Version 1
: Received: 6 October 2020 / Approved: 7 October 2020 / Online: 7 October 2020 (08:26:14 CEST)
How to cite:
Botelho, J.; Machado, V.; Mendes, J.J.; Mascarenhas, P. Causal Association between Periodontitis and Parkinson's Disease: A Bidirectional Mendelian Randomization Study. Preprints2020, 2020100145. https://doi.org/10.20944/preprints202010.0145.v1
Botelho, J.; Machado, V.; Mendes, J.J.; Mascarenhas, P. Causal Association between Periodontitis and Parkinson's Disease: A Bidirectional Mendelian Randomization Study. Preprints 2020, 2020100145. https://doi.org/10.20944/preprints202010.0145.v1
Botelho, J.; Machado, V.; Mendes, J.J.; Mascarenhas, P. Causal Association between Periodontitis and Parkinson's Disease: A Bidirectional Mendelian Randomization Study. Preprints2020, 2020100145. https://doi.org/10.20944/preprints202010.0145.v1
APA Style
Botelho, J., Machado, V., Mendes, J.J., & Mascarenhas, P. (2020). Causal Association between Periodontitis and Parkinson's Disease: A Bidirectional Mendelian Randomization Study. Preprints. https://doi.org/10.20944/preprints202010.0145.v1
Chicago/Turabian Style
Botelho, J., José João Mendes and Paulo Mascarenhas. 2020 "Causal Association between Periodontitis and Parkinson's Disease: A Bidirectional Mendelian Randomization Study" Preprints. https://doi.org/10.20944/preprints202010.0145.v1
Abstract
Latest evidence revealed a possible association between Parkinson’s disease (PD) and periodontitis. We explored the causal relationship of this association through two-sample Mendelian randomization (MR) in European ancestry populations. To this end, we used openly accessible data of genome-wide association studies (GWAS) on PD and periodontitis. As instrumental variables for periodontitis, seventeen single-nucleotide polymorphisms (SNPs) from a GWAS of periodontitis (1817 periodontitis cases vs. 2215 controls) and forty-five SNPs from a GWAS of PD (20,184 cases and 397,324 controls). Eight non-overlapping SNPs of periodontitis from an additional GWAS assisted in the validation of association being studied. Multiple approaches of MR were carried-out. There was no evidence of genetic liability of periodontitis being associated with a higher risk of PD (B= -0.0003, Standard Error [SE] 0.0003, P = 0.26). The eight independent SNPs (B= -0.0000, SE 0.0001, P = 0.99) validated this outcome. We found no association of genetically primed PD towards periodontitis (B= -0.0001, SE 0.0001, P = 0.19). This MR study found no conclusive evidence to support a bidirectional causal genetic liability between PD and periodontitis. Further GWAS studies are needed to confirm the consistency of these results.
Keywords
Parkinson’s disease; Periodontitis; Periodontal disease; Mendelian Randomization; Bioinformatics; Oral Health
Subject
Medicine and Pharmacology, Immunology and Allergy
Copyright:
This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
