Preprint Article Version 1 Preserved in Portico This version is not peer-reviewed

Simultaneous Motor and Visual Intraoperative Neuromonitoring in Asleep Parietal Lobe Surgery: Dual Strip Technique

Version 1 : Received: 12 August 2022 / Approved: 17 August 2022 / Online: 17 August 2022 (05:08:09 CEST)

A peer-reviewed article of this Preprint also exists.

Rajashekar, D.; Lavrador, J.P.; Ghimire, P.; Keeble, H.; Harris, L.; Pereira, N.; Patel, S.; Beyh, A.; Gullan, R.; Ashkan, K.; Bhangoo, R.; Vergani, F. Simultaneous Motor and Visual Intraoperative Neuromonitoring in Asleep Parietal Lobe Surgery: Dual Strip Technique. J. Pers. Med. 2022, 12, 1478. Rajashekar, D.; Lavrador, J.P.; Ghimire, P.; Keeble, H.; Harris, L.; Pereira, N.; Patel, S.; Beyh, A.; Gullan, R.; Ashkan, K.; Bhangoo, R.; Vergani, F. Simultaneous Motor and Visual Intraoperative Neuromonitoring in Asleep Parietal Lobe Surgery: Dual Strip Technique. J. Pers. Med. 2022, 12, 1478.

Journal reference: J. Pers. Med. 2022, 12, 1478
DOI: 10.3390/jpm12091478

Abstract

Background: The role played by the non-dominant parietal lobe in motor cognition, attention and spatial awareness networks has potentiated the use of awake surgery. When this is not feasible, asleep monitoring and mapping techniques should be used to achieve an onco-functional balance. Objective: This study aims to assess the feasibility of a dual-strip method to obtain direct cortical stimulation for continuous real-time cortical monitoring and subcortical mapping of motor and visual pathways simultaneously in parietal lobe tumour surgery. Methods: Single-centre prospective study between May’19-November’20 of patients with intrinsic non-dominant parietal-lobe tumours. Two subdural strips were used to simultaneously map and monitor motor and visual pathways. Results: Fifteen patients were included. With regards to motor function, a large proportion of patients had abnormal interhemispheric resting motor threshold ratio (iRMTr) (71.4%), abnormal Cortical Excitability Score (CES) (85.7%), close distance to the corticospinal tract – Lesion-To-Tract Distance (LTD) – 4.2mm, Cavity-To-Tract Distance (CTD) – 7mm and intraoperative subcortical distance - 6.4mm. Concerning visual function, the LTD and CTD for optic radiations (OR) were 0.5mm and 3.4mm, respectively; the mean intensity for positive subcortical stimulation of OR was 12mA±2.3mA and 5/6 patients with deterioration of VEPs>50% had persistent hemianopia and transgression of ORs. 12 patients remained stable, one patient had a de-novo transitory hemiparesis, and two showed improvements in motor symptoms. A higher iRMTr for lower limbs was related with a worse motor outcome (p=0.013) and a longer CTD to OR was directly related with a better visual outcome (p=0.041). At 2 weeks after hospital discharge, all patients were ambulatory at home and all proceeded to have oncological treatment. Conclusion: We propose motor and visual function boundaries for asleep surgery of intrinsic non-dominant parietal tumours. Pre-operative abnormal cortical excitability of the motor cortex, deterioration of the VEP recordings and CTD<2mm from the OR were related to poorer outcomes.

Keywords

corticospinal tract; optic radiations; tractography; transcranial magnetic stimulation; subdural strip electrodes; intra-operative neuro-monitoring; parietal lobe

Subject

MEDICINE & PHARMACOLOGY, Oncology & Oncogenics

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