management, utilization and genetic improvement of the species in Nigeria.

Preprint ARTICLE | doi:10.20944/preprints201807.0053.v1

Characterization of the Fat Channel for Intra-Body Communication at R-Band Frequencies

Noor Badariah Asan, Emadeldeen Hassan, Jacob Velander, Syaiful Redzwan Mohd Shah, Daniel Noreland, Taco J. Blokhuis, Eddie Wadbro, Martin Berggren, Thiemo Voigt, Robin Augustine

Subject: Engineering, Electrical And Electronic Engineering Keywords: Intra-body communication; path loss; microwave probes; channel characterization; fat tissue; ex-vivo; phantom; dielectric properties; topology optimization.

Online: 3 July 2018 (15:08:56 CEST)

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Preprint ARTICLE | doi:10.20944/preprints202404.0699.v1

Development of a Compartment Model to Study the Pharmacokinetics of Medical THC after Oral Administration

Thanachok Mahahong, Teerapol Saleewong

Subject: Computer Science And Mathematics, Computational Mathematics Keywords: compartment model; delta9-tetrahydrocannabinol (THC); nonstandard finite difference (NSFD); oral administration; pharmacokinetics

Online: 10 April 2024 (10:53:56 CEST)

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Preprint ARTICLE | doi:10.20944/preprints202403.1570.v1

Comparative Analysis of Biofilm Removal Efficiency and Tooth Wear between Mechanical Electric and Bioelectric Devices

Jihyun Lee, Hyun M. Park, Young Wook Kim

Subject: Biology And Life Sciences, Biology And Biotechnology Keywords: Bioelectric effect; oral health; plaque formation; plaque removal; tooth wear; gingival index

Online: 26 March 2024 (10:28:34 CET)

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Preprint ARTICLE | doi:10.20944/preprints202402.0002.v1

Candida Variety in the Oral Cavity of Mexican Subjects with Type 2 Diabetes Mellitus and TLR2 Gene Expression

NADIA MABEL PEREZ VIELMA, MODESTO GÓMEZ LÓPEZ, MARÍA DE LOS ANGELES MARTÍNEZ GODÍNEZ, ANA LAURA LUNA TORRES, AARÓN DOMÍNGUEZ LÓPEZ, ANGEL MILIAR GARCÍA

Subject: Biology And Life Sciences, Biochemistry And Molecular Biology Keywords: Candida, type 2 diabetes mellitus, PAP stain, oral cavity, molecular diagnosis, TLR2

Online: 1 February 2024 (09:32:31 CET)

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Preprint ARTICLE | doi:10.20944/preprints202401.0974.v1

Cellulose Nanocrystals Show Anti-adherent and Anti-biofilm Properties Against Oral Microorganisms

Antonella Panio, Andrei C. Ionescu, Barbara La Ferla, Luca Zoia, Paolo Savadori, Gianluca M. Tartaglia, Eugenio Brambilla

Subject: Medicine And Pharmacology, Dentistry And Oral Surgery Keywords: Cellulose nanocrystals; bacterial adherence; biofilms; Streptococcus mutans; Candida albicans; Oral microcosm; Bioreactors

Online: 12 January 2024 (04:08:02 CET)

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Preprint ARTICLE | doi:10.20944/preprints202312.0840.v1

Mean Oral Cavity Organ at Risk Dose Predicts Opioid Use and Hospitalization During Radiotherapy for Patients with Head and Neck Tumors

Robert L. Foote, William S. Harmsen, Adam C. Amundson, Alan B. Carr, Mauricio E. Gamez, Yolanda I. Garces, Scott C. Lester, Daniel J. Ma, Lisa A. McGee, Eric J. Moore, Michelle A. Neben Wittich, Samir H. Patel, David M. Routman, Jean-Claude M. Rwigema, Kathryn M. Van Abel, Linda X. Yin, Olivia M. Muller, Satomi Shiraishi

Subject: Medicine And Pharmacology, Oncology And Oncogenics Keywords: radiotherapy; head and neck cancer; oral cavity; organ at risk; adverse events

Online: 13 December 2023 (06:20:32 CET)

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Preprint REVIEW | doi:10.20944/preprints202311.1826.v1

Oral SERD, A Novel Endocrine Therapy for Estrogen Receptor-Positive Breast Cancer

