Prevention Is Better Than Care. Clinical and Economic Implications of Oral Antiviral Agents in COVID 19: A Prospective Study

How to cite: Pietrantonio, F.; Rosiello, F.; Ruggeri, M.; Materazzo, M.; La Fazia, V.M.; Pierucci, N.; Iodice, R.; Granvillano, G.; Cicerchia, L.M.; Maurici, M.; Delli castelli, M.; Vinci, F.; Ciamei, A.; Sabato, M.; Sparta, A.; Acco, D.; Fortunato, L.; Cattaruzza, M.S.; Vinci, A.; Lordi, M.; Cipriano, E. Prevention Is Better Than Care. Clinical and Economic Implications of Oral Antiviral Agents in COVID 19: A Prospective Study. Preprints 2023, 2023080948. https://doi.org/10.20944/preprints202308.0948.v1 Pietrantonio, F.; Rosiello, F.; Ruggeri, M.; Materazzo, M.; La Fazia, V.M.; Pierucci, N.; Iodice, R.; Granvillano, G.; Cicerchia, L.M.; Maurici, M.; Delli castelli, M.; Vinci, F.; Ciamei, A.; Sabato, M.; Sparta, A.; Acco, D.; Fortunato, L.; Cattaruzza, M.S.; Vinci, A.; Lordi, M.; Cipriano, E. Prevention Is Better Than Care. Clinical and Economic Implications of Oral Antiviral Agents in COVID 19: A Prospective Study. Preprints 2023, 2023080948. https://doi.org/10.20944/preprints202308.0948.v1

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MDPI and ACS Style

Pietrantonio, F.; Rosiello, F.; Ruggeri, M.; Materazzo, M.; La Fazia, V.M.; Pierucci, N.; Iodice, R.; Granvillano, G.; Cicerchia, L.M.; Maurici, M.; Delli castelli, M.; Vinci, F.; Ciamei, A.; Sabato, M.; Sparta, A.; Acco, D.; Fortunato, L.; Cattaruzza, M.S.; Vinci, A.; Lordi, M.; Cipriano, E. Prevention Is Better Than Care. Clinical and Economic Implications of Oral Antiviral Agents in COVID 19: A Prospective Study. Preprints 2023, 2023080948. https://doi.org/10.20944/preprints202308.0948.v1

APA Style

Pietrantonio, F., Rosiello, F., Ruggeri, M., Materazzo, M., La Fazia, V.M., Pierucci, N., Iodice, R., Granvillano, G., Cicerchia, L.M., Maurici, M., Delli castelli, M., Vinci, F., Ciamei, A., Sabato, M., Sparta, A., Acco, D., Fortunato, L., Cattaruzza, M.S., Vinci, A., Lordi, M., & Cipriano, E. (2023). Prevention Is Better Than Care. Clinical and Economic Implications of Oral Antiviral Agents in COVID 19: A Prospective Study. Preprints. https://doi.org/10.20944/preprints202308.0948.v1

Chicago/Turabian Style

Pietrantonio, F., M. Lordi and Enrica Cipriano. 2023 "Prevention Is Better Than Care. Clinical and Economic Implications of Oral Antiviral Agents in COVID 19: A Prospective Study" Preprints. https://doi.org/10.20944/preprints202308.0948.v1

Abstract

Background: COVID-19 represents a threat for frailty patients. Objective: Investigate efficacy, safety and economic value of treatment with Molnupiravir in a cohort of fragile patients affected by COVID-19. Methods: Observational, prospective study. The data collected allowed to assess efficacy and safety of Molnupiravir in real life, compare the results with a subgroup of patients treated with Nirmatrelvir-Ritonavir and to effect a cost-effectiveness analysis. Results: In January-December 2022, 435 patients (225 males, 220 females; median age 72 years), were enrolled; 24 patients were unvaccinated, 280 patients had ≥2 risk factors. Molnupiravir appeared to give better results than the SOC both clinically and economically. In these patients in comparison with literature data or SOC, hospitalization was 2.5% vs 6.8% (p<0.005), overall adverse effects 14,3% vs 30.4% (p<0.0001), severe adverse effects 2.6 vs 6.9% (p<0.001), thus involving a potential total savings of about € 92.954 per patient (8% of standard of care cost). Conclusions: early Molnupiravir treatment helped fragile patients who partially responded to vaccine, or with absolute contraindications to vaccination, to overcome COVID-19 without the need of hospitalization. Molnupiravir represents a clinical and economic effective treatment, avoiding disease progression in old patients suffering from multiple pathologies and taking several drugs.

Keywords

Molnupiravir; SARS-CoV-2; COVID-19; Nirmatrelvir; oral antiviral

Subject

Medicine and Pharmacology, Internal Medicine

Copyright: This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

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