Version 1
: Received: 10 December 2023 / Approved: 12 December 2023 / Online: 12 December 2023 (12:55:56 CET)
How to cite:
FERRARI, I.V. Assessing Antibiotic Safety: A Comparative Study of Four Promising Candidates Using pKCSM Database. Preprints2023, 2023120894. https://doi.org/10.20944/preprints202312.0894.v1
FERRARI, I.V. Assessing Antibiotic Safety: A Comparative Study of Four Promising Candidates Using pKCSM Database. Preprints 2023, 2023120894. https://doi.org/10.20944/preprints202312.0894.v1
FERRARI, I.V. Assessing Antibiotic Safety: A Comparative Study of Four Promising Candidates Using pKCSM Database. Preprints2023, 2023120894. https://doi.org/10.20944/preprints202312.0894.v1
APA Style
FERRARI, I.V. (2023). <strong>Assessing Antibiotic Safety: A Comparative Study of Four Promising Candidates Using pKCSM Database</strong>. Preprints. https://doi.org/10.20944/preprints202312.0894.v1
Chicago/Turabian Style
FERRARI, I.V. 2023 "<strong>Assessing Antibiotic Safety: A Comparative Study of Four Promising Candidates Using pKCSM Database</strong>" Preprints. https://doi.org/10.20944/preprints202312.0894.v1
Abstract
This study centered on examining 60 different antibiotics by assessing their primary toxicity parameters through thepkCSM database. The parameters included Max. Tolerated Dose (Human) (log mg/kg/day), Oral Rat Acute Toxicity (LD50) (mol/kg), Oral Rat Chronic Toxicity (LOAEL) (log mg/kg_bw/day), and Minnow Toxicity (LC50) (log mM). The results highlight four potential antibiotics—cefotaxime, ceftriaxone, imipenem, and meropenem—that exhibited lower toxicity effects compared to other compounds. These findings imply a relatively favorable safety profile for these antibiotics concerning the specified toxicity parameters. However, it is crucial to interpret these outcomes within the context of the specific clinical application and to consider additional factors for a comprehensive safety assessment.It's essential to acknowledge that evaluating toxicity is intricate, and the determination of what is considered "less toxic" can rely on specific criteria and the context of use. Furthermore, individual responses to antibiotics may vary, and the selection of an antibiotic should be based on diverse factors, including the specific infection being treated, the patient's health, and potential side effects.
Keywords
Antibiotics,pkCSM, Max.tolerated dose (human),Oral Rat Chronic Toxicity,Oral Rat Acute Toxicity
Subject
Medicine and Pharmacology, Pharmacology and Toxicology
Copyright:
This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