Niraj Neupane, Sawyer Bawek, Sayuri Gurusinghe, Elham Moases Ghaffary, Omid Mirmosayyeb, Sangharsha Thapa, Carla Falkson, Ruth O’Regan, Ajay Dhakal

Subject: Medicine And Pharmacology, Oncology And Oncogenics Keywords: Breast cancer; Estrogen receptor-positive; endocrine therapies; resistance; selective estrogen degrades; Oral

Online: 29 November 2023 (08:15:18 CET)

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Preprint ARTICLE | doi:10.20944/preprints202308.0899.v1

The Relationship between Oral Health‐Related Quality of Life and Body Mass Index in an Older Population from Southern Italy: The Salus in Apulia Study

Vittorio Dibello, Frank Lobbezoo, Rodolfo Sardone, Madia Lozupone, Fabio Castellana, Roberta Zupo, Alberto Pilotto, Antonio Daniele, Vincenzo Solfrizzi, Daniele Manfredini, Francesco Panza

Subject: Medicine And Pharmacology, Medicine And Pharmacology Keywords: oral health; body mass index; obesity; OHRQoL; OHIP-14; aging; older people

Online: 11 August 2023 (07:51:32 CEST)

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Preprint ARTICLE | doi:10.20944/preprints202307.1343.v1

Head and Neck Cancer in Pan-American Notable People: An International Survey

Josefina Martínez-Ramírez, Cristina Saldivia-Siracusa, Maria E. Pérez-de-Oliveira, Ana Gabriela Normando, Luiz Paulo Kowalski, Maria Paula Curado, Lady Paola Aristizabal Arboleda, Gisele Aparecida Fernandes, Florence Juana María Cuadra-Zelaya, Márcio Ajudarte Lopes, Marco A O Magalhaes, Vidya Sankar, Alessandro Villa, Alan R. Santos-Silva

Subject: Public Health And Healthcare, Health Policy And Services Keywords: Head and neck cancer, oral cancer, prevention, famous people, celebrities, public awareness.

Online: 19 July 2023 (13:01:36 CEST)

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Preprint ARTICLE | doi:10.20944/preprints202307.0622.v1

Tau-Marin Mucoadhesive Gel for Prevention and Treatment of Periodontal Diseases

Giuseppe Giannini, Irene Ragusa, Giulia Nerina Nardone, Sara Soldi, Marina Elli, Piera Valenti, Luigi Rosa

Subject: Medicine And Pharmacology, Dentistry And Oral Surgery Keywords: Tau-Marin; Mucoadhesive gel; oral formulation; probiotics; periodontitis; periodontal diseases; slow delivery

Online: 10 July 2023 (11:34:50 CEST)

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Preprint ARTICLE | doi:10.20944/preprints202304.0939.v1

Systemic Health Factors Related to Rapid Oral Health Deterioration Among Older People

Gert-Jan Van der Putten, Cees De Baat

Subject: Public Health And Healthcare, Public Health And Health Services Keywords: oral health care; older people; multimorbidity; polypharmacy; frailty; sarcopenia; disability; care dependency

Online: 26 April 2023 (03:23:46 CEST)

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Preprint ARTICLE | doi:10.20944/preprints202301.0150.v2

Comparison of Culture Media for in-vitro Expansion of Oral Epithelial Keratinocytes: Implications for Testing E-liquid Flavors

Giancarlo Cuadra, Abrar Shamim, Raivat Shah, Joey Morgan, Dominic L Palazzolo

Subject: Biology And Life Sciences, Cell And Developmental Biology Keywords: oral; mucosa; mucins; tight junctions; wound-healing; E-liquids; cytotoxicity; viability; confluency.

Online: 3 April 2023 (03:33:37 CEST)

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Preprint REVIEW | doi:10.20944/preprints202212.0497.v1

Association between Periodontal Disease and cognitive impairment in Adults

Najwane Said-Sadier, Batoul Sayegh, Raymond Farah, Linda Abou Abbas, Rania Dweik, Norina Tang, David M. Ojcius

Subject: Medicine And Pharmacology, Dentistry And Oral Surgery Keywords: cognitive impairment; dementia; oral pathogens; periodontitis; inflammatory biomarkers; anti-bodies; systematic review

Online: 27 December 2022 (01:41:02 CET)

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Preprint ARTICLE | doi:10.20944/preprints202211.0552.v1

Cryptic Oral Microbiota: What is its Role as OSA-related Periodontal Pathogens?

