Version 1
: Received: 9 April 2024 / Approved: 10 April 2024 / Online: 11 April 2024 (04:02:09 CEST)
How to cite:
Chaudhari, Y.; Chaudhari, M.; Prasad, S. Preparation and Evaluation of Niosomal Formulation for Solubility Enhancement of Anti-fungal Agent for the Treatment of Oral Candidiasis. Preprints2024, 2024040735. https://doi.org/10.20944/preprints202404.0735.v1
Chaudhari, Y.; Chaudhari, M.; Prasad, S. Preparation and Evaluation of Niosomal Formulation for Solubility Enhancement of Anti-fungal Agent for the Treatment of Oral Candidiasis. Preprints 2024, 2024040735. https://doi.org/10.20944/preprints202404.0735.v1
Chaudhari, Y.; Chaudhari, M.; Prasad, S. Preparation and Evaluation of Niosomal Formulation for Solubility Enhancement of Anti-fungal Agent for the Treatment of Oral Candidiasis. Preprints2024, 2024040735. https://doi.org/10.20944/preprints202404.0735.v1
APA Style
Chaudhari, Y., Chaudhari, M., & Prasad, S. (2024). Preparation and Evaluation of Niosomal Formulation for Solubility Enhancement of Anti-fungal Agent for the Treatment of Oral Candidiasis. Preprints. https://doi.org/10.20944/preprints202404.0735.v1
Chicago/Turabian Style
Chaudhari, Y., Manisha Chaudhari and Shikha Prasad. 2024 "Preparation and Evaluation of Niosomal Formulation for Solubility Enhancement of Anti-fungal Agent for the Treatment of Oral Candidiasis" Preprints. https://doi.org/10.20944/preprints202404.0735.v1
Abstract
Human fungal pathogen Candida albicans causes oral infectious diseases such as oral thrush in immunocompromised patients with hyposalivation, diabetes mellitus, prolonged use of anti-biotics or immunosuppressive medicines and poor oral hygiene. An anti-fungal medication classified as a BCS class II drug, Clotrimazole has high permeability and low solubility in water. It is commercially available as lozenges, which do not uniformly distribute the drug within saliva for local therapy. This results in higher dose frequency and lower patient compliance. Therefore, in this study we proposed a niosomal based subgingival film formulation of clotrimazole for enhancing drug efficacy by improving drug solubilization capacity and improving patient compliance by prolonging the release of drug at the targeted site and reducing the dose frequency to show effective anti-fungal activity. The prepared niosomal film showed good entrapment efficiency and anti-fungal activity. Niosomal film showed better release pattern than drug loaded film.
Copyright:
This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