Mayra Alexandra Téllez Corral, Eddy Herrera Daza, Hayde Kamila Cuervo Jimenez, María del Mar Bravo Becerra, Jean Carlos Villamil, Patricia Hidalgo Martinez, Nelly S. Roa Molina, Liliana Otero, María E. Cortés, Claudia M. Parra Giraldo

Subject: Biology And Life Sciences, Immunology And Microbiology Keywords: periodontitis; obstructive sleep apnea; oral microbiota; pathogenic microbiota; chronic diseases; MALDI-TOF

Online: 29 November 2022 (13:09:35 CET)

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Commonly the periodontitis has been linked to periodontopathogens categorized in Socransky's microbial complexes, however, there is a lack of knowledge regarding “other microorganisms” or "cryptic microorganisms", which are rarely thought of as significant oral pathogens and are neither previously categorized nor connected to illnesses in the oral cavity. This study hypothesized that these cryptic microorganisms could contribute to the modulation of oral microbiota present in health or disease (periodontitis and/or OSA patients). For this purpose, the presence and the correlation among these cultivable cryptic oral microorganisms were identified and their possible role in both conditions was determined. Data from oral samples of individuals with or without periodontitis and with or without OSA were obtained from a previous study. Demographic data, clinical oral characteristics, and genera and species of cultivable cryptic oral microorganisms identified by MALDI-TOF were recorded. The data of 75 participants were analyzed to determine the relative frequencies of cultivable cryptic microorganisms’ genus and species, microbial clusters and correlations tests were performed. According to periodontal condition, Gingivitis - dental biofilm-induced in reduced periodontium and stage III periodontitis were found to have the highest diversity of cryptic microorganism species. Based on the experimental condition these findings showed that there are genera related to disease conditions and others related to healthy conditions, with species that could be related to different chronic diseases being highlighted as comorbidities periodontitis and OSA. The cryptic microorganisms within the oral microbiota of patients with periodontitis and OSA are present as potential pathogens, promoting the development of dysbiotic microbiota, and the occurrence of chronic diseases, which have been previously proposed to be common risk factors for periodontitis and OSA. Understanding the function of possible pathogens in the oral microbiota will take more research.

Preprint ARTICLE | doi:10.20944/preprints202210.0330.v1

Megalin Expression in Primary Oral Squamous Cell Carcinoma Is Associated With the Presence of Lymph Node Metastases, Vascular Invasion and Lower Overall Survival

Ana Zulijani, Ana Milardović, Zoran Kovač, Berislav Perić, Hrvoje Jakovac

Subject: Medicine And Pharmacology, Oncology And Oncogenics Keywords: megalin; oral squamous cell carcinoma; lymph node metastases; vascular invasion; overall survival

Online: 21 October 2022 (10:17:46 CEST)

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Preprint REVIEW | doi:10.20944/preprints202106.0680.v1

Impact of an Oncology Clinical Pharmacist on Patient Engagement in Self-Administered Oral Oncolytic Therapy: Case Study of Venetoclax in Acute Myeloid Leukemia Patients

Shannon Palmer, Ashley Chen, Taylor Dennison, Cameron Czech, Jessica Auten, Kaitlyn Buhlinger, Benyam Muluneh

Subject: Social Sciences, Behavior Sciences Keywords: patient activation; patient engagement, behavioral health change; self-administered therapy, oral oncolytic

Online: 28 June 2021 (15:32:14 CEST)

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Preprint REVIEW | doi:10.20944/preprints202007.0471.v1

Fecal Shedding of SARS-CoV-2 and Its Potential Role in Person-To-Person Transmission and the Environment-Based Spread of COVID-19

Davey Jones, Marcos Quintela Baluja, David Graham, Alexander Corbishley, James McDonald, Shelagh Malham, Luke Hillary, Thomas Connor, William Gaze, Ines Moura, Mark Wilcox, Kata Farkas

Subject: Biology And Life Sciences, Virology Keywords: bathing waters; coronavirus; environmental transmission; faecal-oral route; infection risk; waterborne illness

Online: 20 July 2020 (12:02:45 CEST)

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The recent detection of SARS-CoV-2 RNA in feces has led to speculation that it can be transmitted via the fecal-oral/ocular route. This review aims to critically evaluate the incidence of gastrointestinal (GI) symptoms, the quantity and infectivity of SARS-CoV-2 in feces and urine, and whether these pose an infection risk in sanitary settings, sewage networks, wastewater treatment plants, and the wider environment (e.g. rivers, lakes and marine waters). Overall, severe GI dysfunction is only evident in a small number of COVID-19 cases, with 11 ± 2% exhibiting diarrhea and 12 ± 3% exhibiting vomiting and nausea. In addition to these cases, SARS-CoV-2 RNA can be detected in feces from some asymptomatic, mildly- and pre-symptomatic individuals. Fecal shedding of the virus peaks in the symptomatic period and can persist for several weeks, but with declining abundances in the post-symptomatic phase. SARS-CoV-2 RNA is occasionally detected in urine, but reports in fecal samples are more frequent. The abundance of the virus genetic material in both urine (ca. 10²-10⁵ gc/ml) and feces (ca. 10²-10⁷ gc/ml) is much lower than in nasopharyngeal fluids (ca. 10⁵-10¹¹ gc/ml). There is strong evidence of multiplication of SARS-CoV-2 in the GI tract and infectious virus has occasionally been recovered from both urine and stool samples. The level and infectious capability of SARS-CoV-2 in vomit remain unknown. In comparison to enteric viruses transmitted via the fecal-oral route (e.g. norovirus, adenovirus), the likelihood of SARS-CoV-2 being transmitted via feces or urine appears lower due to the lower relative amounts of virus present in feces/urine. The biggest risk of transmission will occur in clinical and care home settings where secondary handling of people and urine/fecal matter occurs. In addition, while SARS-CoV-2 RNA genetic material can be detected by in wastewater, this signal is greatly reduced by conventional treatment. Our analysis also suggests the likelihood of infection due to contact with sewage-contaminated water (e.g. swimming, surfing, angling) or food (e.g. salads, shellfish) is extremely low or negligible based on very low predicted abundances and limited environmental survival of SARS-CoV-2. These conclusions are corroborated by the fact that over eight million global cases of COVID-19 have occurred, but exposure to feces or wastewater has never been implicated as a transmission vector.

Preprint ARTICLE | doi:10.20944/preprints202005.0445.v1

Oral Tumour Cell Migration and the Effect of the Local Soluble Factors from the Microenvironment on Signalling Pathways. Is It All about the Akt?

Hanan Ahmed, Arpa Ghoshal, Sarah Jones, Ian Ellis, Mohammad Islam

Subject: Medicine And Pharmacology, Oncology And Oncogenics Keywords: oral cancer; cancer-associated fibroblasts; metastasis; cell migration; cell invasion; Akt; EGFR

Online: 27 May 2020 (08:25:20 CEST)

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Preprint ARTICLE | doi:10.20944/preprints202005.0335.v1

Influence of Parents’ Oral Health Knowledge and Attitudes on Oral Health Practices of Children (5-12 Years) in a Rural School in KwaZulu Natal, South Africa: A Cross Sectional Survey

Prenisha Neupaul, Ozayr Mahomed

Subject: Medicine And Pharmacology, Dentistry And Oral Surgery Keywords: knowledge; attitude; practice; children’s oral health practice; school going children; rural area

Online: 21 May 2020 (04:01:10 CEST)

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Introduction: Oral health knowledge, beliefs and attitudes of parents have a direct influence on their child’s oral health maintenance, dietary habits and encourage healthy behaviors. The aim of this study was to assess the knowledge, and attitude of parents with regards to the oral health practice of their children and its associated factors. Methods: A self -administered structured questionnaire was administered to parents or guardians of learners aged 5 to 12 years at a low socio-economic rural primary school in the uGu district, KwaZulu Natal, South Africa to collect demographic variables, knowledge of dental health, use of toothbrush, use of toothpaste, dietary practices and dental visits; practice with respect to dental care and attitudes towards oral health. The questionnaire was translated from English to IsiZulu was used. Bivariate and multivariate logistic regressions were used to assess the association between parent’s sociodemographic factors with their oral health knowledge and practice scores. Results: One hundred and forty four completed survey instruments were received with an eighty percent (118) representation of mothers. Ninety five percent of the parents (136) had a positive attitude towards oral health with 86% (124) of the children brushed their tongue and 89% (128) of the children brushed their teeth happily. The mean knowledge score was 70% with a median of 72%. Children were significantly more likely to brush their tongues (AOR: 3.20 95% CI: 1.06-9.66) and were more likely to be happier when brushing their teeth (AOR: 4.65 95% CI: 1.41-15.38) when the caregivers were their mothers, and when parents had an above average knowledge score (AOR: 1.86 95% CI: 0.72-4.85) and had positive attitudes (AOR: 3.20 95%CI: 0.46-22.00). Conclusion: To reduce the gaps in knowledge, oral health promotion should be integrated into all point of care contact with parents at health facilities, increased community awareness and advertising campaigns as well as a more focused school health oral program that addresses primary prevention, screening and appropriate referrals to health facilities

Preprint ARTICLE | doi:10.20944/preprints202306.1239.v1

Resilient Localization and Coverage in the Internet of Things

Yaser Al Mtawa, Hossam S. Hassanein, Nidal Nasser

Subject: Computer Science And Mathematics, Computer Networks And Communications Keywords: Wireless Sensor Network; Internet of Things (IoT); IoT Deployment; Localization; Sensing Coverage; Reliable Services; Intra-triangle Coverage; Delaunay Triangulation

Online: 16 June 2023 (12:08:21 CEST)

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Preprint ARTICLE | doi:10.20944/preprints202212.0372.v1

Particulate Filler and Discontinuous Fiber Filler Resin Composite´S Adaptation and Bonding to Intra-Radicular Dentin

Marco Ferrari, Eugenia Lettieri, Denise Irene Karin Pontoriero, Pekka Vallittu, Edoardo Ferrari Cagidiaco

Subject: Medicine And Pharmacology, Dentistry And Oral Surgery Keywords: Fiber-reinforced composite post; Short-glass fiber reinforced composite; Endodontically-treated teeth; Intra-radicular adhesion; Push-out bond strength

Online: 21 December 2022 (02:08:24 CET)

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: This study was aimed at assessing adaptation and bonding of discontinuous (short) glass fiber-reinforced composite to intraradicular dentin EverX Flow (GC Corporation, Tokyo, Japan), when used as intracanal composite filling and anchorage instead of traditional fiber posts. (2) Methods: Seventy intact extracted human teeth were endodontically treated and randomly divided into 6 groups (n=10), depending on the materials used in the post space. In Group 1, a 2-bottle universal adhesive G2 Bond Universal + EverX Flow were tested. In group 2, a single-component universal adhesive G-Premio Bond + EverX Flow were used. In groups 3 and 4 the same materials are tested, but after cleaning of the canal walls with 17% EDTA and final irrigation with 5.25% NaOCl Ultrasound Activated. In the last three Groups (5-7) traditional prefabricated GC Fiber Posts 1.6 mm silanized with G-Multi Primer for 1 minute are cemented with a dual-cured composite resin cement (GradiaCore), after ultrasonic irrigation in the groups 6 and 7. In each group, 1 mm-thick slices from each sample (n=10) were cut for light microscope and SEM inspection for study materials adaption to the dentin and for measuring push-out strength of post / cemement material to the dentin / prefabricated post. These results were statistically analyzed: as the data distribution was not normal, the Kruskal-Wallis Analysis of Variance by Ranks had to be applied. The level of significance was set at p<0.05. Results: Push-out forces varied between 6.66-8.37 MPa. No statistically significant differences were recorded among the groups. Microscopic examination showed that ultrasonic irri-gation increased adaptation of the materials to the dentin surface. There was a trend of higher bond strength among the tested groups when EverX Flow was used. Also, the type of failure was more often cohesive when ultrasonic irrigation and two-step adhesive system were used. Conclusions: Within the limitations of this in vitro study, it may be concluded that when EverX Flow was used for intracanal anchorage in the post-endodontic recon-struction, similar push-out retentive forces and strength to those of traditional fiber posts cemented with particulate filler resin composite cements were achieved. Although further studies are necessary, EverX Flow represents an effective alternative to traditional fiber post adhesion in particular when used in combination with the two-step adhesive system and ultrasonic activation.

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